While it requires a lot of patience, a viable strategy is to restart until a Mini-Boss Room with Lust is encountered and that it drops The Virus. It will dramatically increase the amount of contact damage inflicted when throwing The Forgotten, making it much easier to attack quick or regenerative enemies.
The Forgotten will move slightly every time it explodes, unless the character has an item that grants flight. Using XII - The Hanged Man could prove useful for keeping The Forgotten in one spot for a room.
The timer for The Forgotten's explosion resets every time a consumable is picked up or an active item is used. This can be used to avoid taking damage in certain situations. Items such as Sharp Key, Mom's Bracelet, Friendly Ball and Bob's Rotten Head can be used to infinitely reset the explosion timer.
Some bomb modifiers affect The Forgotten's explosions, so playing with the Bomb Bum for getting Blood Bombs, Brimstone Bombs, Mr. Mega or Sad Bombs can be quite helpful as it will greatly boost the damage inflicted by The Forgotten's explosions. Glitter Bombs will be triggered with The Forgotten's explosions, allowing to generate infinite pickups. Bomber Boy though, while boosting the damage, will also make dodging the explosions more difficult.
Visiting all libraries is recommended as a Book of Revelations will grant a lot of soul hearts and ensure that Super Meat Boy / Super Bandage Girl is obtained, which will provide the means to do damage to enemies without using The Forgotten.
It is recommended to skip the Devil Room on the second floor to ensure an Angel Room spawns on future floors, due to Tainted Forgotten being a character that can't get heart containers, making devil deals inconvenient. This will also maximize the chances of finding Monstrance, an extremely powerful item for this challenge.
It is also recommended to avoid items that revive the player as a different character (such as Judas' Shadow), as upon revival the player will die immediately.
|1.||Pitch Black||2.||High Brow||3.||Head Trauma||4.||Darkness Falls||5.||The Tank||6.||Solar System||7.||Suicide King|
|8.||Cat Got Your Tongue||9.||Demo Man||10.||Cursed!||11.||Glass Cannon||12.||When Life Gives You Lemons||13.||Beans!||14.||It's in the Cards|
|15.||Slow Roll||16.||Computer Savvy||17.||Waka Waka||18.||The Host||19.||The Family Man||20.||Purist|
|21.||XXXXXXXXL||22.||SPEED!||23.||Blue Bomber||24.||PAY TO PLAY||25.||Have a Heart||26.||I RULE!||27.||BRAINS!|
|28.||PRIDE DAY!||29.||Onan's Streak||30.||The Guardian|
|31.||Backasswards||32.||Aprils Fool||33.||Pokey Mans||34.||Ultra Hard||35.||Pong|
|36.||Scat Man||37.||Bloody Mary||38.||Baptism by Fire||39.||Isaac's Awakening||40.||Seeing Double||41.||Pica Run||42.||Hot Potato|
|43.||Cantripped!||44.||Red Redemption||45.||DELETE THIS|
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|