Binding of Isaac: Rebirth Wiki
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Familiars are small companions, usually generated by passive items, that follow and assist Isaac. Effects of familiars include (but are not limited to) pickup generation, shooting familiars that fire their own tears at enemies, and orbitals that act as projectile shields and/or deal contact damage.

Many of these familiars (especially pickup generation and shooting familiars) follow behind Isaac. When Isaac picks up multiple of these following familiars, they form a line behind him from oldest to newest (with closest familiar behind Isaac being the oldest one picked up) rather than constantly overlapping one another on the same spot behind Isaac.

  • (in Repentance) In addition to being chronologically ordered, certain familiars on the line take priority over others in how close their position is to Isaac. There are 6 priorities:

Isaac cannot have more than 64 total familiars at once. This includes blue spiders and flies, familiar items such as Collectible Dry Baby iconDry Baby, (in Repentance) Character Tainted Eve iconTainted Eve's blood clots, etc. Gaining more than this will result in familiars being destroyed, with blue spiders and flies being destroyed first.

Temporary Familiars[ | ]

Blue Flies[ | ]

Blue Fly

Blue Flies are familiars that will orbit around Isaac and rush towards nearby enemies, dealing damage and dying in the process. Blue Flies deal double Isaac's current tear damage.

Name ID Icon Quote Description (in Repentance) Quality
Guppy's Head 5.100.145
Guppy's Head
1 room
Reusable fly hive Spawns 2-4 friendly Blue Flies that damage enemies. 2
Mom's Pad 5.100.41
Mom's Pad
2 rooms
Mass fear Inflicts fear to all enemies in the room for 4 seconds. (in Repentance) Spawns a blue fly. 0
(except in Rebirth) Jar of Flies 5.100.434
Jar of Flies
Unlimited
Bug catcher Killing an enemy adds a fly to the jar, up to a maximum of 20. On use, releases Blue Flies equal to the number of flies in the jar. 2
(in Afterbirth † and Repentance) Compost 5.100.480
Compost
2 rooms
Gain more friends! Doubles Isaac's Blue Flies and Blue Spiders, or spawns one if Isaac has none. Converts pickups in the current room into Blue Flies or Blue Spiders. 1
(in Repentance) Everything Jar 5.100.720
Everything Jar
12 rooms
Anything is possible Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects. 3
Name ID Icon Quote Description (in Repentance) Quality
Infestation 5.100.148 Infestation Fly revenge (except in Repentance) 1-3 Blue Flies randomly spawn every time Isaac gets hit.
(in Repentance) 2-6 Blue Flies
0
Mom's Underwear 5.100.29 Mom's Underwear Range up (except in Repentance) +5.25 range, +0.5 tear falling speed.
(in Repentance) +2.5 range. Spawns 3-6 Blue Flies on pickup.
1
Rotten Baby 5.100.268 Rotten Baby Infested friend Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. 3
The Mulligan 5.100.151 The Mulligan They grow inside Tears have a 1/6 chance of spawning allied Blue Flies when they hit an enemy. 3
(in Afterbirth † and Repentance) Parasitoid 5.100.461 Parasitoid Egg tears! Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy. 3
(in Repentance) Lil Portal 5.100.681 Lil Portal It hungers A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room. 1
(in Repentance) The Swarm 5.100.693 The Swarm Infest Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. 2
Name ID Icon Quote Description
Fish Head 5.350.29 Fish Head It stinks Spawns a Blue Fly every time Isaac takes damage.
(except in Rebirth) Lil Larva 5.350.86 Lil Larva The poop is moving... Spawns a Blue Fly from every pile of PoopPoop that Isaac destroys.
(in Afterbirth † and Repentance) Fish Tail 5.350.94 Fish Tail It also stinks! Items and trinkets that generate Blue Flies or Locusts will generate twice as many.
(in Afterbirth † and Repentance) Rotten Penny 5.350.126 Rotten Penny Wealth of flies Spawns a Blue Fly every time a coin is picked up.
Name ID Icon Message Description
Rune of Berkano 5.300.38 Rune of Berkano Companionship Summons 3 friendly Blue Flies and 3 friendly Blue Spiders.
(in Afterbirth † and Repentance) Black Rune 5.300.41 Black Rune Void Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades.

Other sources of Blue Flies

  • Red ChestRed Chest: Has a chance to spawn 3 Blue Flies.
  • Dark blue champion: Will create 3 Blue Flies when defeated.
  • (except in Repentance) GuppyGuppy: Isaac will create Blue Flies whenever his tears or his familiars' tears hit enemies.
  • (in Repentance) GuppyGuppy: Isaac's tears have a 66% chance to create Blue Flies whenever they hit enemies.
  • BeelzebubBeelzebub: All enemy flies become Blue Flies.
  • (except in Rebirth) Friends Till The End! pill: Spawns three Blue Flies.
  • As Character Keeper iconKeeper or Character Tainted Keeper iconTainted Keeper, all heart pickups turn into Blue Flies.
  • (in Repentance) Rotten HeartRotten Heart: After clearing a room, a maximum of two Blue Flies spawn for each Rotten Heart in Isaac's life bar.
  • (in Repentance) Corny PoopCorny Poops created by Character Tainted ??? iconTainted ??? or Collectible IBS iconIBS spawn a Blue Fly every two seconds, up to a maximum of 3.

Locusts (in Afterbirth † and Repentance)[ | ]

Red Fly Green Fly Yellow Fly Black Fly (Familiar) White Fly

Locusts are variants of Blue Flies that are spawned by Locust trinkets and Collectible 7 Seals icon7 Seals. They behave like regular Blue Flies but have additional special effects. Red Locusts explode on contact with an enemy, dealing an extra 60 damage in the radius ((in Repentance)explosions are affected by certain bomb modifiers). Green Locusts poison the enemy. Yellow Locusts slow the enemy. Black Locusts deal quadruple Isaac's damage instead of double. White Locusts are identical to Blue Flies, but are generally spawned in high quantities.

Name ID Icon Quote Description (in Repentance) Quality
7 Seals 5.100.526 7 Seals Lil harbingers! Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. 2
Name ID Icon Quote Description
Fish Tail 5.350.94 Fish Tail It also stinks! Items and trinkets that generate Blue Flies or Locusts will generate twice as many.
Locust of Conquest 5.350.117 Locust of Conquest I bring Conquest Upon entering a room with enemies, spawns 1-4 White Locusts which damage enemies.
Locust of Death 5.350.116 Locust of Death I bring Death Upon entering a room with enemies, spawns a Black Locust that does a very high amount of damage.
Locust of Famine 5.350.115 Locust of Famine I bring Famine Upon entering a room with enemies, spawns a Yellow Locust that damages and slows enemies.
Locust of Pestilence 5.350.114 Locust of Pestilence I bring Pestilence Upon entering a room with enemies, spawns a Green Locust which damages and poisons enemies.
Locust of War 5.350.113 Locust of War I bring War Upon entering a room with enemies for the first time, spawns a Red Locust which detonates upon impact with enemies.
(in Repentance) Cricket Leg 5.350.185 Cricket Leg Infested Adds a chance to spawn a random locust when killing an enemy.
Name ID Icon Message Description
(in Repentance) Soul of Apollyon 5.300.94 Soul of Apollyon Bringer of calamity Spawns 15 random locusts.

