Binding of Isaac: Rebirth Wiki
Special Cards
Rebirth Suicide King Chaos Card Credit Card Rules Card A Card Against Humanity
Added in Afterbirth Afterbirth ? Card Get out of Jail Free Card Emergency Contact Dice Shard
Added in Afterbirth † Afterbirth † Huge Growth Ancient Recall Era Walk
Added in Repentance Repentance Cracked Key

Added in Afterbirth †

The Holy Card is a special card added in The Binding of Isaac: Afterbirth †.


  • Grants a one-time Holy Mantle Holy Mantle effect.
    • Removed in Repentance This only applies for the current room.
    • Added in Repentance The effect lasts until damage is taken.
  • Removed in Repentance Has a 25% chance to display the message "You feel blessed!" and spawn another Holy Card.


  • The effect cannot be stacked by using multiple Holy Cards.
  • Added in Repentance Tainted Lost Tainted Lost starts with this card. Additionally, Holy Cards are significantly more common when playing as this character and can be found even if they have not been unlocked.


  • Blanket Blanket: Holy Card's effect takes priority over the shield from Blanket in Boss Room Boss Rooms.
  • Holy Mantle Holy Mantle: Effect stacks with Holy Card.
  • Wooden Cross Wooden Cross: Stacks with Holy Card depending on the order of use. If Wooden Cross is picked up after Holy Card has been used, their effects don't stack. If Holy Card is used after Wooden Cross has been picked up, they do.
  • Little Baggy Little Baggy: Will make Isaac unable to find Holy Cards, as all cards turn into pills. If Holy Card is dropped after taking Little Baggy, the Holy Card will turn into a random pill.