Binding of Isaac: Rebirth Wiki

It's in the Cards is challenge #14. Start off with Deck of Cards, Starter Deck, The Battery, 9 Volt, and 2 random tarot cards. The goal is to defeat Mom. This Challenge is available by default.

Difficulty[]

A straightforward challenge, but no Treasure RoomTreasure Rooms. Don't be afraid to use cards relatively frequently, as they charge fairly quickly.

Strategy[]

  • There will be access to cards throughout much of the run. Know what the cards do and use them accordingly.
  • There isn't any special strategy, however it is not a bad idea to reroll until getting the Error: The given pickup ("Joker") does not exist. card and until getting great items in a Devil/Angel Room.
  • If one has Error: The given pickup ("VI - The Lovers?") does not exist. unlocked, restarting until you obtain one is a viable strategy, as one can get powerful secret room items such as (in Repentance) Rock Bottom. With a decent amount of cards giving stats such as Error: The given pickup ("III - The Empress") does not exist., Error: The given pickup ("VII - The Chariot?") does not exist., Error: The given pickup ("XI - Strength") does not exist., and Error: The given pickup ("XV - The Devil") does not exist., one will quickly accumulate great stats.
  • Picking up Little Baggy can greatly influence the run, as (except in Repentance) the Deck of Cards will create pills instead of cards. (in Repentance) pills will be allowed to spawn alongside cards.
  • Carrying (except in Rebirth) Endless NamelessEndless Nameless can be quite useful, as the 25% chance to duplicate a card upon use is used constantly throughout the run.

Reward[]