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Disambig.png This article is about the conditions that will kill Isaac. For the Death tarot card, see Cards and Runes. For the boss, see Death (Boss).

Death occurs when Isaac runs out of health. There are multiple ways to cause this.

As long as Isaac has health of any type (Red, Black, Soul, or Bone) left, they will not be killed, except if Isaac only has an Eternal Heart, though this is impossible.

Extra Lives[edit | edit source]

Typically, when Isaac dies, the game over screen appears; however, there are certain revival items, characters, and abilities that can resurrect Isaac after death. It is possible to obtain extra lives throughout a run by picking up various items. When Isaac dies, they will be revived in the previous room under the new life. Below is a list of these items and special death / extra life conditions that they bestow; take note that reviving as a different character than your current one gives any further Completion Marks to the new one, and the transformation may change stats if the new character has different base values. The order of revives is independent of order of item pickup, determined by the list below from highest to lowest placing:

1up![edit | edit source]

The 15►1up! 1up! grants Isaac an extra life. Upon death of the previous life, Isaac will be revived with full Red Heart containers. If he lacks any, he will revive with one Half Soul Heart. For characters that can't use Red hearts, they will respawn with 3 of their respective heart type (Soul Hearts for ???, The Soul, Tainted ???, and Tainted Bethany, Black Hearts for Added in RepentanceDark Judas and Tainted Judas, and Bone Hearts for The Forgotten).

Lazarus and Lazarus' Rags[edit | edit source]

While holding 15►Lazarus' Rags Lazarus' Rags, Isaac will be revived as Lazarus Risen with 1 Red Heart container. Note that unlike other items, the Rags will revive Isaac on the spot with brief invincibility, as opposed to in the previous room.

Dead Cat[edit | edit source]

15►Dead Cat Dead Cat grants Isaac nine extra lives. Isaac will be revived with one Red Heart container unless playing as ??? or Tainted Judas, where he will be revived with one soul heart/black heart.

Guppy's Collar[edit | edit source]

15►Guppy's Collar Guppy's Collar grants Isaac a 50% chance to be revived with one Red Heart container half-filled. If he lacks any, he will be revived at half a Soul Heart instead. If the collar fails to activate, any other items after Guppy's Collar will be checked. The revives from Guppy's Collar are seeded per death.

Ankh[edit | edit source]

The 15►Ankh Ankh revives Isaac as ??? with 3 Soul Hearts.

Broken Ankh[edit | edit source]

When held, Broken Ankh Broken Ankh has a 2/9 chance to resurrect Isaac as ??? with 3 Soul Hearts. The revives from Broken Ankh are seeded per death.

Judas' Shadow[edit | edit source]

15►Judas' Shadow Judas' Shadow revives Isaac as Dark Judas with 2 Black Hearts.

Missing Poster[edit | edit source]

Added in Afterbirth While holding this trinket Isaac will be revived as The Lost and Missing Poster Missing Poster will be removed. If already playing as The Lost, Isaac will respawn as normal in the previous room.

Inner Child (Unsorted)[edit | edit source]

Soul of Lazarus (Unsorted)[edit | edit source]

Unlockable Achievements[edit | edit source]

Bugs[edit | edit source]

Bug Bug! Quitting the game before the death animation is completed does not allow the player to continue the run, but does not add a death on the stats screen.

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