Modifies drops from Champion enemies depending on certain conditions.
Also modifies room clear drops.
The priorities of the drops, in order, are as follows:
Soul Hearts: When Isaac has no Red Heart containers and less than 2 Soul Hearts.
Full Red Hearts: While at 0.5 Red Hearts.
Keys: When Isaac has no keys.
Bombs: When Isaac has no bombs.
Full Red Hearts: When Isaac has at least half a Red Heart container empty.
Pennies: While Isaac has less than 15 pennies.
Keys: When Isaac has less than 5 keys.
Bombs: When Isaac has less than 5 bombs.
Trinkets: If Isaac has no trinkets and there are no trinkets on the ground in the room.
Soul Hearts: When Isaac has less than 6 total Heart containers of any kind.
If none of the above conditions are true, items dropped will be rolled as normal.
The Glyph has no effect in Greed Mode or Greedier Mode aside from Soul Hearts; champions still never drop anything.
Because of how the item works in the priorities listed above, this item is not recommended for The Lost (except in combination with Immaculate Conception) as he is always considered to be at half a Soul Heart, and all drops from champions are replaced with Soul Hearts.
The Lost and Tainted Lost ignore both rules for Soul Heart generation. This prevents the item from generating mostly useless Soul Hearts.
When playing as The Forgotten, the priority of the drops is based on the active form's health: for example, if The Forgotten has half a red heart or less, but The Soul was active right before the pickup drop and it had more than 2 soul hearts, the Glyph will skip over the full red heart drops to the next condition. Also if The Forgotten is full on pickups and health, has a trinket but has less than 6 bone hearts, the Glyph will always drop soul hearts unless The Soul is active at the moment of the drop.