Binding of Isaac: Rebirth Wiki
High   Brow
Character Isaac appearance.png
Full red heartFull red heartFull red heart
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Challenge Number
Available Rooms
Item Pool Treasure Room.png: no          Item Pool Shop.png: yes
Boss Mom portrait.png
Rune of Jera Rune of Jera

High Brow is challenge #2. Isaac begins this challenge with Number One Number One, E. Coli E. Coli, Butt Bombs Butt Bombs, Flush! Flush!, and Petrified Poop Petrified Poop. The goal is to defeat Mom Mom. This challenge is unlocked by default.


Starting with Number One limits Isaac's range significantly. Getting close to enemies is required to defeat them.

Added in Repentance The starting item set grants Isaac the Oh Crap Oh Crap transformation, significantly increasing his survivability.


  • Flush! can be powerful when dealing with a large number of enemies, such as in a 2x2 room. Turning all the enemies into poop allows for rapid clearing of rooms, and Petrified Poop increases the chance of those poops containing pickups.
  • E. Coli can turn enemies into Poop Poop. Given the short range granted by Number One, enemies will be more likely to do contact damage. Enemies that do not do contact damage ( Fly Fly, Mulligan Mulligan, Host Host, etc) are valuable, as they can be transformed into poop with no drawbacks.
    • Skatole Skatole is a highly useful item, due to the amount of Black Flies it creates that can be transformed into poop.
    • Added in RepentanceDirty Mind Dirty Mind spawns friendly Dip Dips when a poop is broken, making E. Coli even more valuable.
  • Butt Bombs gives 5 extra Bomb Bombs to start with, which can make items or Secret Room Secret Rooms easier to find in the first 2 levels.
  • Because of Number One's synergy with Brimstone Brimstone, it is highly recommended, despite the Health cost.
  • While it is slow, Mysterious Candy Mysterious Candy can be helpful if resources are scarce in a run.
  • Added in Repentance Due to starting with the Oh Crap Oh Crap transformation in Repentance, it's possible to adopt a similar strategy to Tainted Magdalene Tainted Magdalene, where Isaac touches enemies to trigger E. Coli, then breaks the resulting poop to gain health back.

Unlockable Achievements[]