Binding of Isaac: Rebirth Wiki

Infestation 2 is a passive item.

Effects[ | ]

  • Spawns an allied Blue Spider from each enemy that is killed.
  • (in Repentance) This item belongs to the Spider BabySpider Baby set. Collecting three items from this set will transform Isaac into a humanoid spider.

Notes[ | ]

  • Enemies do not spawn Blue Spiders when killed by anything not controlled by Isaac (environmental hazards, charmed enemies, death upon clearing room, etc).
  • Enemies do not spawn Blue Spiders when killed by Blue Spiders.
  • Blue Flies can also spawn Blue Spiders.
  • Enemies killed by familiars will spawn Blue Spiders.
  • Destroying dead ShopkeeperShopkeepers will spawn Blue Spiders.
  • Killing Boss Pin ingamePin will give one Blue Spider for each of his segments.
  • Killing Boss Chub ingameChub will spawn a lot of Blue Spiders.
  • Killing a HomunculusHomunculus or a BegottenBegotten will sometimes spawn a Blue Spider for each segment in the chains holding them to the wall.
  • (except in Rebirth) Dark BallDark Balls spawned by (except in Rebirth) Boss Little Horn ingameLittle Horn can also drop Blue Spiders upon death.

Interactions[ | ]

  • (in Repentance)Ace Cards: Enemies that are turned into pickups can’t spawn spiders.
  • Collectible E. Coli iconE. Coli/Collectible Flush! iconFlush!: Enemies that are turned into poop can’t spawn spiders.
  • (except in Rebirth)Collectible Jar of Flies iconJar of Flies: Blue Flies spawned by Jar of Flies spawn Blue Spiders, and Blue Spiders spawned by Infestation 2 grant extra flies for Jar of Flies

In-game Footage[ | ]