Blue Spiders[ | ]

Blue Spider

Blue Spiders are familiars similar to Blue Flies that crawl erratically and rush towards nearby enemies, dealing damage and dying in the process.

(except in Repentance) Blue Spiders deal 2.5 times Isaac's current tear damage. (in Repentance) Blue Spiders deal twice Isaac's current tear damage.

Unlike Blue Flies, Blue Spiders cannot attack over obstacles such as rocks and pits.

Bug Bug! 3DS Exiting the game and re-entering will cause all Blue Spiders to disappear.
Name ID Icon Quote Description (in Repentance) Quality
Box of Spiders 5.100.288
Box of Spiders
2 rooms
It's a box of spiders (except in Repentance) Spawns 1-4 Blue Spiders that deal 2.5x Isaac's damage to enemies.
(in Repentance) Spawns 4-8 Blue Spiders that deal 2x Isaac's damage to enemies.
1
(in Afterbirth † and Repentance) Compost 5.100.480
Compost
2 rooms
Gain more friends! Doubles Isaac's Blue Flies and Blue Spiders, or spawns one if Isaac has none. Converts pickups in the current room into Blue Flies or Blue Spiders. 1
(in Repentance) Everything Jar 5.100.720
Everything Jar
12 rooms
Anything is possible Spawns certain pickups based on how many charges it has. If fully charged, instead has one of many unique effects. 3
Name ID Icon Quote Description (in Repentance) Quality
Dark Bum 5.100.278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects Red HeartRed Hearts. For every 1½ Red Hearts collected, Dark Bum will give a reward. 3
Infestation 2 5.100.234 Infestation 2 Infestation shot Spawns allied Blue Spiders from killed enemies. 3
Juicy Sack 5.100.266 Juicy Sack Sticky babies Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. 2
Mom's Wig 5.100.217 Mom's Wig You feel itchy... Adds a chance to spawn Blue Spiders when firing tears. Restores 1 Red HeartRed Heart. 2
Sissy Longlegs 5.100.280 Sissy Longlegs She loves you Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. (in Repentance) Briefly charms enemies on contact. 1
Spiderbaby 5.100.211 Spiderbaby Spider revenge (except in Repentance) Spawns 1-2 Blue Spiders when Isaac takes damage.
(in Repentance) Spawns 3-5 Blue Spiders when Isaac takes damage.
0
(except in Rebirth) Spider Mod 5.100.403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' BatteryLil' Battery/Blue spider upon clearing a room. 1
(except in Rebirth) Sticky Bombs 5.100.367 Sticky Bombs Egg sack bombs! +5 BombBombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy. (in Repentance) They also leave a long-lasting puddle of slowing white creep. 2
(in Afterbirth † and Repentance) Parasitoid 5.100.461 Parasitoid Egg tears! Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy. 3
(in Repentance) Keeper's Kin 5.100.717 Keeper's Kin Under a rock Rocks and other Obstacles spawn blue spiders over time while in a room with enemies, and spawn two blue spiders when destroyed. 2
(in Repentance) Strawman 5.100.667 Strawman A helping hand Spawns a controllable Character Keeper iconKeeper to fight enemies alongside Isaac, functioning similarly to Character Jacob and Esau iconJacob and Esau. If Keeper dies, he spawns 5 blue spiders and Strawman is removed from Isaac's inventory. 2
(in Repentance) The Intruder 5.100.575 The Intruder Invasive friend A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. 3
(in Repentance) Tinytoma 5.100.645 Tinytoma Itching for revenge Gives Isaac a Boss Teratoma ingameTeratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. 1
Name ID Icon Quote Description
(except in Rebirth) Louse 5.350.70 Louse Itchy, tasty... Occasionally spawns a Blue Spider.
(in Repentance) Apple of Sodom 5.350.140 Apple of Sodom It feels empty Picking up Red HeartRed Hearts, even while at full health, can convert them into blue spiders. The effect may consume hearts needed for healing.
Name ID Icon Message Description
Rune of Berkano 5.300.38 Rune of Berkano Companionship Summons 3 friendly Blue Flies and 3 friendly Blue Spiders.
(in Afterbirth † and Repentance) Black Rune 5.300.41 Black Rune Void Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into Blue Flies and Spiders. Consumes all pedestal items in the room and turns them into random stat upgrades.

Other sources of Blue Spiders

  • (except in Rebirth) Infested? pill: Spawns Blue Spiders equal to the number of enemies in the room.
  • (except in Rebirth) Infested! pill: Spawns a Blue Spider under Isaac and every pile of poop in the room.

Dips (in Repentance)[ | ]

Dip Familiar

Dips are temporary familiars that are spawned when destroying poops. They move erratically around the room and behave similarly to their hostile counterpart dealing contact damage to enemies and blocking projectiles. There are a variety of Dips with unique effects that correlate to different types of PoopPoops.

Name ID Icon Quote Description Quality
Dirty Mind 5.100.576 Dirty Mind Filthy friends Destroying poop spawns Dip Familiars that follow Isaac and damage enemies. Destroying different types of poop spawns different Dips with special effects. 1
Name ID Icon Quote Description
Dingle Berry 5.350.163 Dingle Berry Oops! Spawns a Dip Familiar upon clearing a room.

Other sources of Dips

Wisps (in Repentance)[ | ]

Familiar Wisp

Wisps are temporary orbital familiars that are mostly associated with Character Bethany iconBethany. By default, they orbit Isaac, blocking shots and dealing contact damage. They also fire spectral tears that deal 1.6-2.4 damage. Normal wisps have 2 health. There are many variants of wisps, most of which can be spawned randomly or through combinations with Collectible Book of Virtues iconBook of Virtues. See here for a full list of wisps.

Other unique variants of wisps include item wisps from Collectible Lemegeton iconLemegeton which only mimic the effects of passive items while alive, and red wisps from Collectible Vengeful Spirit iconVengeful Spirit, which are invulnerable, but disappear upon entering a new floor.

