Binding of Isaac: Rebirth Wiki

D4 is an unlockable activated item.


  • Upon use, re-rolls each of Isaac's passive items into new ones.
    • Removed in Afterbirth † The new items will be drawn from the Treasure Room item pool.
    • Added in Afterbirth † The game attempts to match the new item to the pool where the item it replaces was acquired but this is glitched, see the Bugs section.
      • Added in Repentance If health upgrade items are removed by a reroll the health they granted is subtracted.
        • Tainted Isaac Tainted Isaac can avoid this health subtraction by dropping health items for full inventory before rerolling.


  • Removed in Repentance Items rerolled away from Isaac do not return to circulation and can't be encountered again.
    • Added in Repentance Items rerolled away are returned to circulation and can be encountered again later in the run.
  • The D4 does not re-roll Removed in RepentanceDead Cat Dead Cat, Removed in RepentanceHalo of Flies Halo of Flies, Key Piece 1 Key Piece 1, Key Piece 2 Key Piece 2, Missing No. Missing No., The Negative The Negative, The Polaroid The Polaroid, or Added in Afterbirth † / Removed in RepentanceTonsil Tonsil.
  • The D4 does not remove traits or abilities inherent to a character, i.e. Azazel Azazel's Brimstone-like attack, Lilith Lilith's Incubus or The Forgotten The Forgotten's Bone club.
    • Starting items from Challenges will also not be rerolled
  • Items that grant pickups (like Pyro Pyro or A Dollar A Dollar) do not remove their bonuses when rerolled.
  • Removed in Repentance The D4 does not remove gained hearts from health up items.
  • Added in Repentance The D4 does not give hearts that would be otherwise gained from item pickups.
  • Removed in Repentance If Isaac has a transformation, its effects will not be lost upon re-rolling.
    • Added in Repentance Transformations are removed with the items being rerolled.
  • The D4 can grant items that have not yet been unlocked.
  • The items gained by the D4 count towards the collection page.
  • Added in Afterbirth / Removed in Repentance If it is unlocked, The Lost The Lost starts with this item along with spectral tears and flight. Using it will reroll Holy Mantle Holy Mantle.
    • Added in Repentance The Lost no longer starts with the D4. If used however, it will no longer reroll their Holy Mantle.
  • Removed in Repentance Every Cube of Meat Cube of Meat produced using Added in Afterbirth †Potato Peeler Potato Peeler count as an item for rerolling to the D4. Because health usually is not removed in rerolling items this is useful to increase the number of items at the expense of the item pool.
  • Multiple copies of the same item (as generated by Added in AfterbirthDiplopia Diplopia, the Debug Console, or gathering them from multiple item pools (e.g. Steam Sale Steam Sale from both the Shop Shop and Greed) will each be rerolled into a different item, Removed in Repentance even though the duplicates are not present on the pause screen.
  • There is a small chance that D4 will not reroll every item: the game makes a number of attempts to reroll each item, but if they all fail to produce a new item that is available and applicable, the original remains unchanged.
  • Added in Repentance If used while playing as Jacob and Esau Jacob and Esau or Tainted Lazarus Tainted Lazarus, it will only reroll the items on the character that used it.
  • Smelted/Swallowed trinkets (via Added in Afterbirth †Marbles Marbles, Added in Afterbirth †Smelter Smelter or Gulp!) will not be rerolled.


  • Added in RepentanceBook of Virtues Book of Virtues: Removes all of Isaac's wisps and gives him one random wisp for every two items rerolled. Book of Virtues will not be rerolled in the process.

In-game Footage[]


  • The image of the D4 that appears on activation is incorrect; it shows the numbers 9, 7, and 8 on the right face of the die, when it should depict numbers consistent with the left face (i.e. 1 at the top, 3 at the front, and 4 at the right).



Bug Bug! Removed in Afterbirth Previously held items are not removed from the pause menu, which makes it difficult to determine which items Isaac currently has.
Bug Bug! When D4 is used with a co-op baby present, the baby's sprite will turn into a glitched sprite of Isaac.
Bug Bug! If Tech.5 Tech.5 is fired while D4 is used, the laser will appear to continue firing for the rest of the room.
Bug Bug! Added in Afterbirth † / Removed in Repentance If Isaac rerolls Schoolbag Schoolbag, he will keep both active items, but if he picks up a new active item it will swap with the one currently selected and the other will disappear.
Bug Bug! Added in Repentance When Schoolbag Schoolbag is rerolled away while another active item is held along D4, the other active item will be dropped on a pedestal. Activating D4 after the other active item is dropped will then reroll D4 itself.
Bug Bug! Added in Afterbirth † An item picked up is assigned the pool of the most recently generated item; usually this has correct results but a difference can be seen, for instance, by killing a boss, entering a Devil Deal that has items and collecting the boss reward after seeing the Devil items. The boss item will be rerolled to a Devil pool item with D4. Items with no item pool (starting items, fixed drops etc.) will always use the item pool of the most recently generated item from an item pool as a result; if no items from item pools were encountered yet, the treasure room pool is used.
Bug Bug! Added in Afterbirth † / Removed in Repentance Items that are rerolled are assigned the pool of the item with the highest item ID. This means one reroll with the D4 will probably go as expected, but further rerolls will be proliferated by items from the pool that had the highest ID before the first reroll.


PC Hard mode only F4BR 0P86 (Treasure Room adjacent to spawn)

PC Added in Afterbirth † Normal mode only DMM6 TWQV

PC Added in Afterbirth † Normal and hard modes only 30TN DBY4 (Treasure Room adjacent to spawn)

PS4 89EX S9KG (Treasure Room south of spawn)

Vita 7VC9 TRMS (Treasure Room adjacent to spawn)

Switch ZDA0 CMV4 (First Treasure Room)