Familiar

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Familiars are small companions, usually generated by passive items, that follow and assist Isaac. Effects of familiars include (but are not limited to) pickup generation, shooting familiars that fire their own tears at enemies, and orbitals that act as projectile shields and/or deal contact damage.

Temporary Familiars[edit | edit source]

Blue Flies[edit | edit source]

Blue Fly.png

Blue Flies are familiars that will orbit around Isaac and rush towards nearby enemies, dealing damage and dying in the process. Blue Flies deal double Isaac's current tear damage. Isaac cannot have more than 64 Blue Flies/Spiders combined.

Name ID Icon Quote Description Added in Repentance Quality
Guppy's Head 5.100.145
Guppy's Head
1 rooms
Reusable fly hive Spawns 2-4 friendly Blue Flies that damage enemies. 3
Added in Afterbirth Jar of Flies 5.100.434
Jar of Flies
Unlimited
Gotta catch 'em all? Killing an enemy adds a fly to the jar, up to a maximum of 20. On use, releases Blue Flies equal to the number of flies in the jar. 2
Added in Afterbirth † Compost 5.100.480
Compost
2 rooms
Gain more friends! Doubles Isaac's Blue Flies and Blue Spiders, or spawns one if Isaac has none. Converts pickups in the current room into Blue Flies or Blue Spiders. 2
Name ID Icon Quote Description Added in Repentance Quality
Infestation 5.100.148 Infestation Fly revenge 1-3 Blue Flies randomly spawn every time Isaac gets hit. 0
Rotten Baby 5.100.268 Rotten Baby Infested friend Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. 3
The Mulligan 5.100.151 The Mulligan They grow inside Tears have a 1/6 chance of spawning allied Blue Flies when they hit an enemy. 3
Added in Afterbirth † Parasitoid 5.100.461 Parasitoid Egg tears! Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy. 3
Added in Repentance Lil Portal 5.100.681 Lil Portal It hungers A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room. 1
Added in Repentance The Swarm 5.100.693 The Swarm Infest Spawns nine orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. 2
Name ID Icon Quote Description
Fish Head 5.350.29 Fish Head It stinks Spawns a Blue Fly every time Isaac takes damage.
Added in Afterbirth Lil Larva 5.350.86 Lil Larva The poop is moving... Spawns a Blue Fly from every pile of poop that Isaac destroys.
Added in Afterbirth † Fish Tail 5.350.94 Fish Tail It also stinks! Items and trinkets that generate Blue Flies or Blue Spiders will generate twice as many.
Added in Afterbirth † Rotten Penny 5.350.126 Rotten Penny Wealth of flies Spawns a Blue Fly every time a coin is picked up.

Other sources of Blue Flies

  • Red Chest: Has a chance to spawn 3 Blue Flies.
  • Dark blue champion: Will create 3 Blue Flies when defeated.
  • Guppy transformation: Isaac will create Blue Flies whenever his tears or his familiars' tears hit enemies.
  • Beelzebub transformation: All enemy flies become Blue Flies.
  • Rune of Berkano Rune of Berkano: Spawns 3 Blue Flies and 3 Blue Spiders upon use.
  • Added in Afterbirth Friends Till The End! pill: Spawns three Blue Flies.
  • Added in Afterbirth As Keeper, all heart pickups turn into Blue Flies.
  • Added in Afterbirth †Black Rune Black Rune: Turns pickups into Blue Flies and Blue Spiders.
  • Added in Repentance 15►Mom's Underwear Mom's Underwear: Spawns 3-6 Blue Flies on pickup.
  • Added in Repentance Rotten Heart: After clearing a room, two Blue Flies spawn for each Rotten Heart in Isaac's life bar.

Locusts Added in Afterbirth †[edit | edit source]

Red Fly.png Green Fly.png Yellow Fly.png Black Fly (Familiar).png White Fly.png

Locusts are variants of Blue Flies that are spawned by Locust trinkets and 15►7 Seals 7 Seals. They behave like regular Blue Flies but have additional special effects. Red Locusts explode on contact with an enemy, dealing an extra 60 damage in the radius. Green Locusts poison the enemy. Yellow Locusts slow the enemy. Black Locusts deal quadruple Isaac's damage instead of double. White Locusts are identical to Blue Flies, but are spawned in high quantities.

Name ID Icon Quote Description Added in Repentance Quality
7 Seals 5.100.526 7 Seals Lil harbingers! Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. 2
Name ID Icon Quote Description
Locust of Conquest 5.350.117 Locust of Conquest I bring Conquest Upon entering a room with enemies, spawns 2-5 White Locusts which damage enemies.
Locust of Death 5.350.116 Locust of Death I bring Death Upon entering a room with enemies, spawns a Black Locust that does a very high amount of damage.
Locust of Famine 5.350.115 Locust of Famine I bring Famine Upon entering a room with enemies, spawns a Yellow Locust that damages and slows enemies.
Locust of Pestilence 5.350.114 Locust of Pestilence I bring Pestilence Upon entering a room with enemies, spawns a Green Locust which damages and poisons enemies.
Locust of War 5.350.113 Locust of War I bring War Upon entering a room with enemies, spawns a Red Locust which detonates upon impact with enemies.
Added in Repentance Cricket Leg 5.350.185 Cricket Leg Infested Adds a chance to spawn a random locust when killing an enemy.

