Guppy's Head is an activated item.
Effects[]
- Spawns 2-4 friendly Blue Flies.
- This item belongs to the Guppy set. Collecting three items from this set will transform Isaac into Guppy.
Notes[]
- Each Blue Fly deals 2x Isaac's damage.
Synergies[]
Book of Virtues: Summons wisps in the outer ring instead of flies. Wisps summon Blue Flies when destroyed. One wisp contains one Blue Fly.- Fish Tail: Doubles flies spawned.
In-game Footage[]
Trivia[]
- This item is used in Cat Got Your Tongue (challenge #8).
- The item is a reference to Edmund McMillen's cat also named Guppy.
- Box of Spiders is essentially the spider equivalent to Guppy's Head.
Gallery[]
3DS The icon of Guppy's Head as seen on the lower 3DS screen.
Seeds[]
PC TK1W XHLH (first 
Curse Room)
PS4 J304 8T8Y (first Curse Room)
 Pet Items
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| Cricket |
| Guppy |
| Tammy |
 The Binding of Isaac: Rebirth
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