Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Glaucoma is a passive item added in The Binding of Isaac: Afterbirth †.


  • Adds a chance to shoot concussive tears, causing enemies to walk around randomly.
    • The confusion caused by Glaucoma tears is effectively permanent for normal enemies, and a very long duration compared to most status effects for bosses.
  • Makes the screen darker.


  • Not affected by Luck.


In-game Footage[]


  • Glaucoma is a group of eye diseases that result in damage to the optic nerve and vision loss.
  • This item bears a strong resemblance to 15►Cain's Other Eye Cain's Other Eye.


PC Added in Repentance Z0P0 QZGH (Treasure room adjacent to spawn)

Switch Greedier mode only LG8R 219Y (First Golden Treasure Room)

Switch Hard mode only G9ZE YETP (First Treasure Room, Curse of the Unknown)

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