Familiar
Familiars are small companions, usually generated by passive items, that follow and assist Isaac. Effects of familiars include (but are not limited to) pickup generation, shooting familiars that fire their own tears at enemies, and orbitals that act as projectile shields and/or deal contact damage.
Contents
Temporary Familiars[edit | edit source]
Blue Flies[edit | edit source]
Blue Flies are familiars that will orbit around Isaac and rush towards nearby enemies, dealing damage and dying in the process. Blue Flies deal double Isaac's current tear damage. Isaac cannot have more than 64 Blue Flies/Spiders combined.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Guppy's Head | 5.100.145 | ![]() |
Reusable fly hive | Spawns 2-4 friendly Blue Flies that damage enemies. | 3 |
![]() |
5.100.434 | ![]() |
Gotta catch 'em all? | Killing an enemy adds a fly to the jar, up to a maximum of 20. On use, releases Blue Flies equal to the number of flies in the jar. | 2 |
![]() |
5.100.480 | ![]() |
Gain more friends! | Doubles Isaac's Blue Flies and Blue Spiders, or spawns one if Isaac has none. Converts pickups in the current room into Blue Flies or Blue Spiders. | 2 |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Infestation | 5.100.148 | ![]() |
Fly revenge | 1-3 Blue Flies randomly spawn every time Isaac gets hit. | 0 |
Rotten Baby | 5.100.268 | ![]() |
Infested friend | Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. | 3 |
The Mulligan | 5.100.151 | ![]() |
They grow inside | Tears have a 1/6 chance of spawning allied Blue Flies when they hit an enemy. | 3 |
![]() |
5.100.461 | ![]() |
Egg tears! | Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy. | 3 |
![]() |
5.100.681 | ![]() |
It hungers | A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room. | 1 |
![]() |
5.100.693 | ![]() |
Infest | Spawns nine orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. | 2 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Fish Head | 5.350.29 | ![]() |
It stinks | Spawns a Blue Fly every time Isaac takes damage. |
![]() |
5.350.86 | ![]() |
The poop is moving... | Spawns a Blue Fly from every pile of poop that Isaac destroys. |
![]() |
5.350.94 | ![]() |
It also stinks! | Items and trinkets that generate Blue Flies or Blue Spiders will generate twice as many. |
![]() |
5.350.126 | ![]() |
Wealth of flies | Spawns a Blue Fly every time a coin is picked up. |
Other sources of Blue Flies
- Red Chest: Has a chance to spawn 3 Blue Flies.
- Dark blue champion: Will create 3 Blue Flies when defeated.
- Guppy transformation: Isaac will create Blue Flies whenever his tears or his familiars' tears hit enemies.
- Beelzebub transformation: All enemy flies become Blue Flies.
Rune of Berkano: Spawns 3 Blue Flies and 3 Blue Spiders upon use.
Friends Till The End! pill: Spawns three Blue Flies.
As Keeper, all heart pickups turn into Blue Flies.
Black Rune: Turns pickups into Blue Flies and Blue Spiders.
Mom's Underwear: Spawns 3-6 Blue Flies on pickup.
Rotten Heart: After clearing a room, two Blue Flies spawn for each Rotten Heart in Isaac's life bar.
