D20 + Schoolbag: Rerolled pickups have a chance to reroll into an item from the current room's item pool.
Keeper's Sack: Stat upgrades from the spawned pickups/items can be gained even when shops become unavailable (Floors after the Mom fight excluding ???).
Restock: Buying spawned pickups in the Shop will always respawn them as items and their prices will never increase. This does not work outside of the shop. It also works in Greed and Greedier modes, although it will respawn them as (random) pickups.
Steam Sale: Spawned pickups/items will be on sale.
Interactions[ | ]
Adoption Papers: Does not affect Keeper's Box' items, meaning both familiars and shop items can be purchased in tandem over the course of a run.