Binding of Isaac: Rebirth Wiki

Hard mode changes the gameplay compared to Normal in some ways to make it more difficult. When playing in Hard mode, a small red pentagram (Hard mode only) appears on the HUD, below the pickups.


  • 2-3 more rooms generate each floor.
  • Removed in Repentance Standard rooms with a difficulty of "1" cannot generate.
    • Added in Repentance Standard rooms with a difficulty of "1" have a reduced chance of appearing.
    • Most rooms with this difficulty are very easy, making difficult rooms more common.
  • Added in Afterbirth † Rooms with a difficulty of "15" are able to generate on the second floor of chapters 1-4.
    • Additionally, they can always spawn on single floor chapters.
  • Enemies have a base 20% chance to become Champions instead of only 5%; additionally, they only award pickups 33% of the time.
  • Removed in Repentance Hearts are 66% less likely to drop after completing a room.
    • Added in RepentanceHearts are 33% less likely to drop after completing a room.
  • Removed in Repentance Only champion bosses will drop hearts; normal bosses will not.
  • Floors are more likely to have curses.
  • Blood Donation Machines only give out one coin per use.
    • Added in Repentance Also applies to IV Bag.
  • Beggars require a minimum of 6 donations before paying out.
    • Added in Repentance This doesn't apply to Bomb Bums or Key Masters.
  • Added in Repentance The Shop Shop can be a lower level even if the store upgrades have been unlocked.
  • Added in RepentanceThe drop rate of soul hearts from blue fires is 10%, while it's 25% in normal mode.
  • Added in Repentance Certain enemies and bosses have increased shot and movement speed.
  • Added in RepentanceDogma Dogma does not provide the effect ofThe Wafer The Wafer.

Unlocks for Hard Mode[]

Character Mom's Heart Added in Afterbirth All completion marks
Isaac Isaac Lost Baby Buddy Baby
Magdalene Magdalene Cute Baby Colorful Baby
Cain Cain Glass Baby Picky Baby
Judas Judas Shadow Baby Belial Baby
??? ??? Dead Baby Hive Baby
Eve Eve Crow Baby Whore Baby
Samson Samson Fighting Baby Revenge Baby
Azazel Azazel Begotten Baby Sucky Baby
Lazarus Lazarus Wrapped Baby

Added in Repentance Bethany Bethany (without losing a life)

Dripping Baby
Eden Eden Glitch Baby Cracked Baby
The Lost The Lost -0- Baby Godhead
Added in Afterbirth Lilith Lilith Goat Head Baby Dark Baby
Added in Afterbirth Keeper Keeper Super Greed Baby Sale Baby
Added in Afterbirth † Apollyon Apollyon Smelter Apollyon Baby
Added in Afterbirth † The Forgotten The Forgotten Marrow Bone Baby
Added in Repentance Bethany Bethany Wisp Baby Hope Baby
Added in Repentance Jacob and Esau Jacob and Esau Double Baby Solomon's Baby
Added in Repentance All non-Tainted characters Mega Mush
Added in Repentance All characters Death Certificate


  • Before update 1.03, the reduced drop-rate affected all pickups (not just Red Hearts).
  • For update 4.00 hard mode also reduced the amount of tinted rocks appearing. This was removed with 4.01 a few days later.
  • Most Hard mode unlocks are co-op babies, with the notable exceptions of Godhead Godhead, Added in Afterbirth †Smelter Smelter, Added in Afterbirth †Marrow Marrow, Added in RepentanceMega Mush Mega Mush, Added in RepentanceDeath Certificate Death Certificate and the character Added in Repentance Bethany Bethany.
  • Godhead Godhead's unlock requirements were extended in later DLCs due to the addition of more completion marks, but it can still be unlocked in the base game using the same method.
  • Added in Repentance None of the tainted characters have unlocks tied to getting all completion marks, apart from Death Certificate Death Certificate.