Infestation 2 is a passive item.
Effects[]
- Spawns an allied Blue Spider from each enemy that is killed.
This item belongs to the Spider Baby set. Collecting three items from this set will transform Isaac into a humanoid spider.
This item belongs to the 
Notes[]
- Enemies do not spawn Blue Spiders when killed by anything not controlled by Isaac (environmental hazards, charmed enemies, death upon clearing room, etc).
- Enemies do not spawn Blue Spiders when killed by Blue Spiders.
- Blue Flies can also spawn Blue Spiders.
- Enemies killed by familiars will spawn Blue Spiders.
- Destroying dead Shopkeepers will spawn Blue Spiders.
- Killing Pin will give one Blue Spider for each of his segments.
- Killing Chub will spawn a lot of Blue Spiders.
- Killing a Homunculus or a Begotten will sometimes spawn a Blue Spider for each segment in the chains holding them to the wall.
- Dark Balls spawned by Little Horn can also drop Blue Spiders upon death.
Interactions[]
- Ace Cards: Enemies that are turned into pickups can’t spawn spiders.
- E. Coli/Flush!: Enemies that are turned into poop can’t spawn spiders.
- Jar of Flies: Blue Flies spawned by Jar of Flies spawn Blue Spiders, and Blue Spiders spawned by Infestation 2 grant extra flies for Jar of Flies
In-game Footage[]
 Spider Items
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 The Binding of Isaac: Rebirth
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