Items with this tag grant the Seraphim transformation.
Activated Collectibles[]
| Name | ID | Icon | Quote | Description | Quality |
|---|---|---|---|---|---|
| The Bible | 5.100.33 |  
|
Temporary flight | On use, Isaac gains flight for the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but kills Isaac when used on Satan. | 1 |
Passive Collectibles[]
| Name | ID | Icon | Quote | Description | Quality |
|---|---|---|---|---|---|
| Celtic Cross | 5.100.162 | 
|
Blessing of protection | Grants a chance to trigger the  Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
|
1 |
| Dead Dove | 5.100.185 | 
|
Flight + spectral tears | Grants spectral tears and flight. | 3 |
| Godhead | 5.100.331 | 
|
God tears | Grants homing tears with a damaging halo. +0.5 damage, -0.3 tears, +1.2 range, -0.3 shot speed, +0.8 tear height. | 4 |
| Holy Grail | 5.100.184 | 
|
Flight + HP up | Grants flight and one Red Heart container. | 3 |
| Holy Mantle | 5.100.313 | 
|
Holy shield | Upon entering a room, grants a shield that negates the first damage taken. | 4 |
| Mitre | 5.100.173 | 
|
Blessing of purity | Grants a chance of converting any Red Heart pickups into Soul Hearts instead. | 3 |
| Rosary | 5.100.72 | 
|
Tears + faith up | Adds 3 Soul Hearts. The Bible will appear in any item pool.Also a +0.5 tears up.
|
1 |
| Sacred Heart | 5.100.182 | 
|
Homing shots + DMG up | Grants homing tears, x2.3 damage multiplier, +1 flat damage, +4.125 range, +0.75 tear height, -0.4 tears, -0.25 shot speed, a red Heart Container and replenishes all Red Hearts. | 4 |
| Scapular | 5.100.142 | 
|
Pray for a miracle | Once per room, when Isaac is reduced to his last half heart, he is granted one Soul Heart. | 2 |
| The Halo | 5.100.101 | 
|
All stats up | Grants one full Red Heart container, +0.3 damage, +0.2 tears, +0.25 range, +0.3 speed, and +0.5 tear height. | 2 |
| Holy Light | 5.100.374 | 
|
Holy death shot | Adds a chance to fire holy tears, which will create a damaging light beam in the area if they hit an enemy. | 3 |
| Divine Intervention | 5.100.568 | 
|
Double tap shield | Double tapping a fire key creates a shield that pushes away enemies and reflects enemy projectiles and lasers. | 2 |
| Immaculate Heart | 5.100.573 | 
|
Halo of tears | Adds one Red Heart Container and fully restores health. x1.2 damage multiplier. Isaac will occasionally fire extra tears that orbit around him. | 3 |
| Revelation | 5.100.643 | 
|
Awaken your faith | Grants flight and two soul hearts. In addition to tears, Isaac can charge up and fire a powerful holy laser. | 4 |
| Sacred Orb | 5.100.691 | 
|
Destined for greatness | Prevents low-quality items from spawning, greatly increasing the quality of items received from all item pools. | 4 |
| Salvation | 5.100.696 | 
|
Divine protection | Gives Isaac a halo that summons beams of light on enemies inside it. The halo grows larger the more times Isaac has taken damage this floor. | 2 |
