Binding of Isaac: Rebirth Wiki
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Binding of Isaac: Rebirth Wiki
Added in Afterbirth

Items in this pool can be found in the Devil Room in Greed mode. All items can be bought for some number of Red Heart containers. If Isaac has no Red Heart containers, items can be bought for three Soul Hearts.

Activated Collectibles[]

Name ID Icon Weight Description
Full red heart 1 Heart Cost
Guppy's Head 5.100.145
Guppy's Head
1 rooms
1
Spawns 2-4 friendly Blue Flies that damage enemies.
Guppy's Paw 5.100.133
Guppy's Paw
Unlimited
1
Upon use, converts one Heart Container into three Soul Hearts.
The Book of Belial 5.100.34
The Book of Belial
3 rooms
1
+2 damage for the current room.
Removed in Afterbirth Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it. Added in Afterbirth Increases the chance by 12.5%.
The Book of Sin 5.100.97
The Book of Sin
4 rooms
1
Spawns a random pickup, pill, card, or trinket.
The Necronomicon 5.100.35
The Necronomicon
4 rooms
1
Deals 40 damage to every enemy in the room.
Mega Blast 5.100.441
Mega Blast
12 rooms
0.2
Upon use, Isaac fires a laser similar to the one used by Mega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active.
Added in Repentance Gello 5.100.728
Gello
2 rooms
1
Spawns a demon familiar that's attached to Isaac and moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects.
Added in Repentance Monster Manual 5.100.123
Monster Manual
6 rooms
1
Removed in Repentance Spawns a familiar from a specific selection for the current room.

Added in Repentance Spawns a familiar from a specific selection for the current floor.

Added in Repentance Sulfur 5.100.556
Sulfur
3 rooms
1
Grants 15►Brimstone Brimstone for the current room.
Added in Repentance Abyss 5.100.706
Abyss
4 rooms
0.5
Destroys all items in the room and gives Isaac a unique locust familiar for each item destroyed.
Added in Repentance Berserk! 5.100.704
Berserk!
With damage dealt
0.5
Causes Isaac to go berserk for 5 seconds, greatly increasing his speed, tears, and damage, but restricting him to using a melee weapon instead of his tears. This item charges by dealing damage to enemies instead of clearing rooms.
Added in Repentance Dark Arts 5.100.705
Dark Arts
6 seconds
0.5
Makes Isaac invulnerable and intangible for one second. When the effect ends, all enemies Isaac ran through take damage and Isaac temporarily gains +1 damage for each one.
Added in Repentance Lemegeton 5.100.712
Lemegeton
6 rooms
0.5
Spawns the ghost of a random passive item, which orbits Isaac but can be destroyed. While the ghost is alive, Isaac gains that item's effects.
Full red heartFull red heart 2 Hearts Cost
Satanic Bible 5.100.292
Satanic Bible
6 rooms
1
Gives one Black Heart. Added in Repentance Replaces the boss room item on the current floor with a Devil deal.
The Nail 5.100.83
The Nail
6 rooms
1
Gives Removed in Repentance one Soul Heart Added in Repentance half a Black Heart. For the current room; +0.7 damage, -0.18 speed, allows Isaac to break rocks and damage enemies by walking over them.
Added in Afterbirth † Sacrificial Altar 5.100.536
Sacrificial Altar
One time use
1
Sacrifices up to 2 familiars and spawns an item from the Devil Room pool for each familiar sacrificed. Converts all friendly spiders and flies into coins.
Added in Repentance Damocles 5.100.577
Damocles
One time use
1
Spawns a sword above Isaac's head, which doubles all item pedestals. After Isaac takes damage, the sword can randomly fall at any point, instantly killing him.

Passive Collectibles[]

