Items with this tag cannot be rerolled in most circumstances, and bypass character-specific limitations. Most items in this list are progression-related.
-
Tainted Isaac: Items do not have a second option, and do not contribute to the 8-item limit. -
Tainted Cain: Items will not be decomposed into pickups, and can be picked up as normal. -
Tainted Eden: Items will not be rerolled upon hit.
Activated Collectibles[ | ]
| Name | ID | Icon | Quote | Description | Quality |
|---|---|---|---|---|---|
| Broken Shovel | 5.100.550 |  
|
It feels cursed | While held, causes Mom to continuously attempt to stomp on Isaac. Activating makes her stop for the current room or wave. One of two parts necessary to create  Mom's Shovel.
|
4 |
| Mom's Shovel | 5.100.552 | 
|
Lost but not forgotten | Creates a trapdoor that leads to the next floor upon activation. Unlocks  The Forgotten when used on a mound of dirt that appears in  Dark Room.
|
4 |
Passive Collectibles[ | ]
| Name | ID | Icon | Quote | Description | Quality |
|---|---|---|---|---|---|
| Key Piece 1 | 5.100.238 | 
|
??? | Combined with  Key Piece 2, unlocks the golden gate in the starting room of  Chest and Dark Room to fight  Mega Satan.
|
0 |
| Key Piece 2 | 5.100.239 | 
|
??? | Combined with  Key Piece 1, unlocks the golden gate in the starting room of Chest and Dark Room to fight Mega Satan.
|
0 |
| The Negative | 5.100.328 | 
|
Fate chosen | If Isaac has half a red heart or no red hearts after taking damage, all enemies in the room take significant damage. Allows entrance into the Dark Room. +1 Damage and also allows access to  Home.
|
2 |
| The Polaroid | 5.100.327 | 
|
Fate chosen | If Isaac has half a red heart or no red hearts after taking damage, he gains a shield that nullifies all types of damage for 5 seconds. Allows entrance into Chest. Also allows access to Home.
|
2 |
| Broken Shovel | 5.100.551 | 
|
It feels cursed | One of two parts necessary to create Mom's Shovel. No effect if somehow obtained on its own.
|
4 |
| Dad's Note | 5.100.668 | 
|
... | Sends Isaac on an Ascent toward Home.
|
0 |
| Dogma | 5.100.633 | 
|
Ascended | Grants flight, +2 damage, and increases speed to 1.1. Grants enough health to have 6 full hearts, if possible. Grants the  Holy Mantle effect for the room it was obtained in. Automatically given to Isaac after defeating Dogma.
|
3 |
| Knife Piece 1 | 5.100.626 | 
|
??? | Combined with  Knife Piece 2, creates a knife familiar that damages enemies and can open the door to the  Corpse.
|
0 |
| Knife Piece 2 | 5.100.627 | 
|
??? | Combined with  Knife Piece 1, creates a knife familiar that damages enemies and can open the door to the Corpse.
|
0 |
 The Binding of Isaac: Rebirth
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