|Health||Damage||Tears||Range||Shot Speed||Speed||Luck||Hidden Attributes|
Damage refers to the amount of damage each tear deals to enemies, and is represented by a sword. As damage increases, the size of the tears increases as well. However, tear size is not always a valid indication of how much damage your tears will do, a good example of this is Tropicamide. Tears will grow and shrink when your damage changes, but tears of a certain size do not have a specific damage value, and two tears of the same size (in two different runs) are likely to have different damage values.
- Polyphemus is an example of an item that provides a very high Damage stat.
The formula for damage is:
- CharBaseDmg = The character's base damage multiplied by their multiplier,
- TotalDmgUps = the total of all regular damage ups collected (not including special exceptions or damage multipliers),
- FlatDmgUps = the total of all damage ups that are excluded from the above (for example, Curved Horn or Ipecac), and
- EffectiveDmg = the approximate damage that can be expected per tear, or per 'tick' when using Brimstone or Technology 2.
This formula makes most damage upgrades less potent the more that Isaac has. For example, a Pentagram on Isaac would make his total damage (1 * 1.2 + 1)^0.5 = 1.48 * 3.5 = 5.19. Another Pentagram increases this to 6.45 (a 1.26 increase instead of a 1.69 increase). The higher a character's base damage, the more effective damage ups will be for that character. Flat damage modifiers and special adjustments like Polyphemus or Sacred Heart happen after the main formula.
The character base damage is defined by a base number and a multiplier.
- Eve†: 0.75 • 3.50 = 2.625
- Jacob: 1.00 • 2.75 = 2.75
- Isaac, Magdalene, Samson, Lazarus, Eden, Lilith, The Lost, Apollyon, The Soul, Bethany: 1.00 • 3.50 = 3.50
- ???: 1.05 • 3.50 = 3.675
- Esau: 1.00 * 3.75 = 3.75
- Keeper, Cain, and Lazarus Risen: 1.20 • 3.50 = 4.20
- Judas: 1.35 • 3.50 = 4.725
- Azazel: 1.50 • 3.50 = 5.25
- The Forgotten: 1.50 • 3.50 = 5.25
- Dark Judas: 2 • 3.50 = 7.00
†: Whore of Babylon has the unique effect of increasing Eve's damage modifier from 0.75 to 1.00 when active. This does not apply to other characters, however.
Some items multiply damage rather than simply adding to it. Damage multipliers do not simply multiply the character's damage once; the damage stat is constantly recalculated and the damage multipliers are multiplied with the end result. This means that if a character starts with 3.50 damage and gets a 2x multiplier, their effective damage will be 3.5*2 = 7.00. If an item that grants +1 damage is picked up, the character's effective damage will be 3.5*(1*1.2+1)^0.5*2 = 3.5*(2.2)^0.5*2 = 3.5*1.48*2 = 10.38, and not 7.00 + 1.
Most damage multipliers stack; for example, Proptosis and Eve's Mascara both provide a 2x multiplier; picking up both will give a total multiplier of 4x. The exception to this is the 1.5x damage multipliers provided by Cricket's Head, Magic Mushroom, and the combination of Blood of the Martyr and The Book of Belial. These multipliers do not stack; for example, picking up both Cricket's Head and Magic Mushroom will result in an overall 1.5x multiplier rather than the expected 2.25x.
Consequently, the reverse formula to determine your damage bonuses from the displayed value is Multipliers is the product of all damage multipliers in effect.
Items that affect damage
|Razor Blade||5.100.126||Feel my pain||On use, takes one heart of health and grants +1.2 damage for the current room.||0|
|The Book of Belial||5.100.34||Temporary DMG up||+2 damage for the current room.
Guarantees a Devil Room or Angel Room will be open after beating a boss while holding it. Increases the chance by 12.5%.
