Binding of Isaac: Rebirth Wiki

Added in Repentance

Keeper's Box is an unlockable activated item added in The Binding of Isaac: Repentance.


  • Spawns a random pickup or item, which must be bought for its normal Shop Shop price.


  • The items spawned by the box are affected by Steam Sale Steam Sale and can be made free by Coupon Coupon.
  • All items and pickups spawned by the Keeper's Box can be rerolled by a Dice Room Dice Room number 3 as if they were consumables.
  • Keeper's Box can spawn hearts when used as Keeper Keeper or Tainted Keeper Tainted Keeper, unlike normal shops. They cannot be purchased by these characters, however.


  • Stat upgrades from the items spawned can be gained using Keeper's Sack Keeper's Sack even when shops become unavailable (Floors after the Mom Mom fight excluding ??? ???)
  • Book of Virtues Book of Virtues: Spawns glowing coin wisps on the middle ring. Enemies killed by the wisps' tears have a 20% chance to drop a Penny Penny.


  • Adoption Papers Adoption Papers: Does not affect Keeper's Box' items, meaning both familiars and shop items can be purchased in tandem over the course of a run.
  • Chaos Chaos / Sacred Orb Sacred Orb / TMTRAINER TMTRAINER: Affects items spawned by the box.
  • A Pound of Flesh A Pound of Flesh: Items spawned by Keeper's Box are purchased with red heart containers and pickups are purchased with health, just like a regular shop item.
  • Store Credit Store Credit: Cannot be used on consumables or items spawned by Keeper's Box.

In-game footage[]


  • Keeper's Box has a similar shape to Pandora's Box Pandora's Box, along with a keyhole in the same position.
  • This item is similar to Portable Slot Portable Slot, and the pickup quote (Portable shop) may be a reference to it.