Binding of Isaac: Rebirth Wiki

(except in Rebirth)

Immaculate Conception is an unlockable passive item added in The Binding of Isaac: Afterbirth.

Effects[ | ]

Notes[ | ]

  • After all five familiars have been spawned, a Soul HeartSoul Heart will still drop every 15 hearts collected.
  • All types of hearts except Gold HeartGold Hearts and (in Afterbirth † and Repentance) Blended HeartBlended Hearts count.
  • Items that directly add health such as Collectible Yum Heart iconYum Heart, Collectible Book of Revelations iconBook of Revelations, Collectible Satanic Bible iconSatanic Bible, and Collectible The Nail iconThe Nail do not count towards spawning a familiar.
  • Character The Lost iconThe Lost can pick up Soul Hearts and Black Hearts despite having no health and thus can activate Immaculate Conception.
  • Character Keeper iconKeeper cannot encounter hearts, thus the item is useless for him.
  • As the short-lived Half Red HeartHalf Red Hearts dropped by Character Tainted Magdalene iconTainted Magdalene also count, it is an excellent choice for her since she will constantly be picking up hearts and gain all five familiars quickly.
  • Familiars spawned by the item do not affect item pools, so multiple copies of one familiar can be obtained. For example, a second Seraphim can be purchased after Immaculate Conception spawns one.

Interactions[ | ]

  • (in Repentance)Collectible Hypercoagulation iconHypercoagulation: By intentionally taking damage with something like a fire and grabbing the half-red hearts, Isaac can easily generate powerful familiars for free.
  • Collectible The Jar iconThe Jar: Hearts collected in the jar do not count towards activation.

In-game Footage[ | ]

Trivia[ | ]