The only weapons are bombs, which can harm Isaac if he's too close. The Remote Detonator works on the Dr. Fetus bombs that replace tears but does not prevent them from exploding after their fuse runs out.
Match Stick causes more bomb drops than other drops, such as hearts or chests. Since there is an unlimited supply of bombs, this can be a hindrance.
Since every run starts with Dr. Fetus, there is a virtually infinite supply of bombs. Anything that would normally use bombs can be done by attacking.
While Remote Detonator does not prevent bombs from detonating, using it will still cause them to explode prematurely.
Shot speed will cause the bombs to launch faster and farther.
The infinite bombs allows testing every wall for Secret Rooms and Super Secret Rooms. They also enable Isaac to escape rooms without clearing them by blowing open the doors.
Match Stick causes more bomb drops than other drops. Since regular bombs are more powerful than the Dr. Fetus bombs, this can be a boon. Dr. Fetus bombs can blast obstacles and walls, allowing placed bombs to be saved for combat.
Combined with the Remote Detonator, more control can be had over placed bombs and can lay traps with them. This is especially useful during boss fights with invincibility periods, such as Mom's Heart and Pin, as multiple placed bombs can be laid near the boss's spawning point and detonated all at once.
If a placed bomb is misplaced, they can be moved by walking into them. Placed bombs will not explode until Remote Detonator is used, so Isaacs can move out of the way of explosive damage.
It is possible to drop the Match Stick by using Ctrl(PC), R2(PS4), or ZR(3DS, Switch).