Items with this tag grant the Spider Baby transformation.
|Box of Spiders||5.100.288||It's a box of spiders|| Spawns 1-4 Blue Spiders that deal 2.5x damage to enemies.
Spawns 4-8 Blue Spiders that deal 2x damage to enemies.
|Spider Butt||5.100.171||Mass enemy slowdown + damage||Deals 10 damage to all enemies in the room and slows them for 4 seconds. Enemies killed by Spider Butt spawn Blue Spiders.||1|
|Daddy Longlegs||5.100.170||Daddy's love||Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total.||3|
|Hive Mind||5.100.248||Giant spiders and flies||Increases the size of Blue Spiders and Blue Flies and doubles the amount of damage they deal. Also increases the effectiveness of fly and spider familiars.||2|
|Infestation 2||5.100.234||Infestation shot||Spawns allied Blue Spiders from killed enemies.||4|
|Juicy Sack||5.100.266||Sticky babies||Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room.||2|
|Mutant Spider||5.100.153||Quad shot||Grants quadruple shot but decreases tears.||3|
|Sissy Longlegs||5.100.280||She loves you||Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders.||1|
|Spider Bite||5.100.89||Slow effect||Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.||2|
|Spiderbaby||5.100.211||Spider revenge|| When hit, spawns 1-2 Blue Spiders.
When hit, spawns 3-5 Blue Spiders.
|Bursting Sack||5.100.377||Spider love||Spider enemies no longer target or deal contact damage to Isaac.||1|
|Spider Mod||5.100.403||Mod buddy!||Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery/Blue spider upon clearing a room.||1|
|Sticky Bombs||5.100.367||Egg sack bombs!||+5 bombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy.||1|
|Parasitoid||5.100.461||Egg tears!||Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy.||3|
|Keeper's Kin||5.100.717||Under a rock||Rocks and props spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed.||2|
|The Intruder||5.100.575||Invasive friend||A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room.||3|