Curse Room (Item Pool)

Item Pool
Normal/Hard	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest	Red Chest	Beggar
	Devil Beggar	Key Master	Bomb Bum	Planetarium	Crane Game	Rotten Beggar	Battery Bum	Old Chest	Wooden Chest	Mom's Chest	Baby Shop
Greed Greedier	Treasure Room	Shop	Library	Curse Room	Boss	Secret Room	Devil Room	Angel Room	Golden Chest

Items in this pool can spawn in the Curse Room. This does not apply to Red Chests.

Activated Collectibles

Name	ID	Icon	Weight	Description
Guppy's Head	5.100.145		1	Spawns 2-4 friendly Blue Flies that damage enemies.
Guppy's Paw	5.100.133		1	Upon use, converts one Heart Container into three Soul Hearts.
Sacrificial Altar	5.100.536		1	Sacrifices up to 2 familiars and spawns an item from the Devil Room pool for each familiar sacrificed. Converts all friendly spiders and flies into coins.
Plan C	5.100.475		0.2	Kills all enemies in the room, then kills Isaac three seconds later.
Magic Skin	5.100.642		1	Consumes one heart container or two soul hearts to spawn an item and give Isaac a broken heart container that can never be filled. If Magic Skin isn't being held after being used, it is very likely to replace any future items.
Red Key	5.100.580		1	Creates a new room adjacent to a viable wall, indicated by the outline of a door. These rooms have a chance to be various special rooms.

Passive Collectibles

Name	ID	Icon	Weight	Description
Black Candle	5.100.260		1	Prevents curses. Grants one Black Heart. Increases the chance for a Devil or Angel Room to appear.
Ceremonial Robes	5.100.216		1	Grants 3 Black Hearts, and +1 damage.
Contract From Below	5.100.241		1	Doubles the number of most room clear awards, but reduces the overall chance of getting one by 1/3.
Dead Cat	5.100.81		1	Sets Isaac's Red Heart containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container.
Gimpy	5.100.225		1	Gives chance of spawning a Soul Heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Goat Head	5.100.215		1	A Devil Room / Angel Room will always spawn after every boss fight, excluding the first floor and floors after Chapter 4.
Guppy's Collar	5.100.212		1	Grants a permanent 50% chance to respawn with 1/2 of a Red Heart after death.
Guppy's Tail	5.100.134		1	Room clear awards have a 1/3 chance of being replaced with a chest and a 1/3 chance being replaced with nothing.
The Mark	5.100.79		1	Grants one Soul Heart, +1 damage, and +0.2 speed.
The Pact	5.100.80		1	Grants two Soul Hearts Black Hearts, +0.5 damage, and +0.7 tears.
Pentagram	5.100.51		1	+1 damage, increases Devil Room / Angel Room chance by 10%.
Athame	5.100.408		1	When Isaac takes damage, a black ring briefly appears around him, dealing damage to all nearby enemies.
Curse of the Tower	5.100.371		1	Upon taking damage, spawns six Troll Bombs around the room, similar to the effect of XVI - The Tower.
Dark Prince's Crown	5.100.442		1	When at exactly one Red Heart, grants +0.75 +2.0 tears, +1.5 range, +1 tear height, +0.2 shot speed.
Euthanasia	5.100.496		1	Adds a chance to fire needles that instantly kill basic enemies and deal triple damage to bosses. If a needle kills an enemy, it bursts into more tears/needles.
Little Horn	5.100.503		1	Adds a chance to fire a piercing tear that instantly kills any enemy that it touches. Adds a chance to fire a tear that summons Big Horn's hand to crush the first enemy it hits, instantly killing monsters or greatly damaging bosses.
Mom's Razor	5.100.508		1	Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time.
Shade	5.100.468		1	Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers.
Tarot Cloth	5.100.451		1	Drops a random card or rune. Doubles the effects of most cards and runes. Doubles the effects of tarot cards.
Blood Oath	5.100.569		1	Stabs Isaac at the beginning of each floor, draining his red hearts. Increases damage and speed for the floor based on the amount drained.
Blood Puppy	5.100.565		1	Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful and drops red hearts after killing enemies, but will also try to hurt Isaac. Attacking it returns it to normal.
Sanguine Bond	5.100.692		1	Spawns a special set of spikes in the Devil Room. Taking damage from the spikes has a chance to grant a reward.
Vengeful Spirit	5.100.702		1	After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots.
False PHD	5.100.654		0.5	Converts good pills into bad pills and identifies all pills. Bad pills now have secondary positive effects. Grants one Black Heart.
Heartbreak	5.100.694		0.5	Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts.
Vanishing Twin	5.100.697		0.5	Spawns a familiar that becomes a clone of the floor's boss when entering the boss room. Defeating it drops an extra item.