Locusts
[edit | edit source]
Locusts are variants of Blue Flies that are spawned by Locust trinkets and 7 Seals. They behave like regular Blue Flies but have additional special effects. Red Locusts explode on contact with an enemy, dealing an extra 60 damage in the radius. Green Locusts poison the enemy. Yellow Locusts slow the enemy. Black Locusts deal quadruple Isaac's damage instead of double. White Locusts are identical to Blue Flies, but are spawned in high quantities.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
7 Seals | 5.100.526 | ![]() |
Lil harbingers! | Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. | 2 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Locust of Conquest | 5.350.117 | ![]() |
I bring Conquest | Upon entering a room with enemies, spawns 2-5 White Locusts which damage enemies. |
Locust of Death | 5.350.116 | ![]() |
I bring Death | Upon entering a room with enemies, spawns a Black Locust that does a very high amount of damage. |
Locust of Famine | 5.350.115 | ![]() |
I bring Famine | Upon entering a room with enemies, spawns a Yellow Locust that damages and slows enemies. |
Locust of Pestilence | 5.350.114 | ![]() |
I bring Pestilence | Upon entering a room with enemies, spawns a Green Locust which damages and poisons enemies. |
Locust of War | 5.350.113 | ![]() |
I bring War | Upon entering a room with enemies, spawns a Red Locust which detonates upon impact with enemies. |
![]() |
5.350.185 | ![]() |
Infested | Adds a chance to spawn a random locust when killing an enemy. |
Blue Spiders[edit | edit source]
Blue Spiders are familiars similar to Blue Flies that crawl erratically and rush towards nearby enemies, dealing damage and dying in the process.
Blue Spiders deal 2.5 times Isaac's current tear damage.
Blue Spiders deal twice Isaac's current tear damage.
Unlike Blue Flies, Blue Spiders cannot attack over obstacles such as rocks and pits. Isaac cannot have more than 64 Blue Flies/Spiders combined.
![]() |
3DS Exiting the game and re-entering will cause all Blue Spiders to disappear. |
---|
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Box of Spiders | 5.100.288 | ![]() |
It's a box of spiders | ![]()
|
1 |
![]() |
5.100.480 | ![]() |
Gain more friends! | Doubles Isaac's Blue Flies and Blue Spiders, or spawns one if Isaac has none. Converts pickups in the current room into Blue Flies or Blue Spiders. | 2 |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Dark Bum | 5.100.278 | ![]() |
He wants to take your life | Spawns a familiar that follows Isaac around and collects Red Hearts for himself. For every 1½ Red Hearts collected, Dark Bum will give a Soul Heart, a hostile Spider, a friendly Blue Spider, ![]() |
4 |
Infestation 2 | 5.100.234 | ![]() |
Infestation shot | Spawns allied Blue Spiders from killed enemies. | 4 |
Juicy Sack | 5.100.266 | ![]() |
Sticky babies | Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. | 2 |
Mom's Wig | 5.100.217 | ![]() |
You feel itchy... | Adds a chance to spawn Blue Spiders when firing tears. Restores 1 red heart. | 3 |
Sissy Longlegs | 5.100.280 | ![]() |
She loves you | Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. | 1 |
Spiderbaby | 5.100.211 | ![]() |
Spider revenge | When hit, spawns up to 2 Blue Spiders. | 1 |
![]() |
5.100.403 | ![]() |
Mod buddy! | Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery/Blue spider upon clearing a room. | 1 |
![]() |
5.100.367 | ![]() |
Egg sack bombs! | +5 bombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy. | 1 |
![]() |
5.100.461 | ![]() |
Egg tears! | Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy. | 3 |
![]() |
5.100.717 | ![]() |
Under a rock | Rocks and props spawn spiders over time while in a room with enemies, and spawn two blue spiders when destroyed. | 2 |
![]() |
5.100.667 | ![]() |
A helping hand | Spawns Keeper to fight enemies alongside Isaac. If Keeper dies, he spawns blue spiders and Strawman is removed from Isaac's inventory. | 2 |
![]() |
5.100.575 | ![]() |
Invasive friend | A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. | 3 |
![]() |
5.100.645 | ![]() |
Itching for revenge | Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. | 1 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
![]() |
5.350.70 | ![]() |
Itchy, tasty... | Occasionally spawns a Blue Spider. |
![]() |
5.350.94 | ![]() |
It also stinks! | Items and trinkets that generate Blue Flies or Blue Spiders will generate twice as many. |
![]() |
5.350.140 | ![]() |
It feels empty | Picking up red hearts, even while at full health, can convert them into blue spiders. The effect may consume hearts needed for healing. |
Other sources of Blue Spiders
Rune of Berkano: Spawns 3 Blue Flies and 3 Blue Spiders upon use.
