Binding of Isaac: Rebirth Wiki

Added in Afterbirth †

Death's List is an unlockable passive item added in The Binding of Isaac: Afterbirth † (Booster Pack #4).


  • Upon entering a room, a skull appears over an enemy's head.
    • Killing the marked enemy will cause the skull to move to a different enemy.
    • If all enemies in the room are cleared in the order they are marked, Isaac gains one of the following rewards at random:
    • If a non-marked enemy is killed, the skull will disappear and no bonuses will be granted for that room.


  • As long as the room is not cleared, Isaac can re-attempt a Death's List by leaving and re-entering.
  • The marked enemies are chosen in the same order in a given room, starting from the top-left corner with enemies that are vulnerable at their spawn time. If new enemies are spawned via Portals or on death, they are added to the end of the marked queue.
  • Added in Repentance Bishop Bishops can shield the marked enemy unless frozen or petrified beforehand.
  • A room with no enemies that instead requires Silver Button Silver Buttons to be pressed will also give a reward when cleared.
  • If a reward stat is chosen that is already at maximum, the sound effect and Isaac's thumbs up animation will play, but there is no other effect.
  • Bosses may also be marked.
  • If a Portal Portal is marked and despawns, no other enemy will be marked and the bonus is lost.
  • Enemies that are not spawned when the room is entered (such as Angels from bombed Angel Statues and enemies in Challenge Room Challenge Rooms, Greed Mode, and Boss Rush Boss Rush) will not be marked.
  • In the Mom Mom boss fight, each of Mom's body parts (eyes, foot, and hands) is considered as a different enemy, and Isaac has to kill the foot to get the bonus.
  • If the doors open automatically due to spending a long enough time in the room, any existing mark will disappear.
  • When playing as Tainted Jacob Tainted Jacob, Dark Esau can be marked by this item, and will be marked first if he is alive when you enter a room. This makes this item much less useful for Tainted Jacob.
  • Familiars, especially ones that passively or actively damage enemies of their own accord, may make killing enemies in order difficult, if not impossible.
  • Ace cards will kill the enemies in the correct order when possible.
  • If a Mr. Maw Mr. Maw is marked, killing either part of its body will not forfeit Death's List, as the remaining enemy of said Mr. Maw will still be marked.
  • This item has little to no effect in Greed Mode.


  • Door Stop Door Stop: If the player has failed Death's List but hasn't cleared the room, leaving and re-entering will reset the list.
  • Flush! Flush!: When a room is cleared with Flush!, a bonus will be awarded.


  • Added in Repentance Freezing attacks: Enemies that die by freezing do not disrupt the Death's List chain, though the shards caused by them breaking do.
  • Toxic Shock Toxic Shock: Not recommended. If multiple enemies are killed by Toxic Shock at the same time, the mark will disappear and no reward will be given, even if the enemy next in line to be marked was killed at the same time as the marked one.

In-game Footage[]




Bug Bug! Swarmer Swarmers will lose the mark and no reward will be granted.
Bug Bug! Removed in Repentance Multisegmented enemies such as Mr. Maw Mr. Maw and Pin Pin may be impossible to kill in the correct order, as each segment is considered a separate entity and are destroyed as the enemy on the whole dies.
Bug Bug! Other multisegmented enemies such as Larry Jr. Larry Jr. can have their segments destroyed in a proper order, but the skull marker is displayed on the wrong segment.