Binding of Isaac: Rebirth Wiki
Added in Repentance

Items with this tag can be spawned as wisps by Lemegeton Lemegeton and copied by Modeling Clay Modeling Clay .

Passive Collectibles[]

Name ID Icon Quote Description Quality
???'s Only Friend 5.100.320 ???'s Only Friend Controlled friend Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys 2
20/20 5.100.245 20/20 Double shot Isaac fires two tears at once, one from each eye.
Added in Repentance 0.75x damage multiplier.
3 Dollar Bill 5.100.191 3 Dollar Bill Rainbow tears Removed in Afterbirth Gives Isaac a random tear effect every room.
Added in Afterbirth Gives Isaac a random tear effect every few seconds.
9 Volt 5.100.116 9 Volt Quicker charge Reduces the charge of any activated item by 1. Any 1 charge items instead have timed recharges. 2
A Lump of Coal 5.100.132 A Lump of Coal My Xmas present The more distance tears travel, the more damage they will do. 3
Abaddon 5.100.230 Abaddon Evil + DMG up + fear shot Removed in Repentance +1.5 damage, +0.2 speed. Removes all Red Heart containers, grants six Black Hearts, and adds a chance to shoot fear tears.
Added in Repentance +1.5 damage, +0.2 speed. Grants two Black Hearts, converts all Red Heart Containers into Black Hearts, and adds a chance to shoot fear tears.
Abel 5.100.188 Abel Mirrored buddy Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction. 0
Anemic 5.100.214 Anemic Toxic blood Removed in Repentance +5 Added in Repentance +1.5 range. After Isaac is damaged, a trail of red creep will be left behind him until he leaves the current room. 1
Anti-Gravity 5.100.222 Anti-Gravity Anti-gravity tears + tears up -2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in. 2
Aquarius 5.100.308 Aquarius Trail of tears A trail of blue creep is left behind Isaac, which damages enemies. Added in Repentance The creep inherits most of Isaac's tear effects, like homing, etc. 1
Aries 5.100.300 Aries Ramming speed +0.25 Speed. Running into enemies while at a high speed will deal damage. Added in Repentance Prevents Isaac from taking contact damage while moving at high speed. 2
Ball of Bandages 5.100.207 Ball of Bandages Gotta lick 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
Ball of Tar 5.100.231 Ball of Tar Sticky feet... Adds a chance to shoot slowing tears. Isaac leaves a trail of slowing creep behind as he moves, impeding enemies' speed. 2
BBF 5.100.272 BBF Big Beautiful Fly Spawns a familiar that flies around the room in a zig-zag pattern and explodes on contact with an enemy. Respawns after ten seconds. 1
Best Bud 5.100.274 Best Bud Sworn protector When hit, spawns a quickly orbiting attack fly similar to Forever Alone Forever Alone for the current room that deals high damage. 0
BFFS! 5.100.247 BFFS! Your friends rule! Increases the size and effectiveness of most familiars. 2
Big Fan 5.100.279 Big Fan Fat protector Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies. 2
Black Candle 5.100.260 Black Candle Curse immunity + evil up Prevents curses. Grants one Black Heart. Increases the chance for a Devil or Angel Room to appear. 3
Blood Clot 5.100.254 Blood Clot DMG + range up Tears fired from the left eye have +1 flat damage, +5 range, and +0.5 tear height. 2
Blood of the Martyr 5.100.7 Blood of the Martyr DMG up Increases damage by 1, and turns Isaac's tears into blood tears. 3
Bloody Lust 5.100.157 Bloody Lust RAGE! Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor. 3
Blue Cap 5.100.342 Blue Cap HP + tears up + shot speed down Gives one full Red Heart container, +0.7 tears, and -0.16 shot speed. Added in Repentance Heals 2 additional hearts of health. 3
Blue Map 5.100.246 Blue Map Secrets Reveals the locations of Secret Room Secret Rooms and Super Secret Room Super Secret Rooms on the map. 2
Bob's Brain 5.100.273 Bob's Brain Explosive thoughts Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. 1
Bob's Curse 5.100.140 Bob's Curse +5 poison bombs Gives 5 bombs and grants Isaac's bombs a poison effect. Added in Repentance Gives Isaac immunity to poison. 1
Bobby-Bomb 5.100.125 Bobby-Bomb Homing bombs! +5 bombs. Bombs gain a homing effect, slowly moving towards the nearest enemy. 2
Bogo Bombs 5.100.250 Bogo Bombs 1+1 BOOM! All normal Bomb Bombs become Double Bomb Double Bombs. 1
Bomb Bag 5.100.131 Bomb Bag Gives bombs Spawns a familiar that drops a Bomb Bomb every 3 rooms. 2
Brimstone 5.100.118 Brimstone Blood laser barrage Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period. 4
Broken Watch 5.100.337 Broken Watch I think it's broken Chance upon entering a room to slow down or speed up every enemy and their attacks. The chance to slow enemies is quite higher than the chance to speed them up. 1
Brother Bobby 5.100.8 Brother Bobby Friends 'till the end A familiar that follows Isaac around shooting normal tears. 1
Bum Friend 5.100.144 Bum Friend He's greedy Spawns a familiar that picks up Error: The given entity ("coin") does not exist.s for himself, giving random pickups in return. Does not spawn collectibles. 0
Butt Bombs 5.100.209 Butt Bombs Toxic blast +5 bombs +5 bombs. Bombs now cloud up the screen, briefly damaging and confusing all enemies. 2
Caffeine Pill 5.100.340 Caffeine Pill Speed up + size down Grants +0.3 speed, reduces character size, and gives a random pill. 1
Cain's Other Eye 5.100.319 Cain's Other Eye Near-sighted friend Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper The Peeper and shoots normal tears in the same direction as Isaac. 0
Cancer 5.100.301 Cancer HP up + you feel protected Adds 3 Soul Hearts. Grants The Wafer The Wafer effect for the current room after taking damage. 3
Capricorn 5.100.307 Capricorn All stats up Removed in Repentance Adds 1 Red Heart Container, gives +0.5 Damage, +0.1 Speed, +1.5 Range, and -1.0 Tear Delay, and gives 1 Bomb, Coin, and Key.
Added in Repentance Adds 1 Red Heart Container, gives +0.5 Damage, +0.1 Speed, +0.75 Range, and -1.0 Tear Delay, and gives 1 Bomb, Coin, and Key.
Cat-O-Nine-Tails 5.100.165 Cat-O-Nine-Tails Shot speed + damage up +1 damage, +0.23 shot speed. 3
Celtic Cross 5.100.162 Celtic Cross Blessing of protection Grants a chance to trigger the Book of Shadows Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds. 1
Ceremonial Robes 5.100.216 Ceremonial Robes DMG + evil up Grants 3 Black Heart Black Hearts, and +1 damage. 3
Champion Belt 5.100.208 Champion Belt DMG + challenge up Increases damage, but also increases the chance of champion enemies appearing. 3
Charm of the Vampire 5.100.62 Charm of the Vampire Kills heal Heals Isaac for a Half Red Heart Half Red Heart for every 13 enemies killed. Added in Repentance +0.3 damage. 1
Chemical Peel 5.100.154 Chemical Peel DMG up Tears fired from the left eye have +2 flat damage. 2
Chocolate Milk 5.100.69 Chocolate Milk Charge shots Grants charged tears that deal greater damage when fully charged. 3
Contract From Below 5.100.241 Contract From Below Wealth... but at what cost? Doubles the number of most room clear awards, but reduces the overall chance of getting one by 1/3. 3
Cricket's Body 5.100.224 Cricket's Body Bursting shots + tears up Grants -1 tear delay and reduces range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose range and damage scale with Isaac's. 3
Cricket's Head 5.100.4 Cricket's Head DMG up Increases Damage by 0.5, and increases damage multiplier by x1.5. 4
Cube of Meat 5.100.73 Cube of Meat Gotta meat 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
Cupid's Arrow 5.100.48 Cupid's Arrow Piercing shots Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them. 3
Cursed Eye 5.100.316 Cursed Eye Cursed charge shot Grants charged tears that can be fired in a tight burst. Getting hit while charging will teleport Isaac to another room. 0
Daddy Longlegs 5.100.170 Daddy Longlegs Daddy's love Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total. 3
Dark Bum 5.100.278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects Red Hearts. For every 1½ Red Hearts collected, Dark Bum will give a reward. 3
Dark Matter 5.100.259 Dark Matter DMG up + fear shot +1 damage, adds a chance to shoot fear tears. 3
Dead Bird 5.100.117 Dead Bird Protective buddy After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~5 damage per second. 0
Dead Dove 5.100.185 Dead Dove Flight + spectral tears Grants spectral tears and flight. 3
Dead Onion 5.100.336 Dead Onion Toxic aura tears Grants piercing and spectral tears. Increases tear size (without increasing damage) while greatly reducing range and shot speed. 3
Death's Touch 5.100.237 Death's Touch Piercing shots + DMG up +1.5 damage, -0.3 tears. Tears are replaced with large piercing scythes. 3
Demon Baby 5.100.113 Demon Baby Auto-turret friend Spawns a familiar that follows Isaac and automatically fires at enemies in its reach. 2
Distant Admiration 5.100.57 Distant Admiration Attack fly Spawns an attack fly that circles further out than 15►Halo of Flies Halo of Flies, but closer than 15►Forever Alone Forever Alone, dealing 75 damage per second. 2
Dr. Fetus 5.100.52 Dr. Fetus ??? Tears are replaced by bombs that benefit from bomb-enhancing effects and slide for a fixed time after being fired. 4
Dry Baby 5.100.265 Dry Baby Immortal friend Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon The Necronomicon effect. 3
E. Coli 5.100.236 E. Coli Turdy touch Enemies that touch Isaac are transformed into poop. 1
Epic Fetus 5.100.168 Epic Fetus On-demand air strike Isaac's tears are replaced with guided missiles, like those used by the Doctor's Remote Doctor's Remote. 4
Eve's Mascara 5.100.310 Eve's Mascara DMG up, tears + shot speed down Doubles damage, halves tears stat, and greatly reduces shot speed. 2
Experimental Treatment 5.100.240 Experimental Treatment Some stats up, some stats down Removed in Afterbirth † Randomly increases and decreases some of Isaac's stats.