Infested? pill: Spawns Blue Spiders equal to the number of enemies in the room.
Infested! pill: Spawns a Blue Spider under Isaac and every pile of poop in the room.
Chasing Familiars[edit | edit source]
Familiars in this category actively chase enemies, dealing contact damage to them.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
The Pinking Shears | 5.100.107 | ![]() |
Cut and Run | Gives flight for the current room, while turning Isaac's body into a fast, high damage familiar. | 3 |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Ball of Bandages | 5.100.207 | ![]() |
Gotta lick 'em all! | Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies gives it the ability to shoot charm tears, then chase enemies, then increases the damage. | 2 |
Cube of Meat | 5.100.73 | ![]() |
Gotta meat 'em all! | Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies grants it the ability to shoot, then chase enemies, then increases the damage. | 2 |
Daddy Longlegs | 5.100.170 | ![]() |
Daddy's love | Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total. | 3 |
Dead Bird | 5.100.117 | ![]() |
Protective buddy | After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~5 damage per second. | 0 |
Gemini | 5.100.318 | ![]() |
Conjoined friend | Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~8 damage per second. | 1 |
Leech | 5.100.270 | ![]() |
Blood sucker | Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a Half Red Heart whenever Leech kills an enemy. | 1 |
Lil Haunt | 5.100.277 | ![]() |
Fear him | Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear. | 1 |
Smart Fly | 5.100.264 | ![]() |
Revenge fly | Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. | 3 |
![]() |
5.100.385 | ![]() |
Bumbo want coin! | Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. | 1 |
![]() |
5.100.526 | ![]() |
Lil harbingers! | Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. | 2 |
![]() |
5.100.610 | ![]() |
Fat buddy | The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to ![]() |
1 |
![]() |
5.100.565 | ![]() |
What a cute little thing! | Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac. Attacking it returns it to normal. | 2 |
![]() |
5.100.575 | ![]() |
Invasive friend | A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. | 3 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
Eve's Bird Foot | 5.350.60 | ![]() |
Revenge from beyond | 5% chance to spawn a ![]() |
Note: Only third and fourth stage Cube of Meat and
Ball of Bandages chase enemies.
Note: Only fourth stage
Bumbo chases enemies.
Note: Only War and Death in
7 Seals chase enemies.
Orbital Familiars[edit | edit source]
Familiars that orbit Isaac, absorbing enemy projectiles and dealing contact damage. Despite their different apparent sizes, most of them have the same effective size with regard of blocking shots or damaging enemies.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
![]() |
5.100.584 | ![]() |
Spiritual companionship | On use, spawns an orbital Wisp familiar that fires spectral tears but can be destroyed. Also becomes a passive item that causes other active items to spawn themed Wisps. | 3 |
![]() |
5.100.712 | ![]() |
Item summoner | Spawns the ghost of a random passive item, which orbits Isaac but can be destroyed. While the ghost is alive, Isaac gains that item's effects. | 3 |
![]() |
5.100.655 | ![]() |
Let it rip! | When used, gives Isaac +0.5 speed and greatly increases the rotation speed of Isaac's orbitals for 3 seconds. Gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage to enemies while held. | 1 |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Ball of Bandages | 5.100.207 | ![]() |
Gotta lick 'em all! | Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies gives it the ability to shoot charm tears, then chase enemies, then increases the damage. | 2 |
Best Bud | 5.100.274 | ![]() |
Sworn protector | When hit, spawns a quickly orbiting attack fly similar to ![]() |
