Binding of Isaac: Rebirth Wiki

Harlequin Baby is an unlockable passive item.


  • Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern which deal 4 damage each.
    • Removed in Repentance Harlequin Baby shoots once per second.
    • Added in Repentance Harlequin Baby shoots once every 3/4ths of a second.
  • Added in Afterbirth This item belongs to the Conjoined set. Collecting three items from this set will transform Isaac into a three-faced version of himself.

In-game Footage[]


  • This item refers to a condition called Harlequin Ichthyosis, which is a rare skin condition from birth, which on babies gives puffy red eyes, green or red crackled/scaly skin, and stretched out lips.


PS4 QA47 BN3P (First floor Treasure Room)

PC RLLR 8LDZ (Treasure Room adjacent to spawn)

PC 1PNA Q2Q3 (Treasure Room adjacent to spawn)

PC LNBD TW04 (Treasure Room adjacent to spawn)

Switch Greedier mode only RPYA V2PX (First Golden Treasure Room)