Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Guppy's Paw is an activated item.


  • Upon use, converts one Red Heart Container into three Soul Hearts.
  • This item belongs to the Guppy set. Collecting three items from this set will transform Isaac into Guppy.


  • Added in Afterbirth †Full bone heart Bone Hearts cannot be converted.


  • Removed in Repentance 15►Converter Converter: Allows Isaac to attain up to 10 Heart Containers and 1 Soul Heart.
    • Added in Repentance Allows Isaac to attain up to 12 Heart Containers or any combination of Heart Containers and Soul Hearts.


  • Added in Repentance Bethany Bethany: Guppy's Paw will remove one Heart Container in exchange for Soul Heart charges. This will kill Bethany if she has no health left afterward.
  • Added in Repentance15►Book of Virtues Book of Virtues: Spawns 3 wisps in the middle ring for every heart container consumed, in addition to granting soul hearts. These wisps have a large amount of health.
  • Removed in AfterbirthBroken Remote Broken Remote: The teleport will activate whenever Guppy's Paw is used, even if Isaac has no Red Heart containers to trade. This can give ??? ???, Azazel Azazel, or The Lost The Lost (or other characters with no Red Hearts) the ability to teleport an infinite number of times without any cost.
  • Added in Afterbirth15►Car Battery Car Battery: No effect.
  • Added in Afterbirth Keeper Keeper: Guppy's Paw will take away one Coin Heart, but will only grant Blue Flies in return.
  • XI - Strength XI - Strength: Converts the temporary Red Heart container into three Soul Hearts (however, Isaac will still lose one Red Heart container upon leaving the room if he has any left).

In-game Footage[]



  • This item is the first (by item ID) to appear in The Binding of Isaac: Wrath of the Lamb DLC. The last one is 15►Box Box.
  • It is also a reference to Edmund McMillen's cat Guppy.
  • Added in Repentance This item is used in Baptism by Fire (challenge #38).


PC Added in Repentance Hard mode only 6QN8 VV6L (Curse Room adjacent to spawn)


Bug Bug! If Keeper uses Guppy's Paw to remove all his Coin Hearts, it will remove all of his Coin Hearts but will not kill him until he picks up an item.