Blue Spiders[edit | edit source]

Blue Spider.png

Blue Spiders are familiars similar to Blue Flies that crawl erratically and rush towards nearby enemies, dealing damage and dying in the process.

Removed in Repentance Blue Spiders deal 2.5 times Isaac's current tear damage.

  • Added in Repentance Blue Spiders deal twice Isaac's current tear damage.

Unlike Blue Flies, Blue Spiders cannot attack over obstacles such as rocks and pits. Isaac cannot have more than 64 Blue Flies/Spiders combined.

Bug Bug! 3DS Exiting the game and re-entering will cause all Blue Spiders to disappear.
Name ID Icon Quote Description Added in Repentance Quality
Box of Spiders 5.100.288
Box of Spiders
2 rooms
It's a box of spiders Removed in Repentance Spawns 1-4 Blue Spiders that deal 2.5x damage to enemies.

Added in Repentance Spawns 4-8 Blue Spiders that deal 2x damage to enemies.

1
Added in Afterbirth † Compost 5.100.480
Compost
2 rooms
Gain more friends! Doubles Isaac's Blue Flies and Blue Spiders, or spawns one if Isaac has none. Converts pickups in the current room into Blue Flies or Blue Spiders. 2
Name ID Icon Quote Description Added in Repentance Quality
Dark Bum 5.100.278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects Red Hearts for himself. For every 1½ Red Hearts collected, Dark Bum will give a Soul Heart, a hostile Spider, a friendly Blue Spider, Added in Repentance or a random card, rune or pill. 4
Infestation 2 5.100.234 Infestation 2 Infestation shot Spawns allied Blue Spiders from killed enemies. 4
Juicy Sack 5.100.266 Juicy Sack Sticky babies Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. 2
Mom's Wig 5.100.217 Mom's Wig You feel itchy... Adds a chance to spawn Blue Spiders when firing tears. Restores 1 red heart. 3
Sissy Longlegs 5.100.280 Sissy Longlegs She loves you Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. 1
Spiderbaby 5.100.211 Spiderbaby Spider revenge When hit, spawns up to 2 Blue Spiders. 1
Added in Afterbirth Spider Mod 5.100.403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery/Blue spider upon clearing a room. 1
Added in Afterbirth Sticky Bombs 5.100.367 Sticky Bombs Egg sack bombs! +5 bombs. Bombs stick to enemies and spawn 2-4 Blue Spiders if they kill an enemy. 1
Added in Afterbirth † Parasitoid 5.100.461 Parasitoid Egg tears! Adds a chance to fire an egg sack which creates slowing creep and spawns a Blue Fly or Blue Spider upon hitting an enemy. 3
Added in Repentance Keeper's Kin 5.100.717 Keeper's Kin Under a rock Rocks and props spawn spiders over time while in a room with enemies, and spawn two blue spiders when destroyed. 2
Added in Repentance Strawman 5.100.667 Strawman A helping hand Spawns Keeper to fight enemies alongside Isaac. If Keeper dies, he spawns blue spiders and Strawman is removed from Isaac's inventory. 2
Added in Repentance The Intruder 5.100.575 The Intruder Invasive friend A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. 3
Added in Repentance Tinytoma 5.100.645 Tinytoma Itching for revenge Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. 1
Name ID Icon Quote Description
Added in Afterbirth Louse 5.350.70 Louse Itchy, tasty... Occasionally spawns a Blue Spider.
Added in Afterbirth † Fish Tail 5.350.94 Fish Tail It also stinks! Items and trinkets that generate Blue Flies or Blue Spiders will generate twice as many.
Added in Repentance Apple of Sodom 5.350.140 Apple of Sodom It feels empty Picking up red hearts, even while at full health, can convert them into blue spiders. The effect may consume hearts needed for healing.

Other sources of Blue Spiders

  • Rune of Berkano Rune of Berkano: Spawns 3 Blue Flies and 3 Blue Spiders upon use.
  • Added in Afterbirth Infested? pill: Spawns Blue Spiders equal to the number of enemies in the room.
  • Added in Afterbirth Infested! pill: Spawns a Blue Spider under Isaac and every pile of poop in the room.

Chasing Familiars[edit | edit source]

Familiars in this category actively chase enemies, dealing contact damage to them.