|The Nail||5.100.83||Temporary demon form||Gives one Soul Heart half a Black Heart. For the current room; +0.7 damage, -0.18 speed, allows Isaac to break rocks and damage enemies by walking over them.||3|
|D8||5.100.406||Reroll stats||Re-rolls Isaac's damage, tears, range, and speed.||2|
|Dataminer||5.100.481||109||Displaces enemy sprites for the current room, randomly increases one stat and decreases another.||0|
|Potato Peeler||5.100.487||A pound of flesh||Removes a heart container, increases damage and range, and grants a Cube of Meat.||3|
|Void||5.100.477||Consume||Consumes all pedestal items in the room. Active items will have their effects added to Void, and passive items will grant stat upgrades.||4|
|Berserk!||5.100.704||Rip and tear||Causes Isaac to go berserk for 5 seconds, greatly increasing his speed, tears, and damage, but restricting him to using a melee weapon instead of his tears. This item charges by dealing damage to enemies instead of clearing rooms.||3|
|Dark Arts||5.100.705||One with the shadows||Makes Isaac invulnerable and intangible for one second. When the effect ends, all enemies Isaac ran through take damage and Isaac temporarily gains +1 damage for each one.||2|
|Golden Razor||5.100.555||Pain from gain||Spends five coins to increase Isaac's damage by 1.2 for the current room.||2|
|Mega Mush||5.100.625||I'm a big boy now!||Gigantifies Isaac for 30 seconds, increasing damage and range while lowering tears, granting invulnerability, and allowing Isaac to crush enemies and obstacles he walks on. The effect persists between rooms.||4|
|Sulfur||5.100.556||Temporary demon form||Grants Brimstone for the current room.||2|
|A Lump of Coal||5.100.132||My Xmas present||The more distance tears travel, the more damage they will do.||3|
|Abaddon||5.100.230||Evil + DMG up + fear shot||+1.5 damage, +0.2 speed. Removes all Red Heart containers, grants six Black Hearts, and adds a chance to shoot fear tears.
+1.5 damage, +0.2 speed. Grants two Black Hearts, converts all Red Heart containers into Black Hearts, and adds a chance to shoot fear tears.
|Blood Clot||5.100.254||DMG + range up||Tears fired from the left eye have +1 flat damage, +5 range, and +0.5 tear height.||2|
|Blood of the Martyr||5.100.7||DMG up||Increases damage by 1, and turns Isaac's tears into blood tears.||3|
|Bloody Lust||5.100.157||RAGE!||Increases Isaac's damage whenever he takes damage, up to six times. The bonus resets when entering a new floor.||3|
|Brimstone||5.100.118||Blood laser barrage||Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.||4|
|Capricorn||5.100.307||All stats up||Increases health, damage, speed, and range, lowers tear delay, and gives one coin, bomb, and key.||3|
|Cat-O-Nine-Tails||5.100.165||Shot speed + damage up||+1 damage, +0.23 shot speed.||3|
|Ceremonial Robes||5.100.216||DMG + evil up||Grants 3 Black Hearts, and +1 damage.||3|
|Champion Belt||5.100.208||DMG + challenge up||Increases damage, but also increases the chance of champion enemies appearing.||3|
|Chemical Peel||5.100.154||DMG up||Tears fired from the left eye have +2 flat damage.||1|
|Cricket's Head||5.100.4||DMG up||Increases damage by 0.5, and multiplies it by 1.5x.||4|
|Dark Matter||5.100.259||DMG up + fear shot||+1 damage, adds a chance to shoot fear tears.||3|
|Death's Touch||5.100.237||Piercing shots + DMG up||+1.5 damage, -0.3 tears. Tears are replaced with large piercing scythes.||3|
|Eve's Mascara||5.100.310||DMG up, tears + shot speed down||Doubles damage, halves tears stat, and greatly reduces shot speed.||1|
|Experimental Treatment||5.100.240||Some stats up, some stats down|| Randomly increases and decreases some of Isaac's stats.
Increases four random stats and decreases the other two.