Added in Afterbirth † Increases four random stats and decreases the other two.
Fanny Pack 5.100.204 Fanny Pack Filled with goodies Has a chance to drop a random pickup when Isaac takes damage. 1
Fate 5.100.179 Fate Flight eternal Grants flight and one Eternal Heart Eternal Heart. 3
Fire Mind 5.100.257 Fire Mind Flaming tears Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion. 2
Forever Alone 5.100.128 Forever Alone Attack fly Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second. 1
Gemini 5.100.318 Gemini Conjoined friend Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~8 damage per second. 1
Ghost Baby 5.100.163 Ghost Baby Spectral buddy Spawns a familiar that follows Isaac around and fires spectral tears. 1
Gimpy 5.100.225 Gimpy Sweet suffering Gives chance of spawning a Soul Heart Soul Heart when taking damage. Enemies have a chance to drop a Half Red Heart Half Red Heart after being killed. 2
Gnawed Leaf 5.100.210 Gnawed Leaf Unbreakable After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots. 1
Goat Head 5.100.215 Goat Head He accepts your offering A Devil Room Devil Room / Angel Room Angel Room will always spawn after every boss fight, excluding the first floor and floors after Chapter 4. 3
Godhead 5.100.331 Godhead God tears Removed in Repentance Grants homing tears with a damaging halo. +0.5 Damage, -0.3 Tears -0.3 Shot Speed, +0.8 Tear Height, and +1.2 Range.
Added in Repentance Grants homing tears with a damaging halo. +0.5 Damage, -0.3 Tears -0.3 Shot Speed, and +0.8 Tear Height.
Growth Hormones 5.100.70 Growth Hormones Speed + DMG up Removed in Repentance +1 damage, +0.4 speed.
Added in Repentance +1 damage, +0.2 speed.
Guardian Angel 5.100.112 Guardian Angel Extra protection Spawns an orbital familiar that blocks enemy shots, deals 105 damage per second to enemies, and increases the speed of all orbital familiars. 2
Guillotine 5.100.206 Guillotine DMG + tears up. An out-of-body experience! Isaac's head is removed from his body and floats around him as an orbital. Gives +1 damage and grants -1 tear delay. 2
Guppy's Hair Ball 5.100.187 Guppy's Hair Ball Swing it Spawns a familiar that loosely follows behind Isaac, which blocks shots can be swung like a flail to damage enemies. Grows bigger by killing enemies. 1
Guppy's Tail 5.100.134 Guppy's Tail Cursed? Room Clear Awards have a 1/3 chance of being replaced with a Chest and a 1/3 chance being replaced with nothing. 2
Habit 5.100.156 Habit Item martyr When Isaac is hit, his active item gains 1 room's worth of charge. 2
Halo of Flies 5.100.10 Halo of Flies Projectile protection Spawns two Pretty Flies that block enemy shots and deal contact damage to flies. 2
Harlequin Baby 5.100.167 Harlequin Baby Double shot buddy Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern. 1
Headless Baby 5.100.269 Headless Baby Bloody friend Spawns a familiar that follows Isaac, leaving blood creep on the ground. 1
Hive Mind 5.100.248 Hive Mind Giant spiders and flies Increases the size of Blue Spiders and Blue Flies and doubles the amount of damage they deal. Added in Repentance Also increases the effectiveness of fly and spider familiars. 2
Holy Grail 5.100.184 Holy Grail Flight + HP up Grants flight and one Red Heart container. 3
Holy Mantle 5.100.313 Holy Mantle Holy shield Grants a shield that negates the first instance of damage taken, once per room. Does not apply to or negate self-damage (Blood Donation Machine.png Blood Donation Machines, etc). 4
Holy Water 5.100.178 Holy Water Splash! Removed in Repentance Spawns a bottle familiar that breaks when Isaac takes damage, leaving a puddle of blue creep.
Added in Repentance A bottle familiar that flies forward when Isaac shoots. It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies.
Hot Bombs 5.100.256 Hot Bombs Burning blast +5 bombs Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact. 1
Humbling Bundle 5.100.203 Humbling Bundle 1+1 free 4Evar Transforms Bomb Bombs, Key Keys, Penny Pennies, and Red Heart Red Hearts into their respective Double versions. Added in Repentance This will occur only 50% of the time. 3
Infamy 5.100.242 Infamy Blocks damage... sometimes Chance to block projectiles coming from any direction. 2
Infestation 5.100.148 Infestation Fly revenge Removed in Repentance 1-3 Blue Flies randomly spawn every time Isaac gets hit.
Added in Repentance 2-6 Blue Flies randomly spawn every time Isaac gets hit.
Infestation 2 5.100.234 Infestation 2 Infestation shot Spawns allied Blue Spiders from killed enemies. 4
Ipecac 5.100.149 Ipecac Explosive shots Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth. 4
Iron Bar 5.100.201 Iron Bar DMG up + concussive tears Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly. 2
Isaac's Heart 5.100.276 Isaac's Heart Protect it Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. Added in Repentance The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released. 0
Jesus Juice 5.100.197 Jesus Juice Damage + range up +0.5 damage, +0.25 range, +0.5 tear height. 2
Juicy Sack 5.100.266 Juicy Sack Sticky babies Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. 2
Latch Key 5.100.343 Latch Key Luck up Grants 1 Soul Heart and +1 luck. Spawns 2 Keys. 2
Leech 5.100.270 Leech Blood sucker Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a Half Red Heart whenever Leech kills an enemy. 1
Leo 5.100.302 Leo Stompy Isaac can destroy rocks by walking into them. 1
Libra 5.100.304 Libra You feel balanced Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes. 1
Lil Brimstone 5.100.275 Lil Brimstone Evil friend Grants a familiar that charges a thin Brimstone Brimstone laser while Isaac is shooting. 3
Lil Haunt 5.100.277 Lil Haunt Fear him Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear. 1
Little Baggy 5.100.252 Little Baggy Extra pill room Isaac can hold 2 pills at once and all cards and runes are replaced by pills. 1
Little C.H.A.D. 5.100.96 Little C.H.A.D. Gives kisses Spawns a familiar who drops a Half Red Heart Half Red Heart every 3 rooms. 2
Little Chubby 5.100.88 Little Chubby Attack buddy Spawns a charger familiar that charges forward and deals contact damage to any enemies in its path. 1
Little Gish 5.100.99 Little Gish Sticky friend Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed. 2
Little Steven 5.100.100 Little Steven Psychic friend Spawns a familiar who follows Isaac around and fires homing tears. 1
Loki's Horns 5.100.87 Loki's Horns Cross tears Gives a random chance for projectiles to fire in all 4 cardinal directions. 1
Lord of the Pit 5.100.82 Lord of the Pit Demon wings Grants flight and +0.3 speed. 3
Lost Contact 5.100.213 Lost Contact Shielded tears Isaac's tears can hit and destroy enemy projectiles. -0.16 shot speed. 2
Lucky Foot 5.100.46 Lucky Foot Luck up +1 luck. Increases chance of winning Shell Games and Fortune Tellers (independent from the luck stat).
Added in Repentance Converts all bad pills into good pills, without identifying them.
Maggy's Bow 5.100.312 Maggy's Bow HP up + you feel healthy Gives one Red Heart Container and doubles the healing provided by Red Heart Red Hearts. Added in Repentance Also heals 1 Red Heart when obtained. 2
Magic 8 Ball 5.100.194 Magic 8 Ball Shot speed up +0.16 shot speed, spawns a random tarot card. Added in Repentance Increases the chance of finding a Planetarium. 1
Magic Mushroom 5.100.12 Magic Mushroom All stats up! Makes Isaac bigger. Adds one Red Heart Container, +0.3 Damage, x1.5 damage multiplier, Removed in Repentance +5.25 / Added in Repentance +1.5 Range, and +0.3 Speed, and restores all Health. 4
Magneto 5.100.53 Magneto Item snatcher Pulls pickups towards Isaac. 1
Match Book 5.100.344 Match Book Evil up Grants Isaac one Black Heart, spawns two or three Bombs. 1
MEAT! 5.100.193 MEAT! DMG + HP up Grants one full Red Heart container, +0.3 damage. 2
Midas' Touch 5.100.202 Midas' Touch Golden touch Enemies that touch Isaac are temporarily petrified and turn to gold. Any enemy killed while in this state will drop coins. 2
Mini Mush 5.100.71 Mini Mush Speed + range up Decreases Isaac's size, making him less likely to be hit. Removed in Repentance+0.3 speed, +1.5 tear height, -4.25 range (effective range is increased). Added in Repentance +0.3 speed, +1.50 range. 2
Missing No. 5.100.258 Missing No. Syntax error Randomizes all passive items and stats upon pickup and at the start of each succeeding floor. 1
Missing Page 2 5.100.262 Missing Page 2 Evil up. Your enemies will pay! Grants one Black Heart. Upon taking damage that reduces Isaac's health to one heart or less, deals damage to all enemies in the room.
