Binding of Isaac: Rebirth Wiki

This article is about Ipecac, similar in appearance to Rubber Cement.

Ipecac is a passive item.

Effects[ | ]

  • Replaces tears with explosive and poisoning projectiles fired in an arc.
  • (except in Repentance) Tears down - (Delay * 2) + 10
  • (in Repentance) 1/3 Fire Rate
  • (except in Repentance) Tear Falling Speed is set to 13.
  • (in Repentance) -0.2 shot speed.
  • (in Repentance) 0.8x range multiplier.
  • +40 flat damage (See Effective Damage)
  • Tear size multiplier: 0.4x
  • (except in Rebirth) This item belongs to the BobBob set. Collecting three items from this set will transform Isaac into Bob.

Notes[ | ]

  • Enemies within the blast radius of an Ipecac explosion will also be poisoned.
  • The damage boost mitigates the very small tear size multiplier.
  • Ipecac's damage bonus does not apply to Burn or Poison fully; only (except in Repentance)+4/(in Repentance)+2 is applied to their damage per tick.
  • Character damage multipliers do not apply to Ipecac's flat bonus.
  • Since explosions that deal less than 85 damage hurt Isaac for half a heart, Ipecac shots usually hurt Isaac for half a heart.
    • Self-damage is increased to a full heart with 85 or higher damage stat.
  • Explosions that deal more than or equal to (except in Repentance) 100/(in Repentance) 166 damage shake the screen.
  • Using Ipecac in a Crawl SpaceCrawl Space will cause the tear to bounce off the ceiling, bounce off the floor at a low height, and eventually explode. The same applies to using it on a Crawl Space wall.
  • (in Repentance) The height of the shots scales with range. At base stats, Ipecac shots won't be able to fly over obstacles, but the more range ups Isaac gets, the higher shots will be launched.
  • (in Repentance) It is possible that with low shot speed and high range/tear height, Isaac won't be able to hit obstacles up close with Ipecac shots.
  • (except in Repentance) The range of the explosion is a circle roughly 3 blocks in diameter, regardless of damage.
    • As Ipecac's explosion range does not scale with tear size, with enough tear size increasing items (e.g. Collectible Death's Touch iconDeath's Touch), it can become nearly impossible to hit enemies with Ipecac's explosions.
  • (in Repentance) Ipecac's explosion range increases with tear size.

Synergies[ | ]

