Curse Room (Item Pool)

Items in this pool can spawn in the Curse Room. This does not apply to Red Chests.

Activated Collectibles[]

Name	ID	Weight	Description
Guppy's Head	5.100.145	1	Spawns 2-4 friendly Blue Flies that damage enemies.
Guppy's Paw	5.100.133	1	Converts one Red Heart Container into three Soul Hearts.
Sacrificial Altar	5.100.536	1	Sacrifices up to 2 familiars and spawns an item for each familiar sacrificed. Converts all friendly spiders and flies into coins.
Plan C	5.100.475	0.2	Kills all enemies in the room, then kills Isaac three seconds later.
Flip	5.100.711	1	Item pedestals have a second uninteractable "ghostly" item behind them. Activating will flip the real and ghostly items around. If playing as Tainted Lazarus, also flips between them and Dead Tainted Lazarus.
Magic Skin	5.100.642	1	Consumes one heart container or two Soul Hearts to spawn an item and give Isaac a broken heart container that can never be filled. If Magic Skin isn't being held after being used, it is very likely to replace any future items.
Razor Blade	5.100.126	1	Takes one Heart of health and grants +1.2 damage for the current room. Repeated uses in the same room only take half a heart.
Red Key	5.100.580	1	Creates a Red Room adjacent to a viable wall, indicated by the outline of a door. These rooms have a 10% chance to be a special room.

Passive Collectibles[]

Name	ID	Weight	Description
Black Candle	5.100.260	1	Prevents curses. Grants one Black Heart. Increases the chance for a Devil Room or Angel Room to appear.
Ceremonial Robes	5.100.216	1	Grants 3 Black Hearts and +1 damage.
Contract From Below	5.100.241	1	Doubles the number of most room clear awards, but reduces the overall chance of getting one by 1/3.
Dead Cat	5.100.81	1	Sets Isaac's Red Heart Containers to 1, but grants 9 extra lives. After dying, Isaac respawns with 1 Red Heart Container.
Gimpy	5.100.225	1	Gives chance of spawning a Soul Heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Goat Head	5.100.215	1	A Devil Room / Angel Room will always spawn after every boss fight, excluding the first floor and floors after Chapter 4.
Guppy's Collar	5.100.212	1	Grants a permanent 50% chance to respawn with 1/2 of a Red Heart after death.
Guppy's Tail	5.100.134	1	Room Clear Awards have a 1/3 chance of being replaced with a Chest and a 2/9 chance being replaced with nothing.
The Mark	5.100.79	1	Grants one Soul Heart, +1 damage, and +0.2 speed. Grants one Black Heart, +1 damage, and +0.2 speed.
The Pact	5.100.80	1	Grants two Soul Hearts, +0.5 damage, and +0.7 tears. Grants two Black Hearts, +0.5 damage, and +0.7 tears.
Pentagram	5.100.51	1	+1 damage, increases Devil Room / Angel Room chance by 10%.
Athame	5.100.408	1	When Isaac takes damage, a damaging black ring briefly appears around him. This ring can cause enemies to drop Black Hearts. After Isaac kills an enemy, adds a luck-based chance to spawn a damaging black ring around them.
Curse of the Tower	5.100.371	1	Upon taking damage, spawns six Troll Bombs around the room, similar to the effect of XVI - The Tower.
Dark Prince's Crown	5.100.442	1	When at exactly one Red Heart, +0.75 tears, +1.5 range, and +0.2 shot speed. When at exactly one Red Heart, +2 fire rate, +1.5 range, and +0.2 shot speed.
Euthanasia	5.100.496	1	Adds a luck-based chance to fire needles that instantly kill basic enemies and deal triple damage to bosses. If a needle kills an enemy, it bursts into more tears/needles.
Little Horn	5.100.503	1	Adds a chance to fire a piercing tear that instantly kills any enemy that it touches. Adds a chance to fire a tear that summons Big Horn's hand to crush the first enemy it hits, instantly killing monsters or greatly damaging bosses.
Shade	5.100.468	1	Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies. After dealing enough damage, it is absorbed by Isaac and spawns friendly Chargers.
Tarot Cloth	5.100.451	1	Drops a random card or rune. Doubles the effects of most cards and runes. Doubles the effects of tarot cards.
Mom's Razor	5.100.508	1	Spawns an orbiting razor that deals contact damage and inflicts bleeding on enemies, causing them to slowly take damage over time.
Blood Oath	5.100.569	1	Stabs Isaac at the beginning of each floor, draining his Red Hearts. Increases damage and speed for the floor based on the amount drained.
Blood Puppy	5.100.565	1	Spawns a familiar that chases enemies. After killing enough enemies, it becomes more powerful but will also try to hurt Isaac, it will also generate Half Red Hearts on enemy kills. It can increase in power one more stage after killing even more enemies. Dealing enough damage to it returns it to normal.
Guppy's Eye	5.100.665	1	Shows the contents of Chests, Fire Places, Grab Bags, and Shopkeepers before they're opened/destroyed.
Sanguine Bond	5.100.692	1	Spawns a special set of spikes in the Devil Room. Taking damage from the spikes has a chance to grant a reward.
Vengeful Spirit	5.100.702	1	After taking damage, spawns an orbital wisp that lasts for the entire floor, up to a maximum of six. They fire tears but do not block shots.
False PHD	5.100.654	0.5	Converts good pills into bad pills and identifies all pills. Bad pills now have secondary positive effects. Grants one Black Heart.
Heartbreak	5.100.694	0.5	Grants 3 broken hearts and +0.25 damage for every broken heart Isaac has. Every otherwise fatal hit will add 2 more until Isaac has nothing but broken hearts.
Vanishing Twin	5.100.697	0.5	Spawns a familiar that becomes a weaker clone of the floor's boss when entering the Boss Room. Defeating it drops an extra item.

The Binding of Isaac: Rebirth