Added in Repentance Increases the damage of Black Hearts and The Necronomicon The Necronomicon-like effects by 40.
Mitre 5.100.173 Mitre Blessing of purity Grants a chance of converting any Red Heart pickups into Soul Hearts instead. 3
Mom's Contacts 5.100.110 Mom's Contacts Freeze effect +0.25 range. Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. 3
Mom's Eye 5.100.55 Mom's Eye Eye in the back of your head Gives Isaac a chance to fire tears from the back of his head. 1
Mom's Eyeshadow 5.100.200 Mom's Eyeshadow Charm tears Tears have a chance to charm enemies. 1
Mom's Heels 5.100.30 Mom's Heels Range up +5.25 range, +0.5 tear height. Added in Repentance Enemies that touch Isaac take 12 damage. 1
Mom's Key 5.100.199 Mom's Key Better chest loot +2 keys Adds 2 keys. Chests will drop additional pickups. 3
Mom's Knife 5.100.114 Mom's Knife Stab stab stab Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power. 4
Mom's Lipstick 5.100.31 Mom's Lipstick Range up +5.25 range, +0.5 tear height. Added in Repentance Spawns one random heart. 1
Mom's Perfume 5.100.228 Mom's Perfume Fear shot + tears up Adds a chance to shoot fear tears and decreases tear delay by 1. 2
Mom's Purse 5.100.139 Mom's Purse More trinket room Allows Isaac to hold one additional trinket. Added in Repentance Drops a random trinket. 3
Mom's Underwear 5.100.29 Mom's Underwear Range up +5.25 range, +0.5 tear height. Added in Repentance Spawns 3-6 Blue Flies on pickup. 1
Mom's Wig 5.100.217 Mom's Wig You feel itchy... Adds a chance to spawn Blue Spiders when firing tears. Restores 1 Red Heart Red Heart. 3
Money = Power 5.100.109 Money = Power $$$ = DMG Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins. 3
Mongo Baby 5.100.322 Mongo Baby Mongo friend Spawns a familiar that copies the tears of Isaac's other familiars. 2
Monstro's Lung 5.100.229 Monstro's Lung Charged burst attack Replaces normal tears with a charged shot that fires 14 tears in the same fashion as Monstro. 2
Mutant Spider 5.100.153 Mutant Spider Quad shot Grants quadruple shot but decreases Tears. 3
My Reflection 5.100.5 My Reflection Boomerang tears Gives Isaac's tears a boomerang effect. +1.5 range, +1 tear height, x1.6 shot speed multiplier. 0
Mysterious Liquid 5.100.317 Mysterious Liquid Toxic splash damage Tears leave a small, short lasting pool of creep on impact or when their range is depleted. 3
Mystery Sack 5.100.271 Mystery Sack ? Spawns a familiar that drops a Heart, coin, Bomb Bomb, or Key Key every 5-6 rooms. 2
Number One 5.100.6 Number One Tears up + range down Grants +1.5 tears, but severely reduces range. 2
Odd Mushroom 5.100.121 Odd Mushroom HP + DMG up, speed down Grants one empty Heart container, +0.3 damage, +0.25 range, +0.5 tear height, and -0.1 speed. 2
Odd Mushroom 5.100.120 Odd Mushroom Tears + speed up, DMG down +1.7 tears, +0.3 speed, slightly reduces damage. 2
Ouija Board 5.100.115 Ouija Board Spectral tears Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them. 2
Pageant Boy 5.100.141 Pageant Boy Ultimate grand supreme Spawns seven random coins around Isaac. 0
Pentagram 5.100.51 Pentagram DMG up +1 damage, increases Devil Room / Angel Room chance by 10%. 3
PHD 5.100.75 PHD Better pills Converts all bad pills into good pills, spawns one pill pickup, and identifies all pills. Restores two Red Hearts and increases the payout of Blood Donation Machines. 2
Piggy Bank 5.100.227 Piggy Bank My life savings Gives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny. 1
Pisces 5.100.309 Pisces Tears up + knock-back shots -1 Tear Delay, adds knock-back shots and increases tear size. 2
Polyphemus 5.100.169 Polyphemus Mega tears Isaac fires huge tears that deal massive damage, but fire rate is greatly decreased. If a tear kills an enemy, it travels on with any leftover damage. 4
Proptosis 5.100.261 Proptosis Short range mega tears Tears start out massive with high damage, and then shrink down and become weaker over a short range. 4
Punching Bag 5.100.281 Punching Bag Scape goat Spawns a Mulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer. 1
Pyromaniac 5.100.223 Pyromaniac It hurts so good +5 bombs +5 bombs. Grants immunity to explosion damage and causes explosions to heal Isaac. Added in Repentance Also grants immunity to fire. 4
Rainbow Baby 5.100.174 Rainbow Baby Random buddy Spawns a familiar that follows Isaac around and fires tears with random effects. 1
Robo-Baby 5.100.95 Robo-Baby Friends 'till the bbbbzzzt Spawns a familiar that shoots 15►Technology Technology lasers. 1
Robo-Baby 2.0 5.100.267 Robo-Baby 2.0 We worked out all the kinks Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears. 1
Roid Rage 5.100.14 Roid Rage Speed and range up Removed in Repentance +0.6 speed, +5.25 range, +0.5 tear height.
Added in Repentance +0.3 speed, +1.50 range, +0.5 tear height.
Rotten Baby 5.100.268 Rotten Baby Infested friend Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. 3
Rubber Cement 5.100.221 Rubber Cement Bouncing tears Tears bounce off walls, enemies, and environmental objects. 3
Sack of Pennies 5.100.94 Sack of Pennies Gives money Spawns a familiar that drops a coin every 2 rooms. 1
Sacred Heart 5.100.182 Sacred Heart Homing shots + DMG up Removed in Repentance Adds a Red Heart Container. Grants homing tears, a x2.3 Damage multiplier, +1 flat Damage, -0.4 Tears, -0.25 Shot Speed, and +4.125 Range.
Added in Repentance Adds a Red Heart Container. Grants homing tears, a x2.3 Damage multiplier, +1 flat Damage, -0.4 Tears, and -0.25 Shot Speed.
Sacrificial Dagger 5.100.172 Sacrificial Dagger My fate protects me Spawns a dagger orbital familiar, blocking enemy shots and dealing a high amount of damage to enemies in contact. 2
Sad Bombs 5.100.220 Sad Bombs Tear blasts +5 bombs +5 Bombs. Upon exploding, bombs shoot 10 tears around them, affected by tear modifiers. 2
Safety Pin 5.100.339 Safety Pin Evil + range + shot speed up Grants one Black Heart, +5.25 range, +0.5 tear height, +0.16 shot speed. 1
Sagittarius 5.100.306 Sagittarius Piercing shots + speed up Increases speed by +0.2 and grants piercing tears. 3
Samson's Chains 5.100.321 Samson's Chains The ol' ball and chain Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most obstacles. 1
Scapular 5.100.142 Scapular Pray for a miracle Once per room, when Isaac is reduced to his last half heart, he is granted one Soul Heart. 2
Scorpio 5.100.305 Scorpio Poison tears Grants poison tears, which deal damage over time when inflicted. 3
Screw 5.100.255 Screw Tears + shot speed up +0.5 tears, +0.2 shot speed. 3
Sharp Plug 5.100.205 Sharp Plug Infinite charge... at a cost Damages Isaac in exchange for fully recharging Isaac's current activated item. 1
Sissy Longlegs 5.100.280 Sissy Longlegs She loves you Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. 1
Sister Maggy 5.100.67 Sister Maggy Friends 'till the end Spawns a familiar that follows Isaac around shooting normal tears. 1
Skatole 5.100.9 Skatole Fly love Flies become harmless or less dangerous depending on the type. 0
Smart Fly 5.100.264 Smart Fly Revenge fly Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. 2
SMB Super Fan 5.100.189 SMB Super Fan All stats up +1 Red Heart container, +0.3 damage, +0.2 tears, +0.2 speed, +0.5 range, +1 tear height. Fully restores all red hearts. 3
Soy Milk 5.100.330 Soy Milk DMG down + tears way up Tears are smaller and do much less damage, but fire in very rapid succession. 2
Speed Ball 5.100.143 Speed Ball Speed + shot speed up +0.3 speed, +0.2 shot speed. 2
Spelunker Hat 5.100.91 Spelunker Hat See-through doors Reveals type of adjacent rooms, including location for Secret Rooms and Super Secret Rooms. 2
Spider Bite 5.100.89 Spider Bite Slow effect Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them. 2
Spiderbaby 5.100.211 Spiderbaby Spider revenge Removed in Repentance When hit, spawns 1-2 Blue Spiders.
Added in Repentance When hit, spawns 3-5 Blue Spiders.
