Astral Projection: During the time-stop period of Astral Projection, there is a chance that the eyes fired will stop in the air instead of flying in a direction, and will last indefinitely until an enemy bump into it, greatly increase the existing time of evil eyes. Triggering of Astral Projection also greatly increase fire rate, giving a higher possibility to fire eyes.
Homing tears: Eyes will fire homing tears; however, the eye itself will not home in on enemies.
Pop!: Eyes will fire eyeball tears but cannot be knocked around by them.
Spirit Sword: Massively powerful, will "swing" in the direction isaac is is firing for as long as it is held and has slightly less range than Isaac's base stat.
Trisagion: Eyes will fire beams. Occasionally causes Trisagion beams to stay static in the air for a few seconds, dealing damage to enemies that come in contact with them.
Items that reduce shot speed, such as Dead Onion, can be beneficial, as eyes will stay on the screen longer.
Mom's Eye: Evil eye has a chance to be shot backwards, but will still fire in the direction Isaac is shooting