0 |
Big Fan | 5.100.279 | ![]() |
Fat protector | Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies. | 2 |
Cube of Meat | 5.100.73 | ![]() |
Gotta meat 'em all! | Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies grants it the ability to shoot, then chase enemies, then increases the damage. | 2 |
Distant Admiration | 5.100.57 | ![]() |
Attack fly | Spawns an attack fly that circles further out than ![]() ![]() |
2 |
Forever Alone | 5.100.128 | ![]() |
Attack fly | Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second. | 1 |
Guardian Angel | 5.100.112 | ![]() |
Extra protection | Spawns an orbital familiar that blocks enemy shots, deals 105 damage per second to enemies, and increases the speed of all orbital familiars. | 2 |
Guillotine | 5.100.206 | ![]() |
An out-of-body experience | Isaac's head is removed from his body and floats around him as an orbital. Gives +1 damage and grants -1 tear delay. | 3 |
Halo of Flies | 5.100.10 | ![]() |
Projectile protection | Spawns two Pretty Flies that block enemy shots and deal contact damage to flies. | 3 |
Sacrificial Dagger | 5.100.172 | ![]() |
My fate protects me | Spawns a dagger orbital familiar, dealing 225 damage per second and blocking enemy shots. | 3 |
Smart Fly | 5.100.264 | ![]() |
Revenge fly | Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. | 3 |
![]() |
5.100.364 | ![]() |
Friendly fly | Spawns a white attack fly that orbits somewhere between ![]() ![]() |
1 |
![]() |
5.100.363 | ![]() |
Protective friend | Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room it drops an Eternal Heart. | 3 |
![]() |
5.100.528 | ![]() |
Eclipsed by the moon | Spawns an orbital familiar with a large orbital radius. Tears that pass through the prism split into four multi-colored tears. | 3 |
![]() |
5.100.509 | ![]() |
Bloody friend | Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds. | 1 |
![]() |
5.100.508 | ![]() |
It's sharp! | Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time. | 1 |
![]() |
5.100.542 | ![]() |
Projectile shield | Spawns a bone familiar that circles around Isaac and reflects enemy shots. | 2 |
![]() |
5.100.629 | ![]() |
Defense drone | Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. | 3 |
![]() |
5.100.581 | ![]() |
Flamboyant protector | Spawns a fly orbital familiar that chases and deflects enemy shots and converts them into homing tears. | 3 |
![]() |
5.100.693 | ![]() |
Infest | Spawns nine orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. | 2 |
![]() |
5.100.645 | ![]() |
Itching for revenge | Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. | 1 |
![]() |
5.100.702 | ![]() |
Hot blooded | After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots. | 2 |
Name | Description |
---|---|
Pretty Fly | Grants 1 fly orbital that circles the player, blocking projectiles and damaging fly-type enemies on touch. |
- Notes
- A maximum of three Pretty Flies can orbit around Isaac.
- It is possible to have more than three orbitals if one has access to co-op mode. If a co-op baby or multiple co-op babies temporarily hold all but two orbitals while Isaac picks up another, and then the co-op baby or co-op babies sign out or die, Isaac will receive their orbitals as well.
Cube of Meat,
Ball of Bandages, and
Sacrificial Dagger take up a Pretty Fly slot.
- For example, If Isaac has three Pretty Flies and picks up a Cube of Meat, the Cube of Meat will replace one of the flies.
- Only first and second stage
Cube of Meat and
Ball of Bandages are orbitals. Therefore, upgrading from level 2 to level 3 will free up a Pretty Fly slot.
- Duplicated orbitals, such as
Forever Alone being copied with the
Box of Friends or
Diplopia, will fly directly opposite the original (having three copies will cause them to fly 120 degrees apart, four will fly at 90 degrees and so on).
- Trivia
- Pretty Fly is a play on the phrase "pretty fly" as a descriptor.
