Globins attempt to directly charge at the player, similar to Gapers; however, they are much faster. Instead of dying, they will crumble into goo after taking a certain amount of damage and then regenerate anew unless destroyed in their puddle-of-goo form. If a Globin regenerates from its broken form, they will have decreased health and will be easier to kill.
Because of their speed, Globins tend to overshoot the player's position in rooms with a large number of obstacles, which can lead to Isaac being quickly surrounded if care is not taken. Unlike other enemies, Globins will do 1 full heart of damage on contact regardless of the floor, although this can be reduced to a half of a heart by obtaining The Wafer.
Variations
Gazing Globin
Gazing Globins are an alternate version of the Globin which has an eye in one of its sockets, larger teeth, and a less contorted face. They can replace regular Globins. Gazing Globins run towards Isaac with increased speed and slide away when they collapse into goo, but otherwise function identically to regular Globins.
Dank Globin
Dank Globins behave identically to regular Globins. Each time they collapse, they leave behind a puddle of slowing Black Creep and spawn a Spider. They spawn another puddle of Black Creep when finished off.
Cursed Globin
Cursed Globins were introduced in The Binding of Isaac: Repentance. They are 
Mausoleum and 
Gehenna variants of Globins. Their attacks are similar to the Gazing Globin's attack. However, they will split on 2 goos instead of one. The goos will regenerate quickly into 2 cursed globins.
Cursed Globins must be killed quickly or it may be a threat for Isaac.
There is a maximum number of times the Cursed Globin can split.
Black Globin
Black Globins walk towards Isaac, spawning Spiders every time it takes damage. Upon death, they spawn another spider and split into their head and their body. This makes them the only Globin variant that doesn't have a goo form.
Notes
- Dark Red Champion Globins will turn into goo twice.
Trivia
- Sloth is a recolored Globin.
- Super Sloth is a recolored Gazing Globin with a large head.
- The name of the monster is a type of protein and is also similar to a goblin.
- Globins appear to be based on the Red Skeletons from the Castlevania series since they reform from their pile of bones after being killed. They can only be killed using a special weapon or spell.
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 The Binding of Isaac: Rebirth
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