As long as the room is not cleared, Isaac can re-attempt a Death's List by leaving and re-entering.
The marked enemies are chosen in the same order in a given room, starting from the top-left corner with enemies that are vulnerable at their spawn time. If new enemies are spawned via Portals or on death, they are added to the end of the marked queue.
A room with no enemies that instead requires Silver Buttons to be pressed will also give a reward when cleared.
If a reward stat is chosen that is already at maximum, the sound effect and Isaac's thumbs up animation will play but there is no other effect.
Bosses may also be marked.
If a Portal is marked and despawns, no other enemy will be marked and the bonus is lost.
Freezing attacks: Enemies that die by freezing do not disrupt the Death's List chain, though the shards caused by them breaking do.
Toxic Shock: Not recommended. If multiple enemies are killed by Toxic Shock at the same time the mark will disappear and no reward will be given, even if the enemy next in line to be marked was killed at the same time as the marked one.
This page was last edited on 11 April 2021, at 22:46.
Content is available under CC BY-NC-SA 3.0 unless otherwise noted. Game content and materials are trademarks and copyrights of their respective publisher and its licensors. All rights reserved.
This site is a part of Fandom, Inc. and is not affiliated with the game publisher.