Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

IV Bag is an activated item.


  • Upon use, causes Isaac to lose half a heart of health (or a full heart in Womb Womb and beyond) while spawning coins.
    • Removed in Repentance Each use pays out with 1-3 coins.
    • Added in Repentance Each use pays out with 1-2 coins on Normal mode or 1 coin on Hard mode.
    • Added in Afterbirth Spawns 0-1 coins instead when used by Keeper Keeper.


  • If Isaac doesn't have the required Red Hearts or filled Bone Hearts, then Soul, Black, and empty Bone Hearts are taken instead.
  • This effect is counted as inflicted damage for items that spawn pickups upon said inflicted damage, such as 15►Gimpy Gimpy or 15►Fanny Pack Fanny Pack, but does not decrease the chance of encountering the Devil Room.
  • Invulnerability will not prevent Isaac from losing hearts.
  • Can be used before taking damage (getting hit, walking over spikes, donating to a Blood Donation Machine, donating to a Devil Beggar, or going through a Sacrifice Room) to grant coins without inflicting extra damage. (In Repentance, Isaac can no longer use with Machines of any kind, but can still use while going through Sacrifice Rooms)
  • Using this item as The Lost The Lost will kill him.
  • Added in Repentance Using this item in Mirrored World kills Isaac.


  • Removed in Repentance15►Isaac's Heart Isaac's Heart: Can be used without taking damage, resulting in an infinite amount of coins.
    • Added in Afterbirth Isaac still takes damage from this during The Guardian challenge.
  • Removed in Repentance15►PHD PHD: Increases each payout by 0-2 coins.
  • Added in Repentance15►PHD PHD: IV Bag always pays out with 2 coins
  • 15►Portable Slot Portable Slot: Can be alternated between to gain ridiculous amounts of pickups from only a few initial coins or hearts.
  • Removed in Repentance15►Scapular Scapular: Allows for infinite coins once Isaac is at half a red heart (or full red heart in The Womb or beyond) by moving between rooms to reset Scapular's effect.


  • Added in Afterbirth15►Car Battery Car Battery: No effect.
  • Added in Afterbirth 15►Holy Mantle Holy Mantle: IV Bag ignores Holy Mantle's protection, resulting in the character taking damage regardless.

In-game Footage[]



  • A glitch in the original The Binding of Isaac existed where the player could leave a room and activate the item during the invincibility frames offered during recovery of using the items, effectively spawning infinite coins. This bug has been fixed in The Binding of Isaac: Rebirth.

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