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Item icon
Item altar
"Reroll into something else"
Table dividing line 1.png
Item ID
Table dividing line 2.png
Recharge Time
6 rooms 6 rooms
Table dividing line 3.png
Collection Grid
Added in Afterbirth / Removed in Repentance(page 3, column 19, row 2)
Removed in Afterbirth(page 3, column 9, row 8)
Added in Repentance(page 3, column 20, row 2)
Unlock Method
The D4 Blow up 30 Arcade machines

The D4 is an special unlockable activated item.

Effect[edit | edit source]

  • Upon use, re-rolls each of Isaac's passive items into new ones.
    • Removed in Afterbirth † The new items will be drawn from the Treasure Room item pool.
    • Added in Afterbirth † / Removed in Repentance The game attempts to match the new item to the pool where the item it replaces was acquired but this is glitched, see the Bugs section.
      • If the item has no pool (gained as a starting item, fixed drops such as a 15►Blood Bag Blood Bag from a Blood Donation Machine or 15►The Virus The Virus from Lust, or gained via the debug console), the Treasure Room pool is used.
      • Added in Repentance New items are drawn from the pools the original items were from.

Notes[edit | edit source]

  • Removed in Repentance Items rerolled away from Isaac does not return to circulation and can't be encountered again.
  • Added in Repentance Items rerolled away are returned to circulation and can be encountered again later in the run.
  • The D4 does not re-roll 15►Dead Cat Dead Cat, 15►Halo of Flies Halo of Flies, 15►Key Piece 1 Key Piece 1, 15►Key Piece 2 Key Piece 2, 15►Missing No. Missing No., 15►The Polaroid The Polaroid, 15►The Negative The Negative, or Added in Afterbirth †Tonsil Tonsil.
  • The D4 does not remove Azazel's Brimstone laser.
  • Added in Afterbirth The D4 does not remove Lilith's starting Added in Afterbirth15►Incubus Incubus.
  • Items that grant pickups (like 15►Pyro Pyro or 15►A Dollar A Dollar) do not remove their bonuses when rerolled.
  • The D4 does not remove gained hearts from health up items.
  • Added in RepentanceThe D4 does not give hearts that would be otherwise gained from item pickups.
  • If Isaac has a transformation, its effects will not be lost upon re-rolling.
  • The D4 can grant items that have not yet been unlocked.
  • The items gained by the D4 count towards the collection page.
  • Added in Afterbirth / Removed in Repentance If it is unlocked, The Lost starts with this item along with spectral tears and flight. Using it will reroll 15►Holy Mantle Holy Mantle but will not reroll the spectral tears and the flight effect.
  • Added in Repentance The Lost no longer starts with the D4. If used however, it will no longer reroll his Holy Mantle.
  • Every 15►Cube of Meat Cube of Meat produced using Added in Afterbirth †15►Potato Peeler Potato Peeler count as an item for rerolling to the D4. Because health usually is not removed in rerolling items this is useful to increase the number of items at the expense of the item pool.
  • Multiple copies of the same item (as generated by Added in Afterbirth15►Diplopia Diplopia, cheating, or gathering them from multiple item pools (e.g. 15►Steam Sale Steam Sale from both the Shop and Greed), while not present in duplicate on the pause screen, will each be rerolled into a different item.
  • There is a small chance that D4 will not reroll every item: the game makes a number of attempts to reroll each item, but if they all fail to produce a new item that is available and applicable, the original remains unchanged

In-game Footage[edit | edit source]

Trivia[edit | edit source]

  • The image of the D4 that appears on activation is incorrect; it shows the numbers 9, 7, and 8 on the right face of the dice, when it should depict numbers consistent with the left face (i.e. 1 at the top, 3 at the front, and 4 at the right).

Gallery[edit | edit source]

Bugs[edit | edit source]

Bug Bug! Removed in AfterbirthPreviously held items are not removed from the pause menu, which makes it difficult to determine which items Isaac currently has.
Bug Bug! When D4 is used with a co-op baby present, the baby's sprite will turn into a glitched sprite of Isaac.
Bug Bug! If Tech.5 is fired while D4 is used, the laser will appear to continue firing for the rest of the room.
Bug Bug! If you reroll Added in Afterbirth †15►Schoolbag Schoolbag you will keep both active items but if you pick up a new active item it will swap with the one currently selected and the other will disappear.
Bug Bug! Added in Afterbirth †The way the originating pools for items are tracked is bugged in two ways, making it possible for items to reroll into different pools.
  1. An item picked up is assigned the pool of the most recently generated item; usually this has correct results but a difference can be seen, for instance, by killing a boss, entering a Devil Deal that has items and collecting the boss reward after seeing the Devil items. The boss item will be rerolled to a Devil pool item with D4.
  2. Items that are rerolled are assigned the pool of the item with the highest item ID. This means one reroll with the D4 will probably go as expected, but further rerolls will be proliferated by items from the pool that had the highest ID before the first reroll.

Seeds[edit | edit source]

PC Hard mode only F4BR 0P86 (Treasure Room adjacent to spawn)

PC Added in Afterbirth † Normal mode only DMM6 TWQV

PC Added in Afterbirth † Normal and hard modes only 30TN DBY4 (Treasure Room adjacent to spawn)

PS4 89EX S9KG (Treasure Room south of spawn)

Vita 7VC9 TRMS (Treasure Room adjacent to spawn)

Switch ZDA0 CMV4 (First Treasure Room)

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