Spirit of the Night 5.100.159 Spirit of the Night Scary Grants spectral tears and flight. 3
Spoon Bender 5.100.3 Spoon Bender Homing shots Grants Isaac homing tears. 3
Squeezy 5.100.196 Squeezy Tears up Increases tears by 0.4, spawns 2 Soul Hearts. 3
Starter Deck 5.100.251 Starter Deck Extra card room Isaac can hold 2 cards at once and all pills are replaced by cards. 2
Steam Sale 5.100.64 Steam Sale 50% off Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup. 2
Steven 5.100.50 Steven DMG up Increases damage by 1. 3
Stigmata 5.100.138 Stigmata DMG + HP up +0.3 damage, grants one full Red Heart container. Added in Repentance Heals 1 additional Red Heart Red Heart. 2
Stop Watch 5.100.232 Stop Watch Let's slow this down a bit... Removed in Afterbirth Automatically inflicts slow to all enemies in every room.
Added in Afterbirth / Removed in Repentance Upon taking damage, inflicts slow to all enemies for the current room.
Added in Repentance Slows all enemies in every room to 80% speed.
Strange Attractor 5.100.315 Strange Attractor Magnetic tears Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears. 0
Synthoil 5.100.345 Synthoil DMG + range up +1 damage, +5.25 range, +0.5 tear height. 3
Taurus 5.100.299 Taurus Speed down + rage is building -0.3 Speed. Isaac builds speed while in a room with enemies. At max speed, he gains the My Little Unicorn My Little Unicorn effect for 5 seconds. 1
Tech.5 5.100.244 Tech.5 It's still being tested... Isaac occasionally fires an unlimited range piercing laser alongside his normal tears. The laser can glitch, mimicking the effects of certain items and trinkets. 3
Technology 5.100.68 Technology Laser tears Replaces tears with a piercing laser with unlimited range. 3
Technology 2 5.100.152 Technology 2 Extra laser Replaces the tears fired from Isaac's right eye with a rapid-firing low damage piercing laser. Removed in Repentance Damage down. 2
The Battery 5.100.63 The Battery Stores energy Activated collectibles can store an extra level of charge, allowing them to be used twice in one room. 2
The Belt 5.100.28 The Belt Speed up Increases speed by 0.3. 1
The Black Bean 5.100.180 The Black Bean Toot on touch When taking damage, Isaac farts, causing poison damage to all enemies in range. 0
The Common Cold 5.100.103 The Common Cold Poison damage Adds a chance to shoot poison tears, dealing damage over time when inflicted. 1
The Compass 5.100.21 The Compass The end is near Reveals the locations and types of all special rooms on the map, except Secret Room Secret Rooms and Super Secret Room Super Secret Rooms. 2
The Halo 5.100.101 The Halo All stats up Grants one full Red Heart container, +0.3 damage, +0.2 tears, +0.25 range, +0.3 speed, and +0.5 tear height. 2
The Inner Eye 5.100.2 The Inner Eye Triple shot Grants triple shot but decreases tears. 2
The Ladder 5.100.60 The Ladder Building bridges Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections. 1
The Ludovico Technique 5.100.329 The Ludovico Technique Controlled tears Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy. 2
The Mark 5.100.79 The Mark DMG + speed up Removed in Repentance Grants one Soul Heart Soul Heart, +1 damage, and +0.2 speed.
Added in Repentance Grants one Black Heart Black Heart, +1 damage, and +0.2 speed.
The Mind 5.100.333 The Mind I know all Reveals the entire map, including all special rooms and Secret Room Secret Rooms. 3
The Mulligan 5.100.151 The Mulligan They grow inside Tears have a 1/6 chance of spawning allied Blue Flies when they hit an enemy. 3
The Pact 5.100.80 The Pact DMG + tears up Removed in Repentance Grants two Soul Heart Soul Hearts, +0.5 damage, and +0.7 tears.
Added in Repentance Grants two Black Heart Black Hearts, +0.5 damage, and +0.7 tears.
The Parasite 5.100.104 The Parasite Split shot Isaac's tears split in two when they hit something. 3
The Peeper 5.100.155 The Peeper Plop! Spawns a familiar that floats slowly around the room on a zig-zag pattern, damaging enemies it passes through. 2
The Relic 5.100.98 The Relic Soul generator Spawns a cross familiar that drops a Soul Heart Soul Heart after clearing enough rooms. 3
The Sad Onion 5.100.1 The Sad Onion Tears up Increases tears by 0.7. 3
The Small Rock 5.100.90 The Small Rock DMG up + speed down +1 damage, +0.2 tears, -0.2 speed. 3
The Soul 5.100.335 The Soul I am all Grants two Soul Hearts. Isaac gains a pulsing aura that repels enemies and projectiles. 3
The Virus 5.100.13 The Virus Poison touch + speed up Isaac poisons enemies on contact. Removed in Repentance -0.1 speed. Added in Repentance +0.2 speed. Added in Afterbirth / Removed in Repentance Poisoned enemies have a chance to drop a black heart when killed. 2
The Wafer 5.100.108 The Wafer Damage resistance All sources of damage that would cause more than one-half heart of damage are reduced to one-half heart instead. 4
There's Options 5.100.249 There's Options More options Two items appear after defeating a Boss. Only one can be taken; the other will disappear. 3
Thunder Thighs 5.100.314 Thunder Thighs HP up + speed down + you feel stompy Destroys rocks upon contact with Isaac. Adds one Red Heart container and lowers Speed. 1
Tiny Planet 5.100.233 Tiny Planet Orbiting tears + range up Massively increases Range and grants spectral tears. Tears orbit around Isaac at a fixed distance until they hit the ground. 0
Toothpicks 5.100.183 Toothpicks Tears + shot speed up +0.7 tears, +0.16 shot speed. 3
Torn Photo 5.100.341 Torn Photo Tears + shot speed up +0.7 tears, +0.16 shot speed. 3
Tough Love 5.100.150 Tough Love Tooth shot Adds a chance to shoot a tooth instead of a tear, which deals x3.2 Isaac's damage. 3
Transcendence 5.100.20 Transcendence We all float down here... Grants flight. 3
Treasure Map 5.100.54 Treasure Map Full visible map Reveals the map of each floor. It does not identify special rooms and does not reveal the locations of Secret Room Secret Rooms / Super Secret Room Super Secret Rooms. 2
Trinity Shield 5.100.243 Trinity Shield You feel guarded Isaac gains a shield that protects him from enemy shots. It aims in the direction Isaac fires from. 3
Virgo 5.100.303 Virgo You feel refreshed and protected Adds a chance to give a shield that nullifies all incoming damage for 10 seconds upon taking damage. Also converts bad pills into good pills. 2
Whore of Babylon 5.100.122 Whore of Babylon Curse up Grants +1.5 Damage and +0.3 Speed whenever Isaac has half a Red Heart or less. 2
Wire Coat Hanger 5.100.32 Wire Coat Hanger Tears up Increases tears by 0.7. 3
Wooden Spoon 5.100.27 Wooden Spoon Speed up Increases speed by 0.3. 1
X-Ray Vision 5.100.76 X-Ray Vision I've seen everything Reveals and opens all Secret Room and Super Secret Room entrances. 2
8 Inch Nails 5.100.359 8 Inch Nails Stick it to 'em! +1.5 damage. Replaces Isaac's tears with nails, which have increased knockback. 3
Athame 5.100.408 Athame Call to the void When Isaac takes damage, a black ring briefly appears around him, dealing damage to all nearby enemies. 1
Betrayal 5.100.391 Betrayal Turn your enemy Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac. 0
Binky 5.100.438 Binky Tears up Grants one Soul Heart, +0.75 tears and decreases Isaac's size. 3
Black Powder 5.100.420 Black Powder Spin the black circle! Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it. 1
Bomber Boy 5.100.353 Bomber Boy Cross blast + 5 bombs +5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects player-spawned Troll Bombs. 2
Bumbo 5.100.385 Bumbo Bumbo want coin! Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. 1
Bursting Sack 5.100.377 Bursting Sack Spider love Spider enemies no longer target or deal contact damage to Isaac. 1
Cambion Conception 5.100.412 Cambion Conception Feed them hate After taking damage a certain amount of times, a permanent demonic familiar spawns. 2
Car Battery 5.100.356 Car Battery Active power up Causes Isaac's activated item to activate twice on each use. 3
Censer 5.100.387 Censer Peace be with you Spawns a familiar which creates a circular aura that slows down enemies and enemy shots inside. 3
Chaos 5.100.402 Chaos !!! Drops 1-6 random pickups on the floor. Causes items to be chosen from random item pools. 3
Charged Baby 5.100.372 Charged Baby Bbbzzzzzt! Spawns a familiar that occasionally drops a Lil' Battery Lil' Battery, gives an active item charge, or petrifies all enemies in the room. 3
Circle of Protection 5.100.423 Circle of Protection Protect me from myself Surrounds Isaac with a large white halo that occasionally deals Isaac's tear damage to enemies inside it, and can convert enemy shots into friendly homing tears. 2
Continuum 5.100.369 Continuum Transcendent tears Grants spectral tears and increases range. Tears travel through walls and appear at the opposite side of the room. 2
Crown of Light 5.100.415 Crown of Light The untainted gain power +2 soul hearts. While Isaac has no empty red hearts, grants 2x damage, +5.25 range, and -0.3 shot speed. Regardless of health, the crown deactivates for the current room when Isaac takes damage. 4
Curse of the Tower 5.100.371 Curse of the Tower Embrace chaos Upon taking damage, spawns six Troll Bombs around the room, similar to the effect of XVI - The Tower XVI - The Tower. 1
Dead Eye 5.100.373 Dead Eye Accuracy brings power! Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot. 3
Deep Pockets 5.100.416 Deep Pockets More money! Removed in Repentance Allows Isaac to carry two cards or pills (or a combination of both) at the same time.