Name ID Icon Quote Description Quality
Book of Virtues 5.100.584
Book of Virtues
4 rooms
Spiritual companionship On use, spawns a destroyable orbiting wisp familiar that fires tears and deals contact damage. Also acts as a passive item that causes other active items to spawn themed wisps. 3
Jar of Wisps 5.100.685
Jar of Wisps
12 rooms
Your faith grows Spawns random wisps that shoot various tears, block shots, and deal contact damage. The number of wisps spawned increases every time the jar is used. 2
Lemegeton 5.100.712
Lemegeton
6 rooms
Item summoner Spawns a wisp representing a random passive item, which orbits Isaac but can be destroyed. While the wisp is alive, Isaac gains that item's effects. Generation uses the current room's item pool 25% of the time, otherwise a random pool. 3
Name ID Icon Quote Description Quality
Vengeful Spirit 5.100.702 Vengeful Spirit Hot blooded After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots. 1
Name ID Icon Quote Description
Beth's Essence 5.350.182 Beth's Essence Virtue's reward Upon entering an Angel RoomAngel Room, spawns 5 wisp orbitals. Giving money to BeggarBeggars can spawn wisps.
Beth's Faith 5.350.142 Beth's Faith My faith protects me At the beginning of each floor, spawn 4-8 wisps that orbit Isaac and fires tears alongside him.
Name ID Icon Message Description
Soul of Bethany 5.300.96 Soul of Bethany Friends from beyond Spawns 6 Collectible Book of Virtues iconBook of Virtues wisps with random properties.

Other sources of Wisps

Ghosts (in Repentance)[ | ]

Ghosts are temporary familiars that are summoned by various items. Most ghosts (except those created by Collectible Vade Retro iconVade Retro) will automatically attack enemies after being summoned, quickly homing in on nearby enemies. All ghosts attack enemies by exploding, though some also deal contact damage shortly before doing so. Explosions from ghosts do not damage terrain or hurt Isaac. Unlike other temporary familiars, ghosts do not persist across rooms.

Name ID Icon Quote Description Quality
Vade Retro 5.100.653
Vade Retro
Unlimited
Begone! While held, enemies leave behind ghosts on death. Stronger enemies leave bigger ghosts. Using the item causes the ghosts to explode and damage nearby enemies, and instantly kills all ghost enemies with less than 50% HP. 2
Name ID Icon Quote Description Quality
Ghost Bombs 5.100.727 Ghost Bombs Spooky blast +5 bombs +5 BombBombs. Bombs become spectral and spawn ghosts that deal contact damage to enemies and explode after 10 seconds. 2
Hungry Soul 5.100.684 Hungry Soul Out for blood Enemies have a chance to spawn ghosts on death, which chase and deal contact damage to enemies and explode after a short time. 2
Purgatory 5.100.634 Purgatory Help from beyond While in a room with enemies, spawns cracks on the ground. Walking over these cracks summons ghosts that launch themselves at enemies and explode. 2

Chasing Familiars[ | ]

Familiars in this category actively chase enemies, dealing contact damage to them.

Name ID Icon Quote Description (in Repentance) Quality
The Pinking Shears 5.100.107
The Pinking Shears
4 rooms
Cut and run Separates Isaac's head from his body for the current room, granting flight and turning the body into a familiar that chases enemies. 2
Name ID Icon Quote Description (in Repentance) Quality
Ball of Bandages 5.100.207 Ball of Bandages Gotta lick 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
Cube of Meat 5.100.73 Cube of Meat Gotta meat 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
Daddy Longlegs 5.100.170 Daddy Longlegs Daddy's love Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total. 3
Dead Bird 5.100.117 Dead Bird Protective buddy After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~4 damage per second. 0
Gemini 5.100.318 Gemini Conjoined friend Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~6.43 damage per second. 1
Leech 5.100.270 Leech Blood sucker Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a Half Red HeartHalf Red Heart whenever Leech kills an enemy. 2
Lil Haunt 5.100.277 Lil Haunt Fear him Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear. 1
Smart Fly 5.100.264 Smart Fly Revenge fly Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. 2
(except in Rebirth) Bumbo 5.100.385 Bumbo Bumbo want coin! Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. 1
(in Afterbirth † and Repentance) 7 Seals 5.100.526 7 Seals Lil harbingers! Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. 2
(in Repentance) Bird Cage 5.100.610 Bird Cage Fat buddy The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to Collectible Dead Bird iconDead Bird. 1
(in Repentance) Blood Puppy 5.100.565 Blood Puppy What a cute little thing! Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac, it will also generate Half Red HeartHalf Red Hearts on enemy kills. It can increase in power one more stage after killing even more enemies. Dealing enough damage to it returns it to normal. 1
(in Repentance) The Intruder 5.100.575 The Intruder Invasive friend A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. 3
Name ID Icon Quote Description
Eve's Bird Foot 5.350.60 Eve's Bird Foot Revenge from beyond 5% chance to spawn a Collectible Dead Bird iconDead Bird familiar for the current room each time an enemy dies.
Umbilical Cord 5.350.33 Umbilical Cord Fetal Protection When brought down to only a Half Red HeartHalf Red Heart, spawns a Collectible Little Steven iconLittle Steven familiar for the current room. (in Repentance) Adds a high chance to spawn a Collectible Gemini iconGemini familiar for the current room after taking damage.
Name ID Icon Message Description
(in Repentance) Soul of Eve 5.300.86 Soul of Eve Your very own murder 14 Collectible Dead Bird iconDead Bird familiars fly in and attack enemies. They leave after all enemies are dead or Isaac leaves the room.

Note: Only third and fourth stage Collectible Cube of Meat iconCube of Meat and Collectible Ball of Bandages iconBall of Bandages chase enemies.

Note: (except in Rebirth) Only fourth stage Collectible Bumbo iconBumbo chases enemies.

Note: (in Afterbirth † and Repentance) Only Boss War ingameWar and Boss Death ingameDeath in Collectible 7 Seals icon7 Seals chase enemies.

Orbital Familiars[ | ]

Familiars that orbit Isaac, absorbing enemy projectiles and/or dealing contact damage. Despite their different apparent sizes, most of them have the same effective size with regard of blocking shots or damaging enemies.