|Godhead||5.100.331||God tears||Grants homing tears with a damaging halo. +0.5 damage, -0.3 tears, +1.2 range, -0.3 shot speed, +0.8 tear height.||4|
|Growth Hormones||5.100.70||Speed + DMG up||+1 damage, +0.4 speed, +0.2 speed.||3|
|Guillotine||5.100.206||DMG + tears up. An out-of-body experience!||Isaac's head is removed from his body and floats around him as an orbital. Gives +1 damage and grants -1 tear delay.||3|
|Ipecac||5.100.149||Explosive shots||Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth.||4|
|Iron Bar||5.100.201||DMG up + concussive tears||Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.||3|
|Jesus Juice||5.100.197||Damage + range up||+0.5 damage, +0.25 range, +0.5 tear height.||2|
|Magic Mushroom||5.100.12||All stats up!||Makes Isaac bigger. Adds one Red Heart container, +0.3 damage, x1.5 damage multiplier, +5.25 range, and +0.3 speed. Restores all health on pickup.||4|
|MEAT!||5.100.193||DMG + HP up||Grants one full Red Heart container, +0.3 damage.||2|
|Missing No.||5.100.258||Syntax error||Randomizes all passive items and stats upon pickup and at the start of each succeeding floor.||2|
|Odd Mushroom||5.100.121||HP + DMG up, speed down||Grants one empty Heart container, +0.3 damage, +0.25 range, +0.5 tear height, and -0.1 speed.||2|
|Odd Mushroom||5.100.120||Tears + speed up, DMG down||+1.7 tears, +0.3 speed, slightly reduces damage.||3|
|Pentagram||5.100.51||DMG up||+1 damage, increases Devil Room / Angel Room chance by 10%.||3|
|Polyphemus||5.100.169||Mega tears||Isaac fires huge tears that deal massive damage, but fire rate is greatly decreased. If a tear kills an enemy, it travels on with any leftover damage.||4|
|Proptosis||5.100.261||Short range mega tears||Tears start out massive with high damage, and then shrink down and become weaker over a short range.||4|
|Sacred Heart||5.100.182||Homing shots + DMG up||Grants homing tears, x2.3 damage multiplier, +1 flat damage, +4.125 range, +0.75 tear height, -0.4 tears, -0.25 shot speed, a red Heart Container and replenishes all Red Hearts.||4|
|SMB Super Fan||5.100.189||All stats up||+1 Red Heart container, +0.3 damage, +0.2 tears, +0.2 speed, +0.5 range, +1 tear height. Fully restores all red hearts.||3|
|Soy Milk||5.100.330||DMG down + tears way up||Tears are smaller and do much less damage, but fire in very rapid succession.||2|
|Steven||5.100.50||DMG up||Increases damage by 1.||3|
|Stigmata||5.100.138||DMG + HP up||Increases damage, and adds 1 heart container.||2|
|Synthoil||5.100.345||DMG + range up||+1 damage, +5.25 range, +0.5 tear height.||3|
|Technology 2||5.100.152||Extra laser||Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.||2|
|The Halo||5.100.101||All stats up||Grants one full Red Heart container, +0.3 damage, +0.2 tears, +0.25 range, +0.3 speed, and +0.5 tear height.||2|
|The Mark||5.100.79||DMG + speed up||Grants one Soul Heart, +1 damage, and +0.2 speed.||3|
|The Pact||5.100.80||DMG + tears up||Grants two Soul Hearts Black Hearts, +0.5 damage, and +0.7 tears.||3|
|The Small Rock||5.100.90||DMG up||Increases damage by 1, increases tears by 0.2, and decreases speed by 0.2.||3|
|Whore of Babylon||5.100.122||Curse up||Grants +1.5 damage and +0.3 speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any Soul or Black Hearts.||2|
|8 Inch Nails||5.100.359||Stick it to 'em!||+1.5 damage. Replaces Isaac's tears with nails, which have increased knockback.||3|
|Crown of Light||5.100.415||The untainted gain power||+2 soul hearts. While Isaac has no empty red hearts, grants 2x damage, +5.25 range, and -0.3 shot speed. Regardless of health, the crown deactivates for the current room when Isaac takes damage.||4|
|Dead Eye||5.100.373||Accuracy brings power!||Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.||3|
|Lusty Blood||5.100.411||Their blood brings rage!||Isaac's damage increases for the current room each time he kills an enemy.||3|
|Maw of the Void||5.100.399||Consume thy enemy!||Charged by firing for 2.5 seconds and when released, creates a black ring around Isaac that rapidly deals damage. +1 damage, the ring can cause enemies to drop Black Hearts.||4|
|Purity||5.100.407||Aura stat boost||Boosts one of Isaac's stats depending on the color of the aura around him. The aura disappears upon taking damage and reappears with a random color upon entering a new room. Red boosts damage, blue boosts tears, yellow boosts speed, and orange boosts range.||2|
|Adrenaline||5.100.493||Panic = power||Increases damage based on how many empty Red Heart containers Isaac has.||1|
