Binding of Isaac: Rebirth Wiki

IV Bag is an activated item.


  • Upon use, causes Isaac to lose half a heart of health (or a full heart in Chapter 4 onward) while spawning coins.
    • Removed in Repentance Each use pays out with 1-3 coins.
      • Added in Repentance Each use pays out with 1-2 coins on Normal mode or 1 coin on Hard mode.
    • Added in Afterbirth Spawns 0-1 coins instead when used by Keeper Keeper.



  • Added in RepentanceBook of Virtues Book of Virtues: Spawns wisps in the outer ring, resembling coins. The wisps only have one health.
  • Old Bandage Old Bandage + Humbling Bundle Humbling Bundle/Maggy's Bow Maggy's Bow: The damage from IV Bag has a chance to spawn 2 hearts, which can be picked up to create further coins and possibly even heal hearts with enough Luck.
    • Added in RepentanceHumbling Bundle only has a 50% chance to double the hearts dropped, but Old Bandage may still drop 1 heart.
  • Removed in Repentance Isaac's Heart Isaac's Heart: Can be used without taking damage, resulting in an infinite amount of coins.
    • Added in Afterbirth Isaac still takes damage from this during Added in Afterbirth The Guardian (challenge #30).
  • Removed in Repentance PHD PHD: Increases each payout by 0-2 coins.
    • Added in Repentance PHD PHD: IV Bag always pays out with 2 coins.
  • Portable Slot Portable Slot: Can be alternated between to gain ridiculous amounts of pickups from only a few initial coins or hearts.
  • Removed in Repentance Scapular Scapular: Allows for infinite coins once Isaac is at half a red heart (or full red heart in Chapter 4 onward) by moving between rooms to reset Scapular's effect.


Added in Afterbirth Holy Mantle Holy Mantle and similar items: IV Bag ignores the shield's protection, resulting in Isaac taking damage regardless.

In-game Footage[]



  • A glitch in the original The Binding of Isaac existed where the player could leave a room and activate the item during the invincibility frames offered during recovery of using the items, effectively spawning infinite coins.