  • (in Repentance)Collectible Abyss iconAbyss: When Isaac uses Abyss to absorb Ipecac it turns into a larger slow moving green locust that deals x1.5 Isaac’s damage per tick and poisons enemies.
  • (in Repentance)Brain WormBrain Worm: The Ipecac tears will snap 90 degrees and rain down at nearby enemy should the shot miss, completely eliminating the shortcoming of having too much range and causing Ipecac tears to fly over enemy's head, missing them.
  • Collectible Brimstone iconBrimstone / Character Azazel iconAzazel: Blood beam now does poison damage and will explode on connection with an enemy which can damage the character if close enough. The character doesn't gain the Damage Up or Tears Down effects.
    • (in Afterbirth and Afterbirth †) Isaac shoots Ipecac tears while charging Brimstone. Both Brimstone and Ipecac shots modify Isaac's damage and tear delay stat, meaning that Ipecac fires slower and Brimstone charges slower, but Brimstone does an extra 40*13 damage. Take care to pre-charge Brimstone so that the Ipecac shot is on cooldown as Isaac enters a room.
    • (in Repentance) The flat damage bonus is reduced to +2, but Isaac's tear rate stat is not modified. The beam explodes on the first enemy or obstacle it hits every other tick, dealing 10 + twice of Isaac's Damage. The explosions do not occur when the beam narrows, meaning that they occur only twice per shot without Collectible Soy Milk iconSoy Milk / (in Repentance)Collectible Almond Milk iconAlmond Milk. The beam and its explosions poison enemies. Collectible The Ladder iconThe Ladder, when placed, will trigger the Ipecac-Brimstone explosions. (possibly a bug)
  • Collectible Cricket's Body iconCricket's Body: The main tear splits into four explosive splash tears. The splash tears can still damage Isaac.
    • (in Repentance) Ipecac's x0.8 range multiplier does not stack with Cricket's Body's own x0.8 range multiplier.
  • (in Repentance)Collectible C Section iconC Section: The fetuses explode once they touch an enemy, poisoning and dealing damage equal to Isaac's Damage.
  • Collectible Dr. Fetus iconDr. Fetus: Bombs explode on contact, do no damage to Isaac and become Collectible Bob's Curse iconBob's Curse bombs.
    • (except in Repentance) The damage is massively increased, as the +40 damage from Ipecac is run through the damage multiplier of Dr. Fetus.
    • (in Repentance) The flat damage bonus is reduced to +2. Bombs leave a poison cloud that damages enemies. With Character Jacob and Esau iconJacob and Esau only the character with the items is immune to the explosions.
    • Dr. Fetus + Monstro's Lung: Renders Isaac no longer immune to his shots. (in Repentance) The flat damage bonus is increased back to +40.
    • Dr. Fetus + Sad Bombs: Isaac is not immune to the explosive shots created by the Sad Bombs' effect.
  • Collectible Epic Fetus iconEpic Fetus: Missiles turn green and are poisonous. Damage greatly increases as the flat damage bonus stacks with Epic Fetus' explosive multiplier.
  • (in Afterbirth † and Repentance)Collectible Flat Stone iconFlat Stone: The Ipecac shots cause full-damage explosions instead of lesser splash damage when they bounce off the floor, though they can also harm Isaac.
    • (in Repentance) Each bounce creates an explosion that deals half Isaac's damage as well as dealing the regular splash damage. The bounce explosion radius is slightly larger than the splash radius.
  • Character The Forgotten iconThe Forgotten: The flat damage bonus is reduced to +4. Melee attacks become poisonous and explosive; he cannot be hurt by the blasts but is pushed back by them. The explosions deal 1.5x Damage. The charged throwing attack is only poisonous. The Soul uses Ipecac as normal.
    • (in Repentance) The flat damage bonus is reduced to +2. The thrown bone club can explode once on enemy contact while being sent out, but not while returning. These explosions deal from 10 + 2.8x to 10 + 6x Damage based on how much the attack is charged, and do no self-damage.
    • (in Repentance) When the skeleton form has Collectible Technology iconTechnology, the thrown bone club constantly explodes and deals damage to The Forgotten.
  • (in Afterbirth † and Repentance)Collectible Haemolacria iconHaemolacria: Tear delay is increased by 1/3 compared to either of the items on their own, but Isaac now fires Ipecac shots that release poisonous, high-damage but non-explosive split tears on impact.
    • (in Repentance) Ipecac's x0.8 range multiplier does not stack with Haemolacria's own x0.8 range multiplier.
  • Collectible The Ludovico Technique iconThe Ludovico Technique: Tear damage is increased by 4, explodes when killing an enemy, and comes back to Isaac.
    • (in Afterbirth †) +4 flat damage bonus, no explosion.
    • (in Repentance) +2 flat damage bonus, no explosion.
  • (in Repentance)Collectible Maw Of The Void iconMaw Of The Void: The ring becomes poisonous and explodes on the first enemy or obstacle contact it hits every other tick, dealing 10 + twice of Isaac's Damage. The explosions do not occur for the first four ticks.
  • (in Repentance)Collectible Mega Blast iconMega Blast: The explosions from the beam do not damage Isaac.
  • Collectible Mom's Knife iconMom's Knife: Knife turns green, may poison enemies, and removes Ipecac's damage increase.
    • (in Afterbirth †) Also adds +4 flat damage bonus.
    • (in Repentance) Also adds +2 flat damage bonus. The thrown knife can explode once on enemy contact while being sent out, but not while returning. These explosions deal from 10 + 2.1x to 10 + 6x Damage based on how much the attack is charged.
  • Collectible Monstro's Lung iconMonstro's Lung: Isaac fires a barrage of Ipecac shots, with no increase in charge time compared to Monstro's Lung alone.
    • (in Repentance) Charge time increases by 3x.
  • Collectible Mysterious Liquid iconMysterious Liquid: Leaves a massive pool of creep on the floor on impact.
  • Collectible The Parasite iconThe Parasite: The Ipecac tear will spawn two smaller explosive tears when it collides with a solid object, but not with an enemy. These tears can spawn tears on their own as well, potentially leading to huge chain reactions.
  • (in Repentance)Collectible Revelation iconRevelation: The laser do not benefit from Ipecac's damage bonus, instead it takes +2 flat damage bonus. The laser explodes on the first enemy or obstacle it hits every other tick. The explosions occur 8 times and deal 10 + twice of the laser's damage.
  • (except in Rebirth)Collectible Tech X iconTech X: The flat damage bonus is reduced to +4. The laser ring becomes poisonous.
    • (in Repentance) The flat damage bonus is reduced to +2. The laser ring becomes poisonous and explodes every other tick on contact, deal 10 + twice of the ring's damage. Knockback from the blasts will push enemies along the path of the ring, prolonging damage. The ring will not open Secret RoomSecret Rooms.
  • Collectible Technology iconTechnology: Removes the flat damage bonus, poisonous laser.
    • (in Afterbirth †) +4 flat damage bonus, poisonous laser.
    • (in Repentance) +2 flat damage bonus, poisonous laser that explodes on enemy or obstacle contact, deal 10 + twice of Isaac's damage. Keeps Ipecac's stats other than damage.
      • Note: This combination is not advised if the player has the (except in Rebirth)Collectible Multidimensional Baby iconMultidimensional Baby familiar. When the ipecac technology laser passes through the (except in Rebirth)Collectible Multidimensional Baby iconMultidimensional Baby, it instantly explodes, damaging the player and likely being fatal for the run.
  • (in Afterbirth † and Repentance)Collectible Trisagion iconTrisagion: Trisagion blasts do not explode on hit. The explosion happen once the blast runs out of range or hits a wall and deals damage equal to Isaac's Damage.
    • (in Repentance) Trisagion blasts are poisonous and explode upon impact with an enemy or obstacle, dealing 10 + twice of the blast's damage. When the base of the blast reaches an enemy or obstacle, it explodes and deals damage equal to Isaac's Damage.

