Cursed Skull is a trinket.
Effects[ | ]
- If Isaac has less than one full
Red Heart after taking damage, he will be immediately teleported to a random room.
- The teleportation happens only at half a heart or less left, regardless of health type. Empty Bone Hearts are not counted as health even if they can absorb a hit.
The teleportation happens only at half a heart or less left, regardless of health type. Empty 
Interactions[ | ]
- Scapular: Provided Scapular can always trigger, grants effective immortality, as the soul heart is always given before the teleport takes place.
- +The Wafer: Grants true immortality, plus one hit on the soul heart, allowing the player to get hit once before teleporting.
- +
Notes[ | ]
- Does not affect The Lost, as being hit with Holy Mantle does not count as taking damage.
- It will affect Isaac with Spirit Shackles, teleporting the player out of the room and restoring the Holy Mantle charge.
- It is not recommended to have this item equipped during a boss fight as the boss's health will be restored to 100% if the player is teleported out of the room and returns, placing the player at a disadvantage unless they have acquired a Placenta.
It will affect Isaac with 
In-game Footage[ | ]
 Bones
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| Items |
| Trinkets |
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 The Binding of Isaac: Rebirth
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