Binding of Isaac: Rebirth Wiki

Epic Fetus is an unlockable passive item.

Effects[ | ]

  • Isaac's tears are replaced with guided missiles. Pressing the fire buttons spawns a crosshair that can be moved freely, summoning a missile to its position from above 1.5 seconds later.
    • Missiles deal 20 times Isaac's damage.

Notes[ | ]

  • (except in Repentance) Epic Fetus is a special item.
  • (except in Repentance) Epic Fetus overrides most items in the game and has the highest priority of all tear modifiers, over Collectible Brimstone iconBrimstone and Collectible Mom's Knife iconMom's Knife.
  • Isaac's tear delay determines how quickly a new (set of) missile(s) can be fired after the previous one has landed. Barring very high tear delay, this has little effect on damage rate due to the delay of the missiles themselves.
  • Missiles benefit from some bomb modifier items, though at a lesser scale compared to Collectible Dr. Fetus iconDr. Fetus.
  • Stacking multiple copies of the item causes a barrage of missiles in quick succession without resetting the crosshair's position, up to sixteen at a time.
  • Epic Fetus missiles usually deal a full heart of damage to Isaac.
    • Self-damage is only half a heart if the missile would deal less than 85 damage. In practice this is not common, as even a small damage stat increase will cause the missiles to go over the critical damage level.

Synergies[ | ]

  • (except in Rebirth) Collectible 20 20 icon20/20/ ConjoinedConjoined/(in Afterbirth † and Repentance) BookwormBookworm/Collectible Mutant Spider iconMutant Spider/Collectible The Inner Eye iconThe Inner Eye: Fires a barrage of missiles corresponding with the amount of tears.
  • (in Repentance)Collectible Bomber Boy iconBomber Boy: Missiles explode in a large cross-shaped blast, with each explosion dealing 0.75x times damage. Unlike with regular bombs, getting hit by every separate explosion from Epic Fetus won't decrease the damage for each successive explosion, drastically increasing damage.
  • (in Repentance)Collectible Blood Bombs iconBlood Bombs: Every missile explosion leaves a large, lasting pool of red creep.
  • Collectible Blood Clot iconBlood Clot/Collectible Chemical Peel iconChemical Peel: Each missile has a 50% chance to deal 20 or 40 points more damage, respectively.
  • Poison tears: This is guaranteed by Collectible Bob's Curse iconBob's Curse, Collectible Ipecac iconIpecac, and Collectible Scorpio iconScorpio, and also has a chance to trigger from Collectible The Common Cold iconThe Common Cold, Pinky EyePinky Eye or (except in Rebirth)Collectible Serpent's Kiss iconSerpent's Kiss.
    • (in Repentance) Explosions leave behind a cloud of poison gas that will poison enemies in contact with it aside from the main target.
  • (except in Rebirth)Collectible Brimstone iconBrimstone: Missile explosions shoot ten blood lasers in all directions.
  • (in Repentance)Collectible Brimstone Bombs iconBrimstone Bombs: Missile explosions have a chance to shoot four Brimstone lasers in the cardinal directions. The chance scales with Isaac's luck.
  • Collectible Butt Bombs iconButt Bombs: Missile explosions will cloud up the screen, briefly confusing and dealing 10 damage to all enemies in the room.
  • (in Repentance)Collectible Eye Sore iconEye Sore: More marks appear orbiting around where you're aiming.
  • Collectible Fire Mind iconFire Mind/Collectible Hot Bombs iconHot Bombs: Missile explosions leave behind a fire that damage enemies on contact. Fire Mind's burn effect is overridden.
  • (in Afterbirth † and Repentance) Character The Forgotten iconThe Forgotten: The charge attack is replaced by a missile in the Forgotten's hand and a crosshair that may be moved for an indefinite amount of time. The missile is thrown at the crosshair when all attack buttons are released, with an additional melee swing in the same direction. The melee attack is unaffected.
  • (except in Rebirth)Collectible Glitter Bombs iconGlitter Bombs: Missile explosions have a small chance of spawning pickups.
  • (except in Rebirth) Homing tears: The crosshair slowly slides towards enemies.
  • (except in Rebirth)Collectible Host Hat iconHost Hat/Collectible Pyromaniac iconPyromaniac: Isaac becomes immune to his own airstrikes.
  • (in Repentance)Collectible Incubus iconIncubus: Incubus fires a missile alongside Isaac's.
  • (except in Repentance)Collectible Ipecac iconIpecac: Missiles have a poison effect, have a larger blast radius and deal drastically increased damage, as the +40 damage from Ipecac is run through the damage multiplier of Epic Fetus.
    • (in Repentance) Adds flat +2 damage instead of +40. Explosions leave behind a cloud of poison gas that will poison enemies in contact with it aside from the main target.
  • (in Repentance)Lil ClotLil Clot / Character Tainted Eve iconTainted Eve: The clots have their own targeting reticles and fire simultaneously with Isaac.
  • (except in Rebirth)Collectible Mom's Knife iconMom's Knife: Missile explosions shoot a ring of ten knives.
  • (except in Rebirth)Collectible Monstro's Lung iconMonstro's Lung: 2 to 4 additional crosshairs orbit the main crosshair, and missiles are fired onto each crosshair.
  • Collectible Mr. Mega iconMr. Mega: No effect on Epic Fetus.
  • Collectible Mysterious Liquid iconMysterious Liquid: Every missile explosion leaves a small, lasting pool of creep.
  • (in Repentance)Collectible Nancy Bombs iconNancy Bombs: Explosions have a chance to be affected by any of the bomb-modifier effects that synergize with Epic Fetus.
  • Collectible Polyphemus iconPolyphemus: Increased tear delay, but massively increases the missiles' blast radius and damage, as Polyphemus' damage multiplier is run through the damage multiplier of Epic Fetus.
  • Collectible Sad Bombs iconSad Bombs: Missile explosions fire ten tears in all directions. The shrapnel's damage is not run through the damage multiplier of Epic Fetus.
    • (in Repentance) The chance for the effect to proc is dependent of Isaac's luck. Chance goes up to 100% at 30 luck.
  • (except in Rebirth)Collectible Strange Attractor iconStrange Attractor: Enemies, pickups and trinkets get drawn towards the crosshair.
  • Collectible Technology iconTechnology: Both fire normally and the missile explosions shoot ten Technology beams in all directions.
    • (in Repentance) Only Epic Fetus crosshairs are fired, but missile explosions still shoot ten Technology beams in all directions.
    • (in Repentance)Collectible Ipecac iconIpecac: Not recommended. Technology beams explode and may end up catching you off guard.
  • (in Afterbirth and Afterbirth †)Collectible Technology 2 iconTechnology 2: Both fire normally.
    • (in Repentance) Does not reduce missiles' damage, and both fire normally at the cost of a slightly higher delay between each crosshair appearing.
  • (except in Rebirth)Collectible Tech X iconTech X: Missile explosions shoot ten Technology beams in all directions.