Name ID Icon Quote Description Added in Repentance Quality
The Pinking Shears 5.100.107
The Pinking Shears
4 rooms
Cut and Run Gives flight for the current room, while turning Isaac's body into a fast, high damage familiar. 3
Name ID Icon Quote Description Added in Repentance Quality
Ball of Bandages 5.100.207 Ball of Bandages Gotta lick 'em all! Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies gives it the ability to shoot charm tears, then chase enemies, then increases the damage. 2
Cube of Meat 5.100.73 Cube of Meat Gotta meat 'em all! Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies grants it the ability to shoot, then chase enemies, then increases the damage. 2
Daddy Longlegs 5.100.170 Daddy Longlegs Daddy's love Daddy Long Legs' shadow follows Isaac and occasionally stomps enemies for 40 damage total. 3
Dead Bird 5.100.117 Dead Bird Protective buddy After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~5 damage per second. 0
Gemini 5.100.318 Gemini Conjoined friend Spawns a conjoined familiar which chases enemies close to Isaac, dealing ~8 damage per second. 1
Leech 5.100.270 Leech Blood sucker Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a Half Red Heart whenever Leech kills an enemy. 1
Lil Haunt 5.100.277 Lil Haunt Fear him Spawns a familiar that chases down enemies, dealing 4 damage per second and inflicting fear. 1
Smart Fly 5.100.264 Smart Fly Revenge fly Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. 3
Added in Afterbirth Bumbo 5.100.385 Bumbo Bumbo want coin! Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. 1
Added in Afterbirth † 7 Seals 5.100.526 7 Seals Lil harbingers! Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. 2
Added in Repentance Bird Cage 5.100.610 Bird Cage Fat buddy The first time Isaac takes damage in a room, a familiar leaps on an enemy, dealing damage and releasing a rock wave. For the rest of the room, it chases enemies similar to 15►Dead Bird Dead Bird. 1
Added in Repentance Blood Puppy 5.100.565 Blood Puppy What a cute little thing! Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac. Attacking it returns it to normal. 2
Added in Repentance The Intruder 5.100.575 The Intruder Invasive friend A familiar burrows in Isaac's head, firing 4 slowing tears. Upon taking damage, there's a chance it will burst out of Isaac's head, spawning blue spiders and chasing enemies for the current room. 3
Name ID Icon Quote Description
Eve's Bird Foot 5.350.60 Eve's Bird Foot Revenge from beyond 5% chance to spawn a 15►Dead Bird Dead Bird familiar for the current room each time an enemy dies.

Note: Only third and fourth stage 15►Cube of Meat Cube of Meat and 15►Ball of Bandages Ball of Bandages chase enemies.

Note: Added in Afterbirth Only fourth stage 15►Bumbo Bumbo chases enemies.

Note: Added in Afterbirth † Only War and Death in 15►7 Seals 7 Seals chase enemies.

Orbital Familiars[edit | edit source]

Familiars that orbit Isaac, absorbing enemy projectiles and dealing contact damage. Despite their different apparent sizes, most of them have the same effective size with regard of blocking shots or damaging enemies.

