High Brow

From Binding of Isaac: Rebirth Wiki
Jump to: navigation, search
High   Brow
Character Isaac appearance.png
Full red heartFull red heartFull red heart
Table dividing line 1.png
Challenge Number
Available Rooms
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Boss Mom.png
Rune of Jera Rune of Jera

High Brow is challenge #2. Isaac begins this challenge with 15►Number One Number One, 15►E Coli E Coli, 15►Butt Bombs Butt Bombs, 15►Flush! Flush!, and Petrified Poop Petrified Poop. The goal is to defeat Mom. This challenge is unlocked by default.

Difficulty[edit | edit source]

Starting with Number One limits Isaac's range significantly. Getting close to enemies is required to defeat them.

Added in Repentance The starting item set grants Isaac the Oh Crap transformation, significantly increasing his survivability.

Strategy[edit | edit source]

  • Flush! can be powerful when dealing with a large number of enemies, such as in a 2x2 room. Turning all the enemies into poop allows for rapid clearing of rooms, and Petrified Poop increases the chance of those poops containing pickups.
  • E. Coli can turn enemies into poop. Given the short range granted by Number One, enemies will be more likely to do contact damage. Enemies that do not do contact damage (Black Flies, Mulligan, Hosts, etc) are valuable, as they can be transformed into poop with no drawbacks.
    • 15►Skatole Skatole is a highly useful item, due to the amount of Black Flies it creates that can be transformed into poop.
  • Butt Bombs gives 5 extra bombs to start with, which can make items or Secret Rooms easier to find in the first 2 levels.
  • Because of Number One's synergy with 15►Brimstone Brimstone, it is highly recommended, despite the Health cost.
  • While it is slow, Mysterious Candy Mysterious Candy can be helpful if resources are scarce in a run.

Unlockable Achievements[edit | edit source]

MainPageChallenges.png Challenges MainPageChallenges.png

1. Pitch Black 2. High Brow 3. Head Trauma 4. Darkness Falls 5. The Tank 6. Solar System 7. Suicide King
8. Cat Got Your Tongue 9. Demo Man 10. Cursed! 11. Glass Cannon 12. When Life Gives You Lemons 13. Beans! 14. It's in the Cards
15. Slow Roll 16. Computer Savvy 17. Waka Waka 18. The Host 19. The Family Man 20. Purist
21. XXXXXXXXL 22. SPEED! 23. Blue Bomber 24. PAY TO PLAY 25. Have a Heart 26. I RULE! 27. BRAINS!
28. PRIDE DAY! 29. Onan's Streak 30. The Guardian
Afterbirth †
31. Backasswards 32. Aprils Fool 33. Pokey Mans 34. Ultra Hard 35. Pong
36. Scat Man 37. Bloody Mary 38. Baptism by Fire 39. Isaac's Awakening 40. Seeing Double 41. Pica Run 42. Hot Potato
43. Cantripped! 44. Red Redemption 45. DELETE THIS
The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets