Binding of Isaac: Rebirth Wiki
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In order to make progression, it is necessary to unlock various characters and chapters.

On this page, the unlock requirements for these steps in progression are listed in order of rough availability.

Major Chapter Unlocks[ | ]

WombWomb[ | ]

An entrance to WombWomb is unlocked by beating Boss Mom ingameMom 1 time. The Womb The Womb

This entrance will spawn after beating Boss Mom ingameMom on every subsequent run.

SheolSheol and CathedralCathedral[ | ]

Entrances to SheolSheol and CathedralCathedral are unlocked by beating Boss Mom's Heart ingameMom's Heart 11 times. It Lives! It Lives!

These entrances will spawn after beating Boss It Lives ingameIt Lives, which replaces Boss Mom's Heart ingameMom's Heart on every subsequent run.

(except in Rebirth) The entrances will also spawn after beating Boss Hush ingameHush.

Dark RoomDark Room and ChestChest[ | ]

The player will transport to Dark RoomDark Room when entering the chest spawned by Boss Satan ingameSatan so long as the player holds Collectible The Negative iconThe Negative.

The player will transport to ChestChest when entering the chest spawned by Boss Isaac ingameIsaac so long as the player holds Collectible The Polaroid iconThe Polaroid.

Collectible The Negative iconThe Negative is unlocked by beating Boss Satan ingameSatan 5 times. The Negative The Negative

Collectible The Polaroid iconThe Polaroid is unlocked by beating Boss Isaac ingameIsaac 5 times. The Polaroid The Polaroid

Once unlocked Collectible The Negative iconThe Negative and/or Collectible The Polaroid iconThe Polaroid will always spawn after beating Boss Mom ingameMom(but only one can be taken).

Mega Satan Head ingameMega Satan[ | ]

A door to Mega Satan Head ingameMega Satan will appear at the beginning of Dark RoomDark Room and ChestChest once Boss ??? ingame??? or Boss The Lamb ingameThe Lamb has been beaten once. Angels Angels

This door can be opened by collecting Collectible Key Piece 1 iconKey Piece 1 and Collectible Key Piece 2 iconKey Piece 2, by using Collectible Dad's Key iconDad's Key, (except in Rebirth)Get out of Jail Free CardGet out of Jail Free Card, or (in Repentance)Soul of CainSoul of Cain, using (in Repentance)Collectible Sharp Key iconSharp Key or (in Afterbirth † and Repentance)Collectible Mr. ME! iconMr. ME! on the door, or taking damage while having (in Repentance)Collectible Cracked Orb iconCracked Orb.

It is possible to obtain Collectible Key Piece 1 iconKey Piece 1 and Collectible Key Piece 2 iconKey Piece 2 by bombing the angel statues inside of Angel RoomAngel Rooms and defeating the angel spawned. Alternatively these angels will spawn when using the Sacrifice RoomSacrifice Room.

(except in Rebirth) ??????[ | ]

A door to ?????? is unlocked by beating Boss Mom's Heart ingameMom's Heart 10 times. Blue Womb Blue Womb

This door will spawn after beating Boss It Lives ingameIt Lives in under 30 minutes on any subsequent run.

(in Afterbirth † and Repentance) The VoidThe Void[ | ]

A door to The VoidThe Void is unlocked by beating Boss Hush ingameHush 1 time.

This door will spawn after beating Boss Hush ingameHush on any subsequent run.

A portal to The VoidThe Void will also have a chance to spawn after most major bosses on any subsequent run.

(in Repentance) Alternate Floors[ | ]

Doors to DownpourDownpour, MinesMines, MausoleumMausoleum and CorpseCorpse will unlock by beating Boss Hush ingameHush 3 times. A Secret Exit A Secret Exit

These doors will spawn in the Boss RoomBoss Room once the boss is defeated on chapters I, II, and III on subsequent runs.

(in Repentance) Ascent and HomeHome[ | ]

A door to a special version of MausoleumMausoleum will appear at the beginning of Depths II on every subsequent run once Boss Mother secondphase ingameMother has been beaten 1 time. A Strange Door A Strange Door

This door can be opened by interacting with it, by using either Collectible The Negative iconThe Negative or Collectible The Polaroid iconThe Polaroid.

It can also be opened with Faded PolaroidFaded Polaroid and Collectible Dad's Key iconDad's Key.

This can be done using any form of teleporting (e.g. Collectible Teleport! iconTeleport!) after beating Boss Mom ingameMom. (a Tinted Skullmarked skull (see Rocks) on the floor will always contain a 0 - The Fool0 - The Fool) card

  • Although difficult to achieve under normal circumstances, if Isaac uses (except in Rebirth)Collectible Glowing Hourglass iconGlowing Hourglass in the starting room without entering any other rooms, he will instantly warp to (in Repentance)HomeHome, skipping the Ascent. This works regardless of if (in Repentance) Boss Mother secondphase ingameMother has been defeated or not, meaning that it's theoretically possible to reach (in Repentance)HomeHome without even killing Boss Mom ingameMom once.

Character Unlocks[ | ]

See Characters.


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