Binding of Isaac: Rebirth Wiki

Added in Repentance

Guppy's Eye is an unlockable passive item added in The Binding of Isaac: Repentance.



  • Guppy's Eye does not show the contents of tinted rocks, Poop Poops, and other obstacles.
  • Guppy's Eye does display enemies that can be contained within chests.
  • Chest Chests and Grab Bag Grab Bags can only display up to four pickups at a time. If there are more than four, higher-value pickups like Bomb Bombs, Key Keys, and Soul Heart Soul Hearts will have priority on the display.
  • If a Red Chest Red Chest looks like it doesn't have anything in it, it will teleport Isaac to the floor's Devil Room Devil Room / Angel Room Angel Room.
  • Due to how Trinkets generate, if a Chest displays a trinket, all future Chests will also display/give that trinket until it spawns in some way, at which point all Chests will display a new trinket.
  • Mimic Chest Mimic Chests will change their contents whenever their spikes pop out. The unchanged drops can still be obtained by:
  • This effect works on all non-ending chests, including Mom's Chest Mom's Chest.
  • This item is substantially less useful in Greed Mode, due to the scarcity of chests.
  • The contents of Sacks or Chests that haven't spawned yet will still be revealed (for example, in rooms that spawn such Chests or Sacks when Isaac pressed a hidden switch, etc.).


  • Guppy's Eye Guppy's Eye: Picking up a second copy of the item gives Isaac a unique costume with both eyes replaced. This is purely cosmetic, and it will otherwise have no effect.

In-game Footage[]


  • Guppy's Eye is one of the few items that will give Isaac a unique costume when two copies are acquired, along with Brimstone Brimstone and Glass Eye Glass Eye.
  • This item was suggested on a Reddit post[1] on the Binding of Isaac Subreddit.
  • This item originates from the card game The Binding of Isaac: Four Souls. In it, Guppy's Eye forces all other players to play with their hands face-up on the table.
  • Its pickup text is possibly a reference to the description of the Rasmus mask from Hotline Miami.


PC Hard mode only L4WH 88YF (Curse Room Curse Room adjacent to spawn)