Familiars that can be spawned by 
Monster Manual.
Passive Collectibles[]
| Name | ID | Icon | Quote | Description | Quality |
|---|---|---|---|---|---|
| ???'s Only Friend | 5.100.320 | 
|
Controlled friend | Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys | 2 |
| Ball of Bandages | 5.100.207 | 
|
Gotta lick 'em all! | Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies gives it the ability to shoot charm tears, then chase enemies, then increases the damage. | 2 |
| BBF | 5.100.272 | 
|
Big Beautiful Fly | Spawns a familiar that flies around the room in a zig-zag pattern and explodes on contact with an enemy. Respawns after ten seconds. | 1 |
| Big Fan | 5.100.279 | 
|
Fat protector | Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies. | 2 |
| Bob's Brain | 5.100.273 | 
|
Explosive thoughts | Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. | 1 |
| Brother Bobby | 5.100.8 | 
|
Friends 'till the end | A familiar that follows Isaac around shooting normal tears. | 0 |
| Cube of Meat | 5.100.73 | 
|
Gotta meat 'em all! | Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies grants it the ability to shoot, then chase enemies, then increases the damage. | 2 |
| Demon Baby | 5.100.113 | 
|
Auto-turret friend | Spawns a familiar that follows Isaac and automatically fires at enemies in its reach. | 2 |
| Distant Admiration | 5.100.57 | 
|
Attack fly | Spawns an attack fly that circles further out than  Halo of Flies, but closer than  Forever Alone, dealing 75 damage per second.
|
2 |
| Dry Baby | 5.100.265 | 
|
Immortal friend | Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering  The Necronomicon effect.
|
3 |
| Forever Alone | 5.100.128 | 
|
Attack fly | Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second. | 1 |
| Ghost Baby | 5.100.163 | 
|
Spectral buddy | Spawns a familiar that follows Isaac around and fires spectral tears. | 1 |
| Guardian Angel | 5.100.112 | 
|
Extra protection | Spawns an orbital familiar that blocks enemy shots, deals 105 damage per second to enemies, and increases the speed of all orbital familiars. | 2 |
| Halo of Flies | 5.100.10 | 
|
Projectile protection | Spawns two Pretty Flies that block enemy shots and deal contact damage to flies. | 3 |
| Harlequin Baby | 5.100.167 | 
|
Double shot buddy | Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern. | 1 |
| Headless Baby | 5.100.269 | 
|
Bloody friend | Spawns a familiar that follows Isaac, leaving blood creep on the ground. | 1 |
| Juicy Sack | 5.100.266 | 
|
Sticky babies | Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. | 2 |
| Leech | 5.100.270 | 
|
Blood sucker | Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a Half Red Heart whenever Leech kills an enemy. | 1 |
| Lil Brimstone | 5.100.275 | 
|
Evil friend | Grants a familiar that charges a thin  Brimstone laser while Isaac is shooting.
|
3 |
| Lil Haunt | 5.100.277 | 
|
Fear him | Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear. | 1 |
| Little Chubby | 5.100.88 | 
|
Attack buddy | Spawns a charger familiar that charges forward and deals contact damage to any enemies in its path. | 1 |
| Little Gish | 5.100.99 | 
|
Sticky friend | Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed. | 2 |
| Little Steven | 5.100.100 | 
|
Psychic friend | Spawns a familiar who follows Isaac around and fires homing tears. | 1 |
| Mongo Baby | 5.100.322 | 
|
Mongo friend | Spawns a familiar that copies the tears of Isaac's other familiars. | 2 |
| Robo-Baby | 5.100.95 | 
|
Friends 'till the bbbbzzzt | Spawns a familiar that shoots  Technology lasers.
|
1 |
| Robo-Baby 2.0 | 5.100.267 | 
|
We worked out all the kinks | Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears. | 0 |
| Rotten Baby | 5.100.268 | 
|
Infested friend | Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. | 3 |
| Sissy Longlegs | 5.100.280 | 
|
She loves you | Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. | 1 |
| Sister Maggy | 5.100.67 | 
|
Friends 'till the end | Spawns a familiar that follows Isaac around shooting normal tears. | 0 |
| Smart Fly | 5.100.264 | 
|
Revenge fly | Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. | 3 |
| The Peeper | 5.100.155 | 
|
Plop! | Spawns a familiar that floats slowly around the room on a zig-zag pattern, damaging enemies it passes through. | 0 |
| Farting Baby | 5.100.404 | 
|
He farts! | Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies. | 1 |
| Fate's Reward | 5.100.361 | 
|
Your fate beside you | A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage. | 2 |
| Friend Zone | 5.100.364 | 
|
Friendly fly | Spawns a white attack fly that orbits somewhere between  Distant Admiration and Forever Alone, dealing 45 damage per second.
|
1 |
| Incubus | 5.100.360 | 
|
Dark friend | Spawns a demonic familiar that shoots tears identical to Isaac's in terms of damage, tears, and tear effects. | 4 |
| Lil Gurdy | 5.100.384 | 
|
A gurd of your own! | A Gurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed. | 1 |
| Lil Loki | 5.100.435 | 
|
4-way buddy! | Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern. | 1 |
| Lost Fly | 5.100.365 | 
|
Lost protector | Spawns fly familiar that moves in a straight line and circles around the first wall or obstacle it hits, dealing 105 damage per second on contact. | 0 |
| Papa Fly | 5.100.430 | 
|
Turret follower | Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies. | 1 |
| Seraphim | 5.100.390 | 
|
Sworn friend | Spawns an angel familiar which follows Isaac and fires homing tears which deal 10 damage and have 75% shot speed. | 3 |
| Succubus | 5.100.417 | 
|
Damage booster | Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier. | 3 |
| Sworn Protector | 5.100.363 | 
|
Protective friend | Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal Heart. | 3 |
| Angry Fly | 5.100.511 | 
|
He's violent | Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with. | 1 |
| Big Chubby | 5.100.473 | 
|
Chub chub | Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact. | 1 |
| Bloodshot Eye | 5.100.509 | 
|
Bloody friend | Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds. | 1 |
| Hushy | 5.100.470 | 
|
Lil hush! | Spawns a Hush familiar that bounces diagonally around the room and deals contact damage. While firing tears, it stops moving. | 0 |
| Lil Delirium | 5.100.519 | 
|
Delirious friend | Grants a familiar that transforms into another random familiar every 10 seconds. | 2 |
| Lil Monstro | 5.100.471 | 
|
Ain't he cute? | Spawns a familiar that fires clusters of tears. Must be charged before shooting. | 2 |
| Lil Spewer | 5.100.537 | 
|
Puking buddy | Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type. | 1 |
| Shade | 5.100.468 | 
|
It follows | Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers. | 0 |
| Boiled Baby | 5.100.607 | 
|
Messy friend | Gives Isaac a familiar that fires chaotic bursts of tears in all directions. | 1 |
| Bot Fly | 5.100.629 | 
|
Defense drone | Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. | 3 |
| Freezer Baby | 5.100.608 | 
|
Iced iced baby | Spawns a shooting familiar that has a chance to petrify enemies, and Freezes monsters upon killing them. | 2 |
| Fruity Plum | 5.100.649 | 
|
Bouncy friend | Gives Isaac a miniature Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels. | 1 |
| Lil Abaddon | 5.100.679 | 
|
Abyssal friend | Spawns a familiar that charges a miniature  Maw of the Void attack while Isaac shoots.
|
3 |
| Tinytoma | 5.100.645 | 
|
Itching for revenge | Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. | 1 |