Interactions[ | ]

Overridden by Epic Fetus:

Only stat effects are applied; otherwise overridden by Dr. Fetus:

Other interactions:

  • (except in Rebirth)Collectible 8 Inch Nails icon8 Inch Nails: Missile explosions retain the knockback boost, so enemies that survive the blast will be knocked back far.
  • Collectible Bobby-Bomb iconBobby-Bomb/(in Afterbirth and Afterbirth †)Collectible Bomber Boy iconBomber Boy/(in Repentance)Collectible Ghost Bombs iconGhost Bombs/Collectible Mr. Mega iconMr. Mega/(except in Rebirth)Collectible Scatter Bombs iconScatter Bombs/(except in Rebirth)Collectible Sticky Bombs iconSticky Bombs: No effect.
  • (except in Repentance)Collectible Chocolate Milk iconChocolate Milk: Reduces Isaac's tear delay by 20%. Missiles can't be charged.
  • (except in Rebirth)Collectible Godhead iconGodhead: Stat effects apply and the crosshair gains a homing effect, but missiles do not have a damaging aura.
  • (in Afterbirth and Afterbirth †)Collectible Incubus iconIncubus: Incubus fires normal tears while the crosshair is being aimed.
  • (in Repentance)Collectible It Hurts iconIt Hurts/Collectible Tammy's Head iconTammy's Head/(in Afterbirth † and Repentance)Collectible Varicose Veins iconVaricose Veins: Fires only normal tears, not missiles.
  • Collectible Loki's Horns iconLoki's Horns: Adds a chance to spawn four crosshairs in cardinal directions. Isaac controls one and the others will mirror the movement keeping their space.
  • (except in Rebirth)Collectible Marked iconMarked: Continuously fires missiles at the marked spot.
    • (in Repentance)If the crosshair is dismissed before the next missile is dropped, it still drops in the crosshair’s last position.
  • Collectible Soy Milk iconSoy Milk: Not recommended. Damage of missiles is drastically reduced, and unlike normal tears, the fire rate will not significantly increase.
  • (in Repentance)Collectible Spirit Sword iconSpirit Sword: Overrides Epic Fetus making it the only item in the game that takes priority over Epic Fetus.
  • (except in Rebirth)Collectible The Wiz iconThe Wiz: Makes two missiles drop in quick succession, and control of the crosshair is rotated 45 degrees clockwise. Not recommended, as it makes controlling the crosshair harder. However, mouse control is less affected.
  • (in Repentance)Collectible Twisted Pair iconTwisted Pair: Each familiar will fire a missile from a two additional crosshairs. Not Recommended, as the twisted pair crosshairs are not synced to Isaac's crosshair and move at a much slower rate, making self damage much more likely as the additional crosshairs will struggle to make distance from Isaac.

In-game Footage[ | ]

Trivia[ | ]

  • In the original game it was possible to control the crosshair with the mouse. This was removed in Rebirth.
    • (in Repentance) Mouse control can however be re-enabled by editing the options.ini file in C:\Users\<username>\Documents\My Games\Binding of Isaac Afterbirth/Rebirth and changing the line MouseControl=0 into MouseControl=1. Also useful for Collectible The Ludovico Technique iconThe Ludovico Technique.
  • The Collectible Dr. Fetus iconDr. Fetus and Epic Fetus items are based off of Dr. Fetus, the main villain in Super Meat Boy which is a game by Edmund McMillen (the creator of The Binding of Isaac: Rebirth).
  • In Wrath of the Lamb, Epic Fetus could be found in both the Secret Room and Treasure Room item pools.
    • (in Repentance)Epic Fetus was added to the Secret Room item pool.
  • This item is used in Glass Cannon (challenge #11).
  • In Wrath of the Lamb, this item was originally unlocked by beating a challenge titled, "The Doctor's Revenge!".