|Rebirth||Suicide King||Chaos Card||Credit Card||Rules Card||A Card Against Humanity|
|Afterbirth||? Card||Get out of Jail Free Card||Emergency Contact||Dice Shard|
|Afterbirth †||Holy Card||Huge Growth||Ancient Recall||Era Walk|
- Grants a one-time Holy Mantle effect.
- This only applies for the current room.
- The effect lasts until damage is taken.
- Has a 25% chance to display the message "You feel blessed!" and spawn another Holy Card.
- The effect cannot be stacked by using multiple Holy Cards.
- Tainted Lost starts with this card. Additionally, Holy Cards are significantly more common when playing as this character and can be found even if they have not been unlocked.
- Blanket: Holy Card's effect takes priority over the shield from Blanket in Boss Rooms.
- Holy Mantle: Effect stacks with Holy Card.
- Wooden Cross: Does not stack with Holy Card; both are treated as the same shield.
- Little Baggy: Will make Isaac unable to find Holy Cards, as all cards turn into pills. If Holy Card is dropped after taking Little Baggy, the Holy Card will turn into a random pill.
|Bug!||When using the D4, or another item / room which mimics it, the Holy Card effect will be permanently lost.|
|The Lost Unlocks|
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|