Holy Mantle

Holy Mantle is a passive item.

Effects

Grants a shield that negates the first instance of damage taken, once per room.
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Notes

When the shield is broken, Isaac gets invincibility frames like he does when he would normally take damage, based on the damage it negated; 1 second for half a heart of damage, 2 seconds for a full heart, and 4 seconds for 2 full hearts.
Holy Mantle breaking only grants one second of invincibility frames, regardless of the damage source.
Holy Mantle won't be active when initially appearing in the starting room of a floor if it was lost in the room where Isaac left the previous floor.
As the shield gets restored whenever another room is entered, Holy Mantle allows Curse Rooms to be entered and left without taking damage.
Unlike every other protective effect, Holy Mantle (and similar effects) does not prevent damage from Blood Donation Machines, Devil Beggars, and Blood Rights.
- However, Blood Donation Machines and Devil Beggars can be played practically for free during the invincibility frames granted when losing the shield, by taking damage from touching a Fire Place, etc.
Damage from Sacrifice Room spikes can be blocked by Holy Mantle, no payout is rewarded.
The blocked hit does not count as damage taken for related achievements and will not trigger items that activate upon taking damage, like Dead Bird.
The Lost starts with this item after donating 879 coins to the Greed Donation Machine.
When Holy Mantle's shield is broken, a white cross symbol will briefly appear overlaid on top of Isaac and a smashing sound will play.
While Holy Mantle is in effect, a blue cross icon appears in the HUD, next to Isaac's life.

Synergies

Blanket / Dogma / Holy Card / Wooden Cross: All stack with Holy Mantle, and with each other simultaneously. Holy Mantle applies last.
Blind Rage: Doubles the invincibility frames given when damage is negated.
Damocles: The nullified first hit does not trigger the chance of the sword falling. It will not, however, protect Isaac from the falling sword.
E. Coli / Midas' Touch: On-contact effect still applies to enemies if Holy Mantle negates the contact damage taken.
Host Hat: Host Hat's chance of blocking projectiles is applied before the Holy Mantle, allowing the Holy Mantle shield to be saved.
Infamy: Infamy's chance of blocking projectiles is applied before the Holy Mantle, allowing the Holy Mantle shield to be saved.
Isaac's Heart: The shield effect transfers to the heart.
Stop Watch: If damage is blocked with Holy Mantle, Stop Watch will trigger the slow effect.

Interactions

Bad Trip: Damage is blocked by Holy Mantle.
Diplopia: An extra effect is added in the room it was found in, but only a single effect will be given in future rooms.
Dull Razor: Ignores Holy Mantle's shield and works normally.
Glass Cannon: Holy Mantle's effect will apply after Glass Cannon reduces Isaac's health to half a heart.
Holy Mantle / The Lost: An extra shield is given in the room it was found in, but the shield is removed when leaving that room and does not reapply.
Sharp Plug: Holy Mantle blocks the damage from Sharp Plug, but also prevents it from adding charges.

In-game Footage

Seeds

PC ADVA RE37 (Treasure Room adjacent to spawn)

PC 2RTG TZKG (Treasure Room adjacent to spawn)

PC 893G 9AYJ (Treasure Room adjacent to spawn)

PC 1QXB 08E9 (Treasure Room adjacent to spawn)

PC 8WKT GK49 (Treasure Room adjacent to spawn)

PC CJHB BJF8 (Treasure Room adjacent to spawn)

PC HGBT SDKC (Treasure Room adjacent to spawn)

PC 3403 J3ZN (First floor Treasure Room )

PC CEH8 HGYN (Treasure Room adjacent to spawn)

PC DN0F 9GFH ( Eden starting item)

PC 49HP 61H2 (Treasure Room adjacent to spawn)

PS4 S1HX M6V9 (Treasure Room adjacent to spawn)

Vita HPJ6 R873 (Treasure Room adjacent to spawn)

XboxOne J3HV KLK8 (Treasure Room adjacent to spawn)

XboxOne Y6PX GRBK (First Floor Treasure Room )

3DS 8FKH 6SN6 (Treasure Room adjacent to spawn; Curse of the Blind)

Switch KMBW P2MF (First Floor Treasure Room )

Switch 8Q9P RMZV (First Floor Treasure Room )

Bugs

Bug!	If Isaac possesses Pyromaniac, the Holy Mantle will appear to be consumed if hit by an explosion before other damage, but will still protect from the first actual hit.^{[Check ingame]}

Bug!	If the Holy Mantle is removed from Isaac's inventory — for example, when using the D4 — Isaac can still take one damage and it will be negated with Holy Mantle's effect, but only in the room where the items were re-rolled.^{[Check ingame]}

Greed Donation Machine Unlocks

The Binding of Isaac: Rebirth