Binding of Isaac: Rebirth Wiki
Player Effects
Attributes Flight Temporary Buffs
Disambig.png This article is about the conditions that will kill Isaac. For the Death tarot card, see Cards and Runes. For the boss, see Death (Boss).

Death occurs when Isaac runs out of health. There are multiple ways to cause this.

As long as Isaac has health of any type (Red, Black, Soul, Bone or Rotten) left, they will not be killed, except if Isaac only has an Eternal Heart, though this is impossible.

Extra Lives[]

Typically, when Isaac dies, the game over screen appears; however, there are certain revival items, characters, and abilities that can resurrect Isaac after death. It is possible to obtain extra lives throughout a run by picking up various items. When Isaac dies, they will be revived in the previous room under the new life. Below is a list of these items and special death / extra life conditions that they bestow; take note that reviving as a different character than your current one gives any further Completion Marks to the new one, and the transformation may change stats if the new character has different base values. The order of revives is independent of order of item pickup, determined by the list below from highest to lowest placing:

Added in RepentanceSoul of Lazarus[]

When a Soul of Lazarus Soul of Lazarus is used, Isaac immediately dies and is revived in the same room at half a heart and given some invincibility time. Alternatively, if Isaac dies while holding the stone, it is automatically used upon taking the fatal hit, acting as another life (still has the same effect as if it was used manually). If used manually, it does not count as taking damage, so any positive or negative effects associated with taking damage are not triggered.


The 1up! 1up! grants Isaac an extra life. Upon death of the previous life, Isaac will be revived with full Red Heart containers. If he lacks any, he will revive with one Half Soul Heart. For characters that can't use Red hearts, they will respawn with 3 of their respective heart type (Soul Hearts for ??? ???, The Soul The Soul, Tainted ??? Tainted ???, Tainted Soul Tainted Soul, and Tainted Bethany Tainted Bethany, Black Hearts for Added in Repentance Dark Judas Dark Judas and Tainted Judas Tainted Judas, and Bone Hearts for The Forgotten The Forgotten).

Lazarus and Lazarus' Rags[]

While holding Lazarus' Rags Lazarus' Rags or playing as Lazarus Lazarus, the player will be revived as Lazarus Risen Lazarus Risen with 1 Red Heart container. Note that unlike other items, the Rags will revive Isaac on the spot with brief invincibility, as opposed to in the previous room.

Dead Cat[]

Dead Cat Dead Cat grants Isaac nine extra lives. Isaac will be revived with one Red Heart container unless playing as ??? ??? or Tainted Judas Tainted Judas, where he will be revived with one soul heart/black heart.

Added in RepentanceInner Child[]

Inner Child Inner Child grants Isaac another life. Upon death, Isaac respawns in the same room with half a heart left, a massive size down, and +0.2 speed. If Isaac has any heart containers, he will respawn with half a heart container filled; otherwise he will respawn with half a soul heart.

Guppy's Collar[]

Guppy's Collar Guppy's Collar grants Isaac a 50% chance to be revived with one Red Heart container half-filled. If he lacks any, he will be revived at half a Soul Heart instead. If the collar fails to activate, any other items after Guppy's Collar will be checked. The revives from Guppy's Collar are seeded per death.


The Ankh Ankh revives Isaac as ??? with 3 Soul Hearts.

Broken Ankh[]

When held, Broken Ankh Broken Ankh has a 2/9 chance to resurrect Isaac as ??? with 3 Soul Hearts. The revives from Broken Ankh are seeded per death.

Judas' Shadow[]

Judas' Shadow Judas' Shadow revives Isaac as Dark Judas Dark Judas with 2 Black Hearts.

Added in AfterbirthMissing Poster[]

While holding this trinket Isaac will be revived as The Lost The Lost and Missing Poster Missing Poster will be removed. If already playing as The Lost or Added in Repentance Tainted Lost Tainted Lost, Isaac will respawn as normal in the previous room.

Unlockable Achievements[]


Bug Bug! Quitting the game before the death animation is completed does not allow the player to continue the run, but does not add a death on the stats screen.