Binding of Isaac: Rebirth Wiki
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(in Afterbirth † and Repentance)

Depression is a passive item added in The Binding of Isaac: Afterbirth †.

Effects[ | ]

  • Spawns a familiar that follows Isaac and leaves a trail of blue creep that damages enemies.
    • The creep deals 2 damage per tick or 6 damage per second to non-flying enemies.
  • If the cloud touches an enemy, it has a small chance to spawn a damaging Collectible Holy Light iconHoly Light beam onto the enemy.
    • The light beams deal 20 + Isaac's tear damage per tick and may strike an enemy up to 8 times.

Notes[ | ]

  • (in Repentance) Familiars that follow behind Isaac have a certain priority in how close their position is to him over other familiars, with Depression having the lowest priority at 6th and thus being farther from Isaac than familiars of different priorities.

Interactions[ | ]

  • Collectible BFFS! iconBFFS!: Increase cloud size but does not increase damage.

In-game Footage[ | ]

Trivia[ | ]

  • Depression is the emotional state of low mood and aversion to activity.
  • Depression is also a state of air currents which often result in cloudy and wet weather.

Gallery[ | ]


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