Name ID Icon Quote Description (in Repentance) Quality
(in Afterbirth † and Repentance) Book of the Dead 5.100.545
Book of the Dead
6 rooms
Rise from the grave (except in Repentance) Creates a friendly BonyBony, Black BonyBlack Bony, or an orbital bone for each enemy killed in the current room.
(in Repentance)Creates a friendly BonyBony, Black BonyBlack Bony, Bone FlyBone Fly, RevenantRevenant, or an orbital bone for each enemy killed in the current room.
3
(in Repentance) Spin to Win 5.100.655
Spin to Win
3 seconds
Let it rip! When used, gives Isaac +0.5 speed and greatly increases the rotation speed of Isaac's orbitals for 3 seconds. Gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage to enemies while held. 1
Name ID Icon Quote Description (in Repentance) Quality
Ball of Bandages 5.100.207 Ball of Bandages Gotta lick 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
Best Bud 5.100.274 Best Bud Sworn protector When hit, spawns a quickly orbiting attack fly similar to Collectible Forever Alone iconForever Alone for the current room that deals high damage. 0
Big Fan 5.100.279 Big Fan Fat protector Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies. 2
Cube of Meat 5.100.73 Cube of Meat Gotta meat 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
Distant Admiration 5.100.57 Distant Admiration Attack fly Spawns an attack fly that circles further out than Collectible Halo of Flies iconHalo of Flies, but closer than Collectible Forever Alone iconForever Alone, dealing 75 damage per second. 2
Forever alone 5.100.128 Forever alone Attack fly Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second. 1
Guardian Angel 5.100.112 Guardian Angel Extra protection Spawns an orbital familiar that blocks enemy shots, deals (except in Repentance) 105 /(in Repentance) 52.5 damage per second to enemies, and increases the speed of all orbital familiars. 2
Guillotine 5.100.206 Guillotine DMG + tears up. An out-of-body experience! Isaac's head is removed from his body and floats around him as an orbital. (except in Repentance) Gives +1 damage and grants -1 tear delay. (in Repentance) Gives +1 damage and grants +0.5 fire rate. 2
Halo of Flies 5.100.10 Halo of Flies Projectile protection Spawns two Pretty Flies that block enemy shots and deal contact damage to flies. 2
Sacrificial Dagger 5.100.172 Sacrificial Dagger My fate protects me Spawns a dagger orbital familiar, blocking enemy shots and dealing a high amount of damage to enemies in contact. 2
Smart Fly 5.100.264 Smart Fly Revenge fly Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. 2
(except in Rebirth) Friend Zone 5.100.364 Friend Zone Friendly fly Spawns a white attack fly that orbits somewhere between Collectible Distant Admiration iconDistant Admiration and Collectible Forever Alone iconForever Alone, dealing 45 damage per second. 1
(except in Rebirth) Sworn Protector 5.100.363 Sworn Protector Protective friend Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal HeartEternal Heart. 3
(in Afterbirth † and Repentance) Angelic Prism 5.100.528 Angelic Prism Eclipsed by the moon Spawns an orbital familiar with a large orbital radius. Tears that pass through the prism split into four multi-colored tears. 3
(in Afterbirth † and Repentance) Bloodshot Eye 5.100.509 Bloodshot Eye Bloody friend Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds. 1
(in Afterbirth † and Repentance) Leprosy 5.100.525 Leprosy You're tearing me apart! Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots. 1
(in Afterbirth † and Repentance) Mom's Razor 5.100.508 Mom's Razor It's sharp! Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time. 2
(in Afterbirth † and Repentance) Slipped Rib 5.100.542 Slipped Rib Projectile shield Spawns a bone familiar that circles around Isaac and reflects enemy shots. 2
(in Repentance) Bot Fly 5.100.629 Bot Fly Defense drone Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. 3
(in Repentance) Psy Fly 5.100.581 Psy Fly Flamboyant protector Spawns a fly orbital familiar that chases and blocks enemy shots. 4
(in Repentance) The Swarm 5.100.693 The Swarm Infest Spawns eight orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. 2
(in Repentance) Tinytoma 5.100.645 Tinytoma Itching for revenge Gives Isaac a Boss Teratoma ingameTeratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. 1
Pills / Slot MachineSlot Machine

Name Description
Pretty Fly Grants 1 fly orbital that circles the player, blocking projectiles and damaging fly-type enemies on touch.
Notes
  • A maximum of three Pretty Flies can orbit around Isaac.
    • It is possible to have more than three orbitals if one has access to co-op mode. If a co-op baby or multiple co-op babies temporarily hold all but two orbitals while Isaac picks up another, and then the co-op baby or co-op babies sign out or die, Isaac will receive their orbitals as well.
  • Collectible Cube of Meat iconCube of Meat, Collectible Ball of Bandages iconBall of Bandages, and Collectible Sacrificial Dagger iconSacrificial Dagger take up a Pretty Fly slot.
    • For example, If Isaac has three Pretty Flies and picks up a Collectible Cube of Meat iconCube of Meat, the Cube of Meat will replace one of the flies.
    • Only first and second stage Collectible Cube of Meat iconCube of Meat and Collectible Ball of Bandages iconBall of Bandages are orbitals. Therefore, upgrading from level 2 to level 3 will free up a Pretty Fly slot.
  • (except in Rebirth) Duplicated orbitals, such as Collectible Forever alone iconForever alone being copied with the Collectible Box of Friends iconBox of Friends or Collectible Diplopia iconDiplopia, will fly directly opposite the original (having three copies will cause them to fly 120 degrees apart, four will fly at 90 degrees and so on).
Trivia
  • Pretty Fly is a play on the phrase "pretty fly" as a descriptor.

Pickup Generation Familiars[ | ]

Familiars that generate pickups when certain conditions are met.

