Binding of Isaac: Rebirth Wiki
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Guppy's Paw is an activated item.

Effects[ | ]

  • Upon use, converts one Red Heart Container into three Soul HeartSoul Hearts.
  • This item belongs to the GuppyGuppy set. Collecting three items from this set will transform Isaac into Guppy.

Notes[ | ]

Synergies[ | ]

  • (in Repentance) Collectible The Book of Belial iconThe Book of Belial + Collectible Birthright iconBirthright as Character Judas iconJudas / Character Dark Judas iconDark Judas: Grants a permanent 0.5 damage up for every converted heart.
  • (in Repentance)Collectible Book of Virtues iconBook of Virtues: Spawns 3 wisps in the middle ring for every Red Heart Container consumed, in addition to granting Soul Hearts. These wisps have a large amount of health.
  • (except in Repentance)Broken RemoteBroken Remote: The teleport will activate whenever Guppy's Paw is used, even if Isaac has no Red Heart Containers to trade. This can give any characters with no Red Hearts the ability to teleport any number of times for free.
  • Collectible Converter iconConverter:
    • (except in Repentance) Allows Isaac to attain up to 10 Red Heart Containers and 1 Soul Heart.
    • (in Repentance) Allows Isaac to attain up to 12 Red Heart Containers or any combination of Red Heart Containers and Soul Hearts.
  • (in Repentance) Character Tainted Eden iconTainted Eden: Soul Hearts granted by Guppy's Paw are not rerolled when Tainted Eden takes damage.
  • Collectible Dead Cat iconDead Cat: In addition to contributing to the transformation, converting the Red Heart Container obtained after revival into three Soul Hearts effectively triples Isaac's HP.

Interactions[ | ]

  • (in Repentance) Character Bethany iconBethany: Guppy's Paw will remove one Heart Container in exchange for Soul Heart charges. This will kill Bethany if she has no health left afterward.
  • (except in Rebirth)Collectible Car Battery iconCar Battery: No effect.
  • (except in Rebirth) Character Keeper iconKeeper: Guppy's Paw will take away one Coin Heart, but will only grant Blue Flies in return.
  • XI - StrengthXI - Strength: Converts the temporary Red Heart Container into three Soul Hearts (however, Isaac will still lose one Red Heart Container upon leaving the room if he has any left).

In-game Footage[ | ]

Gallery[ | ]

Trivia[ | ]

  • This item is the first (by item ID) to appear in The Binding of Isaac: Wrath of the Lamb DLC. The last one is Collectible Box iconBox.
  • It is also a reference to Edmund McMillen's cat Guppy.
  • (in Repentance) This item is used in Baptism by Fire (challenge #38).

Bugs[ | ]

Bug Bug! (except in Repentance) If Character Keeper iconKeeper uses Guppy's Paw to remove all his Coin Hearts, he will not die until he picks up an item.


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