Name ID Icon Quote Description Added in Repentance Quality
Added in Repentance Book of Virtues 5.100.584
Book of Virtues
4 rooms
Spiritual companionship On use, spawns an orbital Wisp familiar that fires spectral tears but can be destroyed. Also becomes a passive item that causes other active items to spawn themed Wisps. 3
Added in Repentance Lemegeton 5.100.712
Lemegeton
6 rooms
Item summoner Spawns the ghost of a random passive item, which orbits Isaac but can be destroyed. While the ghost is alive, Isaac gains that item's effects. 3
Added in Repentance Spin to Win 5.100.655
Spin to Win
3 seconds
Let it rip! When used, gives Isaac +0.5 speed and greatly increases the rotation speed of Isaac's orbitals for 3 seconds. Gives Isaac a spinning top orbital that blocks enemy shots and deals contact damage to enemies while held. 1
Name ID Icon Quote Description Added in Repentance Quality
Ball of Bandages 5.100.207 Ball of Bandages Gotta lick 'em all! Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies gives it the ability to shoot charm tears, then chase enemies, then increases the damage. 2
Best Bud 5.100.274 Best Bud Sworn protector When hit, spawns a quickly orbiting attack fly similar to 15►Forever Alone Forever Alone for the current room dealing 75 damage per second. 0
Big Fan 5.100.279 Big Fan Fat protector Spawns a large orbital familiar that blocks enemy shots and deals 30 damage per second to enemies. 2
Cube of Meat 5.100.73 Cube of Meat Gotta meat 'em all! Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies grants it the ability to shoot, then chase enemies, then increases the damage. 2
Distant Admiration 5.100.57 Distant Admiration Attack fly Spawns an attack fly that circles further out than 15►Halo of Flies Halo of Flies, but closer than 15►Forever Alone Forever Alone, dealing 75 damage per second. 2
Forever Alone 5.100.128 Forever Alone Attack fly Spawns an attack fly that orbits a long distance from Isaac, dealing 30 damage per second. 1
Guardian Angel 5.100.112 Guardian Angel Extra protection Spawns an orbital familiar that blocks enemy shots, deals 105 damage per second to enemies, and increases the speed of all orbital familiars. 2
Guillotine 5.100.206 Guillotine An out-of-body experience Isaac's head is removed from his body and floats around him as an orbital. Gives +1 damage and grants -1 tear delay. 3
Halo of Flies 5.100.10 Halo of Flies Projectile protection Spawns two Pretty Flies that block enemy shots and deal contact damage to flies. 3
Sacrificial Dagger 5.100.172 Sacrificial Dagger My fate protects me Spawns a dagger orbital familiar, dealing 225 damage per second and blocking enemy shots. 3
Smart Fly 5.100.264 Smart Fly Revenge fly Spawns an orbital familiar that blocks enemy shots. Upon taking damage, the familiar will pursue enemies for the rest of the room, dealing 22.5 damage per second. 3
Added in Afterbirth Friend Zone 5.100.364 Friend Zone Friendly fly Spawns a white attack fly that orbits somewhere between 15►Distant Admiration Distant Admiration and 15►Forever Alone Forever Alone, dealing 45 damage per second. 1
Added in Afterbirth Sworn Protector 5.100.363 Sworn Protector Protective friend Spawns an orbital familiar which does 105 damage per second and attracts and blocks enemy shots. Upon blocking 10 shots in a room it drops an Eternal Heart. 3
Added in Afterbirth † Angelic Prism 5.100.528 Angelic Prism Eclipsed by the moon Spawns an orbital familiar with a large orbital radius. Tears that pass through the prism split into four multi-colored tears. 3
Added in Afterbirth † Bloodshot Eye 5.100.509 Bloodshot Eye Bloody friend Spawns an orbital familiar that deals 30 damage per second and fires a randomly angled tear every 2 seconds. 1
Added in Afterbirth † Mom's Razor 5.100.508 Mom's Razor It's sharp! Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time. 1
Added in Afterbirth † Slipped Rib 5.100.542 Slipped Rib Projectile shield Spawns a bone familiar that circles around Isaac and reflects enemy shots. 2
Added in Repentance Bot Fly 5.100.629 Bot Fly Defense drone Spawns an orbiting fly familiar that fires shielded tears at incoming enemy projectiles. 3
Added in Repentance Psy Fly 5.100.581 Psy Fly Flamboyant protector Spawns a fly orbital familiar that chases and deflects enemy shots and converts them into homing tears. 3
Added in Repentance The Swarm 5.100.693 The Swarm Infest Spawns nine orbital flies, which turn into Blue Flies after they block a shot. Each time a room is cleared, spawns another orbital fly. 2
Added in Repentance Tinytoma 5.100.645 Tinytoma Itching for revenge Gives Isaac a Teratoma orbital that blocks shots, deals contact damage, and splits into smaller versions of itself upon taking damage. The smaller versions break into blue spiders. 1
Added in Repentance Vengeful Spirit 5.100.702 Vengeful Spirit Hot blooded After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots. 2
Pills / Slot Machine

Name Description
Pretty Fly Grants 1 fly orbital that circles the player, blocking projectiles and damaging fly-type enemies on touch.
Notes
  • A maximum of three Pretty Flies can orbit around Isaac.
    • It is possible to have more than three orbitals if one has access to co-op mode. If a co-op baby or multiple co-op babies temporarily hold all but two orbitals while Isaac picks up another, and then the co-op baby or co-op babies sign out or die, Isaac will receive their orbitals as well.
  • 15►Cube of Meat Cube of Meat, 15►Ball of Bandages Ball of Bandages, and 15►Sacrificial Dagger Sacrificial Dagger take up a Pretty Fly slot.
    • For example, If Isaac has three Pretty Flies and picks up a Cube of Meat, the Cube of Meat will replace one of the flies.
    • Only first and second stage 15►Cube of Meat Cube of Meat and 15►Ball of Bandages Ball of Bandages are orbitals. Therefore, upgrading from level 2 to level 3 will free up a Pretty Fly slot.
  • Duplicated orbitals, such as 15►Forever Alone Forever Alone being copied with the Added in Afterbirth15►Box of Friends Box of Friends or Added in Afterbirth15►Diplopia Diplopia, will fly directly opposite the original (having three copies will cause them to fly 120 degrees apart, four will fly at 90 degrees and so on).
Trivia
  • Pretty Fly is a play on the phrase "pretty fly" as a descriptor.

Pickup Generation Familiars[edit | edit source]

Familiars that generate pickups when certain conditions are met.

