Binding of Isaac: Rebirth Wiki

Guppy's Paw is an activated item.


  • Upon use, converts one Red Heart Container into three Soul Heart Soul Hearts.
  • This item belongs to the Guppy set. Collecting three items from this set will transform Isaac into Guppy.



  • Added in RepentanceBook of Virtues Book of Virtues: Spawns 3 wisps in the middle ring for every Red Heart Container consumed, in addition to granting Soul Hearts. These wisps have a large amount of health.
  • Removed in AfterbirthBroken Remote Broken Remote: The teleport will activate whenever Guppy's Paw is used, even if Isaac has no Red Heart Containers to trade. This can give any characters with no Red Hearts the ability to teleport any number of times for free.
  • Removed in RepentanceConverter Converter: Allows Isaac to attain up to 10 Red Heart Containers and 1 Soul Heart.
    • Added in Repentance Allows Isaac to attain up to 12 Red Heart Containers or any combination of Red Heart Containers and Soul Hearts.


  • Added in Repentance Bethany Bethany: Guppy's Paw will remove one Heart Container in exchange for Soul Heart charges. This will kill Bethany if she has no health left afterward.
  • Added in AfterbirthCar Battery Car Battery: No effect.
  • Added in Afterbirth Keeper Keeper: Guppy's Paw will take away one Coin Heart, but will only grant Blue Flies in return.
  • XI - Strength XI - Strength: Converts the temporary Red Heart Container into three Soul Hearts (however, Isaac will still lose one Red Heart Container upon leaving the room if he has any left).

In-game Footage[]



  • This item is the first (by item ID) to appear in The Binding of Isaac: Wrath of the Lamb DLC. The last one is Box Box.
  • It is also a reference to Edmund McMillen's cat Guppy.
  • This item is used in Added in Repentance Baptism by Fire (challenge #38).


PC Added in Repentance Hard mode only 6QN8 VV6L (Curse Room Curse Room adjacent to spawn)


Bug Bug! Removed in Repentance If Keeper Keeper uses Guppy's Paw to remove all his Coin Hearts, he will not die until he picks up an item.