Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Disambig.png This article is about the character. For the boss of The Cathedral, see Isaac (Boss).

Isaac is the main character of the series, returning from the original The Binding of Isaac. Isaac is the only character unlocked by default.

Isaac starts with three Red Heart containers and one bomb. He will also start with 15►The D6 The D6 once it is unlocked (after defeating Isaac as ???).


  • Removed in Repentance 15►The D6 The D6 that Isaac can start with does not increase the special counter.

Item Interactions[]

  • Added in Repentance15►Birthright Birthright: All new item pedestals cycle between two options. Previously-seen items are unaffected.

Unlockable Achievements[]



  • Isaac is a reference to the biblical story of the binding of Isaac, in which Abraham is commanded by God to sacrifice his only son, Isaac, to prove his loyalty and love.
    • "Then God said, 'Take your son, your only son, whom you love — Isaac — and go to the region of Moriah. Sacrifice him there as a burnt offering on a mountain I will show you.'" (Genesis 22:2)
  • In a response to TBoI Youtuber Sinvicta of whether there was any concept art of what Isaac's original design was, Edmund McMillen confirmed that Isaac's design was originally one of an Octorock while showing very similar features of how the gameplay would be modeled by posting an old concept art.
  • Edmund has stated that Isaac is left-handed, but in the opening cutscene, Isaac is holding a pencil with his right hand.[1]
    • This could be a reference to the Catholic bias against left-handedness, stemming from Matthew 25:33 proclaiming that God will put those deserving to ascend to Heaven on his right-hand side and put those deserving to descend to Hell on his left-hand side. Isaac's mother could have forced him to learn things the "righty" way for fear of him being "evil."
  • Contrary to previous theories made about Isaac, he does not have a sister.
  • Isaac is bald because his mother shaved his head. Which could be a reference to the Nazarite Vow in Numbers 6:1–21 [2]
    • Isaac's natural hair color is strawberry blond. [1]
  • Isaac has Irritable Bowel Syndrome. [3]
  • Isaac's dad is a handy man. [4]
  • Isaac's full name is Isaac Moriah. [5]
    • This is in reference of Mount Moriah, the place where Abraham takes his son Isaac to be sacrificed, in the Book of Genesis.
  • Isaac is 5 years old. [6]
  • Isaac is circumcised. This was confirmed by Edmund McMillen during a YouTube stream.
  • Isaac's voiceover in Rebirth was done by Tallulah Bossi, Matthias Bossi (Member of Ridiculon and voice of Dad/Narrator) and Carla Kihlstedt's (Musician and voice of Mom) daughter. For Repentance, the voice was done by their son, Viggo Bossi.



Isaac CharNav New.png Maggy CharNav New.png Cain CharNav New.png Judas CharNav New.png BB CharNav New.png Eve CharNav New.png Samson CharNav New.png Azazel CharNav New.png Lazarus CharNav New.png Eden CharNav New.png Lost CharNav New.png


Tainted Isaac CharNav New.png Tainted Maggy CharNav New.png Tainted Cain CharNav New.png Tainted Judas CharNav New.png Tainted BB CharNav New.png Tainted Eve CharNav New.png Tainted Samson CharNav New.png Tainted Azazel CharNav New.png Tainted Lazarus CharNav New.png Tainted Eden CharNav New.png Tainted Lost CharNav New.png Tainted Lilith CharNav New.png Tainted Keeper CharNav New.png Tainted Apollyon CharNav New.png Tainted Forgotten CharNav New.png Tainted Bethany CharNav New.png Tainted Jacob CharNav New.png

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