Pickup Generation Familiars[edit | edit source]
Familiars that generate pickups when certain conditions are met.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Bomb Bag | 5.100.131 | ![]() |
Gives bombs | Spawns a familiar that drops a bomb every 3 rooms. | 2 |
Bum Friend | 5.100.144 | ![]() |
He's greedy | Spawns a familiar that picks up coins for himself, giving random pickups in return. Does not spawn collectibles. | 0 |
Dark Bum | 5.100.278 | ![]() |
He wants to take your life | Spawns a familiar that follows Isaac around and collects Red Hearts for himself. For every 1½ Red Hearts collected, Dark Bum will give a Soul Heart, a hostile Spider, a friendly Blue Spider, ![]() |
4 |
Little C.H.A.D. | 5.100.96 | ![]() |
Gives kisses | Spawns a familiar who drops a Half Red Heart every 3 rooms. | 2 |
Mystery Sack | 5.100.271 | ![]() |
? | Spawns a familiar that drops a Heart, coin, bomb, or key every 5-6 rooms. | 2 |
Sack of Pennies | 5.100.94 | ![]() |
Gives money | Spawns a familiar that drops a coin every 2 rooms. | 1 |
The Relic | 5.100.98 | ![]() |
Soul generator | Spawns a cross familiar that drops a Soul Heart every 5-6 rooms. | 4 |
![]() |
5.100.385 | ![]() |
Bumbo want coin! | Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. | 1 |
![]() |
5.100.372 | ![]() |
Bbbzzzzzt! | Spawns a familiar that occasionally drops a Lil' Battery, gives an activate item charge, or petrifies all enemies in the room. | 3 |
![]() |
5.100.388 | ![]() |
He wants your keys! | Spawns a familiar that follows Isaac and collects Keys for himself, giving random Chests in return. | 0 |
![]() |
5.100.362 | ![]() |
What's in the box? | Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room. | 2 |
![]() |
5.100.389 | ![]() |
Rune generator | Spawns a familiar that drops a random rune every 5-6 rooms. | 3 |
![]() |
5.100.491 | ![]() |
Pills pills pills! | Spawns a familiar that drops a random pill every 3 rooms. Upon using a pill, all enemies in the room are poisoned. | 2 |
![]() |
5.100.500 | ![]() |
Gives sacks | Spawns a familiar that drops a sack every 5-6 rooms cleared. | 3 |
Shooting Familiars[edit | edit source]
Familiars that attack with their own tears or other effects as long as Isaac is attacking or charging a shot.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Scissors | 5.100.325 | ![]() |
Lose your head | ![]()
|
0 |
![]() |
5.100.713 | ![]() |
Return | Holding down the fire button converts hearts into familiars that fire tears but can be destroyed. Activating converts the familiars back into hearts. | 3 |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Abel | 5.100.188 | ![]() |
Mirrored buddy | Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction. | 0 |
Ball of Bandages | 5.100.207 | ![]() |
Gotta lick 'em all! | Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies gives it the ability to shoot charm tears, then chase enemies, then increases the damage. | 2 |
Brother Bobby | 5.100.8 | ![]() |
Friends 'till the end | A familiar that follows Isaac around shooting normal tears. | 0 |
Cain's Other Eye | 5.100.319 | ![]() |
Near-sighted friend | Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac. | 0 |
Cube of Meat | 5.100.73 | ![]() |
Gotta meat 'em all! | Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies grants it the ability to shoot, then chase enemies, then increases the damage. | 2 |
Demon Baby | 5.100.113 | ![]() |
Auto-turret friend | Spawns a familiar that follows Isaac and automatically fires at enemies in its reach. | 2 |
Ghost Baby | 5.100.163 | ![]() |
Spectral buddy | Spawns a familiar that follows Isaac around and fires spectral tears. | 1 |
Harlequin Baby | 5.100.167 | ![]() |
Double shot buddy | Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern. | 1 |
Lil Brimstone | 5.100.275 | ![]() |
Evil Friend | Grants a familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting. | 3 |
Little Gish | 5.100.99 | ![]() |
Sticky friend | Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed. | 2 |
Little Steven | 5.100.100 | ![]() |
Psychic friend | Spawns a familiar who follows Isaac around and fires homing tears. | 1 |
Mongo Baby | 5.100.322 | ![]() |
