Devil Room (Greed Mode Item Pool)

Item Pool
Normal/Hard	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest	Red Chest	Beggar
	Devil Beggar	Key Master	Bomb Bum	Planetarium	Crane Game	Rotten Beggar	Battery Bum	Old Chest	Wooden Chest	Mom's Chest	Baby Shop
Greed Greedier	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest

Items in this pool can be found in the Devil Room in Greed mode. All items can be bought for some number of Red Heart containers. If Isaac has no Red Heart containers, items can be bought for three Soul Hearts.

Activated Collectibles

Name	ID	Icon	Weight	Description
1 Heart Cost
Guppy's Head	5.100.145		1	Spawns 2-4 friendly Blue Flies that damage enemies.
Guppy's Paw	5.100.133		1	Upon use, converts one Heart Container into three Soul Hearts.
The Book of Belial	5.100.34		1	+2 damage for the current room. Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it. Increases the chance by 12.5%.
The Book of Sin	5.100.97		1	Spawns a random pickup, pill, card, or trinket.
The Necronomicon	5.100.35		1	Deals 40 damage to every enemy in the room.
Mega Blast	5.100.441		0.2	Upon use, Isaac fires a laser similar to the one used by Mega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active.
Gello	5.100.728		1	Spawns a demon familiar that's attached to Isaac and moves and fires in the direction Isaac shoots, using Isaac's damage, tears, range, shot speed, and special tear effects.
Monster Manual	5.100.123		1	Spawns a familiar from a specific selection for the current room. Spawns a familiar from a specific selection for the current floor.
Sulfur	5.100.556		1	Grants Brimstone for the current room.
Abyss	5.100.706		0.5	Destroys all items in the room and gives Isaac a unique locust familiar for each item destroyed.
Berserk!	5.100.704		0.5	Causes Isaac to go berserk for 5 seconds, greatly increasing his speed, tears, and damage, but restricting him to using a melee weapon instead of his tears. This item charges by dealing damage to enemies instead of clearing rooms.
Dark Arts	5.100.705		0.5	Makes Isaac invulnerable and intangible for one second. When the effect ends, all enemies Isaac ran through take damage and Isaac temporarily gains +1 damage for each one.
Lemegeton	5.100.712		0.5	Spawns the ghost of a random passive item, which orbits Isaac but can be destroyed. While the ghost is alive, Isaac gains that item's effects.
2 Hearts Cost
Satanic Bible	5.100.292		1	Gives one Black Heart. Replaces the boss room item on the current floor with a Devil deal.
The Nail	5.100.83		1	Gives one Soul Heart half a Black Heart. For the current room; +0.7 damage, -0.18 speed, allows Isaac to break rocks and damage enemies by walking over them.
Sacrificial Altar	5.100.536		1	Sacrifices up to 2 familiars and spawns an item from the Devil Room pool for each familiar sacrificed. Converts all friendly spiders and flies into coins.
Damocles	5.100.577		1	Spawns a sword above Isaac's head, which doubles all item pedestals. After Isaac takes damage, the sword can randomly fall at any point, instantly killing him.

