Item Tags uniquefamiliar

Items with this tag are familiars which are unique and cannot be duplicated by Box of Friends, and Soul of Lilith can grant them only once. Note that this does not prevent getting multiple copies of the items through duplication effects such as Diplopia.

Activated Collectibles[]

Name	ID	Icon	Quote	Description	Quality
Stitches	5.100.635		Bait and switch	Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar.	1

Passive Collectibles[]

Name	ID	Quote	Description	Quality
Dead Cat	5.100.81	9 lives	Sets Isaac's Red Heart containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container.	3
Isaac's Heart	5.100.276	Protect it	Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released.	0
Key Piece 1	5.100.238	???	Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.	0
Key Piece 2	5.100.239	???	Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.	0
Milk!	5.100.436	Don't cry over it...	Spawns a glass familiar that spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the current room.	1
Blood Oath	5.100.569	Bleed me dry	Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained.	2
Knife Piece 1	5.100.626	???	Combined with Knife Piece 2, creates a knife familiar that damages enemies and can open the door to the Corpse.	0
Knife Piece 2	5.100.627	???	Combined with Knife Piece 1, creates a knife familiar that damages enemies and can open the door to the Corpse.	0
Paschal Candle	5.100.567	Keep the flame burning	Gives Isaac a familiar that grants +0.4 Tears for each consecutive room he's cleared without taking damage. The bonus stacks up to five times.	3
Vanishing Twin	5.100.697	He wants revenge	Spawns a familiar that becomes a clone of the floor's boss when entering the boss room. Defeating it drops an extra item.	3