Name ID Icon Quote Description (in Repentance) Quality
Bomb Bag 5.100.131 Bomb Bag Gives bombs Spawns a familiar that drops a BombBomb every 3 rooms. 2
Bum Friend 5.100.144 Bum Friend He's greedy Spawns a familiar that picks up Pennycoins for himself, giving random pickups in return. (in Repentance) Can spawn Items from the Beggar Item Pool. 1
Dark Bum 5.100.278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects Red HeartRed Hearts. For every 1½ Red Hearts collected, Dark Bum will give a reward. 3
Little C.H.A.D. 5.100.96 Little C.H.A.D. Gives kisses Spawns a familiar who drops a Half Red HeartHalf Red Heart every 3 rooms. 2
Mystery Sack 5.100.271 Mystery Sack ? Spawns a familiar that drops a Heart, coin, BombBomb, or KeyKey every 5-6 rooms. 2
Sack of Pennies 5.100.94 Sack of Pennies Gives money Spawns a familiar that drops a Pennycoin every 2 rooms. 1
The Relic 5.100.98 The Relic Soul generator Spawns a cross familiar that drops a Soul HeartSoul Heart after clearing enough rooms. 3
(except in Rebirth) Bumbo 5.100.385 Bumbo Bumbo want coin! Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. 1
(except in Rebirth) Charged Baby 5.100.372 Charged Baby Bbbzzzzzt! Spawns a familiar that occasionally drops a Lil' BatteryLil' Battery, gives an active item charge, or petrifies all enemies in the room. 3
(except in Rebirth) Key Bum 5.100.388 Key Bum He wants your keys! Spawns a familiar that follows Isaac and collects KeyKeys for himself, giving random ChestChests in return. 0
(except in Rebirth) Lil Chest 5.100.362 Lil Chest What's in the box? Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room. 2
(except in Rebirth) Rune Bag 5.100.389 Rune Bag Rune generator Spawns a familiar that drops a random rune after clearing enough rooms. 3
(except in Rebirth) Spider Mod 5.100.403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' BatteryLil' Battery/Blue spider upon clearing a room. 1
(except in Rebirth) Sworn Protector 5.100.363 Sworn Protector Protective friend Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room, it drops an Eternal HeartEternal Heart. 3
(in Afterbirth † and Repentance) Acid Baby 5.100.491 Acid Baby Pills pills pills! Spawns a familiar that drops a random pill every 3 rooms. Upon using a pill, all enemies in the room are poisoned. 2
(in Afterbirth † and Repentance) Sack of Sacks 5.100.500 Sack of Sacks Gives sacks Spawns a familiar that drops a Grab BagGrab Bag every 5-6 rooms cleared. 3
(in Repentance) Blood Puppy 5.100.565 Blood Puppy What a cute little thing! Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac, it will also generate Half Red HeartHalf Red Hearts on enemy kills. It can increase in power one more stage after killing even more enemies. Dealing enough damage to it returns it to normal. 1
(in Repentance) Lost Soul 5.100.612 Lost Soul Protect him Creates a ghostly familiar that closely follows behind Isaac. It dies in one hit, but respawns at the start of the next floor. Each time it survives until the next floor, it rewards Isaac with Soul HeartSoul Hearts, Eternal HeartEternal Hearts, or an Item. 2

Note: (except in Rebirth) Only the second, third, and fourth stages of Collectible Bumbo iconBumbo generate pickups.

Note: (in Repentance) Only the second and third stages of Collectible Blood Puppy iconBlood Puppy generate pickups.

Shooting Familiars[ | ]

Familiars that attack with their own tears or other ranged effects. Most shooting familiars only shoot as long as Isaac is attacking or charging a shot, though there are others that target and fire automatically.

Name ID Icon Quote Description (in Repentance) Quality
Scissors 5.100.325
Scissors
4 rooms
Lose your head Turns Isaac's head into a stationary familiar for the current room which fires tears automatically. (in Repentance) Isaac's body also shoots a controllable fountain of blood shots for the room. 1
(in Afterbirth † and Repentance) Brown Nugget 5.100.504
Brown Nugget
8 seconds
Friendly fly Spawns a stationary fly turret that lasts for the current room and fires tears at nearby enemies. 0
(in Repentance) Gello 5.100.728
Gello
2 rooms
Demonic gestation Spawns a demon familiar that's attached to Isaac and moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects. 3
(in Repentance) Sumptorium 5.100.713
Sumptorium
10 seconds
Blood to blood Removes half a heart and creates a Clot familiar that mimics Isaac's movements and tear effects. As Character Tainted Eve iconTainted Eve, passively converts health into Clots while firing. Activating returns all Clots to health. 3
Name ID Icon Quote Description (in Repentance) Quality
Abel 5.100.188 Abel Mirrored buddy (in Rebirth) Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction.
(except in Rebirth) Spawns a familiar that mirrors Isaac's movements and shoots towards him.
0
Ball of Bandages 5.100.207 Ball of Bandages Gotta lick 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot Charm tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
Brother Bobby 5.100.8 Brother Bobby Friends 'till the end Spawns a familiar that follows Isaac around shooting tears that deal 3.5 damage. (in Repentance) He shoots more frequently than most familiars. 1
Cain's Other Eye 5.100.319 Cain's Other Eye Near-sighted friend (except in Repentance) Spawns a familiar that slowly floats around the room on a zig-zag pattern and shoots normal tears in the same direction as Isaac.
(in Repentance) Spawns a familiar that follows Isaac and fires tears in random cardinal directions that copy Isaac's tears and tear effects and scale with damage.
2
Cube of Meat 5.100.73 Cube of Meat Gotta meat 'em all! Creates an orbital familiar. Collecting additional copies gives it the ability to shoot tears, then chase enemies to deal contact damage, then deal even more contact damage. 2
Demon Baby 5.100.113 Demon Baby Auto-turret friend Spawns a familiar that follows Isaac and automatically fires at enemies in its reach. 2
Ghost Baby 5.100.163 Ghost Baby Spectral buddy Spawns a familiar that follows Isaac around and fires spectral tears. 1
Harlequin Baby 5.100.167 Harlequin Baby Double shot buddy Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern. 1
Isaac's Heart 5.100.276 Isaac's Heart Protect it Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. (in Repentance) The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released. 0
Lil Brimstone 5.100.275 Lil Brimstone Evil friend Grants a familiar that charges a thin Collectible Brimstone iconBrimstone laser while Isaac is shooting. 2
Little Gish 5.100.99 Little Gish Sticky friend Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed. 2
Little Steven 5.100.100 Little Steven Psychic friend Spawns a familiar who follows Isaac around and fires homing tears. 2
Mongo Baby 5.100.322 Mongo Baby Mongo friend Spawns a familiar that copies the tears of Isaac's other familiars. 2
Rainbow Baby 5.100.174 Rainbow Baby Random buddy Spawns a familiar that follows Isaac around and fires tears with random effects. 1
Robo-Baby 5.100.95 Robo-Baby Friends 'till the bbbbzzzt Spawns a familiar that shoots Collectible Technology iconTechnology lasers. 1
Robo-Baby 2.0 5.100.267 Robo-Baby 2 We worked out all the kinks Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears. 1
Rotten Baby 5.100.268 Rotten Baby Infested friend Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. 3
Sister Maggy 5.100.67 Sister Maggy Friends 'till the end (except in Repentance) Spawns a familiar that follows Isaac around shooting tears that deal 3.5 damage.
(in Repentance) Spawns a familiar that follows Isaac around shooting tears that deal 6 damage.
1
(except in Rebirth) Bumbo 5.100.385 Bumbo Bumbo want coin! Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. 1
(except in Rebirth) Fate's Reward 5.100.361 Fate's Reward Your fate beside you A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage. 2
(except in Rebirth) Incubus 5.100.360 Incubus Dark friend Spawns a demonic familiar that shoots tears identical to Isaac's in terms of damage, tears, and tear effects. 4
(except in Rebirth) Lil Loki 5.100.435 Lil Loki 4-way buddy! Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern. 1
(except in Rebirth) Papa Fly 5.100.430 Papa Fly Turret follower Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies. 1
(except in Rebirth) Seraphim 5.100.390 Seraphim Sworn friend Spawns an angel familiar who follows Isaac and fires homing tears which deal 10 damage and have 75% shot speed. 3
(in Afterbirth † and Repentance) Buddy in a Box 5.100.518 Buddy in a Box What could it be?! Spawns a familiar with a random tear effect. The familiar is randomized at the start of each floor. 2
(in Afterbirth † and Repentance) Lil Monstro 5.100.471 Lil Monstro Ain't he cute? Spawns a familiar that fires clusters of tears. Must be charged before shooting. 2
(in Afterbirth † and Repentance) Lil Spewer 5.100.537 Lil Spewer Puking buddy Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type. 1
(in Repentance) Boiled Baby 5.100.607 Boiled Baby Messy friend Gives Isaac a familiar that fires chaotic bursts of tears in all directions. 1
(in Repentance) Freezer Baby 5.100.608 Freezer Baby Iced iced baby Spawns a shooting familiar that has a chance to petrify enemies, and freezes monsters upon killing them. 2
(in Repentance) Giant Cell 5.100.658 Giant Cell Micro friends Causes Isaac to spawn Minisaac familiars when he takes damage, which chase and shoot at nearby enemies. 1
(in Repentance) Lil Abaddon 5.100.679 Lil Abaddon Abyssal friend Spawns a familiar that charges a miniature Collectible Maw Of The Void iconMaw Of The Void attack while Isaac shoots. 2
(in Repentance) Quints 5.100.661 Quints They lurk inside The first five enemies killed in a room will spawn stationary shooting familiars where they died. 2
(in Repentance) The Intruder 5.100.575 The Intruder Invasive friend A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. 3
(in Repentance) Twisted Pair 5.100.698 Twisted Pair Double trouble! Spawns two familiars that float on either side of Isaac and fire tears that use his tears, range, shot speed, and tear effects, and scale with damage. 4
Name ID Icon Quote Description
???'s Soul 5.350.57 ???'s Soul Imaginary Friend Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Collectible The Peeper iconThe Peeper and fires spectral and homing tears.
Isaac's Head 5.350.54 Isaac's Head Dead friend Spawns Isaac's severed head as a tear-firing familiar. Fires piercing tears.
Umbilical Cord 5.350.33 Umbilical Cord Fetal Protection When brought down to only a Half Red HeartHalf Red Heart, spawns a Collectible Little Steven iconLittle Steven familiar for the current room. (in Repentance) Adds a high chance to spawn a Collectible Gemini iconGemini familiar for the current room after taking damage.
(in Repentance) Found Soul 5.350.180 Found Soul Finally! Spawns a familiar that copies Isaac's movements and scales with damage and tears. If it takes damage, it will die and respawn on the next floor.
(in Repentance) Lil Clot 5.350.176 Lil Clot Mini friend Spawns a clot familiar that mimics Isaac's movements and tears. It dies for the current room after taking too much damage.

