Binding of Isaac: Rebirth Wiki
It's   in   the   Cards
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Table dividing line 1.png
Challenge Number
Available Rooms
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Boss Mom portrait.png

It's in the Cards is challenge #14. Start off with Deck of Cards Deck of Cards, Starter Deck Starter Deck, The Battery The Battery, 9 Volt 9 Volt, and 2 random tarot cards. The goal is to defeat Mom Mom. This Challenge is available by default.


A straightforward challenge but no Treasure Room Treasure Rooms, don't be afraid to use cards relatively frequently, as they charge fairly quickly.


  • There will be access to cards throughout much of the run. Know what the cards do and use them accordingly.
  • There isn't any special strategy, however it is not a bad idea to reroll until getting the Joker Joker card and until getting great items in a Devil/Angel Room.
  • Picking up Little Baggy Little Baggy can greatly influence the run, as Removed in Repentance the Deck of Cards will create pills instead of cards. Added in Repentance pills will be allowed to spawn alongside cards.