Added in Repentance Increases the coin cap to 999. If a room would otherwise yield no reward, 1-3 coins will spawn.
Eden's Blessing 5.100.381 Eden's Blessing Tears up + your future shines brighter +0.7 tears up. Grants a random item at the start of the next run. 3
Empty Vessel 5.100.409 Empty Vessel I reward an empty vessel Grants two Black Heart Black Hearts. While Isaac has no red hearts, grants flight and periodically grants an invincibility shield for a few seconds. 2
Epiphora 5.100.368 Epiphora Intensifying tears Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount. 1
Evil Eye 5.100.410 Evil Eye Eye shot! Adds a chance to fire a slow-moving eye that fires tears in the same direction as Isaac. The eye will be destroyed if it hits an enemy or obstacle. 2
Explosivo 5.100.401 Explosivo Sticky bomb shot! Isaac's tears have a chance to stick to enemies and explode. 2
Farting Baby 5.100.404 Farting Baby He farts! Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies. 1
Fate's Reward 5.100.361 Fate's Reward Your fate beside you A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage. 2
Friend Zone 5.100.364 Friend Zone Friendly fly Spawns a white attack fly that orbits somewhere between 15►Distant Admiration Distant Admiration and 15►Forever Alone Forever Alone, dealing 45 damage per second. 1
Fruit Cake 5.100.418 Fruit Cake Rainbow effects! Isaac's tears gain a random effect that changes every shot. 2
GB Bug 5.100.405 GB Bug Double tap glitch Removed in Repentance Spawns a familiar that bounces diagonally around the room, applying a random status effect to enemies it hits and has a chance to re-roll pickups it passes over.
Added in Repentance Spawns a familiar that follows Isaac. Double tapping the fire button launches it forward, causing it to reroll the first monster or pickup it hits.
Glitter Bombs 5.100.432 Glitter Bombs Prize bombs! +5 Bomb Bombs. Bombs have a chance to drop random pickups or charm enemies when they explode. 2
God's Flesh 5.100.398 God's Flesh Shrink shot! Tears have a chance to shrink enemies, making them run away from Isaac. Shrunk enemies can be crushed and killed by walking over them. 1
Head of the Keeper 5.100.429 Head of the Keeper Penny tears! Isaac's tears become coins and now have a chance to drop Pennies on the floor upon successfully hitting an enemy. 2
Holy Light 5.100.374 Holy Light Holy death shot Adds a chance to fire holy tears, which will create a damaging light beam in the area if they hit an enemy. 3
Host Hat 5.100.375 Host Hat Blast resistance A host familiar that sits on Isaac's head and has a random chance to block enemy shots and retaliate with 3 tears. Grants immunity to explosions. 3
Immaculate Conception 5.100.413 Immaculate Conception Feed them love Upon picking up a certain amount of health, spawn a permanent angelic familiar. 2
Incubus 5.100.360 Incubus Dark friend Spawns a demonic familiar that shoots tears identical to Isaac's in terms of damage, tears, and tear effects. 4
Key Bum 5.100.388 Key Bum He wants your keys! Spawns a familiar that follows Isaac and collects Key Keys for himself, giving random Chest Chests in return. 0
Kidney Stone 5.100.440 Kidney Stone Matt's kidney stone Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. The burst of tears also includes a kidney stone, which deals a lot of damage. 2
Lil Chest 5.100.362 Lil Chest What's in the box? Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room. 2
Lil Gurdy 5.100.384 Lil Gurdy A gurd of your own! A Gurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed. 2
Lil Loki 5.100.435 Lil Loki 4-way buddy! Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern. 1
Lost Fly 5.100.365 Lost Fly Lost protector Removed in Repentance Spawns fly familiar that moves in a straight line and circles around the first wall or obstacle it hits, dealing 105 damage per second on contact.
Added in Repentance Spawns fly familiar that moves in a straight line and circles around the first wall or obstacle it hits, dealing 56 damage per second and forcing nearby enemies to attack it.
Lusty Blood 5.100.411 Lusty Blood Their blood brings rage! Isaac's damage increases for the current room each time he kills an enemy. 3
Marked 5.100.394 Marked Directed tears Isaac will automatically fire tears directed at a red target on the ground. The target can be moved with tear controls. +0.7 tears, +3.15 range. 1
Maw of the Void 5.100.399 Maw of the Void Consume thy enemy! Charged by firing for 2.5 seconds and when released, creates a black ring around Isaac that rapidly deals damage. Removed in Repentance +1 damage, the ring can cause enemies to drop Black Hearts. 4
Milk! 5.100.436 Milk! Don't cry over it... Spawns a glass familiar that spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the current room. 1
Mom's Pearls 5.100.355 Mom's Pearls Range + luck up +1.25 range, +0.5 tear height, +1 luck. Added in Repentance Grants one Soul Heart. 2
More Options 5.100.414 More Options There's options Two item pedestels are presented in every Treasure Room Treasure Room. Only one can be taken; the other will disappear. 3
Mr. Dolly 5.100.370 Mr. Dolly Range + tears up +0.7 tears, +5.25 range, +0.5 tear height, spawns 3 random types of Hearts on the floor when picked up. 3
Multidimensional Baby 5.100.431 Multidimensional Baby ydduB Buddy Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed. 2
My Shadow 5.100.433 My Shadow Me! And my shaaaadow! Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black friendly Charger that will attack enemies. The Charger will be killed if it is damaged too much. 0
Night Light 5.100.425 Night Light Scared of the dark? A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots. 2
Number Two 5.100.378 Number Two Uh oh... Continuously firing tears for three seconds causes Isaac to drop a Butt Bomb, which damages and confuses all enemies in the room when it explodes. 2
Obsessed Fan 5.100.426 Obsessed Fan Follows my every move... Spawns a familiar that follows Isaac's movements on a delay and deals 30 contact damage per second to enemies. 0
Papa Fly 5.100.430 Papa Fly Turret follower Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies. 1
Pay to Play 5.100.380 Pay to Play Money talks +5 Coins. Doors (Removed in Repentance except Added in Repentance including those requiring 2 Key Keys), Added in Repentance Key Blocks, and Chests all now require one Penny Penny to open. 2
Pupula Duplex 5.100.379 Pupula Duplex Wide shot Gives Isaac spectral tears and gives his tears a wide arc shape, increasing their size. 2
Purity 5.100.407 Purity Aura stat boost Boosts one of Isaac's stats depending on the color of the aura around him. The aura disappears upon taking damage and reappears with a random color upon entering a new room. Red boosts damage, blue boosts tears, yellow boosts speed, and orange boosts range. 3
Restock 5.100.376 Restock Never ending stores! Causes shops to instantly restock their items when they are bought. Added in Repentance Outside of Greed Mode, the restocked item's cost is increased after each purchase. 2
Rune Bag 5.100.389 Rune Bag Rune generator Spawns a familiar that drops a random rune after clearing enough rooms. 3
Sack Head 5.100.424 Sack Head More sacks! Coins, bombs, keys, cards, runes and batteries have a chance to become sacks. 3
Scatter Bombs 5.100.366 Scatter Bombs We put bombs in your bombs! Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs. 1
Seraphim 5.100.390 Seraphim Sworn friend Spawns an angel familiar which follows Isaac and fires homing tears which deal 10 damage and have 75% shot speed. 3
Serpent's Kiss 5.100.393 Serpent's Kiss The kiss of death Tears have a chance to apply a poison effect to enemies. Isaac poisons enemies on contact. Poisoned enemies have a chance to drop a black heart when killed. 2
Spear of Destiny 5.100.400 Spear of Destiny Your destiny In addition to tears, Isaac holds a spear in front of him which deals contact damage equal to 2x his tear damage, and occasionally inflicts fear. 1
Spider Mod 5.100.403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery Lil' Battery/Blue spider upon clearing a room. 1
Sticky Bombs 5.100.367 Sticky Bombs Egg sack bombs! +5 bombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy. 1
Succubus 5.100.417 Succubus Damage booster Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier. 3
Sworn Protector 5.100.363 Sworn Protector Protective friend Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal Heart Eternal Heart. 3
Tech X 5.100.395 Tech X Laser ring tears Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the effectiveness of the ring. 4
The Wiz 5.100.358 The Wiz Double wiz shot! Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U a Wizard? pill. Isaac's tears also travel above all obstacles. 1
Toxic Shock 5.100.350 Toxic Shock Mass poison Upon entering a room, poisons all enemies, dealing double Isaac's tear damage. Killing enemies leaves a small, short-lasting pool of green creep on the ground. 3
Tractor Beam 5.100.397 Tractor Beam Controlled tears Increases Tears, Range, and Shot Speed. Isaac emits a beam from his face that his tears are bound to. 3
Zodiac 5.100.392 Zodiac The heavens will change you Gives Isaac a random zodiac item effect that changes every floor. 1
7 Seals 5.100.526 7 Seals Lil harbingers! Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. 2
Acid Baby 5.100.491 Acid Baby Pills pills pills! Spawns a familiar that drops a random pill every 3 rooms. Upon using a pill, all enemies in the room are poisoned. 2
