Binding of Isaac: Rebirth Wiki

Darkness Falls is challenge #4. Character Eve iconEve is the default character for this challenge, and she starts the challenge with Collectible Pentagram iconPentagram, Collectible Dead Bird iconDead Bird, Collectible Whore of Babylon iconWhore of Babylon, Collectible Razor Blade iconRazor Blade, Collectible Sacrificial Dagger iconSacrificial Dagger, and Collectible Dark Matter iconDark Matter. The goal is to defeat Boss Satan ingameSatan.

Difficulty[ | ]

This challenge focuses on a high risk, high reward style of play. When low on health, Eve can inflict more damage. As a result, the majority of the challenge will be spent in a near-death state.

Strategy[ | ]

  • Since the player is playing as Eve, Whore of Babylon will activate when having 1 Red Heart or less, rather than 1/2. Since she starts with 2 hearts, the Razor Blade can activate this effect immediately.
    • Because the Razor Blade inflicts damage, using it will also activate the Dead Bird.
  • Sacrificial Dagger and Dark Matter can be used together. The fear effect can drive enemies away, allowing Eve to chase and kill them with the dagger.
  • Making one Devil deal can permanently activate Whore of Babylon. However, this can put Eve in a very dangerous position with only one Red Heart. A Collectible Dark Bum iconDark Bum can produce (except in Repentance) Soul Hearts or (in Repentance) Black Hearts, which can allow Eve to maintain a buffer of health while maintaining the Whore of Babylon's effect.
  • Since all of the starting items are from the Devil Room pool, Eve has a much higher chance to get some of the stronger items such as Collectible Mom's Knife iconMom's Knife or Collectible Brimstone iconBrimstone. As such, opening the Devil RoomDevil Room as often as possible should be a priority.
    • Also, to prevent Angel Rooms from appearing later on in the run, it is advised to take the first Devil Deal encountered.

Notes[ | ]

  • (in Afterbirth † and Repentance) Killing Boss Delirium ingameDelirium will count as completing the challenge.

Unlockable Achievements[ | ]