Each time you reach a new floor, there is a small chance to be cursed, making the floor much more difficult to complete. The curse lasts only one floor. Some of the curses include:
| Curse | Description |
|---|---|
| Curse of the Blind | All items are replaced with a question mark and are not revealed until they are picked up. |
| Curse of Darkness | The floor is much, much darker, and is only barely lit by the player's natural aura. Occasionally rooms will be filled with swirling clouds of what could be fireflies or glowing motes of dust. Fire, explosions, and lasers will all cast light as normal, as will red creep. |
| Curse of the Lost | Removes the map from the HUD. Same effect as the Amnesia pill. |
| Curse of the Maze | Entering a new room (including teleporting) will occasionally take Isaac to the wrong room, with a screenshake and sound effect to indicate the jump. For example, entering the room on the right may instead take Isaac to the room on the left. Occasionally, discovered rooms can swap contents, without a screenshake or sound effect. Same effect as the  ??? pill.
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| Curse of the Unknown | Removes Isaac's health from the HUD, leaving the player unable to see how many hearts remain of any kind. Health will still be tracked as normal, including soul, black, and eternal hearts. When Isaac is down to half a heart, it is still marked by urine when entering a room. |
| Curse of the Labyrinth | Appears only on the first floor of a chapter. Makes the floor an XL floor, which contain two boss rooms, two items and counts as two floors. If this happens in either The Basement, The Cellar,  or the Burning Basement, both treasure room doors will be unlocked.
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| Curse of the Cursed | Changes normal doors into cursed doors. Found only in the "Cursed!" challenge or enabling the "CVRS ED" seed.
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Notes
- Curse of the Labyrinth can spawn the same boss in both rooms on one floor.
- Because Curse of the Labyrinth causes the two floors in a chapter to merge, it is possible to lower your devil room encounter chance in The Basement I, The Cellar I, or
Burning Basement I. - With the Curse of the Labyrinth, it is possible to teleport into the second boss room and completely skip the first.
- Curse of Darkness can be made somewhat easier by increasing the gamma setting in the game's options.
- Curse of the Unknown has no effect on The Lost, as he is, technically speaking, perpetually under its effect anyways.
- Curse of the Maze can be used to enter locked rooms without spending keys. It can also be used to enter curse rooms without spending health, arcades without spending coins, bedrooms without spending bombs, and secret rooms. Be warned, though, as it can teleport Isaac elsewhere when trying to enter a curse room, forcing him to take a full heart of damage to enter it (unless the player has some form of flight).
- When Curse of the Maze triggers, it takes into account the direction the room was exited. For example, if Isaac leaves a room by a door on the right wall, it can only take Isaac to a room which has a door on its left wall.
- Error: The given collectible ("XIX - The Sun") does not exist. and Error: The given collectible ("Rune of Ansuz") does not exist. do not counteract the effect of Curse of the Lost.
3DS Curse of the Lost can be countered, as the player has the ability to draw a map on the touch screen.
Gallery
- XL Teleport Skip.jpg
Teleported into the second boss room, skipping the first.
Trivia
- Of the three curses that returned from Wrath of the Lamb, (Labyrinth, the Lost, and Darkness), two of them- the Curse of the Lost and the Curse of Darkness- have different effects from Rebirth onwards. Namely, the Curse of the Lost's old effect (which simply made the floor as big as a floor that was one 'tier' higher, meaning a Basement as big as the Caves, or a Depths as big as the Womb) was dropped entirely, the Curse of Darkness's old effect (removal of the map) was given to the Curse of the Lost, and the Curse of Darkness was given the dark-floor effect. The Curse of the Labyrinth, meanwhile, remained untouched.
 The Binding of Isaac: Rebirth
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