Darkness Falls is challenge #4. Eve is the default character for this challenge, and she starts the challenge with Pentagram, Dead Bird, Whore of Babylon, Razor Blade, Sacrificial Dagger, and Dark Matter. The goal is to defeat Satan. This Challenge is unlocked once It Lives, Eve and the Sacrificial Dagger are unlocked.
This challenge focuses on a high risk, high reward style of play. When low on health, Eve can inflict more damage. As a result, the majority of the challenge will be spent in a near-death state.
- Since the player is playing as Eve, Whore of Babylon will activate when having 1 Red Heart or less, rather than 1/2. Since she starts with 2 hearts, the Razor Blade can activate this effect immediately.
- Because the Razor Blade inflicts damage, using it will also activate the Dead Bird.
- Sacrificial Dagger and Dark Matter can be used together. The fear effect can drive enemies away, allowing Eve to chase and kill them with the dagger.
- Making one Devil deal can permanently activate Whore of Babylon. However, this can put Eve in a very dangerous position with only one Red Heart. A Dark Bum can produce Soul Hearts, which can allow Eve to maintain a buffer of health while maintaining the Whore of Babylon's effect.
- Since all of the starting items are from the Devil Room pool, Eve has a much higher chance to get some of the stronger items such as Mom's Knife or Brimstone. As such, opening the Devil Room as often as possible should be a priority.
- Also, to prevent Angel Rooms from appearing later on in the run, it is advised to take the first Devil Deal encountered.
- Killing Delirium will count as completing the challenge.
- To unlock the challenge, the save file must have everything used by this challenge unlocked on top of defeating Mom's Heart 11 times. This means one must unlock Eve herself first, and then defeat both Satan and ??? as Eve to unlock both the Razor Blade and Sacrificial Dagger respectively.
|1.||Pitch Black||2.||High Brow||3.||Head Trauma||4.||Darkness Falls||5.||The Tank||6.||Solar System||7.||Suicide King|
|8.||Cat Got Your Tongue||9.||Demo Man||10.||Cursed!||11.||Glass Cannon||12.||When Life Gives You Lemons||13.||Beans!||14.||It's in the Cards|
|15.||Slow Roll||16.||Computer Savvy||17.||Waka Waka||18.||The Host||19.||The Family Man||20.||Purist|
|21.||XXXXXXXXL||22.||SPEED!||23.||Blue Bomber||24.||PAY TO PLAY||25.||Have a Heart||26.||I RULE!||27.||BRAINS!|
|28.||PRIDE DAY!||29.||Onan's Streak||30.||The Guardian|
|31.||Backasswards||32.||Aprils Fool||33.||Pokey Mans||34.||Ultra Hard||35.||Pong|
|36.||Scat Man||37.||Bloody Mary||38.||Baptism by Fire||39.||Isaac's Awakening||40.||Seeing Double||41.||Pica Run||42.||Hot Potato|
|43.||Cantripped!||44.||Red Redemption||45.||DELETE THIS|
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|