Binding of Isaac: Rebirth Wiki
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Added in Repentance

Items with this tag are familiars which are unique and cannot be duplicated by Box of Friends Box of Friends, and Soul of Lilith Soul of Lilith can grant them only once. Note that this does not prevent getting multiple copies of the items through duplication effects such as Diplopia Diplopia.


Activated Collectibles[]

Name ID Icon Quote Description Quality
Stitches 5.100.635
Stitches
3 seconds
Bait and switch Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar. 1

Passive Collectibles[]

Name ID Icon Quote Description Quality
Dead Cat 5.100.81 Dead Cat 9 lives Sets Isaac's Red Heart containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container. 3
Isaac's Heart 5.100.276 Isaac's Heart Protect it Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. Added in Repentance The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released. 0
Key Piece 1 5.100.238 Key Piece 1 ??? Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan. 0
Key Piece 2 5.100.239 Key Piece 2 ??? Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan. 0
Milk! 5.100.436 Milk! Don't cry over it... Spawns a glass familiar that spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the current room. 1
Blood Oath 5.100.569 Blood Oath Bleed me dry Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained. 2
Knife Piece 1 5.100.626 Knife Piece 1 ??? Combined with Knife Piece 2 Knife Piece 2, creates a knife familiar that damages enemies and can open the door to the Corpse Corpse. 0
Knife Piece 2 5.100.627 Knife Piece 2 ??? Combined with Knife Piece 1 Knife Piece 1, creates a knife familiar that damages enemies and can open the door to the Corpse Corpse. 0
Paschal Candle 5.100.567 Paschal Candle Keep the flame burning Gives Isaac a familiar that grants +0.4 Tears for each consecutive room he's cleared without taking damage. The bonus stacks up to five times. 3
Vanishing Twin 5.100.697 Vanishing Twin He wants revenge Spawns a familiar that becomes a clone of the floor's boss when entering the boss room. Defeating it drops an extra item. 3


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