Adrenaline 5.100.493 Adrenaline Panic = power Increases damage based on how many empty Red Heart containers Isaac has. 1
Analog Stick 5.100.465 Analog Stick 360 tears! +0.35 tears up. Allows Isaac to fire tears diagonally. 2
Angelic Prism 5.100.528 Angelic Prism Eclipsed by the moon Spawns an orbital familiar with a large orbital radius. Tears that pass through the prism split into four multi-colored tears. 3
Angry Fly 5.100.511 Angry Fly He's violent Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with. 1
Apple! 5.100.443 Apple! Trick or treat? Increases tears. Adds a chance to fire a high-damage razor blade. 3
Backstabber 5.100.506 Backstabber Watch your back! Isaac's tears deal double damage and inflict bleeding on enemies if they're facing away from Isaac. 2
Belly Button 5.100.458 Belly Button What's in there? Drops a random trinket. Grants a second trinket slot. 3
Big Chubby 5.100.473 Big Chubby Chub chub Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact. 1
Blanket 5.100.535 Blanket You feel Safe Grants one Soul Heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears. 2
Bloodshot Eye 5.100.509 Bloodshot Eye Bloody friend Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds. 1
Bozo 5.100.513 Bozo Party time! +0.1 flat damage, grants a Soul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop. 2
Broken Modem 5.100.514 Broken Modem Lag! Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals. 2
Buddy in a Box 5.100.518 Buddy in a Box What could it be?! Spawns a familiar with a random tear effect. The familiar is randomized at the start of each floor. 2
Camo Undies 5.100.497 Camo Undies Camo kid Isaac becomes camouflaged at the beginning of each room. Until he shoots, all non-boss enemies will be confused. Added in Repentance Isaac gains +0.5 Speed while camouflaged, and gains Tears and Damage upon breaking it. 2
Compound Fracture 5.100.453 Compound Fracture Bone tears! Increases Range. Tears turn into bones, which shatter into 1-3 bone shards upon hitting an enemy or obstacle. 3
Cone Head 5.100.457 Cone Head Hard headed! Grants a Soul Heart. Gives Isaac a chance to ignore any damage taken. 2
Contagion 5.100.466 Contagion Outbreak! The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death. 2
Dad's Lost Coin 5.100.455 Dad's Lost Coin I remember this... +1.5 range. Drops a Lucky Penny. 2
Dad's Ring 5.100.546 Dad's Ring Father's blessing Creates a ring of light around Isaac that petrifies enemies in contact. 3
Dark Prince's Crown 5.100.442 Dark Prince's Crown Loss is power When at exactly one Red Heart, increases tears, range, tear height, and shot speed. 1
Dead Tooth 5.100.446 Dead Tooth Toxic breath While firing, Isaac gains a green aura that poisons nearby enemies. 1
Death's List 5.100.530 Death's List Just hope you're not next... Grants a pickup or stat upgrade if all enemies in a room are killed in the order they are marked. 2
Depression 5.100.469 Depression :( Spawns a familiar that leaves a trail of creep that damages enemies at 6 damage per second. Has a chance to spawn damaging beams of light onto enemies that touch the cloud. 1
Divorce Papers 5.100.547 Divorce Papers Tears up + you feel empty Grants one Bone Heart, +0.7 tears, spawns a Mysterious Paper. 3
Dog Tooth 5.100.445 Dog Tooth Bark at the moon! +0.3 damage, +0.1 speed. Plays a howl or bark sound when entering a room with undiscovered Secret Room Secret Rooms or Crawl Space Crawl Spaces. 1
Duality 5.100.498 Duality You feel very balanced Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered. 1
Eucharist 5.100.499 Eucharist Peace be with you An Angel Room Angel Room door will always spawn after every boss fight, excluding the first floor and floors after Womb Womb II/Utero Utero II/. 3
Euthanasia 5.100.496 Euthanasia Needle shot Adds a chance to fire needles that instantly kill basic enemies and deal triple damage to bosses. If a needle kills an enemy, it bursts into more tears/needles. 3
Eye of Belial 5.100.462 Eye of Belial Possessed tears! Grants piercing tears. After piercing one enemy, tears start homing and deal double damage. 3
Eye of Greed 5.100.450 Eye of Greed Gold tears! Every 20 tears, Isaac loses 1 coin and shoots an additional gold tear that petrifies enemies and turns them into gold. Any enemy killed while in this state will drop coins. 2
Fast Bombs 5.100.517 Fast Bombs Rapid bomb drops Grants 7 bombs and allows bombs to be placed rapidly. 1
Finger! 5.100.467 Finger! Watch where you point that! Spawns a finger familiar that points at enemies, dealing scaling damage. 1
Flat Stone 5.100.540 Flat Stone Skipping tears Tears bounce off the floor, creating splashes. Splashes deal 25% of Isaac's tear damage to all enemies in a small area. 2
Ghost Pepper 5.100.495 Ghost Pepper Flame tears Removed in RepentanceGives a chance to shoot fires alongside tears that block enemy shots and deal damage to enemies that touch them.
Added in RepentanceGives a chance to shoot blue fires alongside tears that become smaller as they travel.
Glaucoma 5.100.460 Glaucoma Blind tears! Adds a chance to shoot tears that confuse enemies for an extremely long time. 1
Glyph of Balance 5.100.464 Glyph of Balance A gift from above Grants 2 Soul Hearts and modifies drops from Champion monsters based on certain conditions. Added in Repentance Also modifies room clear drops. 3
Greed's Gullet 5.100.501 Greed's Gullet Money = health! Grants a Red Heart container for every 25 coins Isaac has. 1
Haemolacria 5.100.531 Haemolacria I'm seeing red... Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay. 3
Hallowed Ground 5.100.543 Hallowed Ground Portable sanctuary Spawns a white poop familiar, which turns into a White Poop White Poop when Isaac is hurt. White poop has an aura that increases tear fire rate and can block enemy shots. Added in Repentance The aura also increases damage b 20% and gives homing. 1
Hushy 5.100.470 Hushy Lil hush! Spawns a Hush familiar that bounces diagonally around the room and deals contact damage. While firing tears, it stops moving. 0
Jacob's Ladder 5.100.494 Jacob's Ladder Electric tears Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy. 3
Jaw Bone 5.100.548 Jaw Bone Fetch! Spawns a familiar that flies through the room while firing, dealing a flat 7 contact damage to enemies and retrieving pickups. 1
Jumper Cables 5.100.520 Jumper Cables Bloody recharge Grants an active item charge every 15 enemies killed. 3
King Baby 5.100.472 King Baby Hail to the king baby Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, other familiars stop moving. 1
Lachryphagy 5.100.532 Lachryphagy Feed them! Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage. 2
Large Zit 5.100.502 Large Zit Creep shots Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep. 1
Lead Pencil 5.100.444 Lead Pencil He's a bleeder! After every 15 tears fired, Isaac will fire a high-damage cluster of tears. 3
Leprosy 5.100.525 Leprosy You're tearing me apart! Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots. 1
Lil Delirium 5.100.519 Lil Delirium Delirious friend Grants a familiar that transforms into another random familiar every 10 seconds. 2
Lil Monstro 5.100.471 Lil Monstro Ain't he cute? Spawns a familiar that fires clusters of tears. Must be charged before shooting. 2
Lil Spewer 5.100.537 Lil Spewer Puking buddy Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type. 1
Linger Bean 5.100.447 Linger Bean Crying makes me toot Constantly shooting causes Isaac to release gas clouds that can be pushed by his tears and damage nearby enemies. 0
Little Horn 5.100.503 Little Horn Big brother is watching Removed in Repentance Adds a chance to fire a piercing tear that instantly kills any enemy that it touches.
Added in Repentance Adds a chance to fire a tear that summons Big Horn's hand to crush the first enemy it hits, instantly killing monsters or greatly damaging bosses.
Marbles 5.100.538 Marbles Choking hazard Spawns 3 random trinkets, 5% chance to swallow held trinket after taking damage, gaining its effect permanently. 2
Metal Plate 5.100.449 Metal Plate It itches... Grants one Soul Heart. Enemy shots have a chance to be reflected at the shooter as confusing tears. 1
Mom's Razor 5.100.508 Mom's Razor It's sharp! Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time. 2
Mystery Egg 5.100.539 Mystery Egg Sacrificial insemination Spawns an egg familiar, which cracks into a random friendly monster when Isaac is hurt. The egg regenerates upon entering a different room. 1
Parasitoid 5.100.461 Parasitoid Egg tears! Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy. 3
Pointy Rib 5.100.544 Pointy Rib Stabbing time Spawns a bone familiar that hovers back and forth in front of Isaac, dealing damage equal to Isaac's damage. 2
Polydactyly 5.100.454 Polydactyly Hold me! Allows Isaac to carry two cards, pills, or any combination of both. Spawns one random card, rune, or pill. 2
Pop! 5.100.529 Pop! Eyeball tears! Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle. 2
Sack of Sacks 5.100.500 Sack of Sacks Gives sacks Spawns a familiar that drops a sack every 5-6 rooms cleared. 3
Schoolbag 5.100.534 Schoolbag Extra active item room Allows Isaac to hold two active items. 3
Shade 5.100.468 Shade It follows Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers. 0
Shard of Glass 5.100.448 Shard of Glass Blood and guts! Removed in Repentance Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
Added in Repentance Taking damage causes Isaac to bleed, spraying a volley of blood in the direction he fires. Bleeding will eventually damage him, but it can be stopped by picking up a Red Heart Red Heart.
