Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki
It's   in   the   Cards
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Table dividing line 1.png
Challenge Number
Available Rooms
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Boss Mom portrait.png

It's in the Cards is challenge #14. Start off with Deck of Cards Deck of Cards, Starter Deck Starter Deck, The Battery The Battery, 9 Volt 9 Volt, and 2 random tarot cards. The goal is to defeat Mom. This Challenge is available by default.


A straightforward challenge but no Treasure Rooms, don't be afraid to use cards relatively frequently, as they charge fairly quickly.


  • There will be access to cards throughout much of the run. Know what the cards do and use them accordingly.
  • There isn't any special strategy, however it is not a bad idea to reroll until getting the Joker Joker card and until getting great items in a Devil/Angel Room.
  • Picking up Little Baggy can greatly influence the run, as the Deck of cards will create pills instead of cards.