Binding of Isaac: Rebirth Wiki
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(in Repentance)

Hypercoagulation is an unlockable passive item added in The Binding of Isaac: Repentance.

Effects[ | ]

  • After Isaac takes damage from an enemy or donates health, he drops a Red HeartRed Heart that despawns after 1.5 seconds.
    • The heart dropped depends on the source: half-hearts of damage taken drop Half Red HeartHalf Red Hearts, and full hearts of damage taken drop full hearts.
    • The hearts will get launched out of Isaac with momentum, making them difficult to pick up.
    • If Isaac is firing tears as he gets hit, the heart will get launched in that direction.

Notes[ | ]


Synergies[ | ]

  • Collectible Blood Rights iconBlood Rights / Collectible Razor Blade iconRazor Blade: Damage taken to use the item also spawns hearts, reducing the cost of using them. The first usage of these items each room will spawn a full red heart.
  • Collectible Cancer iconCancer / Percs! pill / Collectible The Wafer iconThe Wafer: Damage sources that spawn full red hearts will still spawn a full red heart despite the cost being reduced to half a heart.
  • Collectible Candy Heart iconCandy Heart / Collectible Immaculate Conception iconImmaculate Conception: The hearts will count toward gaining stat boosts/familiars.
  • Collectible Dull Razor iconDull Razor: Can be used to spawn full red hearts for Isaac to pick up. Ideally, this should be done in a confined space so Isaac can easily pick up the heart.
  • Equality!Equality!: As long as Equality is active, all hearts spawned will be doubled and never disappear. Hearts remain on the ground even after the effect is no longer active.
  • Collectible Maggy's Bow iconMaggy's Bow: Doubles the healing received from the hearts spawned.
  • Collectible Magneto iconMagneto / Super MagnetSuper Magnet: Will immediately start pulling the dropped hearts to Isaac, breaking their momentum and making collection much easier.
  • Collectible Cambion Conception iconCambion Conception: By intentionally taking damage with something like a fire and grabbing the half-red hearts, Isaac can easily generate powerful familiars for free.

Interactions[ | ]

In-game footage[ | ]

Trivia[ | ]

  • Hypercoagulation (otherwise known as Thrombophilia) is a medical condition that causes blood clots to spontaneously form in a person’s blood vessels and prevents them from dissolving properly.


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