Mongo Friend | Spawns a familiar that copies the tears of Isaac's other familiars. | 2 |
Rainbow Baby | 5.100.174 | ![]() |
Random buddy | Spawns a familiar that follows Isaac around and fires tears with random effects. | 1 |
Robo-Baby | 5.100.95 | ![]() |
Friends 'till the bbbbzzzt | Spawns a familiar that shoots ![]() |
1 |
Robo-Baby 2.0 | 5.100.267 | ![]() |
We worked out all the kinks | Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears. | 0 |
Rotten Baby | 5.100.268 | ![]() |
Infested friend | Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. | 3 |
Sister Maggy | 5.100.67 | ![]() |
Friends 'till the end | Spawns a familiar that follows Isaac around shooting normal tears. | 0 |
![]() |
5.100.361 | ![]() |
Your fate beside you | A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage. | 2 |
![]() |
5.100.360 | ![]() |
Dark friend | Spawns a demonic familiar that shoots tears identical to Isaac's in terms of damage, tears, and tear effects. | 4 |
![]() |
5.100.435 | ![]() |
4-way buddy! | Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern. | 1 |
![]() |
5.100.390 | ![]() |
Sworn friend | Spawns an angel familiar which follows Isaac and fires homing tears which deal 10 damage and have 75% shot speed. | 3 |
![]() |
5.100.518 | ![]() |
What could it be?! | Spawns a familiar with a random tear effect. The familiar is randomized at the start of each floor. | 2 |
![]() |
5.100.471 | ![]() |
Ain't he cute? | Spawns a familiar that fires clusters of tears. Must be charged before shooting. | 2 |
![]() |
5.100.537 | ![]() |
Puking buddy | Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type. | 1 |
![]() |
5.100.607 | ![]() |
Messy friend | Gives Isaac a familiar that fires chaotic bursts of tears in all directions. | 1 |
![]() |
5.100.608 | ![]() |
Iced iced baby | Spawns a shooting familiar that has a chance to petrify enemies, and Freezes monsters upon killing them. | 2 |
![]() |
5.100.679 | ![]() |
Abyssal friend | Spawns a familiar that charges a miniature ![]() ![]() |
3 |
![]() |
5.100.698 | ![]() |
Double trouble! | Gives Isaac two familiars that stand by Isaac's side and fire tears that use Isaac's tears, range, shot speed, and tear effects and scale with Isaac's damage. | 4 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
???'s Soul | 5.350.57 | ![]() |
Imaginary Friend | Spawns a familiar that floats slowly around the room on a pattern similar to The Peeper and fires spectral and homing tears. |
Isaac's Head | 5.350.54 | ![]() |
Dead friend | Spawns Isaac's severed head as a tear-firing familiar. Fires piercing tears. |
Umbilical Cord | 5.350.33 | ![]() |
Fetal Protection | When brought down to only a Half Red Heart, spawns a ![]() ![]() ![]() |
Note: Only second stage Cube of Meat and
Ball of Bandages shoot tears.
Note: Demon Baby and
Robo-Baby 2.0 shoot even when Isaac is not attacking.
Note: Shooting familiars that follow Isaac take priority over other familiars, always appearing before non-combat familiars in line.
Incubus and
Lil Brimstone have extra priority and will appear at the front, with Incubus taking priority over Lil Brimstone.
Wandering Familiars[edit | edit source]
Familiars that move around the room sporadically.
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
Punching Bag | 5.100.281 | ![]() |
Scape Goat | Spawns a Mulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer. | 1 |
Sissy Longlegs | 5.100.280 | ![]() |
She loves you | Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. | 1 |
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5.100.403 | ![]() |
Mod buddy! | Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery/Blue spider upon clearing a room. | 1 |
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5.100.526 | ![]() |
Lil harbingers! | Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. | 2 |
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5.100.492 | ![]() |
Yo listen! | +1 luck. Spawns a fairy familiar that points out Secret Rooms, Crawl Space entrances, and tinted rocks. | 2 |
Bouncing Familiars[edit | edit source]
Familiars that bounce around the room in a zig-zag pattern, changing directions when hitting a wall.