Name ID Icon Quote Description Added in Repentance Quality
Bomb Bag 5.100.131 Bomb Bag Gives bombs Spawns a familiar that drops a bomb every 3 rooms. 2
Bum Friend 5.100.144 Bum Friend He's greedy Spawns a familiar that picks up coins for himself, giving random pickups in return. Does not spawn collectibles. 0
Dark Bum 5.100.278 Dark Bum He wants to take your life Spawns a familiar that follows Isaac around and collects Red Hearts for himself. For every 1½ Red Hearts collected, Dark Bum will give a Soul Heart, a hostile Spider, a friendly Blue Spider, Added in Repentance or a random card, rune or pill. 4
Little C.H.A.D. 5.100.96 Little C.H.A.D. Gives kisses Spawns a familiar who drops a Half Red Heart every 3 rooms. 2
Mystery Sack 5.100.271 Mystery Sack ? Spawns a familiar that drops a Heart, coin, bomb, or key every 5-6 rooms. 2
Sack of Pennies 5.100.94 Sack of Pennies Gives money Spawns a familiar that drops a coin every 2 rooms. 1
The Relic 5.100.98 The Relic Soul generator Spawns a cross familiar that drops a Soul Heart every 5-6 rooms. 4
Added in Afterbirth Bumbo 5.100.385 Bumbo Bumbo want coin! Spawns a beggar familiar which picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo follows enemies and gains contact damage. 1
Added in Afterbirth Charged Baby 5.100.372 Charged Baby Bbbzzzzzt! Spawns a familiar that occasionally drops a Lil' Battery, gives an activate item charge, or petrifies all enemies in the room. 3
Added in Afterbirth Key Bum 5.100.388 Key Bum He wants your keys! Spawns a familiar that follows Isaac and collects Keys for himself, giving random Chests in return. 0
Added in Afterbirth Lil Chest 5.100.362 Lil Chest What's in the box? Spawns a chest familiar that spawns a random pickup (25% chance) or trinket (10% chance) upon clearing a room. 2
Added in Afterbirth Rune Bag 5.100.389 Rune Bag Rune generator Spawns a familiar that drops a random rune every 5-6 rooms. 3
Added in Afterbirth † Acid Baby 5.100.491 Acid Baby Pills pills pills! Spawns a familiar that drops a random pill every 3 rooms. Upon using a pill, all enemies in the room are poisoned. 2
Added in Afterbirth † Sack of Sacks 5.100.500 Sack of Sacks Gives sacks Spawns a familiar that drops a sack every 5-6 rooms cleared. 3

Shooting Familiars[edit | edit source]

Familiars that attack with their own tears or other effects as long as Isaac is attacking or charging a shot.

Name ID Icon Quote Description Added in Repentance Quality
Scissors 5.100.325
Scissors
4 rooms
Lose your head Removed in Repentance Turns Isaac's head into a stationary familiar for the current room which fires tears automatically.

Added in Repentance Turns Isaac's head into a stationary familiar for the current room which fires tears automatically, while causing Isaac to shoot a controllable fountain of blood shots.

0
Added in Repentance Sumptorium 5.100.713
Sumptorium
1 seconds
Return Holding down the fire button converts hearts into familiars that fire tears but can be destroyed. Activating converts the familiars back into hearts. 3
Name ID Icon Quote Description Added in Repentance Quality
Abel 5.100.188 Abel Mirrored buddy Spawns a familiar that mirrors Isaac's movements and shoots in the opposite direction. 0
Ball of Bandages 5.100.207 Ball of Bandages Gotta lick 'em all! Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies gives it the ability to shoot charm tears, then chase enemies, then increases the damage. 2
Brother Bobby 5.100.8 Brother Bobby Friends 'till the end A familiar that follows Isaac around shooting normal tears. 0
Cain's Other Eye 5.100.319 Cain's Other Eye Near-sighted friend Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac. 0
Cube of Meat 5.100.73 Cube of Meat Gotta meat 'em all! Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies grants it the ability to shoot, then chase enemies, then increases the damage. 2
Demon Baby 5.100.113 Demon Baby Auto-turret friend Spawns a familiar that follows Isaac and automatically fires at enemies in its reach. 2
Ghost Baby 5.100.163 Ghost Baby Spectral buddy Spawns a familiar that follows Isaac around and fires spectral tears. 1
Harlequin Baby 5.100.167 Harlequin Baby Double shot buddy Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern. 1
Lil Brimstone 5.100.275 Lil Brimstone Evil Friend Grants a familiar that shoots a thin Brimstone beam. Must charge like Brimstone before shooting. 3
Little Gish 5.100.99 Little Gish Sticky friend Spawns a familiar that follows Isaac around and fires slowing tears, impeding enemies' speed. 2
Little Steven 5.100.100 Little Steven Psychic friend Spawns a familiar who follows Isaac around and fires homing tears. 1
Mongo Baby 5.100.322 Mongo Baby Mongo Friend Spawns a familiar that copies the tears of Isaac's other familiars. 2
Rainbow Baby 5.100.174 Rainbow Baby Random buddy Spawns a familiar that follows Isaac around and fires tears with random effects. 1
Robo-Baby 5.100.95 Robo-Baby Friends 'till the bbbbzzzt Spawns a familiar that shoots 15►Technology Technology lasers. 1
Robo-Baby 2.0 5.100.267 Robo-Baby 2.0 We worked out all the kinks Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears. 0
Rotten Baby 5.100.268 Rotten Baby Infested friend Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time. 3
Sister Maggy 5.100.67 Sister Maggy Friends 'till the end Spawns a familiar that follows Isaac around shooting normal tears. 0
Added in Afterbirth Fate's Reward 5.100.361 Fate's Reward Your fate beside you A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage. 2
Added in Afterbirth Incubus 5.100.360 Incubus Dark friend Spawns a demonic familiar that shoots tears identical to Isaac's in terms of damage, tears, and tear effects. 4
Added in Afterbirth Lil' Loki 5.100.435 Lil' Loki 4-way buddy! Spawns a Loki familiar that follows Isaac and fires 4 tears in a cross pattern. 1
Added in Afterbirth Seraphim 5.100.390 Seraphim Sworn friend Spawns an angel familiar which follows Isaac and fires homing tears which deal 10 damage and have 75% shot speed. 3
Added in Afterbirth † Buddy in a Box 5.100.518 Buddy in a Box What could it be?! Spawns a familiar with a random tear effect. The familiar is randomized at the start of each floor. 2
Added in Afterbirth † Lil Monstro 5.100.471 Lil Monstro Ain't he cute? Spawns a familiar that fires clusters of tears. Must be charged before shooting. 2
Added in Afterbirth † Lil Spewer 5.100.537 Lil Spewer Puking buddy Drops a random pill, and spawns a familiar that charges up and fires creep. Using pills changes the creep type. 1
Added in Repentance Boiled Baby 5.100.607 Boiled Baby Messy friend Gives Isaac a familiar that fires chaotic bursts of tears in all directions. 1
Added in Repentance Freezer Baby 5.100.608 Freezer Baby Iced iced baby Spawns a shooting familiar that has a chance to petrify enemies, and Freezes monsters upon killing them. 2
Added in Repentance Lil Abaddon 5.100.679 Lil Abaddon Abyssal friend Spawns a familiar that charges a miniature Added in Afterbirth15►Maw of the Void Maw of the Void attack while Isaac shoots. 3
Added in Repentance Twisted Pair 5.100.698 Twisted Pair Double trouble! Gives Isaac two familiars that stand by Isaac's side and fire tears that use Isaac's tears, range, shot speed, and tear effects and scale with Isaac's damage. 4
Name ID Icon Quote Description
???'s Soul 5.350.57 ???'s Soul Imaginary Friend Spawns a familiar that floats slowly around the room on a pattern similar to The Peeper and fires spectral and homing tears.
Isaac's Head 5.350.54 Isaac's Head Dead friend Spawns Isaac's severed head as a tear-firing familiar. Fires piercing tears.
Umbilical Cord 5.350.33 Umbilical Cord Fetal Protection When brought down to only a Half Red Heart, spawns a 15►Little Steven Little Steven familiar for the current room. Added in Repentance Adds a high chance to spawn a 15►Gemini Gemini familiar for the current room after taking damage.