Sinus Infection 5.100.459 Sinus Infection Booger tears! Adds a chance to fire a booger that sticks to enemies and deals damage over time. 3
Slipped Rib 5.100.542 Slipped Rib Projectile shield Spawns a bone familiar that circles around Isaac and reflects enemy shots. 2
Sulfuric Acid 5.100.463 Sulfuric Acid Acid tears! +0.3 damage. Adds a chance to fire acidic tears which can destroy obstacles. 2
Tarot Cloth 5.100.451 Tarot Cloth I see the future Drops a random card or rune. Removed in Repentance Doubles the effects of most cards and runes. Added in Repentance Doubles the effects of tarot cards. 2
Technology Zero 5.100.524 Technology Zero Static tears! Connects Isaac's tears with electricity that can damage enemies. 3
Trisagion 5.100.533 Trisagion Smite thy enemy Damage down. Tears are replaced with piercing white blasts of light that can damage the same enemy multiple times. 2
Varicose Veins 5.100.452 Varicose Veins I'm leaking... Taking damage releases a ring of 10 high damage tears. 2
YO LISTEN! 5.100.492 YO LISTEN! Yo listen! +1 luck. Spawns a fairy familiar that points out Secret Room Secret Rooms, Crawl Space Crawl Space entrances, and tinted rocks. 2
120 Volt 5.100.559 120 Volt Zap! Repeatedly zaps enemies that are close to Isaac. 2
2Spooky 5.100.554 2Spooky 4me Enemies near Isaac are afflicted with fear. 2
4.5 Volt 5.100.647 4.5 Volt Beat the juice out of them! Active items don't charge when clearing rooms. Instead, they're charged by dealing damage to enemies. 2
A Bar of Soap 5.100.564 A Bar of Soap Tears + shot speed up Gives Isaac +0.5 Tears and +0.2 Shot Speed. 3
A Pound of Flesh 5.100.672 A Pound of Flesh Blood money Devil deals now cost coins, Shop Shop items now cost health, and consumables in shops are free but surrounded by spikes. 1
Act of Contrition 5.100.601 Act of Contrition Tears up, you feel forgiven Increases tears and grants an Eternal Heart Eternal Heart. Allows Angel Room Angel Rooms to appear even if a Devil Deal has been taken before. Reduces the Devil/Angel room chance penalty for taking Red heart damage. 3
Akeldama 5.100.641 Akeldama Spill your guts While in an uncleared room, Isaac forms a trail of bloody tears that drags behind him, bursting and dealing damage upon contact with enemies. 2
Almond Milk 5.100.561 Almond Milk DMG down + tears up + you feel nutty Quadruples fire rate, with x0.3 damage multiplier. Tears are given random worm trinket effects. 1
Astral Projection 5.100.677 Astral Projection The true out-of-body experience! Causes Isaac to turn into a ghost if he gets hit while in an uncleared room, giving him flight and spectral tears and blocking the next hit he takes. 2
Azazel's Rage 5.100.699 Azazel's Rage Ancient power Isaac builds rage every time a room is cleared. After four rooms, fires a large Brimstone Brimstone laser when entering the next room. 3
Belly Jelly 5.100.690 Belly Jelly Bounce away! Causes enemies to bounce off of Isaac, dealing damage to them if they hit an enemy or obstacle. Also gives Isaac the chance to deflect enemy shots. 3
Bird Cage 5.100.610 Bird Cage Fat buddy The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to Dead Bird Dead Bird. 1
Birthright 5.100.619 Birthright ??? Grants a character-specific effect that enhances their special abilities. 3
Blood Bombs 5.100.614 Blood Bombs Bloody blast + HP up Grants a Red Heart container and restores 5 hearts. Bombs leave behind damaging red creep. Isaac can place bombs at the cost of half a heart if he doesn't have any. 2
Blood Oath 5.100.569 Blood Oath Bleed me dry Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained. 2
Bloody Gust 5.100.695 Bloody Gust May your rage bring haste The first 6 times Isaac takes damage on a given floor, he gains Speed and Tears for the rest of the floor, up to a maximum of +1.02 and +3.00, respectively. 3
Boiled Baby 5.100.607 Boiled Baby Messy friend Gives Isaac a familiar that fires chaotic bursts of tears in all directions. 1
Bone Spurs 5.100.683 Bone Spurs Break your enemies Enemies spawn floating bones on death, which block shots and damage/repel enemies that touch them. 2
Bot Fly 5.100.629 Bot Fly Defense drone Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. 3
Brimstone Bombs 5.100.646 Brimstone Bombs Demon blast +5 bombs Gives Isaac +5 bombs and causes his bombs to fire Brimstone Brimstone lasers in the cardinal directions upon exploding. 3
C Section 5.100.678 C Section Fetus shots Replaces tears with fetuses that chase down enemies and deal contact damage. Each shot requires a brief charge up. 4
Candy Heart 5.100.671 Candy Heart Power of love Gives Isaac a permanent stat boost whenever he heals with Red Heart Red Heart pickups. 2
Card Reading 5.100.660 Card Reading A link to your future Spawns two portals at the beginning of each floor that each lead to either the Boss Room Boss Room, Treasure Room Treasure Room, or Secret Room Secret Room. 3
Cracked Orb 5.100.675 Cracked Orb Shards of knowledge Unlocks doors and reveals a random room on the map when Isaac takes damage. 1
Dirty Mind 5.100.576 Dirty Mind Filthy friends Destroying poop spawns Dip Familiars that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects. 2
Dream Catcher 5.100.566 Dream Catcher Sweet dreams During the transition between floors, Isaac's nightmare shows the floor's Treasure Room item and boss. Grants half a soul heart when entering a new floor. 2
Echo Chamber 5.100.700 Echo Chamber I can see see the future future future When Isaac uses a Card, Pill, or Rune, he also uses a copy of the previous three Cards/Pills/Runes he used after picking up Echo Chamber. 2
Empty Heart 5.100.676 Empty Heart It multiplies If Isaac has one red heart or less at the beginning of a floor, he gains an empty red heart container. 2
Evil Charm 5.100.632 Evil Charm Luck up + you feel protected Increases luck by 2.0. Provides immunity to burn, confusion, fear, and poison. 2
Eye Drops 5.100.600 Eye Drops Tears up Lowers the tear delay in Isaac's left eye, causing his eyes to fire at different rates. 3
Eye of the Occult 5.100.572 Eye of the Occult DMG up + range up + controlled tears Isaac's tears are now controlled mid-flight with tear controls. Also increases damage and range, but decreases shot speed. 3
Eye Sore 5.100.558 Eye Sore More eyes Causes Isaac to occasionally fire extra tears in random directions while shooting. 2
False PHD 5.100.654 False PHD Worse pills + evil up Converts good pills into bad pills and identifies all pills. Bad pills now have secondary positive effects. Grants one Black Heart Black Heart. 2
Freezer Baby 5.100.608 Freezer Baby Iced iced baby Spawns a shooting familiar that has a chance to petrify enemies, and Freezes monsters upon killing them. 2
Fruity Plum 5.100.649 Fruity Plum Bouncy friend Gives Isaac a miniature Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels. 1
Ghost Bombs 5.100.727 Ghost Bombs Spooky blast +5 bombs +5 Bomb Bombs. Bombs become spectral and spawn ghosts that deal contact damage to enemies and explode after 10 seconds. 2
Giant Cell 5.100.658 Giant Cell Micro friends Causes Isaac to spawn micro-Isaacs when he takes damage, which chase and shoot at nearby enemies. 1
Glitched Crown 5.100.689 Glitched Crown ????? Item pedestals cycle between 5 random items before being picked up. 4
Heartbreak 5.100.694 Heartbreak Eternal sorrow Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts. 3
Hemoptysis 5.100.726 Hemoptysis Double tap sneeze Double-tapping a fire button causes Isaac to sneeze blood, dealing damage to enemies in front of him. 2
Hungry Soul 5.100.684 Hungry Soul Out for blood Enemies have a chance to spawn ghosts on death, which chase and deal contact damage to enemies and explode after a short time. 3
Hypercoagulation 5.100.724 Hypercoagulation Thick blooded After Isaac takes damage from an enemy or donates health, launches red hearts from Isaac that despawn after 1.5 seconds. 3
IBS 5.100.725 IBS Your stomach rumbles Causes Isaac to throw poop, create buffing creep, or drop bombs while fighting enemies. 2
Immaculate Heart 5.100.573 Immaculate Heart Halo of tears Adds one Red Heart Container and fully restores health. x1.2 damage multiplier. Isaac will occasionally fire extra tears that orbit around him. 3
Isaac's Tomb 5.100.701 Isaac's Tomb Buried memories Spawns an Old Chest at the start of each floor. 3
It Hurts 5.100.560 It Hurts No it doesn't... Releases a ring of tears and increases tears for the current room when Isaac takes damage. 1
Jupiter 5.100.594 Jupiter You're a gas giant! +2 red Heart containers, -0.3 speed. Isaac builds speed while standing still, and releases poison gas clouds when he moves afterwards. 2
Keeper's Kin 5.100.717 Keeper's Kin Under a rock Rocks and props spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed. 2
