Friend Zone is a passive item added in The Binding of Isaac: Afterbirth.
- Spawns a white fly familiar that slowly orbits Isaac and deals 3 damage per tick or 45 damage per second on contact.
- This item belongs to the Beelzebub set. Collecting three items from this set will transform Isaac into a giant humanoid fly.
- A reference to the "friend zone", a phenomenon where one person in a platonic relationship has romantic feelings for the other person and the other one does not, seeing them as "just a friend".
- Friend Zone is very similar in appearance to Best Bud and Lost Fly, making them difficult to distinguish.
- Friend Zone is a recolored Obsessed Fan.