Note: Only second stage 15►Cube of Meat Cube of Meat and 15►Ball of Bandages Ball of Bandages shoot tears.
Note: 15►Demon Baby Demon Baby and 15►Robo-Baby 2.0 Robo-Baby 2.0 shoot even when Isaac is not attacking.
Added in Repentance Note: Shooting familiars that follow Isaac take priority over other familiars, always appearing before non-combat familiars in line. 15►Incubus Incubus and 12►Lil Brimstone▼3►Lil' Brimstone Lil Brimstone have extra priority and will appear at the front, with Incubus taking priority over Lil Brimstone.

Wandering Familiars[edit | edit source]

Familiars that move around the room sporadically.

Name ID Icon Quote Description Added in Repentance Quality
Punching Bag 5.100.281 Punching Bag Scape Goat Spawns a Mulligan familiar that wanders randomly. Enemies will attack the Mulligan if it's closer. 1
Sissy Longlegs 5.100.280 Sissy Longlegs She loves you Spawns a familiar that wanders randomly, occasionally spawning Blue Spiders. 1
Added in Afterbirth Spider Mod 5.100.403 Spider Mod Mod buddy! Displays Isaac's tear damage and enemy health bars. Spawns a familiar that wanders around and inflicts random status effects on enemies it touches. Can spawn a Lil' Battery/Blue spider upon clearing a room. 1
Added in Afterbirth † 7 Seals 5.100.526 7 Seals Lil harbingers! Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts. 2
Added in Afterbirth † YO LISTEN! 5.100.492 YO LISTEN! Yo listen! +1 luck. Spawns a fairy familiar that points out Secret Rooms, Crawl Space entrances, and tinted rocks. 2

Bouncing Familiars[edit | edit source]

Familiars that bounce around the room in a zig-zag pattern, changing directions when hitting a wall.