Interactions[ | ]

  • (except in Rebirth)Collectible Crown Of Light iconCrown Of Light / Collectible Polyphemus iconPolyphemus / (except in Repentance)Collectible Proptosis iconProptosis / Collectible Sacred Heart iconSacred Heart / (except in Repentance)Collectible Bloody Lust iconBloody Lust: The damage multipliers from these items do not apply to Ipecac's +40 bonus, resulting in much lower damage increase than expected.
  • Collectible Chocolate Milk iconChocolate Milk: Charged up Ipecac deals expectedly high damage. Rapid-fire can be used against weaker enemies or to clear obstacles when necessary.
  • Collectible Cricket's Head iconCricket's Head / Collectible Eve's Mascara iconEve's Mascara / Collectible Magic Mushroom iconMagic Mushroom: The damage multipliers from these items apply to Ipecac's +40 bonus, unlike others.
  • (except in Repentance)Collectible Death's Touch iconDeath's Touch: Although damage is increased, the tears' hitboxes also grow larger, which may be detrimental.
  • Collectible Fire Mind iconFire Mind: Due to the nature of the Ipecac, all shots will have a 100% chance of leaving a fire at the center of the explosion. (except in Repentance) It will also no longer leave behind green creep and the explosion will be of normal color instead of green.
  • (except in Repentance)Collectible Ghost Pepper iconGhost Pepper: If a fire is generated at the same time as an Ipecac shot, the Ipecac shot will explode instantly.
  • (except in Rebirth)Collectible Glass Cannon iconGlass Cannon: As the Glass Cannon tears are so large, even a modest damage increase or a single tear size increasing item is likely to render the tear unable to damage enemies.
  • GuppyGuppy: Blue Flies are no longer spawned on hit.
    • (except in Rebirth) Ipecac shots spawn Blue Flies on hit, both direct and indirect.
  • (except in Rebirth)Collectible Holy Light iconHoly Light: A beam of light will spawn on top of any enemy within the explosion's radius.
  • (in Afterbirth † and Repentance)Collectible Jacob's Ladder iconJacob's Ladder: The sparks spawn only when they hit a wall.
  • (except in Repentance)Collectible Little Horn iconLittle Horn: If an Ipecac shot has the Little Horn effect, after destroying an enemy, it loses its explosive property and effectively is just a normal Little Horn tear.
  • Collectible Lost Contact iconLost Contact: Ipecac shots will explode on contact with enemy shots.
  • Collectible Mom's Eye iconMom's Eye / Collectible Loki's Horns iconLoki's Horns: Occasionally shoots backwards or in all 4 directions, with high risk of self-damage.
  • (in Repentance)Collectible Number One iconNumber One: Not recommended. Unlike other similar items, Ipecac's x0.8 range multiplier does stack with Number One's own x0.8 range multiplier, making self-damage more likely.
  • Piercing tears: Tears will still explode on enemy contact, nullifying piercing.
  • Collectible Rubber Cement iconRubber Cement: Tears will bounce off walls and rocks and won't explode until they hit the ground. Not recommended, as self-damage is likely.
  • Spectral tears: Ipecac shots no longer explode on contact with obstacles or walls, making accidental self-damage less likely but it's more difficult to open secret doors.
  • Character Tainted Forgotten iconTainted Forgotten: Tainted Forgotten's melee attacks will explode. Tainted Soul is immune only to those explosions, so any further explosions caused by synergies will damage it.
  • (except in Repentance)Collectible Technology 2 iconTechnology 2: The +40 damage bonus is not affected by the Technology 2 multiplier, making the laser very high powered, but only every other Ipecac shot is fired.
  • (in Afterbirth † and Repentance)Collectible Technology Zero iconTechnology Zero: High fire rate needed for explosive shots to be connected.
  • Collectible Tiny Planet iconTiny Planet: Ipecac tears orbit around Isaac for a very long time. They land far enough to not cause self-damage, but that can be relied on only if Isaac is not moving and do not hit enemies.
  • (except in Rebirth)Collectible Tractor Beam iconTractor Beam: The Ipecac tear will travel in an arc along the beam, even if Isaac is moving forward as well. When Isaac changes direction, the tear will snap to the beam, making it very easy to accidentally hit close objects blocking its new path.

In-game Footage[ | ]

Unlockable Achievements[ | ]

Trivia[ | ]

  • "Ipecac" is a shortened name for syrup of ipecac, a powerful emetic (a substance used to induce vomiting). This name is itself derived from a shortening of the source plant's name, Ipecacuanha. Production of ipecac syrup has been discontinued since 2010.
  • If Isaac's damage is above 100, Ipecac's explosions will shake the screen. This is just a visual effect.
    • (in Repentance) 166 damage is required for screen shake.
    • (in Repentance) A big enough tear size (~827 damage with no other tear size modifiers) will cause the explosion sound to change to the one used by Collectible Mama Mega! iconMama Mega!.
  • This item is used in Suicide King (challenge #7).
  • In the Wrath of the Lamb DLC for the original game, this item was unlocked by default.