Binding of Isaac: Rebirth Wiki
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D4 is an unlockable activated item.

Effect[ | ]

  • Upon use, re-rolls each of Isaac's passive items into new ones.
    • (in Rebirth and Afterbirth) The new items will be drawn from the Treasure Room item pool.
      • (in Afterbirth † and Repentance) The game attempts to match the new item to the pool where the item it replaces was acquired but this is glitched, see the Bugs section.
    • (in Repentance) If health upgrade items are removed by a reroll, the health they granted is subtracted.

Notes[ | ]

  • The D4 does not re-roll (except in Repentance)Collectible Dead Cat iconDead Cat, (except in Repentance)Collectible Halo of Flies iconHalo of Flies, Collectible Key Piece 1 iconKey Piece 1, Collectible Key Piece 2 iconKey Piece 2, Collectible Missing No. iconMissing No., Collectible The Negative iconThe Negative, Collectible The Polaroid iconThe Polaroid, or (in Afterbirth †)Collectible Tonsil iconTonsil.
  • The D4 does not remove traits or abilities inherent to a character, i.e. Character Azazel iconAzazel's Brimstone-like attack, Character Lilith iconLilith's Incubus or Character The Forgotten iconThe Forgotten's bone attack.
  • Items that grant pickups (like Collectible Pyro iconPyro or Collectible A Dollar iconA Dollar) do not remove their bonuses when rerolled.
  • The D4 can grant items that have not yet been unlocked.
  • The items gained by the D4 count towards the collection page.
  • Multiple copies of the same item (as generated by (except in Rebirth)Collectible Diplopia iconDiplopia, the Debug Console, or gathering them from multiple item pools (e.g. Collectible Steam Sale iconSteam Sale from both the ShopShop and GreedGreed) will each be rerolled into a different item, (except in Repentance) even though the duplicates are not present on the pause screen.
  • There is a small chance that D4 will not reroll every item: the game makes a number of attempts to reroll each item, but if they all fail to produce a new item that is available and applicable, the original remains unchanged.
  • Smelted/Swallowed trinkets (via (in Afterbirth † and Repentance)Collectible Marbles iconMarbles, (in Afterbirth † and Repentance)Collectible Smelter iconSmelter or Gulp!) will not be rerolled.
  • Will reroll Character Eden iconEden's starting item(s).
  • (except in Repentance) Items rerolled away from Isaac do not return to circulation and can't be encountered again.
    • (in Repentance) Items rerolled away are returned to circulation and can be encountered again later in the run.
  • (except in Repentance) D4 doesn't remove transformation progress, meaning that he will keep a transformation or gain one if he gets a transformation item while having two points of this transformation before rerolling.
    • (in Repentance) D4 removes transformation progress.
  • (except in Repentance) If it is unlocked, Character The Lost iconThe Lost starts with this item along with spectral tears and flight. Using it will reroll Collectible Holy Mantle iconHoly Mantle.
  • (in Repentance) The D4 does not give hearts that would be otherwise gained from item pickups, but will remove previously collected health upgrade items.
  • (in Repentance) If used while playing as Character Jacob and Esau iconJacob and Esau or Character Tainted Lazarus iconTainted Lazarus, it will only reroll the items on the character that used it.
  • (in Repentance) Character Tainted Isaac iconTainted Isaac can avoid having their health subtracted form re-rolling health up items by dropping health items for full inventory before rerolling.

Synergies[ | ]

  • (in Repentance)Collectible Abyss iconAbyss: Locusts created by Abyss are not rerolled.
  • (in Repentance)Collectible Book of Virtues iconBook of Virtues: Removes all of Isaac's wisps and gives him one random wisp for every two items rerolled. Book of Virtues will not be rerolled in the process.

Interactions[ | ]

  • (in Afterbirth and Afterbirth †)Collectible Car Battery iconCar Battery: Instantly re-rolls Isaac's items twice, which doubles the speed at which the item pools are exhausted and transformations are achieved.
  • (in Afterbirth †)Collectible Potato Peeler iconPotato Peeler: Every Collectible Cube of Meat iconCube of Meat produced counts as an item available to reroll. Because health usually is not removed when using the D4, this is useful to increase the number of items at the expense of the item pool.

In-game Footage[ | ]

Gallery[ | ]

Trivia[ | ]

  • The image of the D4 that appears on activation is incorrect; it shows the numbers 9, 7, and 8 on the right face of the die, when it should depict numbers consistent with the left face (i.e. 1 at the top, 3 at the front, and 4 at the right).

Bugs[ | ]

Bug Bug! (in Rebirth) Previously held items are not removed from the pause menu, which makes it difficult to determine which items Isaac currently has if they're too many to appear on the HUD.
Bug Bug! When D4 is used with a co-op baby present, the baby's sprite will turn into a glitched sprite of Isaac.
Bug Bug! (in Afterbirth †) If Isaac rerolls Collectible Schoolbag iconSchoolbag, he will keep both active items, but if he picks up a new active item it will swap with the one currently selected and the other will disappear.
Bug Bug! (in Repentance) When Collectible Schoolbag iconSchoolbag is rerolled away while another active item is held along D4, the other active item will be dropped on a pedestal. Activating D4 after the other active item is dropped will then reroll D4 itself.
Bug Bug! (in Afterbirth † and Repentance) An item picked up is assigned the pool of the most recently generated item; usually this has correct results but a difference can be seen, for instance, by killing a boss, entering a Devil Deal that has items and collecting the boss reward after seeing the Devil items. The boss item will be rerolled to a Devil pool item with D4. Items with no item pool (starting items, fixed drops etc.) will always use the item pool of the most recently generated item from an item pool as a result; if no items from item pools were encountered yet, the treasure room pool is used.
Bug Bug! (in Afterbirth †) Items that are rerolled are assigned the pool of the item with the highest item ID. This means one reroll with the D4 will probably go as expected, but further rerolls will be proliferated by items from the pool that had the highest ID before the first reroll.


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