Name ID Icon Weight Description
Full red heart 1 Heart Cost
A Lump of Coal 5.100.132 A Lump of Coal
1
The more distance tears travel, the more damage they will do.
Athame 5.100.408 Athame
1
When Isaac takes damage, a black ring briefly appears around him, dealing damage to all nearby enemies.
Betrayal 5.100.391 Betrayal
1
Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Black Powder 5.100.420 Black Powder
1
Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.
Cambion Conception 5.100.412 Cambion Conception
1
After taking damage a certain amount of times, a permanent demonic familiar spawns.
Ceremonial Robes 5.100.216 Ceremonial Robes
1
Grants 3 Black Hearts, and +1 damage.
Cube of Meat 5.100.73 Cube of Meat
1
Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies grants it the ability to shoot, then chase enemies, then increases the damage.
Dark Matter 5.100.259 Dark Matter
1
+1 damage, adds a chance to shoot fear tears.
Dead Bird 5.100.117 Dead Bird
1
After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~5 damage per second.
Dead Cat 5.100.81 Dead Cat
1
Sets Isaac's Red Heart containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container.
Demon Baby 5.100.113 Demon Baby
1
Spawns a familiar that follows Isaac and automatically fires at enemies in its reach.
Empty Vessel 5.100.409 Empty Vessel
1
Grants two Black Hearts. While Isaac has no red hearts, grants flight and periodically grants an invincibility shield for a few seconds.
Gimpy 5.100.225 Gimpy
1
Gives chance of spawning a Soul Heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Guppy's Collar 5.100.212 Guppy's Collar
1
Grants a permanent 50% chance to respawn with 1/2 of a Red Heart after death.
Guppy's Hair Ball 5.100.187 Guppy's Hair Ball
1
Spawns a familiar that loosely follows behind Isaac, which blocks shots can be swung like a flail to damage enemies. Grows bigger by killing enemies.
Guppy's Tail 5.100.134 Guppy's Tail
1
Room clear awards have a 1/3 chance of being replaced with a chest and a 1/3 chance being replaced with nothing.
Headless Baby 5.100.269 Headless Baby
1
Spawns a familiar that follows Isaac, leaving blood creep on the ground.
Leech 5.100.270 Leech
1
Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a Half Red Heart whenever Leech kills an enemy.
Multidimensional Baby 5.100.431 Multidimensional Baby
1
Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed.
My Shadow 5.100.433 My Shadow
1
Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black friendly Charger that will attack enemies. The Charger will be killed if it is damaged too much.
Ouija Board 5.100.115 Ouija Board
1
Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
Pentagram 5.100.51 Pentagram
1
+1 damage, increases Devil Room / Angel Room chance by 10%.
Rotten Baby 5.100.268 Rotten Baby
1
Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time.
Sacrificial Dagger 5.100.172 Sacrificial Dagger
1
Spawns a dagger orbital familiar, dealing 225 damage per second and blocking enemy shots.
Sister Maggy 5.100.67 Sister Maggy
1
Spawns a familiar that follows Isaac around shooting normal tears.
The Mark 5.100.79 The Mark
1
Grants one Soul Heart, +1 damage, and +0.2 speed.
Whore of Babylon 5.100.122 Whore of Babylon
1
Grants +1.5 damage and +0.3 speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any Soul or Black Hearts.
Removed in Repentance Contract From Below 5.100.241 Contract From Below
1
Doubles the number of most room clear awards, but reduces the overall chance of getting one by 1/3.
Added in Afterbirth † 7 Seals 5.100.526 7 Seals
1
Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts.
Added in Afterbirth † Death's List 5.100.530 Death's List
1
Grants a pickup or stat upgrade if all enemies in a room are killed in the order they are marked.
Added in Afterbirth † Little Horn 5.100.503 Little Horn
1
Removed in Repentance Adds a chance to fire a piercing tear that instantly kills any enemy that it touches.
Added in Repentance Adds a chance to fire a tear that summons Big Horn's hand to crush the first enemy it hits, instantly killing monsters or greatly damaging bosses.
Added in Afterbirth † Shade 5.100.468 Shade
1
Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers.
Added in Afterbirth † Tarot Cloth 5.100.451 Tarot Cloth
1
Drops a random card or rune. Removed in Repentance Doubles the effects of most cards and runes. Added in Repentance Doubles the effects of tarot cards.
Added in Afterbirth † Lil Delirium 5.100.519 Lil Delirium
1
Grants a familiar that transforms into another random familiar every 10 seconds.
Added in Repentance 2Spooky 5.100.554 2Spooky
1
Enemies near Isaac are afflicted with fear.
Added in Repentance Azazel's Rage 5.100.699 Azazel's Rage
1
Isaac builds rage every time a room is cleared. After four rooms, fires a large 15►Brimstone Brimstone laser when entering the next room.