Passive Collectibles

Name	ID	Icon	Weight	Description
1 Heart Cost
A Lump of Coal	5.100.132		1	The more distance tears travel, the more damage they will do.
Athame	5.100.408		1	When Isaac takes damage, a black ring briefly appears around him, dealing damage to all nearby enemies.
Betrayal	5.100.391		1	Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
Black Powder	5.100.420		1	Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.
Cambion Conception	5.100.412		1	After taking damage a certain amount of times, a permanent demonic familiar spawns.
Ceremonial Robes	5.100.216		1	Grants 3 Black Hearts, and +1 damage.
Cube of Meat	5.100.73		1	Spawns an orbital familiar that blocks enemy shots, dealing 105 damage per second. Collecting additional copies grants it the ability to shoot, then chase enemies, then increases the damage.
Dark Matter	5.100.259		1	+1 damage, adds a chance to shoot fear tears.
Dead Bird	5.100.117		1	After Isaac takes damage, spawns a flying familiar that chases enemies for the current room, dealing ~5 damage per second.
Dead Cat	5.100.81		1	Sets Isaac's Red Heart containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container.
Demon Baby	5.100.113		1	Spawns a familiar that follows Isaac and automatically fires at enemies in its reach.
Empty Vessel	5.100.409		1	Grants two Black Hearts. While Isaac has no red hearts, grants flight and periodically grants an invincibility shield for a few seconds.
Gimpy	5.100.225		1	Gives chance of spawning a Soul Heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Guppy's Collar	5.100.212		1	Grants a permanent 50% chance to respawn with 1/2 of a Red Heart after death.
Guppy's Hair Ball	5.100.187		1	Spawns a familiar that loosely follows behind Isaac, which blocks shots can be swung like a flail to damage enemies. Grows bigger by killing enemies.
Guppy's Tail	5.100.134		1	Room clear awards have a 1/3 chance of being replaced with a chest and a 1/3 chance being replaced with nothing.
Headless Baby	5.100.269		1	Spawns a familiar that follows Isaac, leaving blood creep on the ground.
Leech	5.100.270		1	Spawns a leech familiar that chases enemies, dealing ~3 damage per second. Heals a Half Red Heart whenever Leech kills an enemy.
Multidimensional Baby	5.100.431		1	Spawns a familiar that will follow Isaac's movements on a 2.5-second delay. Tears that pass through the baby will be doubled and increase in speed.
My Shadow	5.100.433		1	Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black friendly Charger that will attack enemies. The Charger will be killed if it is damaged too much.
Ouija Board	5.100.115		1	Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them.
Pentagram	5.100.51		1	+1 damage, increases Devil Room / Angel Room chance by 10%.
Rotten Baby	5.100.268		1	Spawns a familiar that spawns a Blue Fly when Isaac shoots. It can only have one Fly at a time.
Sacrificial Dagger	5.100.172		1	Spawns a dagger orbital familiar, dealing 225 damage per second and blocking enemy shots.
Sister Maggy	5.100.67		1	Spawns a familiar that follows Isaac around shooting normal tears.
The Mark	5.100.79		1	Grants one Soul Heart, +1 damage, and +0.2 speed.
Whore of Babylon	5.100.122		1	Grants +1.5 damage and +0.3 speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any Soul or Black Hearts.
Contract From Below	5.100.241		1	Doubles the number of most room clear awards, but reduces the overall chance of getting one by 1/3.
7 Seals	5.100.526		1	Spawns a random Harbinger familiar that changes every 10 seconds. Harbingers have different behaviors and spawn themed Locusts.
Death's List	5.100.530		1	Grants a pickup or stat upgrade if all enemies in a room are killed in the order they are marked.
Little Horn	5.100.503		1	Adds a chance to fire a piercing tear that instantly kills any enemy that it touches. Adds a chance to fire a tear that summons Big Horn's hand to crush the first enemy it hits, instantly killing monsters or greatly damaging bosses.
Shade	5.100.468		1	Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers.
Tarot Cloth	5.100.451		1	Drops a random card or rune. Doubles the effects of most cards and runes. Doubles the effects of tarot cards.
Lil Delirium	5.100.519		1	Grants a familiar that transforms into another random familiar every 10 seconds.
2Spooky	5.100.554		1	Enemies near Isaac are afflicted with fear.
Azazel's Rage	5.100.699		1	Isaac builds rage every time a room is cleared. After four rooms, fires a large Brimstone laser when entering the next room.
Blood Oath	5.100.569		1	Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained.
Brimstone Bombs	5.100.646		1	Gives Isaac +5 bombs and causes his bombs to fire Brimstone lasers in the cardinal directions upon exploding.
False PHD	5.100.654		1	Converts good pills into bad pills and identifies all pills. Bad pills now have secondary positive effects. Grants one Black Heart.
Guppy's Eye	5.100.665		1	Shows the contents of Chests, Sacks, and Fire Places before they're opened.
Hungry Soul	5.100.684		1	Enemies have a chance to spawn ghosts on death, which chase and deal contact damage to enemies and explode after a short time.
Lil Abaddon	5.100.679		1	Spawns a familiar that charges a miniature Maw of the Void attack while Isaac shoots.
Money = Power	5.100.109		1	Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.
Purgatory	5.100.634		1	While in a room with enemies, spawns cracks on the ground. Walking over these cracks summons ghosts that launch themselves at enemies and explode.
A Quarter	5.100.74		1	Gives Isaac 25 coins.
Sanguine Bond	5.100.692		1	Spawns a special set of spikes in the Devil Room. Taking damage from the spikes has a chance to grant a reward.
Vengeful Spirit	5.100.702		1	After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots.
Heartbreak	5.100.694		0.5	Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts.
Technology	5.100.68		0.2	Replaces tears with a piercing laser with unlimited range.
2 Hearts Cost
Abaddon	5.100.230		1	+1.5 damage, +0.2 speed. Removes all Red Heart containers, grants six Black Hearts, and adds a chance to shoot fear tears. +1.5 damage, +0.2 speed. Grants two Black Hearts, converts all Red Heart containers into Black Hearts, and adds a chance to shoot fear tears.
Death's Touch	5.100.237		1	+1.5 damage, -0.3 tears. Tears are replaced with large piercing scythes.
Incubus	5.100.360		1	Spawns a demonic familiar that shoots tears identical to Isaac's in terms of damage, tears, and tear effects.
Judas' Shadow	5.100.311		1	Adds an extra life; upon death, it respawns Isaac as Dark Judas with two Black Hearts.
Lord of the Pit	5.100.82		1	Grants flight and +0.3 speed.
Maw of the Void	5.100.399		1	Charged by firing for 2.5 seconds and when released, creates a black ring around Isaac that rapidly deals damage. +1 damage, the ring can cause enemies to drop Black Hearts.
Mom's Knife	5.100.114		1	Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Spirit of the Night	5.100.159		1	Grants spectral tears and flight.
The Pact	5.100.80		1	Grants two Soul Hearts Black Hearts, +0.5 damage, and +0.7 tears.
Dark Prince's Crown	5.100.442		1	When at exactly one Red Heart, grants +0.75 +2.0 tears, +1.5 range, +1 tear height, +0.2 shot speed.
Eye of Belial	5.100.462		1	Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
Bloody Gust	5.100.695		1	When Isaac takes damage, he gains speed and tears for the rest of the floor.
Bloody Lust	5.100.157		1	Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor.
Brimstone	5.100.118		1	Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Eye of the Occult	5.100.572		1	Isaac's tears are now controlled mid-flight with tear controls. Also increases damage and range, but decreases shot speed.
Lusty Blood	5.100.411		1	Isaac's damage increases for the current room each time he kills an enemy.
Ocular Rift	5.100.606		1	Gives Isaac the chance to fire tears that create rifts where they land, which damage nearby enemies and pull in enemies, pickups, and tears/shots from all sources.
Twisted Pair	5.100.698		1	Spawns two familiars that float on either side of Isaac and fire tears that use his tears, range, shot speed, and tear effects, and scale with damage.