IV Bag

"Portable blood bank"
Entity ID	5.100.135
Recharge Time	Unlimited
Item Pool	Golden Chest
Collection Grid	(page 2, column 2, row 4) (page 2, column 12, row 1)

IV Bag is an activated item.

Effects

• Upon use, causes Isaac to lose half a heart of health (or a full heart in Womb and beyond) while spawning coins.
  • Each use pays out with 1-3 coins.
  • Each use pays out with 1-2 coins on Normal mode or 1 coin on Hard mode.
  • Spawns 0-1 coins instead when used by Keeper.

Notes

• If Isaac doesn't have the required Red Hearts or filled Bone Hearts, then Soul, Black, and empty Bone Hearts are taken instead.
• This effect is counted as inflicted damage for items that spawn pickups upon said inflicted damage, such as Gimpy or Fanny Pack, but does not decrease the chance of encountering the Devil Room.
• Invulnerability will not prevent Isaac from losing hearts.
• Can be used before taking damage (getting hit, walking over spikes, donating to a Blood Donation Machine, donating to a Devil Beggar, or going through a Sacrifice Room) to grant coins without inflicting extra damage. (In Repentance, Isaac can no longer use with Machines of any kind, but can still use while going through Sacrifice Rooms)
• Using this item as The Lost will kill him.
• Using this item in Mirrored World kills Isaac.

Synergies

• Isaac's Heart: Can be used without taking damage, resulting in an infinite amount of coins.
  • Isaac still takes damage from this during The Guardian challenge.
• PHD: Increases each payout by 0-2 coins.
• PHD: IV Bag always pays out with 2 coins
• Portable Slot: Can be alternated between to gain ridiculous amounts of pickups from only a few initial coins or hearts.
• Scapular: Allows for infinite coins once Isaac is at half a red heart (or full red heart in The Womb or beyond) by moving between rooms to reset Scapular's effect.

Interactions

• Car Battery: No effect.
• Holy Mantle: IV Bag ignores Holy Mantle's protection, resulting in the character taking damage regardless.

Gallery

• 

  lower 3DS sc The icon of IV Bag as seen on the lower 3DS screen.

Trivia

• A glitch in the original The Binding of Isaac existed where the player could leave a room and activate the item during the invincibility frames offered during recovery of using the items, effectively spawning infinite coins. This bug has been fixed in The Binding of Isaac: Rebirth.