Binding of Isaac: Rebirth Wiki
Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Depression is a passive item added in The Binding of Isaac: Afterbirth †.


  • Spawns a familiar that follows Isaac and leaves a trail of blue creep that damages enemies.
    • The creep deals 2 damage per tick or 6 damage per second to non-flying enemies.
  • If the cloud touches an enemy, it has a small chance to spawn a damaging Holy Light beam onto the enemy.
    • The light beams deal 20 + Isaac's tear damage per tick and may strike an enemy up to 8 times.


  • BFFS! BFFS!: Increase cloud size but does not increase damage.

In-game Footage[]


  • Depression is the emotional state of low mood and aversion to activity.
  • Depression is also a state of air currents which often result in cloudy and wet weather.