Binding of Isaac: Rebirth Wiki

Added in Repentance

Hypercoagulation is an unlockable passive item added in The Binding of Isaac: Repentance.


  • After Isaac takes damage from an enemy or donates health, he drops a red heart that despawns after 1.5 seconds.
    • The heart dropped depends on the source: half-hearts of damage taken drop half-hearts, and full hearts of damage taken drop full hearts.
    • The hearts will get launched out of Isaac with momentum, making them difficult to pick up.




  • Blood Rights Blood Rights / Razor Blade Razor Blade: Damage taken to use the item also spawns hearts, reducing the cost of using them.
  • Cancer Cancer / Percs! pill / The Wafer The Wafer: Damage sources that spawn full red hearts will still spawn a full red heart despite the cost being reduced to half a heart.
  • Candy Heart Candy Heart / Immaculate Conception Immaculate Conception: The hearts will count toward gaining stat boosts/familiars.
  • Dull Razor Dull Razor: Can be used to spawn full red hearts for Isaac to pick up. Ideally, this should be done in a confined space so Isaac can easily pick up the heart.
  • Equality! Equality!: As long as Equality is active, all hearts spawned will be doubled and never disappear. Hearts remain on the ground even after the effect is no longer active.
  • Maggy's Bow Maggy's Bow: Doubles the healing received from the hearts spawned.
  • Magneto Magneto / Super Magnet Super Magnet: Will immediately start pulling the dropped hearts to Isaac, breaking their momentum and making collection much easier.

In-game footage[]


  • Hypercoagulation (otherwise known as Thrombophilia) is a medical condition that causes blood clots to spontaneously form in a person’s blood vessels and prevents them from dissolving properly.


PC Normal and hard modes only QWDF BT6L (Treasure Room adjacent to spawn)