Binding of Isaac: Rebirth Wiki

High Brow is challenge #2. Isaac begins this challenge with Collectible Number One iconNumber One, Collectible E. Coli iconE. Coli, Collectible Butt Bombs iconButt Bombs, Collectible Flush! iconFlush!, and Petrified PoopPetrified Poop. The goal is to defeat Boss Mom ingameMom. This challenge is unlocked by default.

Difficulty[ | ]

Starting with Number One limits Isaac's range significantly. Getting close to enemies is required to defeat them.

(in Repentance) The starting item set grants Isaac the Oh CrapOh Crap transformation, significantly increasing his survivability.

Strategy[ | ]

  • Flush! can be powerful when dealing with a large number of enemies, such as in a 2x2 room. Turning all the enemies into poop allows for rapid clearing of rooms, and Petrified Poop increases the chance of those poops containing pickups.
  • E. Coli can turn enemies into PoopPoop. Given the short range granted by Number One, enemies will be more likely to do contact damage. Enemies that do not do contact damage ( FlyFly, MulliganMulligan, HostHost, etc) are valuable, as they can be transformed into poop with no drawbacks.
    • Collectible Skatole iconSkatole is a highly useful item, due to the amount of Black Flies it creates that can be transformed into poop.
    • (in Repentance)Collectible Dirty Mind iconDirty Mind spawns friendly DipDips when a poop is broken, making E. Coli even more valuable.
  • Butt Bombs gives 5 extra BombBombs to start with, which can make items or Secret RoomSecret Rooms easier to find in the first 2 levels.
  • Because of Number One's synergy with Collectible Brimstone iconBrimstone, it is highly recommended, despite the Health cost.
  • While it is slow, Mysterious CandyMysterious Candy can be helpful if resources are scarce in a run.
  • (in Repentance) Due to starting with the Oh CrapOh Crap transformation in Repentance, it's possible to adopt a similar strategy to Character Tainted Magdalene iconTainted Magdalene, where Isaac touches enemies to trigger E. Coli, then breaks the resulting poop to gain health back.

Unlockable Achievements[ | ]