Name | ID | Icon | Quote | Description | ![]() |
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BBF | 5.100.272 | ![]() |
Big Beautiful Fly | Spawns a familiar that flies around the room in a zig-zag pattern and explodes on contact with an enemy. Respawns after ten seconds. | 1 |
Cain's Other Eye | 5.100.319 | ![]() |
Near-sighted friend | Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac. | 0 |
The Peeper | 5.100.155 | ![]() |
Plop! | Spawns a familiar that floats slowly around the room on a zig-zag pattern, damaging enemies it passes through. | 0 |
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5.100.405 | ![]() |
Double tap glitch | ![]() ![]() |
0 |
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5.100.417 | ![]() |
Damage booster | Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier. | 3 |
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5.100.470 | ![]() |
Lil hush! | Spawns a Hush familiar that bounces diagonally around the room and deals contact damage. While firing tears, it stops moving. | 0 |
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5.100.649 | ![]() |
Bouncy friend | Gives Isaac a miniature Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels. | 1 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
???'s Soul | 5.350.57 | ![]() |
Imaginary Friend | Spawns a familiar that floats slowly around the room on a pattern similar to The Peeper and fires spectral and homing tears. |
Mimicking Familiars
[edit | edit source]
Familiars that copy Isaac's movements after a certain delay.
Name | ID | Icon | Quote | Description | ![]() |
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Multidimensional Baby | 5.100.431 | ![]() |
ydduB Buddy | Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed. | 1 |
Obsessed Fan | 5.100.426 | ![]() |
Follows my every move... | Spawns a familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies. | 0 |
Papa Fly | 5.100.430 | ![]() |
Turret follower | Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies. | 1 |
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5.100.468 | ![]() |
It follows | Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers. | 0 |
Others[edit | edit source]
Familiars that don't fit into any of the above categories or that produce multiple effects.
Name | ID | Icon | Quote | Description | ![]() |
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5.100.504 | ![]() |
Friendly fly | Spawns a stationary fly turret that fires tears at nearby enemies. | 0 |
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5.100.516 | ![]() |
Sprinkles. | Upon use, spawns a sprinkler that rotates and fires tears. | 2 |
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5.100.635 | ![]() |
Bait and switch | Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar. | 1 |
Name | ID | Icon | Quote | Description | ![]() |
---|---|---|---|---|---|
???'s Only Friend | 5.100.320 | ![]() |
Controlled friend | Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys | 2 |
1up! | 5.100.11 | ![]() |
Extra life | Gives Isaac an extra life. Upon death, he will respawn in the previous room with full health and lose the 1up!. | 2 |
Bob's Brain | 5.100.273 | ![]() |
Explosive thoughts | Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. | 1 |
Dead Cat | 5.100.81 | ![]() |
9 lives | Sets Isaac's Red Heart containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container. | 3 |
Dry Baby | 5.100.265 | ![]() |
Immortal Friend | Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering ![]() |
3 |
Guppy's Hair Ball | 5.100.187 | ![]() |
Swing it | Spawns a familiar that loosely follows behind Isaac, which blocks shots can be swung like a flail to damage enemies. Grows bigger by killing enemies. | 1 |
Headless Baby | 5.100.269 | ![]() |
Bloody Friend | Spawns a familiar that follows Isaac, leaving blood creep on the ground. | 1 |
Holy Water | 5.100.178 | ![]() |
Splash! | ![]() ![]() |
0 |
Isaac's Heart | 5.100.276 | ![]() |
Protect It | Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt. | 0 |
Juicy Sack | 5.100.266 | ![]() |
Sticky babies | Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. | 2 |
Key Piece 1 | 5.100.238 | ![]() |
??? | Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan. | 0 |
Key Piece 2 | 5.100.239 | ![]() |
??? | Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan. | 0 |
Little Chubby | 5.100.88 | ![]() |
Attack Buddy | Spawns a charger familiar that charges forward and deals contact damage to any enemies in its path. | 1 |
Samson's Chains | 5.100.321 | ![]() |
The ol' ball and chain | Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most obstacles. | 1 |
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5.100.387 | ![]() |
Peace be with you | Spawns a familiar which creates a circular aura that slows down enemies and enemy shots inside. | 3 |
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5.100.404 | ![]() |