Name ID Icon Quote Description Added in Repentance Quality
BBF 5.100.272 BBF Big Beautiful Fly Spawns a familiar that flies around the room in a zig-zag pattern and explodes on contact with an enemy. Respawns after ten seconds. 1
Cain's Other Eye 5.100.319 Cain's Other Eye Near-sighted friend Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeper and shoots normal tears in the same direction as Isaac. 0
The Peeper 5.100.155 The Peeper Plop! Spawns a familiar that floats slowly around the room on a zig-zag pattern, damaging enemies it passes through. 0
Added in Afterbirth GB Bug 5.100.405 GB Bug Double tap glitch Removed in Repentance Spawns a familiar that bounces diagonally around the room, applying a random status effect to enemies it hits and has a chance to re-roll pickups it passes over.
Added in Repentance Spawns a familiar that follows Isaac. Double tapping the fire button launches it forward, causing it to reroll the first monster or pickup it hits. It respawns after clearing a room.
0
Added in Afterbirth Succubus 5.100.417 Succubus Damage booster Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier. 3
Added in Afterbirth † Hushy 5.100.470 Hushy Lil hush! Spawns a Hush familiar that bounces diagonally around the room and deals contact damage. While firing tears, it stops moving. 0
Added in Repentance Fruity Plum 5.100.649 Fruity Plum Bouncy friend Gives Isaac a miniature Baby Plum familiar that propels itself diagonally around the room, firing tears behind itself as it travels. 1
Name ID Icon Quote Description
???'s Soul 5.350.57 ???'s Soul Imaginary Friend Spawns a familiar that floats slowly around the room on a pattern similar to The Peeper and fires spectral and homing tears.

Mimicking Familiars Added in Afterbirth[edit | edit source]

Familiars that copy Isaac's movements after a certain delay.

Name ID Icon Quote Description Added in Repentance Quality
Multidimensional Baby 5.100.431 Multidimensional Baby ydduB Buddy Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed. 1
Obsessed Fan 5.100.426 Obsessed Fan Follows my every move... Spawns a familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies. 0
Papa Fly 5.100.430 Papa Fly Turret follower Spawns a familiar that follows Isaac's movements on a 3 second delay, firing tears at nearby enemies. 1
Added in Afterbirth † Shade 5.100.468 Shade It follows Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers. 0


Others[edit | edit source]

Familiars that don't fit into any of the above categories or that produce multiple effects.