Keeper's Sack 5.100.716 Keeper's Sack Spending power Gives range, speed, or damage when buying things from a shop. Also spawns three coins and a Key Key on pickup. 3
Knockout Drops 5.100.637 Knockout Drops They pack a punch! Adds a chance to shoot a fist tear that has extremely high knockback and confuses enemies. 3
Lil Abaddon 5.100.679 Lil Abaddon Abyssal friend Spawns a familiar that charges a miniature Maw of the Void Maw of the Void attack while Isaac shoots. 3
Lil Dumpy 5.100.615 Lil Dumpy Puffy buddy Spawns a Dumpy familiar that pushes away nearby enemies and projectiles just before Isaac is about to be hit, then falls asleep. He can be awoken by walking to him. 2
Lil Portal 5.100.681 Lil Portal It hungers A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room. 1
Lodestone 5.100.617 Lodestone Magnetizing tears Gives Isaac the chance to fire tears that magnetize enemies they hit, causing them to attract nearby pickups and enemies, as well as tears/shots from all sources. 3
Lost Soul 5.100.612 Lost Soul Protect him Creates a ghostly familiar that closely follows behind Isaac. It dies in one hit, but respawns at the start of the next floor. Each time it survives until the next floor, it rewards Isaac with Soul Heart Soul Hearts, Eternal Heart Eternal Hearts, or an Item. 2
Luna 5.100.589 Luna The moon's blessing shines upon you Adds an extra Secret Room Secret Room and Super Secret Room Super Secret Room to each floor. Secret Rooms contain a beam of light that increases Tears for the current floor and gives a Half Soul Heart Half Soul Heart. 2
Mars 5.100.593 Mars Double tap dash Dash by double-tapping the movement key, becoming invulnerable and damaging enemies. There's a short cooldown before Isaac can dash again. 2
Member Card 5.100.602 Member Card Exclusive access! Adds a trapdoor to every shop that leads to a second shop with a unique stock and marked-up prices. 2
Mercurius 5.100.590 Mercurius Speed up + you feel elusive +0.4 speed. Doors stay open after entering a room, even in rooms with enemies. 3
Monstrance 5.100.574 Monstrance Purifying light Isaac gains an aura that deals damage to enemies inside it. 2
Montezuma's Revenge 5.100.680 Montezuma's Revenge Oh no... While firing, Isaac charges up a short-ranged Brimstone Brimstone-like diarrhea beam that shoots behind him. 3
Nancy Bombs 5.100.563 Nancy Bombs Random blast +5 bombs Gives Isaac +5 bombs and gives his bombs random bomb synergies. 1
Neptunus 5.100.597 Neptunus Open the floodgates Isaac's mouth fills with tears over time while not firing, up to a cap. Holding the fire button will release all stored tears in rapid succession. 3
Ocular Rift 5.100.606 Ocular Rift Stare into the abyss Gives Isaac the chance to fire tears that create rifts where they land, which damage nearby enemies and pull in enemies, pickups, and tears/shots from all sources. 3
Options? 5.100.670 Options? There might be options If a room gives a reward when cleared, there will be two different rewards to chose from. Taking one causes the other to disappear. 2
Orphan Socks 5.100.571 Orphan Socks Speed up + your feet feel stronger Prevents creep and floor spikes from damaging Isaac. Also gives Isaac +0.3 speed and 2 Soul Heart Soul Hearts. 2
Paschal Candle 5.100.567 Paschal Candle Keep the flame burning Gives Isaac a familiar that grants +0.4 Tears for each consecutive room he's cleared without taking damage. The bonus stacks up to five times. 3
Playdough Cookie 5.100.570 Playdough Cookie Tasty rainbow Grants multicolored tears. Each color comes with a different status or tear effect. 3
Pluto 5.100.598 Pluto Size down +0.7 tears. Significantly shrinks Isaac, allowing him to squeeze between objects and makes some enemy shots pass over him. 3
Psy Fly 5.100.581 Psy Fly Flamboyant protector Spawns a fly orbital familiar that chases and deflects enemy shots and converts them into homing tears that deal 2 damage. Turns some Fly enemies into friendly Blue Flies if it touches them while deflecting shots. 4
Quints 5.100.661 Quints They lurk inside The first five enemies killed in a room will spawn stationary shooting familiars where they died. 2
Redemption 5.100.673 Redemption Deliver me from evil If Isaac enters a Devil Room Devil Room, but leaves without taking/opening anything in it (including Black Heart Black Hearts, etc.), he gets +1 Damage and a Soul Heart Soul Heart at the start of the next floor. 2
Revelation 5.100.643 Revelation Awaken your faith Grants flight and two soul hearts. In addition to tears, Isaac can charge up and fire a powerful holy laser. 4
Rock Bottom 5.100.562 Rock Bottom It's only up from there Locks Isaac's attributes to their highest values reached. 3
Rocket in a Jar 5.100.583 Rocket in a Jar Rocket propulsion +5 bombs +5 bombs. If Isaac is currently firing, placing a bomb will instead shoot a fast-moving, explosive rocket in the direction he's facing. 2
Rotten Tomato 5.100.618 Rotten Tomato Delicious! Adds a chance to fire tears that Mark enemies. Marked enemies are attacked by other enemies. 2
Sacred Orb 5.100.691 Sacred Orb Destined for greatness Prevents items of quality 0-1 from appearing, and items of quality 2 from appearing 33% of the time, greatly increasing the quality of items received from all item pools. Quest items are unaffected. 4
Salvation 5.100.696 Salvation Divine protection Gives Isaac a halo that summons beams of light on enemies inside it. The halo grows larger the more times Isaac has taken damage this floor. 3
Sanguine Bond 5.100.692 Sanguine Bond He awaits your offering Spawns a special set of spikes in the Devil Room Devil Room. Taking damage from the spikes has a chance to grant a reward. 1
Saturnus 5.100.595 Saturnus Ring of tears Upon entering a room, a circle of tears orbits Isaac. Enemy tears have a chance to be caught in orbit, turning them friendly. 2
Sausage 5.100.669 Sausage All stats up Adds a Red Heart Container, fully heals Isaac, and gives +0.2 Speed, +0.5 Damage, +0.5 Tears, +1.5 Range, +0.2 Shot Speed, and +1.0 Luck. Increases the chance of encountering a Devil Room Devil Room, Angel Room Angel Room, and/or Planetarium Planetarium each by 6.9%. 3
Sol 5.100.588 Sol Radiant victory Reveals the location of the Boss room. Upon defeating a boss, activates XIX - The Sun XIX - The Sun, fully recharges Isaac's active item, grants bonus damage and luck for the rest of the floor, and removes curses. 2
Soul Locket 5.100.686 Soul Locket Power of faith Gives Isaac a permanent stat boost whenever he picks up a soul heart. 2
Spirit Sword 5.100.579 Spirit Sword Divine blade Instead of tears, Isaac swings a sword. Charging does a spin attack and fires a projectile, and a projectile is sometimes fired with normal swings if Isaac has no empty red hearts. 3
Stapler 5.100.708 Stapler DMG up +1 Damage. Prevents Isaac from firing tears from his left eye, like Cain Cain. 3
Star of Bethlehem 5.100.651 Star of Bethlehem Follow the light Spawns a star familiar that slowly travels towards the Boss Room Boss Room, giving an aura that increases damage and tears and grants homing tears. 3
Terra 5.100.592 Terra Born to rock +1 Damage. Replaces tears with rocks that deal variable damage, have increased knockback, and can destroy obstacles. 3
The Intruder 5.100.575 The Intruder Invasive friend A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. 3
The Swarm 5.100.693 The Swarm Infest Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. 2
Tinytoma 5.100.645 Tinytoma Itching for revenge Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. 1
Tooth and Nail 5.100.663 Tooth and Nail You feel prickly Isaac periodically turns into a spiked statue, briefly becoming invulnerable and dealing contact damage. 2
Tropicamide 5.100.659 Tropicamide Tear size + range up +1.5 Range, Increases tear size. 1
Twisted Pair 5.100.698 Twisted Pair Double trouble! Spawns two familiars that float on either side of Isaac and fire tears that use his tears, range, shot speed, and tear effects, and scale with damage. 4
Uranus 5.100.596 Uranus Ice tears Isaac shoots ice tears, which slow enemies and freeze monsters they kill. Frozen enemies slide away and explode into ice shards when touched. 3
Vasculitis 5.100.657 Vasculitis Clogged enemies Enemies explode into tears upon death, which inherit the effects of Isaac's tears. 2
Vengeful Spirit 5.100.702 Vengeful Spirit Hot blooded After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots. 2
Venus 5.100.591 Venus HP up + you feel pretty Adds one red Heart container. Enemies near Isaac become charmed. 2
Voodoo Head 5.100.599 Voodoo Head Extra curse rooms Spawns an additional Curse Room Curse Room on each floor. 1
Worm Friend 5.100.682 Worm Friend Clingy buddy Gives Isaac a Nerve Ending familiar that burrows out of the ground to grab and deal damage to enemies over time. 3