Binding of Isaac: Rebirth Wiki
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(in Repentance)

Genesis is an unlockable activated item added in The Binding of Isaac: Repentance.

Effects[ | ]

  • On use, everything that Isaac has, including stats, consumables, trinkets, and all items except for starting items and quest items, are removed. Isaac is teleported to a unique Clean BedroomClean Bedroom that acts like an I AM ERRORI AM ERROR room. It has a Bed, two random ChestChests, two Grab BagGrab Bags, and a random Trinket. The only way out is through the beam of light, which teleports Isaac to the next floor (with some exceptions, seen below).
  • For every item removed using Genesis, there will be a set of three items from the removed item's pool to choose from, each set appearing one after the other.

Notes[ | ]

  • If used on one of the final floors of the game, such as ChestChest, Dark RoomDark Room, The VoidThe Void, or CorpseCorpse II, the beam of light will be replaced with a Crawl SpaceCrawl Space that leads Isaac back to the starting room of the floor he used it on. In addition, on ChestChest or Dark RoomDark Room the aforementioned chests will include items. These items will not disappear along the "choice" pedestals.
  • If used in WombWomb II, UteroUtero II, or ??????, the beam will always teleport Isaac to CathedralCathedral.
  • Does not work during Boss The Beast ingameThe Beast's fight, instead merely teleporting Isaac to a random location in the room. No items will be removed.
  • Genesis will remove all currently active curses, meaning Curse of the BlindCurse of the Blind will not affect the item pedestals present inside the room (except during the Ultra Hard challenge).
  • Trinkets absorbed using a Gulp! pill or an item such as Collectible Smelter iconSmelter will simply be removed with no extra pedestals granted for them.
  • If used as Character Jacob and Esau iconJacob and Esau, both characters' items are removed to offer choices, but Jacob and Esau cannot take two items at once from the choices. Both characters' items are considered in the amount of choices offered.
  • Character Tainted Cain iconTainted Cain will be able to pick up the items that appear normally, one of the few times he is able to do so (along with plot items and Collectible Death Certificate iconDeath Certificate).
  • If used as Character Tainted Lazarus iconTainted Lazarus, both form's items are removed to offer choices, while his initial Collectible Flip iconFlip is granted infinite charges and can be used freely in the special room.
  • Character Tainted Bethany iconTainted Bethany will lose all of her Collectible Lemegeton iconLemegeton wisps upon use, and also her red heart charges.
  • If used as Character Eden iconEden or Character Tainted Eden iconTainted Eden, a new set of items and stats will be generated. The first random passive item Eden starts with is rerolled immediately with no choice of three.
  • If Isaac uses Genesis while in DownpourDownpour II / MinesMines II / MausoleumMausoleum II or their variants, the beam of light will send him back to the regular floors. However, after using Genesis on DownpourDownpour I / MinesMines I / MausoleumMausoleum I / CorpseCorpse I, it sends Isaac to the respective second part of the stage.
  • Since Genesis resets Isaac's health, it is one way to remove Broken Hearts.
  • Crawl SpaceCrawl Spaces can be generated and entered inside the Genesis room, but upon leaving them, Isaac will be returned to the floor Genesis was used on instead of returning to the room.
    • Similarly, JokerJoker can teleport Isaac to a Devil RoomDevil Room or Angel RoomAngel Room, and leaving will return Isaac to the room Genesis was used in, instead of the Genesis room.
  • Item Pools will not be reset, however any lost items can be obtained again if they spawn.
  • Transformations are also removed.
  • Using Genesis will not remove items required for progression (such as Collectible Knife Piece 1 iconKnife Piece 1 or 2, Collectible Mom's Shovel iconMom's Shovel, Collectible The Polaroid iconThe Polaroid, Collectible The Negative iconThe Negative, Collectible Key Piece 1 iconKey Piece 1 or 2, etc.).
  • Take caution; choosing an active item while holding another one will not drop the previous item to the ground, but replace it.
  • If the player acquires Collectible Damocles iconDamocles and uses it before all items have been collected, then each subsequent item spawned after using it will each spawn an extra item. Unlike the Genesis choices, the other extra items will not disappear upon collecting one of them, potentially allowing the player to obtain a much higher amount of items than usual.
  • Using Genesis removes both the damage penalty and schwag bonus on Daily Challenges.

