Guppy's Head is an activated item.
- Spawns 2-4 friendly Blue Flies.
- This item belongs to the Guppy set. Collecting three items from this set will transform Isaac into Guppy.
- Each Blue Fly deals 2x Isaac's damage.
- Car Battery: Spawns more Blue Flies per use.
- Hive Mind: Increases size and damage of Blue Flies.
- Fish Tail: Doubles flies spawned.
- This item is used in Cat Got Your Tongue (challenge #8).
- Box of Spiders is essentially the spider equivalent to Guppy's Head, but can be activated less often.
PC TK1W XHLH (first Curse Room)
PS4 J304 8T8Y (first Curse Room)
- Dead Cat
- Guppy's Collar
- Guppy's Eye
- Guppy's Hair Ball
- Guppy's Head
- Guppy's Paw
- Guppy's Tail
- Kid's Drawing
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