Note: Only second stage Collectible Cube of Meat iconCube of Meat and Collectible Ball of Bandages iconBall of Bandages shoot tears.
Note: (except in Rebirth) Only third stage Collectible Bumbo iconBumbo fires tears.

(in Repentance) Note: Most shooting familiars that follow Isaac take 5th priority along the familiar line. This is the second to last priority with the last being non-combat familiars. There are some exceptions such as Collectible Incubus iconIncubus which has 2nd priority, Collectible Lil Brimstone iconLil Brimstone and Collectible Lil Monstro iconLil Monstro which have 3rd priority, and Collectible Boiled Baby iconBoiled Baby which has 6th priority.
(in Repentance) Note: Using five or more different copies of Collectible Esau Jr. iconEsau Jr. will destroy the item and spawn a familiar that behaves the same way as Collectible Abel iconAbel.

Wandering Familiars[ | ]

Familiars that move around the room sporadically.

Name ID Icon Quote Description (in Repentance) Quality
Punching Bag 5.100.281 Punching Bag Scape goat Spawns a MulliganMulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer. 1
Sissy Longlegs 5.100.280 Sissy Longlegs She loves you Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. (in Repentance) Briefly charms enemies on contact. 1
(except in Rebirth) Spider Mod 5.100.403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' BatteryLil' Battery/Blue spider upon clearing a room. 1
(in Afterbirth † and Repentance) 7 Seals 5.100.526 7 Seals Lil harbingers! Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. 2
(in Afterbirth † and Repentance) YO LISTEN! 5.100.492 YO LISTEN! Yo listen! +1 luck. Spawns a fairy familiar that points out Secret RoomSecret Rooms, Crawl SpaceCrawl Space entrances, and tinted rocks. 2

Note: (in Afterbirth † and Repentance) The Spider BabySpider Baby transformation grants a familiar nearly identical to Collectible Spider Mod iconSpider Mod with the only difference being the lack of ability to see enemy HP bars.

Note: (in Afterbirth † and Repentance) Only Boss Famine ingameFamine, Boss Pestilence ingamePestilence, and Boss Conquest ingameConquest in Collectible 7 Seals icon7 Seals wander randomly.

Bouncing Familiars[ | ]

Familiars that bounce around the room in a zig-zag pattern, changing directions when hitting a wall.

Name ID Icon Quote Description (in Repentance) Quality
(in Repentance) The Scooper 5.100.605
The Scooper
3 rooms
Plop! Summons Collectible The Peeper iconThe Peeper for the current room, which leaves a trail of red creep. 1
Name ID Icon Quote Description (in Repentance) Quality
BBF 5.100.272 BBF Big Beautiful Fly Spawns a familiar that flies around the room in a zig-zag pattern and explodes on contact with an enemy. Respawns after ten seconds. 1
Cain's Other Eye 5.100.319 Cain's Other Eye Near-sighted friend (except in Repentance) Spawns a familiar that slowly floats around the room on a zig-zag pattern and shoots normal tears in the same direction as Isaac.
(in Repentance) Spawns a familiar that follows Isaac and fires tears in random cardinal directions that copy Isaac's tears and tear effects and scale with damage.
2
The Peeper 5.100.155 The Peeper Plop! Spawns a familiar that slowly floats around the room in a zig-zag pattern, damaging enemies it passes through. (in Repentance) Increases the damage of tears from Isaac's left eye by 35%. 2
(except in Rebirth) GB Bug 5.100.405 GB Bug Double tap glitch (except in Repentance) Spawns a familiar that bounces diagonally around the room, applying a random status effect to enemies it hits and has a chance to re-roll pickups it passes over.
(in Repentance) Spawns a familiar that follows Isaac. Double tapping the fire button launches it forward, causing it to reroll the first monster or pickup it hits.
1
(except in Rebirth) Succubus 5.100.417 Succubus Damage booster Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier. 3
(in Afterbirth † and Repentance) Hushy 5.100.470 Hushy Lil hush! Spawns a Boss Hush ingameHush familiar that bounces diagonally around the room and deals contact damage. While firing tears, it stops moving. 0
Name ID Icon Quote Description
???'s Soul 5.350.57 ???'s Soul Imaginary Friend Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Collectible The Peeper iconThe Peeper and fires spectral and homing tears.