|Bozo||5.100.513||Party time!||+0.1 flat damage, grants a Soul Heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.||2|
|Death's List||5.100.530||Just hope you're not next...||Grants a pickup or stat upgrade if all enemies in a room are killed in the order they are marked.||2|
|Dog Tooth||5.100.445||Bark at the moon!||+0.3 damage, +0.1 speed. Plays a howl or bark sound when entering a room with undiscovered Secret Rooms or Crawl Spaces.||1|
|Haemolacria||5.100.531||I'm seeing red...||Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.||2|
|Sulfuric Acid||5.100.463||Acid tears!||+0.3 damage. Adds a chance to fire acidic tears which can destroy obstacles.||2|
|Trisagion||5.100.533||Smite thy enemy||Damage down. Tears are replaced with piercing white blasts of light that can damage the same enemy multiple times.||2|
|Almond Milk||5.100.561||DMG down + tears up + you feel nutty||Quadruples fire rate, with x0.3 damage multiplier. Tears are given random worm trinket effects.||1|
|Binge Eater||5.100.664||All you can eat||+1 red heart container and fully heals Isaac. Item pedestals cycle between their normal items and food, and collecting food grants a temporary damage boost and permanent bonuses to 2 stats.||3|
|Blood Oath||5.100.569||Bleed me dry||Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained.||2|
|Dogma||5.100.633||Ascended||Grants flight, +0.1 speed, +2 damage, and the Holy Mantle effect. Grants enough health to have 6 full hearts, if possible. Automatically given to Isaac after defeating Dogma.||0|
|Eye of the Occult||5.100.572||DMG up + range up + controlled tears||Isaac's tears are now controlled mid-flight with tear controls. Also increases damage and range, but decreases shot speed.||3|
|Heartbreak||5.100.694||Eternal sorrow||Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts.||3|
|Immaculate Heart||5.100.573||Halo of tears||Adds one red heart container and fully restores health. x1.2 damage multiplier. Isaac will occasionally fire extra tears that orbit around him.||3|
|Red Stew||5.100.621||Full HP + temporary DMG up||Refills all heart containers. Grants an enormous damage boost that wears off over time.||0|
|Redemption||5.100.673||Deliver me from evil||Gives Isaac a soul heart and +1 damage if he goes into a Devil Room but doesn't take anything from it.||2|
|Sausage||5.100.669||All stats up||Adds a Red Heart container, and increases speed, damage, tears, range, shot speed, and luck.||3|
|Stapler||5.100.708||DMG up||+1 damage. Prevents Isaac from firing tears from one eye, like Cain.||3|
|Terra||5.100.592||Born to rock||Replaces tears with rocks that deal variable damage, have increased knockback, and can destroy obstacles.||3|
|Curved Horn||5.350.35||DMG up||Increases damage by 2.|
|Red Patch||5.350.40||Your rage grows||Grants a chance of increasing damage by 1.8 for the current room upon taking damage.|
|Samson's Lock||5.350.58||Your rage grows||1/15 chance to increase damage by 0.5 for the current room each time an enemy dies.|
|Black Feather||5.350.80||With darkness comes power||Increases Isaac's damage for possessing certain evil items.|
|Cracked Crown||5.350.92||Stat booster|| Decreases Isaac's tear delay by 20%, and improves the effectiveness of his other stat upgrades by ~33%.|
Improves the effectiveness of other stat upgrades by ~20%.
|Dim Bulb||5.350.101||I think it's broken||Provides a boost to all stats when Isaac's active item is completely uncharged.|
|Vibrant Bulb||5.350.100||It needs power||Provides a boost to all stats when Isaac's active item is fully charged.|
- In co-op, Rage Baby, Revenge Baby, and Belial Baby will occasionally briefly increase damage. Dark Baby will occasionally briefly increase all stats, including damage. Buddy Baby will occasionally briefly grant the Guillotine effect, which increases damage. Whore Baby will occasionally briefly grant the Whore of Babylon effect, which increases damage.
- III - The Empress activates the Whore of Babylon effect for the current room, which increases damage.
- XI - Strength activates the Magic Mushroom effect for the current room, which increases damage.
- XV - The Devil activates The Book of Belial effect for the current room, which increases damage.
- Black Rune consumes all pedestal items in the room and turns them into random stat upgrades. No effect on shop items.
- Huge Growth increases damage, range, and Isaac's size for the current room.
|The Binding of Isaac: Rebirth|
|Achievements||Attributes||Bosses||Cards and Runes||Challenges||Chapters|