Binding of Isaac: Rebirth Wiki
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Binding of Isaac: Rebirth Wiki

E. Coli is a passive item.

Effects[]

  • Enemies that touch Isaac are transformed into poop.
  • Added in Afterbirth This item belongs to the Oh Crap set. Collecting three items from this set will transform Isaac into a walking pile of poop.

Notes[]

  • Bosses cannot be turned into poop.
  • Poop created by this item is not grid-aligned, and flashes red when hit, similar to damaging monsters.
    • Added in Afterbirth † Poops produced by E. Coli crumble upon being attacked, identically to regular poops.
  • If you touch the middle section of a Grub with E. Coli, it will then split and become two heads (rather than destroying and spawning Maggots).
  • Mullibooms can be turned into poop without taking damage.
  • The poops vanish if the room is left and then returned to.
  • Added in Afterbirth / Removed in Repentance Poops created by E. Coli do not heal Isaac when he has the Oh Crap transformation.
  • Added in Repentance Poops created by E. Coli heal Isaac when he has the Oh Crap transformation.

Synergies[]

  • Isaac's Heart Isaac's Heart: Isaac can turn enemies into poop without taking damage.
  • Midas' Touch Midas' Touch: Enemies touched are turned into Golden Poop.
  • Unicorn Stump Unicorn Stump: Provides invincibility during which enemies can be touched.
  • Added in RepentanceLodestone Lodestone: If an enemy is hit by a lodestone tear perfectly simultaneously with it being turned into poop, the resulting poop will be tinted black and have a lodestone aura that sucks in enemies. This poop will return to normal after a few seconds.
  • Added in Repentance Both Midas' Touch Midas' Touch and E. Coli affect Tainted Forgotten Tainted Forgotten's body, causing enemies that touch the body to freeze and turn into poop respectively.

Interactions[]

  • Added in AfterbirthBrown Cap Brown Cap: The generated poops are affected and will explode when destroyed.
  • Added in Afterbirth †Hallowed Ground Hallowed Ground: The generated poops cannot be white.
  • Added in Afterbirth †Meconium Meconium: The generated poops cannot be black.
  • Added in AfterbirthSerpent's Kiss Serpent's Kiss / The Virus The Virus: The poops won't drop Black Hearts, negating the touch effect from these items on non-bosses.

In-game Footage[]

Trivia[]

  • Escherichia coli is a type of intestinal bacteria present naturally in the human intestinal system. However, some harmful strains of E. Coli can cause food poisoning.
  • This item is used in High Brow (challenge #2) and Added in Repentance Scat Man (challenge #36).

Seeds[]

PC DXGN OP4D (Treasure Room adjacent to spawn)

PS4 F1WD FBBN (Treasure Room adjacent to spawn)

Switch Greed mode only 8YRM FTHE (First Golden Treasure Room)


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