Mimicking Familiars (except in Rebirth)[ | ]

Familiars that copy Isaac's movements after a certain delay.

Name ID Icon Quote Description (in Repentance) Quality
Multidimensional Baby 5.100.431 Multidimensional Baby ydduB Buddy Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed. 2
My Shadow 5.100.433 My Shadow Me! And my shaaaadow! (except in Repentance) Inflicts fear on all enemies in the room upon taking damage and spawns black friendly ChargerChargers that attack enemies.
(in Repentance)Spawns a shadow familiar that closely follows behind Isaac. It spawns a black friendly ChargerCharger whenever an enemy touches it.
2
Obsessed Fan 5.100.426 Obsessed Fan Follows my every move... Spawns a familiar that follows Isaac's movements on a delay and deals 30 contact damage per second to enemies. 0
Papa Fly 5.100.430 Papa Fly Turret follower Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies. 1
(in Afterbirth † and Repentance) Shade 5.100.468 Shade It follows Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly My ShadowChargers. 0

Throwable Familiars[ | ]

Familiars that are thrown by Isaac by shooting and can return to him after awhile.

Name ID Icon Quote Description (in Repentance) Quality
(in Repentance) Abyss 5.100.706
Abyss
4 rooms
Come forth from the depths Destroys all items in the room and gives Isaac a unique locust familiar for each item destroyed. Some items generate locusts with special effects. 4
Name ID Icon Quote Description (in Repentance) Quality
Bob's Brain 5.100.273 Bob's Brain Explosive thoughts Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. 1
Holy Water 5.100.178 Holy Water Splash! (except in Repentance) Spawns a bottle familiar that breaks when Isaac takes damage, leaving a puddle of blue creep.
(in Repentance) A bottle familiar that flies forward when Isaac shoots. It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies.
3
Little Chubby 5.100.88 Little Chubby Attack buddy Spawns a ChargerCharger familiar that charges forward and deals contact damage to any enemies in its path. 2
(except in Rebirth) GB Bug 5.100.405 GB Bug Double tap glitch (except in Repentance) Spawns a familiar that bounces diagonally around the room, applying a random status effect to enemies it hits and has a chance to re-roll pickups it passes over.
(in Repentance) Spawns a familiar that follows Isaac. Double tapping the fire button launches it forward, causing it to reroll the first monster or pickup it hits.
1
(in Afterbirth † and Repentance) Big Chubby 5.100.473 Big Chubby Chub chub Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact. 1
(in Afterbirth † and Repentance) Jaw Bone 5.100.548 Jaw Bone Fetch! Spawns a familiar that flies through the room while firing, dealing a flat 7 contact damage to enemies and retrieving pickups. 1
(in Repentance) Knife Piece 1 5.100.626 Knife Piece 1 ??? Combined with Collectible Knife Piece 2 iconKnife Piece 2, creates a knife familiar that damages enemies and can open the door to the CorpseCorpse. 0
(in Repentance) Knife Piece 2 5.100.627 Knife Piece 2 ??? Combined with Collectible Knife Piece 1 iconKnife Piece 1, creates a knife familiar that damages enemies and can open the door to the CorpseCorpse. 0
(in Repentance) Lil Portal 5.100.681 Lil Portal It hungers A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room. 1
Name ID Icon Quote Description
(in Repentance) Apollyon's Best Friend 5.350.186 Apollyon's Best Friend Attack buddy Spawns an attack locust familiar which will fly forward while Isaac shoots.

Note: (in Repentance) Collectible Knife Piece 1 iconKnife Piece 1 and Collectible Knife Piece 2 iconKnife Piece 2 are only throwable when combined.

Controlled Familiars[ | ]

Familiars that move in the direction Isaac is shooting.

Name ID Icon Quote Description (in Repentance) Quality
(in Repentance) Stitches 5.100.635
Stitches
3 seconds
Bait and switch Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar. 1
Name ID Icon Quote Description (in Repentance) Quality
???'s Only Friend 5.100.320 ???'s Only Friend Controlled friend Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys 1
Robo-Baby 2.0 5.100.267 Robo-Baby 2 We worked out all the kinks Spawns a familiar that fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears. 1

Others[ | ]

Familiars that don't fit into any of the above categories or that produce multiple effects.

