E. Coli

Item Icon
Pickup Quote	"Turdy touch"
Entity ID	5.100.236
Character Appearance
Item Pool	Treasure Room Treasure Room
Quality	1
Item Tags
Collection Grid	(page 3, column 2, row 4) (page 2, column 12, row 6)

E. Coli is a passive item.

Effects

• Enemies that touch Isaac are transformed into Poop.
• Poops, including these not created by E.Coli, have now a 6.25% chance to drop a pickup if it normally wouldn't drop anything.
• This item belongs to the Oh Crap set. Collecting three items from this set will transform Isaac into a walking pile of poop.

Notes

• Bosses cannot be turned into poop.
• Enemies that are turned into poop do not count towards on kill effects such as health regeneration from Charm of the Vampire or the damage increase from Lusty Blood.
  • This is especially detrimental for Tainted Keeper or Tainted Magdalene which depend on pickups generated on enemy kills.
• Poop created by this item is not grid-aligned, and flashes red when hit, similar to damaging monsters.
  • Poops produced by E. Coli crumble upon being attacked, identically to regular poops.
• If you touch the middle section of a Grub with E. Coli, it will then split and become two heads (rather than destroying and spawning Maggots).
• Mullibooms can be turned into poop without taking damage.
• The poops vanish if the room is left and then returned to.
• Turning Champion version of a monster into poop will forfeit the chance to get the champion's drop.

Synergies

• Butt Penny/Petrified Poop: Grants poops made from enemies a chance to drop pickups.
• Death's List: Enemies that die by being turned into poop do not disrupt the Death's List chain and clearing a room by turning all its enemies into poop still grants Isaac the Death's List reward.
• Dirty Mind: Enemies that are turned into poop generate double the normal amount of Dips.
• Holy Mantle: On-contact effect still applies to enemies if Holy Mantle negates the contact damage taken.
• Isaac's Heart: Isaac can turn enemies into poop without taking damage.
• Lodestone: If an enemy is hit by a lodestone tear perfectly simultaneously with it being turned into poop, the resulting poop will be tinted black and have a lodestone aura that sucks in enemies. This poop will return to normal after a few seconds.
• Midas' Touch: Enemies touched are turned into Golden Poop.
• Oh Crap: Isaac can heal by destroying poops created from enemies.
• Tainted Forgotten: The body will turn enemies into poop on contact.
• Unicorn Stump: Provides invincibility during which enemies can be touched.

Interactions

• Any on kill effects do not include with
• Bob's Brain: Bob's Brain will explode upon hitting an enemy that has been turned into poop.
  • Bob's Brain no longer explodes upon hitting poops made from enemies.
• Brown Cap: The generated poops are affected and will explode when destroyed.
• Butt Penny/Petrified Poop: Poops made from enemies still do not drop pickups.
• Hallowed Ground: The generated poops cannot be white.
• Meconium: The generated poops cannot be black.
• Oh Crap: Destroying poops created from enemies do not heal Isaac.
• Serpent's Kiss / The Virus: The poops won't drop Black Hearts, negating the touch effect from these items on non-bosses.

Trivia

• Escherichia coli is a type of intestinal bacteria present naturally in the human intestinal system. However, some harmful strains of E. Coli can cause food poisoning.
• This item is used in High Brow (challenge #2) and Scat Man (challenge #36).

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