The D4 is a special unlockable activated item.


  • Upon use, re-rolls each of Isaac's passive items into new ones.
    • Dlc na† indicator.png The new items will be drawn from the Treasure Room item pool.
      • Dlc a†nr indicator.png The game attempts to match the new item to the pool where the item it replaces was acquired but this is glitched, see the Bugs section.
      • Dlc r indicator.png New items are drawn from the pools the original items were from.
        • If health upgrade items are removed by a reroll the health they granted is subtracted.
          • Character Tainted Isaac icon.png Tainted Isaac can avoid this health subtraction by dropping health items for full inventory before rerolling.


  • Dlc nr indicator.png Items rerolled away from Isaac do not return to circulation and can't be encountered again.
    • Dlc r indicator.png Items rerolled away are returned to circulation and can be encountered again later in the run.
  • The D4 does not re-roll Dlc nr indicator.png Collectible Dead Cat icon.png Dead Cat, Dlc nr indicator.png Collectible Halo of Flies icon.png Halo of Flies, Collectible Key Piece 1 icon.png Key Piece 1, Collectible Key Piece 2 icon.png Key Piece 2, Collectible Missing No. icon.png Missing No., Collectible The Negative icon.png The Negative, Collectible The Polaroid icon.png The Polaroid, or Dlc a†nr indicator.png Trinket Tonsil icon.png Tonsil.
  • The D4 does not remove traits or abilities inherent to a character, i.e. Character Azazel icon.png Azazel's Brimstone-like attack, Character Lilith icon.png Lilith's Incubus or Character The Forgotten icon.png The Forgotten's Bone club.
  • Items that grant pickups (like Collectible Pyro icon.png Pyro or Collectible A Dollar icon.png A Dollar) do not remove their bonuses when rerolled.
  • The D4 does not remove gained hearts from health up items.
  • Dlc r indicator.png The D4 does not give hearts that would be otherwise gained from item pickups.
  • Dlc nr indicator.png If Isaac has a transformation, its effects will not be lost upon re-rolling.
    • Dlc r indicator.png Transformations are removed with the items being rerolled.
  • The D4 can grant items that have not yet been unlocked.
  • The items gained by the D4 count towards the collection page.
  • Dlc anr indicator.png If it is unlocked, Character The Lost icon.png The Lost starts with this item along with spectral tears and flight. Using it will reroll Collectible Holy Mantle icon.png Holy Mantle.
    • Dlc r indicator.png The Lost no longer starts with the D4. If used however, it will no longer reroll their Holy Mantle.
  • Dlc nr indicator.png Every Collectible Cube of Meat icon.png Cube of Meat produced using Dlc a† indicator.png Collectible Potato Peeler icon.png Potato Peeler count as an item for rerolling to the D4. Because health usually is not removed in rerolling items this is useful to increase the number of items at the expense of the item pool.
  • Multiple copies of the same item (as generated by Dlc a indicator.png Collectible Diplopia icon.png Diplopia, the Debug Console, or gathering them from multiple item pools (e.g. Collectible Steam Sale icon.png Steam Sale from both the Shop Icon.png Shop and Greed) will each be rerolled into a different item, Dlc nr indicator.png even though the duplicates are not present on the pause screen.
  • There is a small chance that D4 will not reroll every item: the game makes a number of attempts to reroll each item, but if they all fail to produce a new item that is available and applicable, the original remains unchanged.
  • Dlc r indicator.png If used while playing as Character Jacob and Esau icon.png Jacob and Esau, it will only reroll the items on the character that used it.


  • Dlc r indicator.png Collectible Book of Virtues icon.png Book of Virtues: Removes all of Isaac's wisps and gives him one random wisp for every two items rerolled. Book of Virtues will not be rerolled in the process.

In-game Footage


  • The image of the D4 that appears on activation is incorrect; it shows the numbers 9, 7, and 8 on the right face of the die, when it should depict numbers consistent with the left face (i.e. 1 at the top, 3 at the front, and 4 at the right).


Collectible Undefined icon.png Bug! Dlc na indicator.png Previously held items are not removed from the pause menu, which makes it difficult to determine which items Isaac currently has.
Collectible Undefined icon.png Bug! When D4 is used with a co-op baby present, the baby's sprite will turn into a glitched sprite of Isaac.
Collectible Undefined icon.png Bug! If Collectible Tech.5 icon.png Tech.5 is fired while D4 is used, the laser will appear to continue firing for the rest of the room.
Collectible Undefined icon.png Bug! Dlc a†nr indicator.png If Isaac rerolls Collectible Schoolbag icon.png Schoolbag, he will keep both active items, but if he picks up a new active item it will swap with the one currently selected and the other will disappear.
Collectible Undefined icon.png Bug! Dlc r indicator.png When Collectible Schoolbag icon.png Schoolbag is rerolled away while another active item is held along D4, the other active item will be dropped on a pedestal. Activating D4 after the other active item is dropped will then reroll D4 itself.
Collectible Undefined icon.png Bug! Dlc a†nr indicator.png The way the originating pools for items are tracked is bugged in two ways, making it possible for items to reroll into different pools.
  1. An item picked up is assigned the pool of the most recently generated item; usually this has correct results but a difference can be seen, for instance, by killing a boss, entering a Devil Deal that has items and collecting the boss reward after seeing the Devil items. The boss item will be rerolled to a Devil pool item with D4.
  2. Items that are rerolled are assigned the pool of the item with the highest item ID. This means one reroll with the D4 will probably go as expected, but further rerolls will be proliferated by items from the pool that had the highest ID before the first reroll.
Collectible Undefined icon.png Bug! Dlc r indicator.png If Isaac has the shield granted by Holy Card, he will lose it upon activating the D4.


PC HardIndicator.png F4BR 0P86 (Treasure Room adjacent to spawn)

PC Dlc a† indicator.png NormalIndicator.png DMM6 TWQV

PC Dlc a† indicator.png BothIndicator.png 30TN DBY4 (Treasure Room adjacent to spawn)

PS4 89EX S9KG (Treasure Room south of spawn)

Vita 7VC9 TRMS (Treasure Room adjacent to spawn)

Switch ZDA0 CMV4 (First Treasure Room)

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