Name ID Icon Quote Description (in Repentance) Quality
Monster Manual 5.100.123
Monster Manual
6 rooms
Temporary buddy generator (except in Repentance) Spawns a familiar from a specific selection for the current room.
(in Repentance) Spawns a familiar from a specific selection for the current floor.
1
(in Afterbirth † and Repentance) Sprinkler 5.100.516
Sprinkler
4 rooms
Sprinkles. Upon use, creates a stationary sprinkler that rotates and fires tears in 8 directions. The tears copy Isaac's stats and most tear effects. 2
Name ID Icon Quote Description (in Repentance) Quality
1up! 5.100.11 1up! Extra life Gives Isaac an extra life. Upon death, he will respawn in the previous room with full health, after which 1up! will disappear. 2
Dead Cat 5.100.81 Dead Cat 9 lives Sets Isaac's Red Heart Containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container. 3
Dry Baby 5.100.265 Dry Baby Immortal friend Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering Collectible The Necronomicon iconThe Necronomicon effect. 3
Guppy's Hairball 5.100.187 Guppy's Hairball Swing it Spawns a familiar that loosely follows behind Isaac, which blocks shots can be swung like a flail to damage enemies. Grows bigger by killing enemies. 1
Headless Baby 5.100.269 Headless Baby Bloody friend Spawns a familiar that follows Isaac, leaving blood creep on the ground. 1
Holy Water 5.100.178 Holy Water Splash! (except in Repentance) Spawns a bottle familiar that breaks when Isaac takes damage, leaving a puddle of blue creep.
(in Repentance) A bottle familiar that flies forward when Isaac shoots. It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies.
3
Isaac's Heart 5.100.276 Isaac's Heart Protect it Isaac himself is now immune to all damage, and a heart familiar follows him. If the heart is hurt, Isaac is hurt. (in Repentance) The heart charges up as Isaac shoots, firing 8 blood shots, knocking back enemies, and leaving a puddle of creep when released. 0
Juicy Sack 5.100.266 Juicy Sack Sticky babies Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. 2
Key Piece 1 5.100.238 Key Piece 1 ??? Combined with Collectible Key Piece 2 iconKey Piece 2, unlocks the golden gate in the starting room of ChestChest and Dark RoomDark Room to fight Mega Satan Head ingameMega Satan. 0
Key Piece 2 5.100.239 Key Piece 2 ??? Combined with Collectible Key Piece 1 iconKey Piece 1, unlocks the golden gate in the starting room of ChestChest and Dark RoomDark Room to fight Mega Satan Head ingameMega Satan. 0
Samson's Chains 5.100.321 Samson's Chains The ol' ball and chain Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most Obstacles. 1
(except in Rebirth) Cambion Conception 5.100.412 Cambion Conception Feed them hate After taking damage a certain amount of times, a permanent demonic familiar spawns. 2
(except in Rebirth) Censer 5.100.387 Censer Peace be with you Spawns a familiar which creates a circular aura that slows down enemies and enemy shots inside. 3
(except in Rebirth) Farting Baby 5.100.404 Farting Baby He farts! Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which charms, poisons, or knocks back nearby enemies. 1
(except in Rebirth) Immaculate Conception 5.100.413 Immaculate Conception Feed them love Upon picking up a certain amount of health, spawn a permanent angelic familiar. 1
(except in Rebirth) Lil Gurdy 5.100.384 Lil Gurdy A gurd of your own! A Boss Gurdy Jr. ingameGurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed. 2
(except in Rebirth) Lost Fly 5.100.365 Lost Fly Lost protector Spawns fly familiar that moves in a straight line and circles around the first wall or obstacle it hits. (except in Repentance) It deals 105 damage per second on contact. (in Repentance) It deals 56 damage per second and forces nearby enemies to attack it. 2
(except in Rebirth) Milk! 5.100.436 Milk! Don't cry over it... Spawns a glass familiar that spills on the floor upon taking damage. (except in Repentance) After the milk spills, Isaac's tear delay is decreased by 2 for the current room. (in Repentance) After the milk spills, Isaac's fire rate is increased by 1 for the current room. 1
(in Afterbirth † and Repentance) Angry Fly 5.100.511 Angry Fly He's violent Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with. 1
(in Afterbirth † and Repentance) Depression 5.100.469 Depression :( Spawns a familiar that leaves a trail of creep that damages enemies at 6 damage per second. Has a chance to spawn damaging beams of light onto enemies that touch the cloud. 1
(in Afterbirth † and Repentance) Finger! 5.100.467 Finger! Watch where you point that! Spawns a finger familiar that faces in the same direction as Isaac, rapidly damaging enemies it points at for 10% of Isaac's damage. 1
(in Afterbirth † and Repentance) Hallowed Ground 5.100.543 Hallowed Ground Portable sanctuary Spawns a white poop familiar, which turns into a White PoopWhite Poop when Isaac is hurt. White poop has an aura that increases tear fire rate and can block enemy shots. (in Repentance) The aura also increases damage by 20% and gives homing. 1
(in Afterbirth † and Repentance) King Baby 5.100.472 King Baby Hail to the king baby Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, other familiars stop moving. 1
(in Afterbirth † and Repentance) Lil Delirium 5.100.519 Lil Delirium Delirious friend Grants a familiar that transforms into another random familiar every 10 seconds. 2
(in Afterbirth † and Repentance) Mystery Egg 5.100.539 Mystery Egg Sacrificial insemination Spawns an egg familiar, which hatches a random friendly monster when Isaac is hurt once per room. The power of the monster improves for each consecutive room cleared without taking damage. 1
(in Afterbirth † and Repentance) Pointy Rib 5.100.544 Pointy Rib Stabbing time Spawns a bone familiar that hovers back and forth in front of Isaac, dealing damage equal to Isaac's damage. 2
(in Repentance) Blood Oath 5.100.569 Blood Oath Bleed me dry Stabs Isaac at the beginning of each floor, draining his Red HeartRed Hearts. Increases damage and speed for the floor based on the amount drained. 1
(in Repentance) Cube Baby 5.100.652 Cube Baby Kick it! Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. 1
(in Repentance) Fruity Plum 5.100.649 Fruity Plum Bouncy friend Gives Isaac a miniature Boss Baby Plum ingameBaby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels. 1
(in Repentance) Giant Cell 5.100.658 Giant Cell Micro friends Causes Isaac to spawn Minisaac familiars when he takes damage, which chase and shoot at nearby enemies. 1
(in Repentance) Knife Piece 1 5.100.626 Knife Piece 1 ??? Combined with Collectible Knife Piece 2 iconKnife Piece 2, creates a knife familiar that damages enemies and can open the door to the CorpseCorpse. 0
(in Repentance) Knife Piece 2 5.100.627 Knife Piece 2 ??? Combined with Collectible Knife Piece 1 iconKnife Piece 1, creates a knife familiar that damages enemies and can open the door to the CorpseCorpse. 0
(in Repentance) Lil Dumpy 5.100.615 Lil Dumpy Puffy buddy Spawns a Dumpy familiar that pushes away nearby enemies and projectiles just before Isaac is about to be hit, then falls asleep. He can be awoken by walking to him. 3
(in Repentance) Paschal Candle 5.100.567 Paschal Candle Keep the flame burning Gives Isaac a familiar that grants +0.4 Fire Rate for each consecutive room he's cleared without taking damage. The bonus stacks up to five times. 3
(in Repentance) Star of Bethlehem 5.100.651 Star of Bethlehem Follow the light Spawns a star familiar that slowly travels towards the Boss RoomBoss Room, giving an aura that increases damage and tears and grants homing tears. 3
(in Repentance) Vanishing Twin 5.100.697 Vanishing Twin He wants revenge Spawns a familiar that becomes a clone of the floor's boss when entering the Boss RoomBoss Room. Defeating it drops an extra item. 2
(in Repentance) Worm Friend 5.100.682 Worm Friend Clingy buddy Gives Isaac a Nerve EndingNerve Ending familiar that burrows out of the ground to grab and deal damage to enemies over time. 3
Name ID Icon Quote Description
(in Afterbirth † and Repentance) Tonsil 5.350.97 Tonsil Sick... When hit, there is a small chance to spawn a permanent tonsil familiar that blocks enemy shots. This can happen twice, after which the trinket is destroyed.
Name ID Icon Message Description
(in Repentance) Soul of Lilith 5.300.92 Soul of Lilith Motherhood Adds one permanent familiar from the Baby Shop pool, except Collectible Stitches iconStitches. Can give familiars that Isaac already has. Unique familiars can be received only once.

Unlockable Achievements[ | ]


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