Name ID Icon Quote Description Added in Repentance Quality
Added in Afterbirth † Brown Nugget 5.100.504
Brown Nugget
7 seconds
Friendly fly Spawns a stationary fly turret that fires tears at nearby enemies. 0
Added in Afterbirth † Sprinkler 5.100.516
Sprinkler
4 rooms
Sprinkles. Upon use, spawns a sprinkler that rotates and fires tears. 2
Added in Repentance Stitches 5.100.635
Stitches
5 seconds
Bait and switch Passively spawns a familiar that moves in the direction Isaac shoots. On use, Isaac swaps places with the familiar. 1
Name ID Icon Quote Description Added in Repentance Quality
???'s Only Friend 5.100.320 ???'s Only Friend Controlled friend Spawns a controllable familiar that deals 37.5 damage per second on touch. It can be moved using the shooting directional keys 2
1up! 5.100.11 1up! Extra life Gives Isaac an extra life. Upon death, he will respawn in the previous room with full health and lose the 1up!. 2
Bob's Brain 5.100.273 Bob's Brain Explosive thoughts Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds. 1
Dead Cat 5.100.81 Dead Cat 9 lives Sets Isaac's Red Heart containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container. 3
Dry Baby 5.100.265 Dry Baby Immortal Friend Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering 15►The Necronomicon The Necronomicon effect. 3
Guppy's Hair Ball 5.100.187 Guppy's Hair Ball Swing it Spawns a familiar that loosely follows behind Isaac, which blocks shots can be swung like a flail to damage enemies. Grows bigger by killing enemies. 1
Headless Baby 5.100.269 Headless Baby Bloody Friend Spawns a familiar that follows Isaac, leaving blood creep on the ground. 1
Holy Water 5.100.178 Holy Water Splash! Removed in Repentance Spawns a bottle familiar that breaks when Isaac takes damage, leaving a puddle of blue creep. The bottle respawns upon entering a different room.
Added in Repentance A bottle familiar that flies forward when Isaac shoots. It breaks upon hitting an enemy, leaving a puddle of blue creep that petrifies enemies. The bottle respawns after a few seconds.
0
Isaac's Heart 5.100.276 Isaac's Heart Protect It Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt. 0
Juicy Sack 5.100.266 Juicy Sack Sticky babies Spawns a familiar that follows Isaac and drips a trail of slow creep, spawning 1-2 Blue Spiders after each room. 2
Key Piece 1 5.100.238 Key Piece 1 ??? Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan. 0
Key Piece 2 5.100.239 Key Piece 2 ??? Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan. 0
Little Chubby 5.100.88 Little Chubby Attack Buddy Spawns a charger familiar that charges forward and deals contact damage to any enemies in its path. 1
Samson's Chains 5.100.321 Samson's Chains The ol' ball and chain Attaches a ball and chain to Isaac that pulls behind him that damages enemies, blocks shots, and destroys most obstacles. 1
Added in Afterbirth Censer 5.100.387 Censer Peace be with you Spawns a familiar which creates a circular aura that slows down enemies and enemy shots inside. 3
Added in Afterbirth Farting Baby 5.100.404 Farting Baby He farts! Spawns a familiar that follows Isaac and blocks enemy shots. If a shot hits Farting Baby, it has a chance to fart, which Charms, Poisons, or knocks back nearby enemies. 1
Added in Afterbirth Lil Gurdy 5.100.384 Lil Gurdy A gurd of your own! A Gurdy Jr. familiar that charges up while Isaac is firing, bouncing around the room when released and dealing contact damage based on its speed. 1
Added in Afterbirth Lost Fly 5.100.365 Lost Fly Lost protector Spawns fly familiar that moves in a straight line and circles around the first wall or obstacle it hits, dealing 105 damage per second on contact. 0
Added in Afterbirth Milk! 5.100.436 Milk! Don't cry over it... Spawns a glass familiar that spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the current room. 1
Added in Afterbirth † Angry Fly 5.100.511 Angry Fly He's violent Spawns a fly familiar that orbits around a random enemy and deals 30 damage per second to enemies it comes in contact with. 1
Added in Afterbirth † Big Chubby 5.100.473 Big Chubby Chub chub Spawns a familiar that follows Isaac and charges across the room when Isaac fires, blocking shots and dealing 40.5 damage per second on contact. 1
Added in Afterbirth † Depression 5.100.469 Depression :( Spawns a familiar that leaves a trail of creep that damages enemies at 6 damage per second. Has a chance to spawn damaging beams of light onto enemies that touch the cloud. 1
Added in Afterbirth † Finger! 5.100.467 Finger! Watch where you point that! Spawns a finger familiar that points at enemies, dealing scaling damage. 1
Added in Afterbirth † Hallowed Ground 5.100.543 Hallowed Ground Portable sanctuary Spawns a white poop familiar, which turns into a white poop when Isaac is hurt. White poop has an aura that halves tear delay and can block enemy shots. 1
Added in Afterbirth † Jaw Bone 5.100.548 Jaw Bone Fetch! Spawns a familiar that flies through the room while firing, dealing a flat 7 contact damage to enemies retrieving pickups. 1
Added in Afterbirth † King Baby 5.100.472 King Baby Hail to the king, baby! Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, other familiars stop moving. 0
Added in Afterbirth † Lil Delirium 5.100.519 Lil Delirium Delirious friend Grants a familiar that transforms into another random familiar every 10 seconds. 2
Added in Afterbirth † Mystery Egg 5.100.539 Mystery Egg Sacrificial insemination Spawns an egg familiar, which cracks into a random friendly monster when Isaac is hurt. The egg regenerates upon entering a different room. 1
Added in Afterbirth † Pointy Rib 5.100.544 Pointy Rib Stabbing time Spawns a bone familiar that hovers back and forth in front of Isaac, dealing damage equal to Isaac's damage. 2
Added in Repentance Blood Oath 5.100.569 Blood Oath Bleed me dry Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained. 2
Added in Repentance C Section 5.100.678 C Section Fetus shots 4
Added in Repentance Cube Baby 5.100.652 Cube Baby Kick it! Spawns an ice cube familiar that slides around when walked into. It slows and deals contact damage, freezing monsters it kills. 1
Added in Repentance Knife Piece 1 5.100.626 Knife Piece 1 ??? Combined with Added in Repentance15►Knife Piece 2 Knife Piece 2, creates a knife familiar that damages enemies and can open the door to the Corpse Corpse. 0
Added in Repentance Knife Piece 2 5.100.627 Knife Piece 2 ??? Combined with Added in Repentance15►Knife Piece 1 Knife Piece 1, creates a knife familiar that damages enemies and can open the door to the Corpse Corpse. 0
Added in Repentance Lil Dumpy 5.100.615 Lil Dumpy Puffy buddy Gives Isaac a Dumpy familiar that, when it takes damage, pushes/stuns/poisons nearby enemies and flies in a random direction. 0
Added in Repentance Lil Portal 5.100.681 Lil Portal It hungers A familiar that flies forward, consuming pickups in its path. Each one will increase its size and damage and spawn a Blue Fly. Every four pickups, it opens a portal that leads to an unexplored room. 1
Added in Repentance Lost Soul 5.100.612 Lost Soul Protect him Gives Isaac a soul familiar that dies in one hit, respawning at the start of the next floor. If it survives an entire floor, it rewards Isaac with hearts or items. 2
Added in Repentance Star of Bethlehem 5.100.651 Star of Bethlehem Follow the light Spawns a star familiar that slowly travels towards the Boss Room, giving an aura that increases damage and tears and grants homing. 2
Added in Repentance Vanishing Twin 5.100.697 Vanishing Twin He wants revenge Spawns a familiar that becomes a clone of the floor's boss when entering the boss room. Defeating it drops an extra item. 3
Name ID Icon Quote Description
Added in Afterbirth † Tonsil 5.350.97 Tonsil Sick... When hit, there is a small chance a removed tonsil familiar starts following Isaac, blocking enemy shots.

Unlockable Achievements[edit | edit source]


The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth The Binding of Isaac: Rebirth
Achievements Achievements Attributes Attributes Bosses Bosses TarotCard.png Cards and Runes Challenges Challenges Chapters Chapters
Characters Characters MainPageBabies.png Co-op Items Items Item pools Item pools Monsters Monsters Objects Objects
Pickups Pickups Pills Pills Rooms Rooms Seeds Seeds Transformations Transformations Trinkets Trinkets