Flight is an ability that can be gained by Isaac upon pick up of various items. When Isaac has flight, he can pass over all obstacles, including rocks, poop, and pits, and won't be damaged by hazards such as creep or spikes (except Sacrifice Room spikes). He can still be damaged by Fire Places and spike blocks. Azazel and The Lost start with the ability to fly.
Passively grants flight and increases speed to 1.5. Upon use, Isaac charges in the direction the pony is facing, giving invulnerability during the charge and dealing damage to enemies hit.
Passively grants flight and increases speed to 1.5. Upon use, Isaac charges in the direction the pony is facing, giving invulnerability during the charge while also creating damaging beams of light.
Swaps between the current character and Esau Jr., who has +2 flat damage and flight. Characters have independent items and health. Dying as either character ends the run.
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Note: The Pony and White Pony passively grant flight while they are in Isaac's possession.
Grants flight, +2 damage, and increases speed to 1.1. Grants enough health to have 6 full hearts, if possible. Grants the Holy Mantle effect for the room it was obtained in. Automatically given to Isaac after defeating Dogma.