He farts! | Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which Charms, Poisons, or knocks back nearby enemies. | 1 |
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5.100.384 | ![]() |
A gurd of your own! | A Gurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed. | 1 |
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5.100.365 | ![]() |
Lost protector | Spawns fly familiar that moves in a straight line and circles around the first wall or obstacle it hits, dealing 105 damage per second on contact. | 0 |
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5.100.436 | ![]() |
Don't cry over it... | Spawns a glass familiar that spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the current room. | 1 |
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5.100.511 | ![]() |
He's violent | Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with. | 1 |
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5.100.473 | ![]() |
Chub chub | Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact. | 1 |
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5.100.469 | ![]() |
:( | Spawns a familiar that leaves a trail of creep that damages enemies at 6 damage per second. Has a chance to spawn damaging beams of light onto enemies that touch the cloud. | 1 |
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5.100.467 | ![]() |
Watch where you point that! | Spawns a finger familiar that points at enemies, dealing scaling damage. | 1 |
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5.100.543 | ![]() |
Portable sanctuary | Spawns a white poop familiar, which turns into a white poop when Isaac is hurt. White poop has an aura that halves tear delay and can block enemy shots. | 1 |
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5.100.548 | ![]() |
Fetch! | Spawns a familiar that flies through the room while firing, dealing a flat 7 contact damage to enemies retrieving pickups. | 1 |
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5.100.472 | ![]() |
Hail to the king, baby! | Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, other familiars stop moving. | 0 |
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5.100.519 | ![]() |
Delirious friend | Grants a familiar that transforms into another random familiar every 10 seconds. | 2 |
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5.100.539 | ![]() |
Sacrificial insemination | Spawns an egg familiar, which cracks into a random friendly monster when Isaac is hurt. The egg regenerates upon entering a different room. | 1 |
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5.100.544 | ![]() |
Stabbing time | Spawns a bone familiar that hovers back and forth in front of Isaac, dealing damage equal to Isaac's damage. | 2 |
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5.100.569 | ![]() |
Bleed me dry | Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained. | 2 |
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5.100.678 | ![]() |
Fetus shots | 4 | |
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5.100.652 | ![]() |
Kick it! | Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. | 1 |
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5.100.626 | ![]() |
??? | Combined with ![]() ![]() ![]() |
0 |
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5.100.627 | ![]() |
??? | Combined with ![]() ![]() ![]() |
0 |
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5.100.615 | ![]() |
Puffy buddy | Gives Isaac a Dumpy familiar that, when it takes damage, pushes/stuns/poisons nearby enemies and flies in a random direction. | 0 |
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5.100.681 | ![]() |
It hungers | A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room. | 1 |
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5.100.612 | ![]() |
Protect him | Gives Isaac a soul familiar that dies in one hit, respawning at the start of the next floor. If it survives an entire floor, it rewards Isaac with hearts or items. | 2 |
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5.100.651 | ![]() |
Follow the light | Spawns a star familiar that slowly travels towards the Boss Room, giving an aura that increases damage and tears and grants homing. | 2 |
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5.100.697 | ![]() |
He wants revenge | Spawns a familiar that becomes a clone of the floor's boss when entering the boss room. Defeating it drops an extra item. | 3 |
Name | ID | Icon | Quote | Description |
---|---|---|---|---|
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5.350.97 | ![]() |
Sick... | When hit, there is a small chance a removed tonsil familiar starts following Isaac, blocking enemy shots. |
Unlockable Achievements[edit | edit source]
Buddy in a Box - Pick up 5 familiars in a single run.
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