Binding of Isaac: Rebirth Wiki
Character Magdalene appearance.png
Full red heartFull red heartFull red heartFull red heart
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Challenge Number
Available Rooms
Item Pool Treasure Room.png: yes          Item Pool Shop.png: yes
Boss Mom portrait.png
Credit Card Credit Card
Unlock Method

Cursed! Have 7 or more Red Heart Containers at one time

Cursed! is challenge #10. This challenge play as Magdalene Magdalene and start with Yum Heart Yum Heart, Raw Liver Raw Liver, The Compass The Compass, Treasure Map Treasure Map, Blue Map Blue Map, and Child's Heart Child's Heart. Every floor is cursed with Curse of the Cursed.png Curse of the Cursed. The goal is to defeat Mom Mom. This challenge is unlocked by unlocking Magdalene Magdalene.


  • Curse of the Cursed changes doors between normal rooms to cursed doors, like those found in Curse Room Curse Rooms. This will cause a lot of damage to Magdalene. Despite its name, Curse of the Cursed is not a regular curse, and cannot be encountered in regular gameplay, it is unique to this challenge.
  • Flight will NOT prevent damage from the curse room doors, despite how it works in normal curse rooms.


  • Unlike regular curse rooms, bombs can be used to blow open cursed doors.
  • A door that looks like a normal door that doesn't get replaced by curse door leads to a mini-boss fight.


  • Maggy will begin the challenge with two extra Red Heart containers from Raw Liver. Items and trinkets which collectively increase heart drops and provide other means of healing go a long way toward survival.
  • Use of teleportation and Bomb Bombs to move through Secret Room Secret Rooms, along with observing the mini-map, can significantly reduce the number of cursed doors entered.
  • It can be useful to balance procuring resources for floors ahead and moving through each floor by as short a route possible.
  • Added in RepentanceGiant Cell Giant Cell is a fantastic item to have for this challenge, as each pass through the curse doors generates one Minisaac, and all familiars will regenerate their health entirely upon every curse door contact, steadily increasing Magdalene's damage.
  • Placenta Placenta removes the difficulty of the challenge in exchange for time, as health can be regenerated simply by waiting. Charm of the Vampire Charm of the Vampire doesn't make the challenge quite as trivial, but also provides for helpful passive health regeneration.
  • Black Candle Black Candle will not prevent Curse of the Cursed, but it will prevent other curses from activating. This can be extremely helpful in cases where the Curse of the Lost would remove Maggy's mapping abilities.
  • Items that grant a large number of soul hearts, like Added in AfterbirthPJs PJs or Rosary Rosary can make it easier to obtain Devil Deals, where strongly helpful items may await.
  • See Holy Mantle Holy Mantle, Breath of Life Breath of Life, Isaac's Heart Isaac's Heart, Added in AfterbirthVentricle Razor Ventricle Razor, Added in RepentanceTooth and Nail Tooth and Nail, and Added in RepentanceStitches Stitches; six items which can be used to repeatedly avoid damage from cursed doors.
  • In most cases, the best idea is to head directly for the Boss Room on every floor to minimize damage taken. Avoid taking extensive routes towards Treasure Rooms if they branch out far because there's a low chance the item will be worth taking so much damage.
  • Getting Unicorn Stump Unicorn Stump early enough can be one of the best replacements for Yum Heart in terms of active items. Its one-room charge time allows the use of it after clearing a room to navigate the floor much more safely. Damage isn't entirely avoided from this method, however, as rooms without enemies can still be mixed in and not give it a charge.
  • Added in AfterbirthCar Battery Car Battery can make the challenge easier by doubling the effects of Yum Heart, as can The Battery The Battery, which allows for two charges, and 9 Volt 9 Volt by making Yum Heart charge faster.
  • Added in RepentanceFlat File Flat File also removes the spikes from every door in the challenge.
  • Bugs that apply to crossing curse room doors can be abused on the challenge to avoid damage.



  • Added in Afterbirth The "CVRS ED" seed turns normal doors into cursed doors, and is the only way to encounter this curse outside of the challenge.