Added in Repentance Blood Oath 5.100.569 Blood Oath
1
Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained.
Added in Repentance Brimstone Bombs 5.100.646 Brimstone Bombs
1
Gives Isaac +5 bombs and causes his bombs to fire 15►Brimstone Brimstone lasers in the cardinal directions upon exploding.
Added in Repentance False PHD 5.100.654 False PHD
1
Converts good pills into bad pills and identifies all pills. Bad pills now have secondary positive effects. Grants one Black Heart.
Added in Repentance Guppy's Eye 5.100.665 Guppy's Eye
1
Shows the contents of Chests, Sacks, and Fire Places before they're opened.
Added in Repentance Hungry Soul 5.100.684 Hungry Soul
1
Enemies have a chance to spawn ghosts on death, which chase and deal contact damage to enemies and explode after a short time.
Added in Repentance Lil Abaddon 5.100.679 Lil Abaddon
1
Spawns a familiar that charges a miniature 15►Maw of the Void Maw of the Void attack while Isaac shoots.
Added in Repentance Money = Power 5.100.109 Money = Power
1
Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.
Added in Repentance Purgatory 5.100.634 Purgatory
1
While in a room with enemies, spawns cracks on the ground. Walking over these cracks summons ghosts that launch themselves at enemies and explode.
Added in Repentance A Quarter 5.100.74 A Quarter
1
Gives Isaac 25 coins.
Added in Repentance Sanguine Bond 5.100.692 Sanguine Bond
1
Spawns a special set of spikes in the Devil Room. Taking damage from the spikes has a chance to grant a reward.
Added in Repentance Vengeful Spirit 5.100.702 Vengeful Spirit
1
After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots.
Added in Repentance Heartbreak 5.100.694 Heartbreak
0.5
Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts.
Added in Repentance Technology 5.100.68 Technology
0.2
Replaces tears with a piercing laser with unlimited range.
Full red heartFull red heart 2 Hearts Cost
Abaddon 5.100.230 Abaddon
1
Removed in Repentance+1.5 damage, +0.2 speed. Removes all Red Heart containers, grants six Black Hearts, and adds a chance to shoot fear tears.
Added in Repentance+1.5 damage, +0.2 speed. Grants two Black Hearts, converts all Red Heart containers into Black Hearts, and adds a chance to shoot fear tears.
Death's Touch 5.100.237 Death's Touch
1
+1.5 damage, -0.3 tears. Tears are replaced with large piercing scythes.
Incubus 5.100.360 Incubus
1
Spawns a demonic familiar that shoots tears identical to Isaac's in terms of damage, tears, and tear effects.
Judas' Shadow 5.100.311 Judas' Shadow
1
Adds an extra life; upon death, it respawns Isaac as Dark Judas Dark Judas with two Black Hearts.
Lord of the Pit 5.100.82 Lord of the Pit
1
Grants flight and +0.3 speed.
Maw of the Void 5.100.399 Maw of the Void
1
Charged by firing for 2.5 seconds and when released, creates a black ring around Isaac that rapidly deals damage. Removed in Repentance +1 damage, the ring can cause enemies to drop Black Hearts.
Mom's Knife 5.100.114 Mom's Knife
1
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Spirit of the Night 5.100.159 Spirit of the Night
1
Grants spectral tears and flight.
The Pact 5.100.80 The Pact
1
Grants two Removed in RepentanceSoul Hearts Added in RepentanceBlack Hearts, +0.5 damage, and +0.7 tears.
Added in Afterbirth † Dark Prince's Crown 5.100.442 Dark Prince's Crown
1
When at exactly one Red Heart, grants Removed in Repentance+0.75 Added in Repentance+2.0 tears, +1.5 range, +1 tear height, +0.2 shot speed.
Added in Afterbirth † Eye of Belial 5.100.462 Eye of Belial
1
Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
Added in Repentance Bloody Gust 5.100.695 Bloody Gust
1
When Isaac takes damage, he gains speed and tears for the rest of the floor.
Added in Repentance Bloody Lust 5.100.157 Bloody Lust
1
Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor.
Added in Repentance Brimstone 5.100.118 Brimstone
1
Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Added in Repentance Eye of the Occult 5.100.572 Eye of the Occult
1
Isaac's tears are now controlled mid-flight with tear controls. Also increases damage and range, but decreases shot speed.
Added in Repentance Lusty Blood 5.100.411 Lusty Blood
1
Isaac's damage increases for the current room each time he kills an enemy.
Added in Repentance Ocular Rift 5.100.606 Ocular Rift
1
Gives Isaac the chance to fire tears that create rifts where they land, which damage nearby enemies and pull in enemies, pickups, and tears/shots from all sources.
Added in Repentance Twisted Pair 5.100.698 Twisted Pair
1
Spawns two familiars that float on either side of Isaac and fire tears that use his tears, range, shot speed, and tear effects, and scale with damage.


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