Synergies[ | ]

Interactions[ | ]

  • ? Card? Card: If ? Card is used in place of Genesis, Genesis will be counted as an extra item for the choice set.
  • Collectible Abyss iconAbyss: The locusts created by Abyss are removed without creating items to replace them making Genesis one of the few effects that can remove them.
  • Character Azazel iconAzazel / Character Tainted Azazel iconTainted Azazel: Both have the ability to return to the floor Genesis was used on, due to them starting with a 0 - The Fool0 - The Fool card.
  • Collectible Book of Revelations iconBook of Revelations/Collectible Satanic Bible iconSatanic Bible: Effects on the Boss RoomBoss Room and boss item still apply to the floor even after using Genesis.
  • Collectible Brittle Bones iconBrittle Bones: Genesis removes the fire rate upgrades upon use.
  • Collectible Car Battery iconCar Battery: No effect.
  • Collectible Crooked Penny iconCrooked Penny: Using it on the choice pedestals has the 50/50 chance of duplicating them as normal, or make them disappear, in which case no new ones will spawn.
  • Collectible Damocles iconDamocles / Collectible Missing No. iconMissing No.: Genesis removes these items as well, making it the only item or effect that can remove them besides Butter!Butter!
  • Collectible Death Certificate iconDeath Certificate: After taking an item in the Death Certificate area, Isaac will return to the Genesis room and the current 3 item pedestals can all be be taken, with the next set spawning on top of them.
  • Collectible Echo Chamber iconEcho Chamber: The consumable pool is reset when Genesis is used, so if it's re-obtained after using Genesis, the previously stored consumable types won't be activated.
  • Collectible Eden's Blessing iconEden's Blessing: Using Genesis after collecting the blessing during the run will spawn Isaac in the Genesis room already holding a random item. This consumes Eden's Blessing, and the next run Isaac starts will not begin with a random item.
  • Collectible Esau Jr. iconEsau Jr.: Using Genesis as Esau Jr. will revert back to the original character.
  • Collectible Lazarus' Rags iconLazarus' Rags / Collectible Ankh iconAnkh / Collectible Clicker iconClicker: Using Genesis after Lazarus' Rags, Ankh or Clicker activates will continue as the new character.
  • Collectible Glowing Hourglass iconGlowing Hourglass: Using it works as intended and will give back all previous stats, items, pickups, and health.
  • Collectible Magic Skin iconMagic Skin: Genesis does NOT remove the downside of Magic Skin; any of the choice pedestals can be replaced by Magic Skin.
  • Collectible Sacred Orb iconSacred Orb: Will affect future items while inside the Genesis Room.
  • Collectible Teleport! iconTeleport! / Collectible Teleport 2.0 iconTeleport 2.0 / Telepills / Teleport Cards: Should such items/consumables be obtained in the Genesis room, they can be used to circumvent the forced floor skip.
    • In the case of pills, unidentified pills should only be consumed after taking all of the items in case telepills is rolled, for the Genesis room cannot be returned to after leaving.
  • Collectible Void iconVoid: All effects granted by absorbed items including stat ups and active item abilities Void takes are removed without creating items to replace them. Since Void is stripped of any active item abilities it would have gained, any other Void found will also have no other active effects stored in it.
    • Void's active effects are reset even if Isaac is currently not holding it.
  • Wild CardWild Card: Can't activate Genesis.

In-game Footage[ | ]

Trivia[ | ]

  • Genesis refers to the first book in the Bible, and is an Ancient Greek term for "birth". The item description refers to the very first words in the Book of Genesis.

Bugs[ | ]

Bug Bug! Using Genesis immediately after taking Collectible Dad's Note iconDad's Note will teleport Isaac to the Genesis room, then to the start of the ascent with no items except those that cannot be removed (Dad's Note, Key Pieces, etc.).
Bug Bug! Genesis removes wisps created by Collectible Lemegeton iconLemegeton but not the item effects associated with them. These remain permanently active until Lemegeton is used again.


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