It's in the Cards is challenge #14. Start off with Deck of Cards, Starter Deck, The Battery, 9 Volt, and 2 random tarot cards. The goal is to defeat Mom. This Challenge is available by default.
A straightforward challenge but no Treasure Rooms, don't be afraid to use cards relatively frequently, as they charge fairly quickly.
- There will be access to cards throughout much of the run. Know what the cards do and use them accordingly.
- There isn't any special strategy, however it is not a bad idea to reroll until getting the Joker card and until getting great items in a Devil/Angel Room.
- Picking up Little Baggy can greatly influence the run, as the Deck of cards will create pills instead of cards.