Items with this tag are familiars which are unique and cannot be duplicated by Box of Friends, and Soul of Lilith can grant them only once. Note that this does not prevent getting multiple copies of the items through duplication effects such as Diplopia.
Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released.
Spawns a glass familiar that spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the current room. After the milk spills, Isaac's fire rate is increased by 1 for the current room.