Binding of Isaac: Rebirth Wiki

E. Coli is a passive item.

Effects[ | ]

  • Enemies that touch Isaac are transformed into PoopPoop.
  • PoopPoops, including these not created by E.Coli, have now a 6.25% chance to drop a pickup if it normally wouldn't drop anything.
  • (except in Rebirth) This item belongs to the Oh CrapOh Crap set. Collecting three items from this set will transform Isaac into a walking pile of poop.

Notes[ | ]

  • Bosses cannot be turned into poop.
  • Enemies that are turned into poop do not count towards on kill effects such as health regeneration from Collectible Charm of the Vampire iconCharm of the Vampire (except in Rebirth) or the damage increase from Collectible Lusty Blood iconLusty Blood.
  • Poop created by this item is not grid-aligned, and flashes red when hit, similar to damaging monsters.
    • (in Afterbirth † and Repentance) Poops produced by E. Coli crumble upon being attacked, identically to regular poops.
  • If you touch the middle section of a GrubGrub with E. Coli, it will then split and become two heads (rather than destroying and spawning MaggotMaggots).
  • (except in Repentance) MulliboomMullibooms can be turned into poop without taking damage.
  • The poops vanish if the room is left and then returned to.
  • Turning Champion version of a monster into poop will forfeit the chance to get the champion's drop.

Synergies[ | ]

  • (in Afterbirth † and Repentance)Butt PennyButt Penny/Petrified PoopPetrified Poop: Grants poops made from enemies a chance to drop pickups.
  • (in Afterbirth † and Repentance)Collectible Death's List iconDeath's List: Enemies that die by being turned into poop do not disrupt the Death's List chain and clearing a room by turning all its enemies into poop still grants Isaac the Death's List reward.
  • (in Repentance)Collectible Dirty Mind iconDirty Mind: Enemies that are turned into poop generate double the normal amount of Dips.
  • Collectible Holy Mantle iconHoly Mantle: On-contact effect still applies to enemies if Holy Mantle negates the contact damage taken.
  • Collectible Isaac's Heart iconIsaac's Heart: Isaac can turn enemies into poop without taking damage.
  • (in Repentance)Collectible Lodestone iconLodestone: If an enemy is hit by a lodestone tear perfectly simultaneously with it being turned into poop, the resulting poop will be tinted black and have a lodestone aura that sucks in enemies. This poop will return to normal after a few seconds.
  • Collectible Midas' Touch iconMidas' Touch: Enemies touched are turned into Golden PoopGolden Poop.
  • (in Repentance) Oh CrapOh Crap: Isaac can heal by destroying poops created from enemies.
  • (in Repentance) Character Tainted Forgotten iconTainted Forgotten: The body will turn enemies into poop on contact.
  • Collectible Unicorn Stump iconUnicorn Stump: Provides invincibility during which enemies can be touched.

Interactions[ | ]

  • Any on kill effects do not include with
  • (except in Repentance)Collectible Bob's Brain iconBob's Brain: Bob's Brain will explode upon hitting an enemy that has been turned into poop.
    • (in Repentance) Bob's Brain no longer explodes upon hitting poops made from enemies.
  • (except in Rebirth)Brown CapBrown Cap: The generated poops are affected and will explode when destroyed.
  • (in Rebirth and Afterbirth)Butt PennyButt Penny/Petrified PoopPetrified Poop: Poops made from enemies still do not drop pickups.
  • (in Afterbirth † and Repentance)Collectible Hallowed Ground iconHallowed Ground: The generated poops cannot be white.
  • (in Afterbirth † and Repentance)MeconiumMeconium: The generated poops cannot be black.
  • (in Afterbirth and Afterbirth †) Oh CrapOh Crap: Destroying poops created from enemies do not heal Isaac.
  • (except in Rebirth)Collectible Serpent's Kiss iconSerpent's Kiss / (in Afterbirth and Afterbirth †)Collectible The Virus iconThe Virus: The poops won't drop Black Hearts, negating the touch effect from these items on non-bosses.

In-game Footage[ | ]

Trivia[ | ]

  • Escherichia coli is a type of intestinal bacteria present naturally in the human intestinal system. However, some harmful strains of E. Coli can cause food poisoning.
  • This item is used in High Brow (challenge #2) and (in Repentance) Scat Man (challenge #36).