Guppy's Head is an activated item.
Effects[ | ]
- Spawns 2-4 friendly Blue Flies.
- This item belongs to the
Guppy set. Collecting three items from this set will transform Isaac into Guppy.
Synergies[ | ]
- Book of Virtues: Summons wisps in the outer ring instead of flies. Wisps summon Blue Flies when destroyed. One wisp contains one Blue Fly.
- Car Battery: Increases range of flies spawned to 4-8.
- Fish Tail: Doubles flies spawned.
- 9 Volt: Guppy's Head slowly gains charge while in a hostile room.
In-game Footage[ | ]
Gallery[ | ]
3DS The icon of Guppy's Head as seen on the lower 3DS screen.
Trivia[ | ]
- This item is used in Cat Got Your Tongue (challenge #8).
- The item is a reference to Edmund McMillen's cat also named Guppy.
- Box of Spiders is essentially the spider equivalent to Guppy's Head.
 Pet Items
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| Cricket |
| Guppy |
| Tammy |
 The Binding of Isaac: Rebirth
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