Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Disambig.png This article is about the boss. For the character, see Isaac.

Isaac is the boss of the Cathedral Cathedral, and the final boss of Ending 13.


Isaac lies on the ground in the middle of the room and does not begin attacking until he takes damage.
During all three of Isaac's phases, he continuously shoots multiple projectiles in the player's direction at fixed intervals when not performing other attacks. After taking enough damage, he begins to shoot double projectiles and triple projectiles.

Phase 1[]

Isaac remains stationary on the ground and performs the following attacks:

  • Shoots 10 lines of projectiles in every direction.
  • Shoots 8 groups of projectiles that curve back towards him.
  • Shoots 8 groups of long-range spinning projectiles along with 10 slightly curved lines of shorter-range projectiles in every direction.

Phase 2[]

Isaac stands up but remains stationary and performs the following attack:

  • Isaac alternates between two projectile patterns:
    • Shoots 4 projectiles in a cross pattern, which splits into four short-ranged projectiles after a short time, similar to 15►Cricket's Body Cricket's Body.
    • Shoots 8 projectiles in all directions.

Independently of his projectile attack:

Phase 3[]

Isaac grows a pair of angelic wings and is no longer stationary, moving towards where the player is predicted to go with short dashes. During which he also performs the following attacks:

  • Teleports off-screen and summons 15►Crack the Sky Crack the Sky beams to cover the screen, starting from one of the top corners to the opposite bottom corner. After teleporting back on-screen, he shoots the 10 lines of projectiles from the first phase. He always performs this attack at the start of this phase and repeats this process every time he takes 200 damage.
    • Added in Repentance Shadows indicate ahead of time where the beams strike.
  • Can perform all projectile patterns from the first phase.


Unlockable Achievements[]


  • Every time Isaac is defeated, the current savefile's image changes until 15►The Polaroid The Polaroid is unlocked.
  • Isaac does not begin attacking until he has been damaged. This can be exploited to make the fight much easier by dealing large amounts of damage in the first hit. Methods of doing this include saving up a large amount of tears with 15►Anti-Gravity Anti-Gravity, waiting for Added in Afterbirth15►Kidney Stone Kidney Stone to activate before shooting Isaac, or placing multiple bombs and detonating them all at once with 15►Remote Detonator Remote Detonator. Added in Afterbirth15►Glass Cannon Glass Cannon can also provide a high-damage initial shot, but doing this is extremely risky due to Glass Cannon's additional effect of reducing health to one half-heart.
    • Added in RepentanceGlass Cannon no longer reduces health on use, so it can be used against Isaac much more effectively.


  • Isaac was added in the Wrath of the Lamb DLC for the original The Binding of Isaac.
  • Isaac, along with ???, teleport away upon defeat and do not "die".
  • Isaac's expression as he changes phases during the fight goes from a somber, scared tone to him smiling in his third phase. This supports the theory that Isaac has made peace with himself and realized what he must do, as seen through the multiple endings of the game.
  • The music that plays during this boss fight is titled Infanticide.[1] The term infanticide refers to the act of killing an infant or newborn.
    • In the original Wrath of the Lamb DLC, the song was My Innermost Apocalypse.
  • During his first phase, Isaac makes the same crying sound as Mulligans. This also applies to ???.


Bug Bug! Added in Afterbirth † The Angelic Babies always spawn in the bottom center of the room at the same position.


Bosses Boss Monstro.png
Chapter 1
Stage Basement icon.pngStage Cellar icon.pngStage Burning Basement icon.png
GeminiStevenBlighted OvumDingleThe Duke of FliesFamineGurglingsThe HauntLarry Jr.MonstroPinWidowThe FallenThe Headless Horseman
DangleLittle HornRag ManTurdlings
Baby Plum
Chapter 1.5
Stage Downpour icon.pngStage Dross icon.png
Lil BlubWormwoodThe RainmakerMin-MinClogColostomiaTurdlet
Chapter 2
Stage Caves icon.pngStage Catacombs icon.pngStage Flooded Caves icon.png
FistulaChubC.H.A.D.Carrion QueenDark OneGurdyGurdy Jr.The HollowThe HuskMega FattyMega MawPeepPestilencePolycephalusThe WretchedThe FallenThe Headless Horseman
The ForsakenThe FrailThe Stain
Big HornRag Mega
Chapter 2.5
Stage Mines icon.pngStage Ashpit icon.png
Reap CreepTuff TwinsHornfelGreat GideonSingeThe ShellThe Pile
Chapter 3
Stage Depths icon.pngStage Necropolis icon.pngStage Dank Depths icon.png
The AdversaryThe BloatThe CageThe GateMonstro IIGishLokiMask of InfamyWarThe FallenThe Headless HorsemanMom
Sisters Vis
Reap CreepThe Pile
Chapter 3.5
Stage Mausoleum icon.pngStage Gehenna icon.png
The SirenThe HereticThe VisageThe Horny BoysMomMom's Heart
Chapter 4
Stage Womb icon.pngStage Utero icon.pngStage Scarred Womb icon.png
BlastocystThe BloatConquestDaddy Long LegsTriachnidDeathLokiiMama GurdyMr. FredScolexTeratomaThe FallenThe Headless HorsemanMom's HeartIt Lives
Sisters VisThe Matriarch
Stage Corpse icon.png
ChimeraThe ScourgeRotgutMother
Chapter 5
Stage Sheol icon.pngStage Cathedral icon.png
Chapter 6
Stage Dark Room icon.pngStage Chest icon.png
???The LambMega Satan
The Void
Stage The Void icon.png
Stage Home icon.png
DogmaThe BeastUltra DeathUltra FamineUltra PestilenceUltra War
Greed Mode
Ultra Greed
Ultra Greed
Ultra Greedier
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
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