Binding of Isaac: Rebirth Wiki

Cursed Skull is a trinket.


  • If Isaac has less than one full Red Heart Red Heart after taking damage, he will be immediately teleported to a random room.
    • Added in Afterbirth † The teleportation happens only at half a heart or less left, regardless of health type. Empty Bone Heart Bone Hearts are not counted as health even if they can absorb a hit.


  • Scapular Scapular: Provided Scapular can always trigger, grants effective immortality, as the soul heart is always given before the teleport takes place.
    • +The Wafer The Wafer: Grants true immortality, plus one hit on the soul heart, allowing the player to get hit once before teleporting.


  • Does not affect The Lost The Lost, as being hit with Holy Mantle Holy Mantle does not count as taking damage.
    • It will effect Isaac with Added in RepentanceSpirit Shackles Spirit Shackles, teleporting the player out of the room and restoring the Holy Mantle charge.
  • It is not recommended to have this item equipped during a boss fight as the boss's health will be restored to 100% if the player is teleported out of the room and returns, placing the player at a disadvantage unless they have acquired a Placenta Placenta.

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